Search Results - "MINSHALL, Richard D"

Neurogenesis and Inflammation after Ischemic Stroke: What is Known and Where We Go from Here by Tobin, Matthew K, Bonds, Jacqueline A, Minshall, Richard D, Pelligrino, Dale A, Testai, Fernando D, Lazarov, Orly

“…This review covers the pathogenesis of ischemic stroke and future directions regarding therapeutic options after injury. Ischemic stroke is a devastating…”
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Size and Dynamics of Caveolae Studied Using Nanoparticles in Living Endothelial Cells by Wang, Zhenjia, Tiruppathi, Chinnaswamy, Minshall, Richard D, Malik, Asrar B

“…Caveolae are plasma membrane invaginations prominent in all endothelial cells lining blood vessels. Caveolae characteristically bud to form free cytoplasmic…”
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Editorial: Chemokine receptors and signaling in wound healing by Chen, Zhenlong, Minshall, Richard D.

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Endothelial Transcytosis in Acute Lung Injury: Emerging Mechanisms and Therapeutic Approaches by Jones, Joshua H, Minshall, Richard D

“…Acute Lung Injury (ALI) is characterized by widespread inflammation which in its severe form, Acute Respiratory Distress Syndrome (ARDS), leads to compromise…”
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Bidirectional regulation of neutrophil migration by mitogen-activated protein kinases by Liu, Xiaowen, Ma, Bo, Malik, Asrar B, Tang, Haiyang, Yang, Tao, Sun, Bo, Wang, Gang, Minshall, Richard D, Li, Yan, Zhao, Yong, Ye, Richard D, Xu, Jingsong

“…Neutrophils are early responders and must navigate using spatial cues to arrive at infection sites. Xu and colleagues show that the opposing activities of MAP…”
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Src-dependent phosphorylation of caveolin-1 Tyr-14 promotes swelling and release of caveolae by Zimnicka, Adriana M, Husain, Yawer S, Shajahan, Ayesha N, Sverdlov, Maria, Chaga, Oleg, Chen, Zhenlong, Toth, Peter T, Klomp, Jennifer, Karginov, Andrei V, Tiruppathi, Chinnaswamy, Malik, Asrar B, Minshall, Richard D

“…Caveolin 1 (Cav1) is a required structural component of caveolae, and its phosphorylation by Src is associated with an increase in caveolae-mediated…”
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Caveolin-1 controls mitochondrial damage and ROS production by regulating fission - fusion dynamics and mitophagy by Jiang, Ying, Krantz, Sarah, Qin, Xiang, Li, Shun, Gunasekara, Hirushi, Kim, Young-Mee, Zimnicka, Adriana, Bae, Misuk, Ma, Ke, Toth, Peter T., Hu, Ying, Shajahan-Haq, Ayesha N., Patel, Hemal H., Gentile, Saverio, Bonini, Marcelo G., Rehman, Jalees, Liu, Yiyao, Minshall, Richard D.

“…As essential regulators of mitochondrial quality control, mitochondrial dynamics and mitophagy play key roles in maintenance of metabolic health and cellular…”
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Phosphorylation of Caveolin-1 Regulates Oxidant–Induced Pulmonary Vascular Permeability via Paracellular and Transcellular Pathways by Sun, Yu, Hu, Guochang, Zhang, Xiumei, Minshall, Richard D

“…RATIONALE:Oxidants are important signaling molecules known to increase endothelial permeability, although the mechanisms underlying permeability regulation are…”
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The GTPase Rab1 Is Required for NLRP3 Inflammasome Activation and Inflammatory Lung Injury by Zhang, Yuehui, Wang, Lijun, Lv, Yang, Jiang, Chunling, Wu, Guangyu, Dull, Randal O, Minshall, Richard D, Malik, Asrar B, Hu, Guochang

“…Uncontrolled inflammatory response during sepsis predominantly contributes to the development of multiorgan failure and lethality. However, the cellular and…”
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Caveolin-1 stabilizes ATP7A, a copper transporter for extracellular SOD, in vascular tissue to maintain endothelial function by Sudhahar, Varadarajan, Okur, Mustafa Nazir, O'Bryan, John P, Minshall, Richard D, Fulton, David, Ushio-Fukai, Masuko, Fukai, Tohru

“…Caveolin-1 (Cav-1) is a scaffolding protein and a major component of caveolae/lipid rafts. Previous reports have shown that endothelial dysfunction in…”
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Caveolin-1 is a primary determinant of endothelial stiffening associated with dyslipidemia, disturbed flow, and ageing by Le Master, Elizabeth, Paul, Amit, Lazarko, Dana, Aguilar, Victor, Ahn, Sang Joon, Lee, James C., Minshall, Richard D., Levitan, Irena

“…Endothelial stiffness is emerging as a major determinant in endothelial function. Here, we analyzed the role of caveolin-1 (Cav-1) in determining the stiffness…”
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Caveolin-1: a critical regulator of lung injury by Jin, Yang, Lee, Seon-Jin, Minshall, Richard D, Choi, Augustine M K

“…Caveolin-1 (cav-1), a 22-kDa transmembrane scaffolding protein, is the principal structural component of caveolae. Cav-1 regulates critical cell functions…”
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Endothelial pannexin 1-TRPV4 channel signaling lowers pulmonary arterial pressure in mice by Daneva, Zdravka, Ottolini, Matteo, Chen, Yen Lin, Klimentova, Eliska, Kuppusamy, Maniselvan, Shah, Soham A, Minshall, Richard D, Seye, Cheikh I, Laubach, Victor E, Isakson, Brant E, Sonkusare, Swapnil K

“…Pannexin 1 (Panx1), an ATP-efflux pathway, has been linked with inflammation in pulmonary capillaries. However, the physiological roles of endothelial Panx1 in…”
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ICAM-1–activated Src and eNOS signaling increase endothelial cell surface PECAM-1 adhesivity and neutrophil transmigration by Liu, Guoquan, Place, Aaron T., Chen, Zhenlong, Brovkovych, Viktor M., Vogel, Stephen M., Muller, William A., Skidgel, Randal A., Malik, Asrar B., Minshall, Richard D.

“…Polymorphonuclear neutrophil (PMN) extravasation requires selectin-mediated tethering, intercellular adhesion molecule-1 (ICAM-1)–dependent firm adhesion, and…”
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Neutralization of excessive CCL28 improves wound healing in diabetic mice by Chen, Zhenlong, Haus, Jacob M, DiPietro, Luisa A, Koh, Timothy J, Minshall, Richard D

“…Chronic, non-healing skin wounds such as diabetic foot ulcers (DFUs) are common in patients with type 2 diabetes mellitus (T2DM) and often result in limb…”
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Nitric oxide-dependent Src activation and resultant caveolin-1 phosphorylation promote eNOS/caveolin-1 binding and eNOS inhibition by Chen, Zhenlong, Bakhshi, Farnaz R, Shajahan, Ayesha N, Sharma, Tiffany, Mao, Mao, Trane, Andy, Bernatchez, Pascal, van Nieuw Amerongen, Geerten P, Bonini, Marcelo G, Skidgel, Randal A, Malik, Asrar B, Minshall, Richard D

“…Endothelial nitric oxide synthase (eNOS)-mediated NO production plays a critical role in the regulation of vascular function and pathophysiology. Caveolin-1…”
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Regulation of transendothelial permeability by Src Kinase by Hu, Guochang, Minshall, Richard D.

“…Transcellular transport of albumin from the endothelial lumen to the abluminal perivascular interstitium via caveolae is a primary determinant of basal…”
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Interaction Between Pannexin 1 and Caveolin-1 in Smooth Muscle Can Regulate Blood Pressure by DeLalio, Leon J, Keller, Alexander S, Chen, Jiwang, Boyce, Andrew K.J, Artamonov, Mykhaylo V, Askew-Page, Henry R, Keller, T.C Stevenson, Johnstone, Scott R, Weaver, Rachel B, Good, Miranda E, Murphy, Sara A, Best, Angela K, Mintz, Ellen L, Penuela, Silvia, Greenwood, Iain A, Machado, Roberto F, Somlyo, Avril V, Swayne, Leigh Anne, Minshall, Richard D, Isakson, Brant E

“…OBJECTIVE—Sympathetic nerve innervation of vascular smooth muscle cells (VSMCs) is a major regulator of arteriolar vasoconstriction, vascular resistance, and…”
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Volatile Anesthetics Improve Survival after Cecal Ligation and Puncture by HERRMANN, Inge K, CASTELLON, Maricela, SCHWARTZ, David E, HASLER, Melanie, URNER, Martin, GUOCHANG HU, MINSHALL, Richard D, BECK-SCHIMMER, Beatrice

“…Sepsis remains a leading cause of death in intensive care units. There is growing evidence that volatile anesthetics have beneficial immunomodulatory effects…”
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Intercellular Adhesion Molecule-1–Dependent Neutrophil Adhesion to Endothelial Cells Induces Caveolae-Mediated Pulmonary Vascular Hyperpermeability by Hu, Guochang, Vogel, Stephen M, Schwartz, David E, Malik, Asrar B, Minshall, Richard D

“…We investigated the role of caveolae in the mechanism of increased pulmonary vascular permeability and edema formation induced by the activation of…”
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