Search Results - "MIRTTI, Tuomas"

Active surveillance versus initial surgery in the long-term management of Bosniak IIF–IV cystic renal masses by Luomala, Lassi, Rautiola, Juhana, Järvinen, Petrus, Mirtti, Tuomas, Nisén, Harry

“…There may be surgical overtreatment of complex cystic renal masses (CRM). Growing evidence supports active surveillance (AS) for the management for Bosniak…”
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Adiponectin receptor agonist AdipoRon ameliorates renal inflammation in diet-induced obese mice and endotoxin-treated human glomeruli ex vivo by Lindfors, Sonja, Polianskyte-Prause, Zydrune, Bouslama, Rim, Lehtonen, Eero, Mannerla, Miia, Nisen, Harry, Tienari, Jukka, Salmenkari, Hanne, Forsgård, Richard, Mirtti, Tuomas, Lehto, Markku, Groop, Per-Henrik, Lehtonen, Sanna

“…Aims/hypothesis Chronic low-grade inflammation with local upregulation of proinflammatory molecules plays a role in the progression of obesity-related renal…”
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Metformin increases glucose uptake and acts renoprotectively by reducing SHIP2 activity by Polianskyte-Prause, Zydrune, Tolvanen, Tuomas A., Lindfors, Sonja, Dumont, Vincent, Van, Mervi, Wang, Hong, Dash, Surjya N., Berg, Mika, Naams, Jette-Britt, Hautala, Laura C., Nisen, Harry, Mirtti, Tuomas, Groop, Per-Henrik, Wähälä, Kristiina, Tienari, Jukka, Lehtonen, Sanna

“…ABSTRACT Metformin, the first‐line drug to treat type 2 diabetes (T2D), inhibits mitochondrial glycerolphosphate dehydrogenase in the liver to suppress…”
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Prognostic and predictive value of ALDH1, SOX2 and SSEA-4 in bladder cancer by Blomqvist, Matias, Koskinen, Ilmari, Löyttyniemi, Eliisa, Mirtti, Tuomas, Boström, Peter J., Taimen, Pekka

“…Transurethral resection of bladder tumor (TUR-BT) and radical cystectomy (RC) are standard treatment options for bladder cancer (BC). Neoadjuvant chemotherapy…”
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Metabolomic Profiling of Extracellular Vesicles and Alternative Normalization Methods Reveal Enriched Metabolites and Strategies to Study Prostate Cancer-Related Changes by Puhka, Maija, Takatalo, Maarit, Nordberg, Maria-Elisa, Valkonen, Sami, Nandania, Jatin, Aatonen, Maria, Yliperttula, Marjo, Laitinen, Saara, Velagapudi, Vidya, Mirtti, Tuomas, Kallioniemi, Olli, Rannikko, Antti, Siljander, Pia R-M, Af Hällström, Taija Maria

“…Body fluids are a rich source of extracellular vesicles (EVs), which carry cargo derived from the secreting cells. So far, biomarkers for pathological…”
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FZD4 as a Mediator of ERG Oncogene―Induced WNT Signaling and Epithelial-to-Mesenchymal Transition in Human Prostate Cancer Cells by GUPTA, Santosh, ILJIN, Kristiina, SARA, Henri, MPINDI, John Patrick, MIRTTI, Tuomas, VAINIO, Paula, RANTALA, Juha, ALANEN, Kalle, NEES, Matthias, KALLIONIEMI, Olli

“…TMPRSS2-ERG and other gene fusions involving ETS factors and genes with strong promoter elements are common in prostate cancer. Although ERG activation has…”
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Validation of IMPROD biparametric MRI in men with clinically suspected prostate cancer: A prospective multi-institutional trial by Jambor, Ivan, Verho, Janne, Ettala, Otto, Knaapila, Juha, Taimen, Pekka, Syvänen, Kari T, Kiviniemi, Aida, Kähkönen, Esa, Perez, Ileana Montoya, Seppänen, Marjo, Rannikko, Antti, Oksanen, Outi, Riikonen, Jarno, Vimpeli, Sanna Mari, Kauko, Tommi, Merisaari, Harri, Kallajoki, Markku, Mirtti, Tuomas, Lamminen, Tarja, Saunavaara, Jani, Aronen, Hannu J, Boström, Peter J

“…Magnetic resonance imaging (MRI) combined with targeted biopsy (TB) is increasingly used in men with clinically suspected prostate cancer (PCa), but the long…”
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The tumor and plasma cytokine profiles of renal cell carcinoma patients by Lee, Moon Hee, Laajala, Essi, Kreutzman, Anna, Järvinen, Petrus, Nísen, Harry, Mirtti, Tuomas, Hollmén, Maija, Mustjoki, Satu

“…Renal cell carcinoma (RCC) accounts for 90% of all renal cancers and is considered highly immunogenic. Although many studies have reported the circulating…”
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T and NK cell abundance defines two distinct subgroups of renal cell carcinoma by Lee, Moon Hee, Järvinen, Petrus, Nísen, Harry, Brück, Oscar, Ilander, Mette, Uski, Ilona, Theodoropoulos, Jason, Kankainen, Matti, Mirtti, Tuomas, Mustjoki, Satu, Kreutzman, Anna

“…Renal cell carcinoma (RCC) is considered as an immunogenic cancer. Because not all patients respond to current immunotherapies, we aimed to investigate the…”
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Rac1 Nucleocytoplasmic Shuttling Drives Nuclear Shape Changes and Tumor Invasion by Navarro-Lérida, Inmaculada, Pellinen, Teijo, Sanchez, Susana A., Guadamillas, Marta C., Wang, Yinhai, Mirtti, Tuomas, Calvo, Enrique, Del Pozo, Miguel A.

“…Nuclear membrane microdomains are proposed to act as platforms for regulation of nuclear function, but little is known about the mechanisms controlling their…”
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Tumor-Associated Macrophages Provide Significant Prognostic Information in Urothelial Bladder Cancer by Boström, Minna M, Irjala, Heikki, Mirtti, Tuomas, Taimen, Pekka, Kauko, Tommi, Ålgars, Annika, Jalkanen, Sirpa, Boström, Peter J

“…Inflammation is an important feature of carcinogenesis. Tumor-associated macrophages (TAMs) can be associated with either poor or improved prognosis, depending…”
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OSCAR: Optimal subset cardinality regression using the L0-pseudonorm with applications to prognostic modelling of prostate cancer by Halkola, Anni S, Joki, Kaisa, Mirtti, Tuomas, Mäkelä, Marko M, Aittokallio, Tero, Laajala, Teemu D

“…In many real-world applications, such as those based on electronic health records, prognostic prediction of patient survival is based on heterogeneous sets of…”
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Protocol liver biopsy predicts graft survival after liver transplantation by Liukkonen, Ville H., Nordin, Arno J., Färkkilä, Martti A., Mirtti, Tuomas K., Arola, Johanna T., Åberg, Fredrik O.

“…Background The use of protocol liver biopsy to monitor liver allograft status remains controversial. There is limited data from modern transplantation…”
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Repeat multiparametric MRI in prostate cancer patients on active surveillance by Eineluoto, Juho T, Järvinen, Petrus, Kenttämies, Anu, Kilpeläinen, Tuomas P, Vasarainen, Hanna, Sandeman, Kevin, Erickson, Andrew, Mirtti, Tuomas, Rannikko, Antti

“…This study was conducted to describe the changes in repeat multiparametric MRI (mpMRI) occurring in prostate cancer (PCa) patients during active surveillance…”
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Differential Predictive Roles of A- and B-Type Nuclear Lamins in Prostate Cancer Progression by Saarinen, Irena, Mirtti, Tuomas, Seikkula, Heikki, Boström, Peter J, Taimen, Pekka

“…Prostate cancer (PCa) is the most common cancer among men in western countries. While active surveillance is increasingly utilized, the majority of patients…”
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Prostate MRI added to CAPRA, MSKCC and Partin cancer nomograms significantly enhances the prediction of adverse findings and biochemical recurrence after radical prostatectomy by Sandeman, Kevin, Eineluoto, Juho T, Pohjonen, Joona, Erickson, Andrew, Kilpeläinen, Tuomas P, Järvinen, Petrus, Santti, Henrikki, Petas, Anssi, Matikainen, Mika, Marjasuo, Suvi, Kenttämies, Anu, Mirtti, Tuomas, Rannikko, Antti, Kim, Isaac Yi

“…Background To determine the added value of preoperative prostate multiparametric MRI (mpMRI) supplementary to clinical variables and their role in predicting…”
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Stat3 Promotes Metastatic Progression of Prostate Cancer by Abdulghani, Junaid, Gu, Lei, Dagvadorj, Ayush, Lutz, Jacqueline, Leiby, Benjamin, Bonuccelli, Gloria, Lisanti, Michael P, Zellweger, Tobias, Alanen, Kalle, Mirtti, Tuomas, Visakorpi, Tapio, Bubendorf, Lukas, Nevalainen, Marja T

“…There are currently no effective therapies for metastatic prostate cancer because the molecular mechanisms that underlie the metastatic spread of primary…”
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Association of Angiopoietin-2 and Ki-67 Expression with Vascular Density and Sunitinib Response in Metastatic Renal Cell Carcinoma by Rautiola, Juhana, Lampinen, Anita, Mirtti, Tuomas, Ristimäki, Ari, Joensuu, Heikki, Bono, Petri, Saharinen, Pipsa

“…The Angiopoietin-2 (Ang2, Angpt2) growth factor is a context-dependent antagonist/agonist ligand of the endothelial Tie2 receptor tyrosine kinase and known to…”
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Immunological tumor status may predict response to neoadjuvant chemotherapy and outcome after radical cystectomy in bladder cancer by Tervahartiala, Minna, Taimen, Pekka, Mirtti, Tuomas, Koskinen, Ilmari, Ecke, Thorsten, Jalkanen, Sirpa, Boström, Peter J.

“…Bladder cancer (BC) is the ninth most common cancer worldwide. Radical cystectomy (RC) with neoadjuvant chemotherapy (NAC) is recommended for muscle-invasive…”
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Arachidonic Acid Pathway Members PLA2G7 , HPGD , EPHX2 , and CYP4F8 Identified as Putative Novel Therapeutic Targets in Prostate Cancer by Vainio, Paula, Gupta, Santosh, Ketola, Kirsi, Mirtti, Tuomas, Mpindi, John-Patrick, Kohonen, Pekka, Fey, Vidal, Perälä, Merja, Smit, Frank, Verhaegh, Gerald, Schalken, Jack, Alanen, Kalle A, Kallioniemi, Olli, Iljin, Kristiina

“…The arachidonic acid and prostaglandin pathway has been implicated in prostate carcinogenesis, but comprehensive studies of the individual members in this key…”
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