Search Results - "MIRA, Emilia"

Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibition by Caffarel, María M, Andradas, Clara, Mira, Emilia, Pérez-Gómez, Eduardo, Cerutti, Camilla, Moreno-Bueno, Gema, Flores, Juana M, García-Real, Isabel, Palacios, José, Mañes, Santos, Guzmán, Manuel, Sánchez, Cristina

“…ErbB2-positive breast cancer is characterized by highly aggressive phenotypes and reduced responsiveness to standard therapies. Although specific…”
Get full text

Notch activation stimulates migration of breast cancer cells and promotes tumor growth by Bolós, Victoria, Mira, Emilia, Martínez-Poveda, Beatriz, Luxán, Guillermo, Cañamero, Marta, Martínez-A, Carlos, Mañes, Santos, de la Pompa, José Luis

“…Dysregulated NOTCH receptor activity has been implicated in breast cancer but the mechanisms by which NOTCH contributes to transformation are not yet clear, as…”
Get full text

CX3CL1 Promotes Breast Cancer via Transactivation of the EGF Pathway by TARDAGUILA, Manuel, MIRA, Emilia, GARCIA-CABEZAS, Miguel A, FEIJOO, Anna M, QUINTELA-FANDINO, Miguel, AZCOITIA, Iñigo, LIRA, Sergio A, MANES, Santos

“…Chemokines are relevant molecules in shaping the tumor microenvironment, although their contributions to tumorigenesis are not fully understood. We studied the…”
Get full text

SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α by Mira, Emilia, Carmona-Rodríguez, Lorena, Pérez-Villamil, Beatriz, Casas, Josefina, Fernández-Aceñero, María Jesús, Martínez-Rey, Diego, Martín-González, Paula, Heras-Murillo, Ignacio, Paz-Cabezas, Mateo, Tardáguila, Manuel, Oury, Tim D., Martín-Puig, Silvia, Lacalle, Rosa Ana, Fabriás, Gemma, Díaz-Rubio, Eduardo, Mañes, Santos

“…One drawback of chemotherapy is poor drug delivery to tumor cells, due in part to hyperpermeability of the tumor vasculature. Extracellular superoxide…”
Get full text

SOD3 boosts T cell infiltration by normalizing the tumor endothelium and inducing laminin-α4 by Carmona-Rodríguez, Lorena, Martínez-Rey, Diego, Mira, Emilia, Mañes, Santos

“…The conversion of a non-T cell-inflamed into a T cell-inflamed tumor microenvironment (TME) is a key to sensitizing tumors to T-cell-based immunotherapies…”
Get full text

Extracellular Superoxide Dismutase, the Endothelial Basement Membrane, and the WNT Pathway: New Players in Vascular Normalization and Tumor Infiltration by T-Cells by Martínez-Rey, Diego, Carmona-Rodríguez, Lorena, Fernández-Aceñero, María Jesús, Mira, Emilia, Mañes, Santos

“…Tumor-infiltrating lymphocytes (TILs) are major players in the immune-mediated control of cancer and the response to immunotherapy. In primary cancers,…”
Get full text

SOD3 induces a HIF-2α-dependent program in endothelial cells that provides a selective signal for tumor infiltration by T cells by Carmona-Rodríguez, Lorena, Martínez-Rey, Diego, Fernández-Aceñero, Maria Jesús, González-Martín, Alicia, Paz-Cabezas, Mateo, Rodríguez-Rodríguez, Noe, Pérez-Villamil, Beatriz, Sáez, Maria Eugenia, Díaz-Rubio, Eduardo, Mira, Emilia, Mañes, Santos

“…BackgroundTumor-infiltrating lymphocytes (TILs), mainly CD8+ cytotoxic T lymphocytes (CTL), are linked to immune-mediated control of human cancers and response…”
Get full text

Immunomodulatory and anti-inflammatory activities of statins by Mira, Emilia, Mañes, Santos

“…The statins are a group of inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase that are used extensively in medical practice because of their ability…”
Get more information

Statins inhibit HIV-1 infection by down-regulating Rho activity by del Real, Gustavo, Jiménez-Baranda, Sonia, Mira, Emilia, Lacalle, Rosa Ana, Lucas, Pilar, Gómez-Moutón, Concepción, Alegret, Marta, Peña, Jose María, Rodríguez-Zapata, Manuel, Alvarez-Mon, Melchor, Martínez-A, Carlos, Mañes, Santos

“…Human immunodeficiency virus (HIV)-1 infectivity requires actin-dependent clustering of host lipid raft-associated receptors, a process that might be linked to…”
Get full text

Segregation of Leading-Edge and Uropod Components into Specific Lipid Rafts during T Cell Polarization by Gómez-Moutón, Concepción, Abad, Jose Luis, Mira, Emilia, Lacalle, Rosa Ana, Gallardo, Eduard, Jiménez-Baranda, Sonia, Illa, Isabel, Bernad, Antonio, Mañes, Santos, Carlos Martinez-A.

“…Redistribution of specialized molecules in migrating cells develops asymmetry between two opposite cell poles, the leading edge and the uropod. We show that…”
Get full text

Dynamic Redistribution of Raft Domains as an Organizing Platform for Signaling during Cell Chemotaxis by Gómez-Moutón, Concepción, Lacalle, Rosa Ana, Mira, Emilia, Jiménez-Baranda, Sonia, Barber, Domingo F., Carrera, Ana C., Carlos Martínez-A, Mañes, Santos

“…Spatially restricted activation of signaling molecules governs critical aspects of cell migration; the mechanism by which this is achieved nonetheless remains…”
Get full text

CCR5 in cancer immunotherapy: More than an "attractive" receptor for T cells by González-Martín, Alicia, Mira, Emilia, Mañes, Santos

“…Despite intensive study, the role of CCR5 in cancer remains elusive. We showed that CCR5 expression by both CD4+ and CD8+ T cells is necessary to boost…”
Get full text

CCR5 as a potential target in cancer therapy: inhibition or stimulation? by González-Martin, Alicia, Mira, Emilia, Mañes, Santos

“…Extensive evidence implicates CCR5 and its ligands in the biology of tumors, although there is considerable controversy regarding the role of this chemokine…”
Get more information

Forced expression of MMP9 rescues the loss of angiogenesis and abrogates metastasis of pancreatic tumors triggered by the absence of host SPARC by Arnold, Shanna, Mira, Emilia, Muneer, Sabeeha, Korpanty, Grzegorz, Beck, Adam W, Holloway, Shane E, Mañes, Santos, Brekken, Rolf A

“…Pancreatic adenocarcinoma is characterized by desmoplasia, local invasion, and metastasis. These features are regulated in part by MMP9 and SPARC. To explore…”
Get more information

Secreted MMP9 promotes angiogenesis more efficiently than constitutive active MMP9 bound to the tumor cell surface by Mira, Emilia, Lacalle, Rosa Ana, Buesa, José María, de Buitrago, Gonzalo González, Jiménez-Baranda, Sonia, Gómez-Moutón, Concepción, Martínez-A, Carlos, Mañes, Santos

“…Association of matrix metalloprotease 9 (MMP9) to the cell membrane is considered important in tumor growth and angiogenesis. To dissect this regulatory…”
Get full text

Membrane raft microdomains mediate lateral assemblies required for HIV-1 infection by Mañes, Santos, del Real, Gustavo, Lacalle, Rosa Ana, Lucas, Pilar, Gómez-Moutón, Concepción, Sánchez-Palomino, Sonsoles, Delgado, Rafael, Alcamí, José, Mira, Emilia, Martínez-A, Carlos

“…HIV‐1 infection triggers lateral membrane diffusion following interaction of the viral envelope with cell surface receptors. We show that these membrane…”
Get full text

Membrane raft microdomains mediate front-rear polarity in migrating cells by Mañes, Santos, Mira, Emilia, Gómez-Moutón, Concepción, Ana Lacalle, Rosa, Keller, Patrick, Pablo Labrador, Juan, Martínez-A, Carlos

“…The acquisition of spatial and functional asymmetry between the rear and the front of the cell is a necessary step for cell chemotaxis. Insulin‐like growth…”
Get full text

The hepatitis B virus X protein promotes tumor cell invasion by inducing membrane-type matrix metalloproteinase-1 and cyclooxygenase-2 expression by Lara-Pezzi, Enrique, Gómez-Gaviro, Maria Victoria, Gálvez, Beatriz G, Mira, Emilia, Iñiguez, Miguel A, Fresno, Manuel, Martínez-A, Carlos, Arroyo, Alicia G, López-Cabrera, Manuel

“…Hepatocellular carcinoma is strongly associated with chronic infection by the hepatitis B virus (HBV) and has poor prognosis due to intrahepatic metastasis…”
Get full text

CCR5 expression influences the progression of human breast cancer in a p53-dependent manner by Mañes, Santos, Mira, Emilia, Colomer, Ramón, Montero, Sagrario, Real, Luis M, Gómez-Moutón, Concepción, Jiménez-Baranda, Sonia, Garzón, Alfredo, Lacalle, Rosa Ana, Harshman, Keith, Ruíz, Agustín, Martínez-A, Carlos

“…Chemokines are implicated in tumor pathogenesis, although it is unclear whether they affect human cancer progression positively or negatively. We found that…”
Get full text

Concerted Activity of Tyrosine Phosphatase SHP-2 and Focal Adhesion Kinase in Regulation of Cell Motility by Mañes, Santos, Mira, Emilia, Gómez-Mouton, Concepción, Zhao, Zhizuang Joe, Lacalle, Rosa Ana, Martínez-A., Carlos

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text