Search Results - "MIO, Kazuhiro"

Direct observation of 890 ns dynamics of carbon black and polybutadiene in rubber materials using diffracted x-ray blinking by Kuramochi, Masahiro, Kirkwood, Henry J., Koliyadu, Jayanath C. P., Letrun, Romain, de Wijn, Raphael, Kim, Chan, Masui, Tomomi, Mio, Kazuhiro, Arai, Tatsuya, Sekiguchi, Hiroshi, Kishimoto, Hiroyuki, Mancuso, Adrian P., Sato, Tokushi, Sasaki, Yuji C.

“…Dynamic behavior in soft matter physics, biology, and nanoscience frequently occurs on submicrosecond timescales. Diffracted x-ray blinking (DXB) is a unique…”
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Low Cholesterol Triggers Membrane Microdomain-dependent CD44 Shedding and Suppresses Tumor Cell Migration by Murai, Toshiyuki, Maruyama, Yuusuke, Mio, Kazuhiro, Nishiyama, Hidetoshi, Suga, Mitsuo, Sato, Chikara

“…CD44 is a cell surface adhesion molecule for hyaluronan and is implicated in tumor invasion and metastasis. Proteolytic cleavage of CD44 plays a critical role…”
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Time-Resolved X-ray Observation of Intracellular Crystallized Protein in Living Animal by Kuramochi, Masahiro, Sugawara, Ibuki, Shinkai, Yoichi, Mio, Kazuhiro, Sasaki, Yuji C

“…Understanding the cellular environment as molecular crowding that supports the structure-specific functional expression of biomolecules has recently attracted…”
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Tilting and rotational motions of silver halide crystal with diffracted X-ray blinking by Kuramochi, Masahiro, Omata, Hiroki, Ishihara, Masaki, Hanslin, Sander Ø., Mizumaki, Masaichiro, Kawamura, Naomi, Osawa, Hitoshi, Suzuki, Motohiro, Mio, Kazuhiro, Sekiguchi, Hiroshi, Sasaki, Yuji C.

“…The dynamic properties of crystalline materials are important for understanding their local environment or individual single-grain motions. A new time-resolved…”
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Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains by Ogura, Toshihiko, Tong, Kit I, Mio, Kazuhiro, Maruyama, Yuusuke, Kurokawa, Hirofumi, Sato, Chikara, Yamamoto, Masayuki

“…Keap1 is a substrate adaptor of a Cullin 3-based E3 ubiquitin ligase complex that recognizes Nrf2, and also acts as a cellular sensor for xenobiotics and…”
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Expression of Ice-Binding Proteins in Caenorhabditis elegans Improves the Survival Rate upon Cold Shock and during Freezing by Kuramochi, Masahiro, Takanashi, Chiaki, Yamauchi, Akari, Doi, Motomichi, Mio, Kazuhiro, Tsuda, Sakae, Sasaki, Yuji C.

“…Ice-binding proteins (IBPs) are capable of binding ice crystals and inhibiting their growth at freezing temperatures. IBPs are also thought to stabilize the…”
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Molecular Dynamics Mappings of the CCT/TRiC Complex-Mediated Protein Folding Cycle Using Diffracted X-ray Tracking by Araki, Kazutaka, Watanabe-Nakayama, Takahiro, Sasaki, Daisuke, Sasaki, Yuji C., Mio, Kazuhiro

“…The CCT/TRiC complex is a type II chaperonin that undergoes ATP-driven conformational changes during its functional cycle. Structural studies have provided…”
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X-ray-based living-cell motion analysis of individual serotonin receptors by Mio, Kazuhiro, Ishihara, Masaki, Fujimura, Shoko, Sasaki, Daisuke, Nozawa, Shunsuke, Ichiyanagi, Kohei, Fukaya, Ryo, Adachi, Shin-ichi, Kuramochi, Masahiro, Sekiguchi, Hiroshi, Kubo, Tai, Sasaki, Yuji C.

“…G protein-coupled receptors (GPCRs) are seven-transmembrane proteins, which transmit extracellular signals inside cells via activating G proteins. GPCRs are…”
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Real-time tilting and twisting motions of ligand-bound states of α7 nicotinic acetylcholine receptor by Yang, Yue, Arai, Tatsuya, Sasaki, Daisuke, Kuramochi, Masahiro, Inagaki, Hidetoshi, Ohashi, Sumiko, Sekiguchi, Hiroshi, Mio, Kazuhiro, Kubo, Tai, Sasaki, Yuji C.

“…The α7 nicotinic acetylcholine receptor is a member of the nicotinic acetylcholine receptor family and is composed of five α7 subunits arranged symmetrically…”
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Living-Cell Diffracted X-ray Tracking Analysis Confirmed Internal Salt Bridge Is Critical for Ligand-Induced Twisting Motion of Serotonin Receptors by Mio, Kazuhiro, Fujimura, Shoko, Ishihara, Masaki, Kuramochi, Masahiro, Sekiguchi, Hiroshi, Kubo, Tai, Sasaki, Yuji C.

“…Serotonin receptors play important roles in neuronal excitation, emotion, platelet aggregation, and vasoconstriction. The serotonin receptor subtype 2A…”
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Observation of molecular motions in polymer thin films by laboratory grazing incidence diffracted X-ray blinking by Inamasu, Rena, Yamaguchi, Hiroki, Arai, Tatsuya, Chang, Jaewon, Kuramochi, Masahiro, Mio, Kazuhiro, Sasaki, Yuji C.

“…Research on polymer surfaces has shown that the mobilities of polymer chains, which affect the aggregation state and thus the physical properties of the…”
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Cutting Edge: Class II-like Structural Features and Strong Receptor Binding of the Nonclassical HLA-G2 Isoform Homodimer by Kuroki, Kimiko, Mio, Kazuhiro, Takahashi, Ami, Matsubara, Haruki, Kasai, Yoshiyuki, Manaka, Sachie, Kikkawa, Masahide, Hamada, Daizo, Sato, Chikara, Maenaka, Katsumi

“…HLA-G is a natural tolerogenic molecule and has the following unique features: seven isoforms (HLA-G1 to HLA-G7), formation of disulfide-linked homodimers, and…”
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Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound by Kiyonaka, Shigeki, Kato, Kenta, Nishida, Motohiro, Mio, Kazuhiro, Numaga, Takuro, Sawaguchi, Yuichi, Yoshida, Takashi, Wakamori, Minoru, Mori, Emiko, Numata, Tomohiro, Ishii, Masakazu, Takemoto, Hiroki, Ojida, Akio, Watanabe, Kenta, Uemura, Aya, Kurose, Hitoshi, Morii, Takashi, Kobayashi, Tsutomu, Sato, Yoji, Sato, Chikara, Hamachi, Itaru, Mori, Yasuo

“…Canonical transient receptor potential (TRPC) channels control influxes of Ca²⁺ and other cations that induce diverse cellular processes upon stimulation of…”
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A mutation to a fish ice-binding protein synthesized in transgenic Caenorhabditis elegans modulates its cold tolerance by Kuramochi, Masahiro, Zhu, Shumiao, Takanashi, Chiaki, Yang, Yue, Arai, Tatsuya, Shinkai, Yoichi, Doi, Motomichi, Mio, Kazuhiro, Tsuda, Sakae, Sasaki, Yuji C

“…A cryoprotectant known as ice-binding protein (IBP) is thought to facilitate the cold survival of plants, insects, and fungi. Here, we prepared a genetically…”
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Diffracted X-ray Tracking Method for Measuring Intramolecular Dynamics of Membrane Proteins by Fujimura, Shoko, Mio, Kazuhiro, Ohkubo, Tatsunari, Arai, Tatsuya, Kuramochi, Masahiro, Sekiguchi, Hiroshi, Sasaki, Yuji C

“…Membrane proteins change their conformations in response to chemical and physical stimuli and transmit extracellular signals inside cells. Several approaches…”
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Diffracted X-ray blinking measurements of interleukin 15 receptors in the inner/outer membrane of living NK cells by Chang, Jaewon, Baek, Yonugseok, Lee, Injee, Sekiguchi, Hiroshi, Ichiyanagi, Kouhei, Mio, Kazuhiro, Nozawa, Shunsuke, Fukaya, Ryo, Adachi, Shin-ichi, Kuramochi, Masahiro, Sasaki, Yuji C.

“…Interleukin 15 receptor (IL-15R) is a transmembrane signalling protein consisting of 3 subsets: α, β (IL-15Rβ), and γ (γc). IL-2 and IL-15 share the signalling…”
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The Blinking of Small-Angle X-ray Scattering Reveals the Degradation Process of Protein Crystals at Microsecond Timescale by Arai, Tatsuya, Mio, Kazuhiro, Onoda, Hiroki, Chavas, Leonard M G, Umena, Yasufumi, Sasaki, Yuji C

“…X-ray crystallography has revolutionized our understanding of biological macromolecules by elucidating their three-dimensional structures. However, the use of…”
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Characterization of the multimeric structure of poly(A)-binding protein on a poly(A) tail by Sawazaki, Ryoichi, Imai, Shunsuke, Yokogawa, Mariko, Hosoda, Nao, Hoshino, Shin-ichi, Mio, Muneyo, Mio, Kazuhiro, Shimada, Ichio, Osawa, Masanori

“…Eukaryotic mature mRNAs possess a poly adenylate tail (poly(A)), to which multiple molecules of poly(A)-binding protein C1 (PABPC1) bind. PABPC1 regulates…”
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Visualizing Intramolecular Dynamics of Membrane Proteins by Ohkubo, Tatsunari, Shiina, Takaaki, Kawaguchi, Kayoko, Sasaki, Daisuke, Inamasu, Rena, Yang, Yue, Li, Zhuoqi, Taninaka, Keizaburo, Sakaguchi, Masaki, Fujimura, Shoko, Sekiguchi, Hiroshi, Kuramochi, Masahiro, Arai, Tatsuya, Tsuda, Sakae, Sasaki, Yuji C, Mio, Kazuhiro

“…Membrane proteins play important roles in biological functions, with accompanying allosteric structure changes. Understanding intramolecular dynamics helps…”
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Atmospheric scanning electron microscope observes cells and tissues in open medium through silicon nitride film by Nishiyama, Hidetoshi, Suga, Mitsuo, Ogura, Toshihiko, Maruyama, Yuusuke, Koizumi, Mitsuru, Mio, Kazuhiro, Kitamura, Shinichi, Sato, Chikara

“…Direct observation of subcellular structures and their characterization is essential for understanding their physiological functions. To observe them in open…”
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