Search Results - "MIO, Mitsunobu"

Editorial: The Challenge of New Therapeutic Approaches for Unmet Therapeutic Needs by Rosa, Arianna Carolina, Mio, Mitsunobu, Andreadou, Ioanna, Sumbayev, Vadim V.

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Intracranial self-stimulation and immobilization had different effects on neurite extension and the p38 MAPK pathway in PC12m3 cells by Gomita, Yutaka, Esumi, Satoru, Kitamura, Yoshihisa, Motoda, Hirotoshi, Sendo, Toshiaki, Sagara, Hidenori, Araki, Hiroaki, Mio, Mitsunobu, Inoue, Shigeki, Kano, Yoshio

“…In mammals, rewarding and aversive states are motivational drivers of behavioral expression. However, it is unclear whether such states affect neuronal…”
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Reaction of Acetaldehyde with 5-Aminolevulinic Acid via Dihydropyrazine Derivative by Suzuki, Toshinori, Yasuhara, Naoki, Ueda, Takashi, Inukai, Michiyo, Mio, Mitsunobu

“…When a solution of 5-aminolevulinic acid (ALA) was incubated with acetaldehyde at neutral pH, a product was generated. This product was identified as…”
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Acute Hyperglycemia and Hyperinsulinemia Enhance Adrenergic Vasoconstriction and Decrease Calcitonin Gene−Related Peptide−Containing Nerve−Mediated Vasodilation in Pithed Rats by Zamami, Yoshito, Takatori, Shingo, Yamawaki, Kousuke, Miyashita, Satoko, Mio, Mitsunobu, Kitamura, Yoshihisa, Kawasaki, Hiromu

“…Recent clinical studies have demonstrated that transient postprandial hyperglycemia and hyperinsulinemia may contribute to the development of hypertension…”
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The Akt-nitric oxide-cGMP pathway contributes to nerve growth factor-mediated neurite outgrowth in apolipoprotein E knockout mice by Hashikawa-Hobara, Narumi, Hashikawa, Naoya, Yutani, Chikao, Zamami, Yoshito, Jin, Xin, Takatori, Shingo, Mio, Mitsunobu, Kawasaki, Hiromu

“…Apolipoprotein E (apo)-deficient [apoE(-/-)] mice have peripheral sensory nerve defects and a reduced and delayed response to noxious thermal stimuli. However,…”
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Role of direct cytotoxic effects of NSAIDs in the induction of gastric lesions by Tomisato, Wataru, Tsutsumi, Shinji, Hoshino, Tatsuya, Hwang, Hyun-Jung, Mio, Mitsunobu, Tsuchiya, Tomofusa, Mizushima, Tohru

“…A major clinical problem encountered with the use of non-steroidal anti-inflammatory drugs (NSAIDs), is gastrointestinal complications. We previously reported…”
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Chronic Hyperinsulinemia Enhances Adrenergic Vasoconstriction and Decreases Calcitonin Gene-Related Peptide-Containing Nerve-Mediated Vasodilation in Pithed Rats by Takatori, Shingo, Zamami, Yoshito, Mio, Mitsunobu, Kurosaki, Yuji, Kawasaki, Hiromu

“…The present study investigated the influence of chronic hyperinsulinemia on vascular responsiveness induced by adrenergic nerves and calcitonin gene-related…”
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Pharmacodynamic Characterization of Nitric Oxide-Mediated Vasodilatory Activity in Isolated Perfused Rat Mesenteric Artery Bed by Inoue, Shinsuke, Aiba, Tetsuya, Masaoka, Yasuyuki, Shimizu, Keiko, Komori, Yukiko, Mio, Mitsunobu, Takatori, Shingo, Kawasaki, Hiromu, Kurosaki, Yuji

“…Vasodilation profiles following a short-term infusion of nitric oxide (NO), acetylcholine (ACh), and sodium nitroprusside (SNP) into an isolated perfused…”
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Effects of short-acting hypnotics on sleep latency in rats placed on grid suspended over water by Shinomiya, Kazuaki, Shigemoto, Yuki, Okuma, Chihiro, Mio, Mitsunobu, Kamei, Chiaki

“…The present study was performed to develop a new sleep disturbance model for evaluating hypnotic potencies by placing rats on a grid suspended over water up to…”
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Reaction of Acetaldehyde with 5-Aminolevulinic Acid via Dihydropyrazine Derivative by Toshinori Suzuki, Naoki Yasuhara, Takashi Ueda, Michiyo Inukai, Mitsunobu Mio

“…When a solution of 5-aminolevulinic acid (ALA) was incubated with acetaldehyde at neutral pH, a product was generated. This product was identified as…”
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Effects of second-generation histamine H1 receptor antagonists on the sleep-wakefulness cycle in rats by SHIGEMOTO, Yuki, SHINOMIYA, Kazuaki, MIO, Mitsunobu, AZUMA, Nobuhide, KAMEI, Chiaki

“…The present study was performed to examine the sedative effects of second-generation histamine H(1) receptor antagonist using power spectrum analysis in the…”
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Effects of three hypnotics on the sleep-wakefulness cycle in sleep-disturbed rats by SHINOMIYA, Kazuaki, SHIGEMOTO, Yuki, OMICHI, Junji, UTSU, Yoshiaki, MIO, Mitsunobu, KAMEI, Chiaki

“…New sleep disturbance model in rats is useful for estimating the characteristics of some hypnotics. The present study was undertaken to investigate the utility…”
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Development of Amygdaloid Kindling in Histidine Decarboxylase–deficient and Histamine H 1 Receptor–deficient Mice by Hirai, Tadashi, Okuma, Chihiro, Harada, Chie, Mio, Mitsunobu, Ohtsu, Hiroshi, Watanabe, Takeshi, Kamei, Chiaki

“…Purpose: This study attempted to clarify the role of histamine or histamine H 1 receptors in the development of amygdaloid kindling by using histidine…”
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Influence of Cyclophosphamide on L-Asparaginase-Induced Allergy in Animal Model by Nogami-Hara, Ai, Shimada, Akira, Mio, Mitsunobu

“…BACKGROUND: L-Asparaginase (L-ASP) is one of the essential drugs for acute lymphoblastic leukemia and lymphoma. Since L-ASP proteins used clinically are…”
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The role of histamine H1 receptors in late-phase reaction of allergic conjunctivitis by IZUSHI, Keiji, NAKAHARA, Hiroto, TAI, Nobuyuki, MIO, Mitsunobu, WATANABE, Takeshi, KAMEI, Chiaki

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L-Asparaginase-Induced Allergy in Mice: Effects of Concomitant Drugs and Anti-IgE Antibody by Nogami-Hara, Ai, Hara, Kazuki, Kawakami, Yasuhiro, Shimada, Akira, Mio, Mitsunobu

“…BACKGROUND: L-Asparaginase (L-Asp) derived from E. coliis one of the essential drugs for the treatment of acute lymphoblastic leukemia (ALL) and lymphoma…”
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Adrenergic stimulation‐released 5‐HT stored in adrenergic nerves inhibits CGRPergic nerve‐mediated vasodilatation in rat mesenteric resistance arteries by Fujii, Hirohito, Takatori, Shingo, Zamami, Yoshito, Hashikawa‐Hobara, Narumi, Miyake, Natsuki, Tangsucharit, Panot, Mio, Mitsunobu, Kawasaki, Hiromu

“…BACKGROUND AND PURPOSE 5‐HT is taken up by and stored in adrenergic nerves and periarterial nerve stimulation (PNS) releases 5‐HT to cause vasoconstriction in…”
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食後高血糖が血管反応性に及ぼす影響 by 座間味, 義人, 高取, 真吾, 岩谷, 有希子, 山脇, 康佑, 宮下, 智子, 藪前, 奈々, 高山, 房子, 見尾, 光庸, 川崎, 博己

“…「1. はじめに」 疫学的な研究において, 糖尿病患者の約40%が高血圧を合併していることから糖尿病と高血圧の関連性が示唆されている. 1-3) 糖尿病の病態には血糖値とインスリン分泌動態が関与していて, 正常な人では食後の血糖の上昇に対してすぐにインスリンが分泌され速やかに血糖値が下がるのに対して, 近年,…”
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Analysis of the mechanism of histamine release induced by substance P by Shibata, H, Mio, M, Tasaka, K

“…Substance P causes release of histamine from rat peritoneal mast cells; the structure-activity relationship shows that N-terminal residue is essential and the…”
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腸間膜動脈血管の内皮除去による血管弛緩反応増強機序 by 岩谷, 有希子, 沼, 裕美, 能木, 沙織, 高山, 房子, 見尾, 光庸, 川崎, 博己

“…「はじめに」血管内皮細胞(endothelial cell)は血液と血管壁の中間に位置する単層の細胞である. 従来, 血管内皮細胞は血液が直接血管壁に接着しないための障壁と考えられてきたが, 近年, 内腔側に様々な生理活性物質を生産することによって, 血栓形成や炎症の抑制, 血管緊張度の調節,…”
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