Search Results - "MINN, A. J"

Expression of Bcl-XL can confer a multidrug resistance phenotype by MINN, A. J, RUDIN, C. M, BOISE, L. H, THOMPSON, C. B

“…It has been suggested that genes that regulate apoptotic cell death may play an important role in determining the sensitivity of tumor cells to chemotherapy…”
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MicroRNA-124 expression counteracts pro-survival stress responses in glioblastoma by Mucaj, V, Lee, S S, Skuli, N, Giannoukos, D N, Qiu, B, Eisinger-Mathason, T S K, Nakazawa, M S, Shay, J E S, Gopal, P P, Venneti, S, Lal, P, Minn, A J, Simon, M C, Mathew, L K

“…Glioblastomas are aggressive adult brain tumors, characterized by inadequately organized vasculature and consequent nutrient and oxygen (O 2 )-depleted areas…”
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Growth Factors can Enhance Lymphocyte Survival without Committing the Cell to Undergo Cell Division by Boise, Lawrence H., Minn, Andy J., June, Carl H., Lindsten, Tullia, Thompson, Craig B.

“…Growth factors have been defined by their ability to promote the proliferative expansion of receptor-bearing cells. For example, antigen-activated T cells…”
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Identifying site-specific metastasis genes and functions by Gupta, G P, Minn, A J, Kang, Y, Siegel, P M, Serganova, I, Cordón-Cardo, C, Olshen, A B, Gerald, W L, Massagué, J

“…Metastasis is a multistep and multifunctional biological cascade that is the final and most life-threatening stage of cancer progression. Understanding the…”
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Bcl-x(L) forms an ion channel in synthetic lipid membranes by Minn, A J, Vélez, P, Schendel, S L, Liang, H, Muchmore, S W, Fesik, S W, Fill, M, Thompson, C B

“…Bcl-2-related proteins are critical regulators of cell survival that are localized to the outer mitochondrial, outer nuclear and endoplasmic reticulum…”
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Identification of a novel regulatory domain in Bcl-X(L) and Bcl-2 by Chang, B S, Minn, A J, Muchmore, S W, Fesik, S W, Thompson, C B

“…Bcl-X(L), a member of the Bcl-2 family, can inhibit many forms of programed cell death. The three-dimensional structure of Bcl-X(L) identified a 60 amino acid…”
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Final Results of a Phase I “RadVax” Trial of Hypofractionated Radiation Combined With Pembrolizumab in Patients With Metastatic Solid Tumors by Lukens, J.N., Mick, R., Huang, A.C., Han, N., Farwell, M.D., Mitchell, T.C., Amaravadi, R., Schuchter, L.M., Berman, A.T., O'Hara, M., Maity, A., Miller, D., Minn, A.J., Vonderheide, R.H., Wherry, E.J., Maity, A.

“…Many patients treated with anti-PD-1 therapy do not show a clinical response. Preclinical studies suggest that adding hypofractionated radiotherapy (HFRT) to…”
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Targeting of TGFβ signature and its essential component CTGF by miR-18 correlates with improved survival in glioblastoma by Fox, Jamie L, Dews, Michael, Minn, Andy J, Thomas-Tikhonenko, Andrei

“…The miR-17∼92 cluster is thought to be an oncogene, yet its expression is low in glioblastoma multiforme (GBM) cell lines. This could allow unfettered…”
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Recent progress on the regulation of apoptosis by Bcl-2 family members by Minn, A J, Swain, R E, Ma, A, Thompson, C B

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Expression of Bcl-xL and loss of p53 can cooperate to overcome a cell cycle checkpoint induced by mitotic spindle damage by Minn, A J, Boise, L H, Thompson, C B

“…During somatic cell division, faithful chromosomal segregation must follow DNA replication to prevent aneuploidy or polyploidy. Damage to the mitotic spindle…”
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Tumour exosome integrins determine organotropic metastasis by Hoshino, Ayuko, Costa-Silva, Bruno, Shen, Tang-Long, Rodrigues, Goncalo, Hashimoto, Ayako, Tesic Mark, Milica, Molina, Henrik, Kohsaka, Shinji, Di Giannatale, Angela, Ceder, Sophia, Singh, Swarnima, Williams, Caitlin, Soplop, Nadine, Uryu, Kunihiro, Pharmer, Lindsay, King, Tari, Bojmar, Linda, Davies, Alexander E., Ararso, Yonathan, Zhang, Tuo, Zhang, Haiying, Hernandez, Jonathan, Weiss, Joshua M., Dumont-Cole, Vanessa D., Kramer, Kimberly, Wexler, Leonard H., Narendran, Aru, Schwartz, Gary K., Healey, John H., Sandstrom, Per, Jørgen Labori, Knut, Kure, Elin H., Grandgenett, Paul M., Hollingsworth, Michael A., de Sousa, Maria, Kaur, Sukhwinder, Jain, Maneesh, Mallya, Kavita, Batra, Surinder K., Jarnagin, William R., Brady, Mary S., Fodstad, Oystein, Muller, Volkmar, Pantel, Klaus, Minn, Andy J., Bissell, Mina J., Garcia, Benjamin A., Kang, Yibin, Rajasekhar, Vinagolu K., Ghajar, Cyrus M., Matei, Irina, Peinado, Hector, Bromberg, Jacqueline, Lyden, David

“…Ever since Stephen Paget’s 1889 hypothesis, metastatic organotropism has remained one of cancer’s greatest mysteries. Here we demonstrate that exosomes from…”
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Bcl-xL regulates apoptosis by heterodimerization-dependent and -independent mechanisms by Minn, Andy J., Kettlun, Claudia S., Liang, Heng, Kelekar, Ameeta, Vander Heiden, Matthew G., Chang, Brian S., Fesik, Steven W., Fill, Michael, Thompson, Craig B.

“…A hydrophobic cleft formed by the BH1, BH2 and BH3 domains of Bcl‐xL is responsible for interactions between Bcl‐xL and BH3‐containing death agonists. Mutants…”
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CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-XL by Boise, L H, Minn, A J, Noel, P J, June, C H, Accavitti, M A, Lindsten, T, Thompson, C B

“…T cell activation through the TCR can result in either cell proliferation or cell death. The role of costimulatory receptors in regulating T cell survival has…”
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Receptors that regulate T-cell susceptibility to apoptotic cell death by Boise, L H, Minn, A J, Thompson, C B

“…The immune system provides a useful model system in which to study the signal transduction events involved in the regulation of programmed cell death. Mature…”
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Structure of Bcl-xL-Bak peptide complex : Recognition between regulators of apoptosis by SATTLER, M, LIANG, H, THOMPSON, C. B, FESIK, S. W, NETTESHEIM, D, MEADOWS, R. P, HARLAN, J. E, EBERSTADT, M, HO SUP YOON, SHUKER, S. B, CHANG, B. S, MINN, A. J

“…Heterodimerization between members of the Bcl-2 family of proteins is a key event in the regulation of programmed cell death. The molecular basis for…”
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Genes that mediate breast cancer metastasis to lung by Massagué, Joan, Minn, Andy J, Gupta, Gaorav P, Siegel, Peter M, Bos, Paula D, Shu, Weiping, Giri, Dilip D, Viale, Agnes, Olshen, Adam B, Gerald, William L

“…By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and…”
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interferon-related gene signature for DNA damage resistance is a predictive marker for chemotherapy and radiation for breast cancer by Weichselbaum, Ralph R, Ishwaran, Hemant, Yoon, Taewon, Nuyten, Dimitry S.A, Baker, Samuel W, Khodarev, Nikolai, Su, Andy W, Shaikh, Arif Y, Roach, Paul, Kreike, Bas, Roizman, Bernard, Bergh, Jonas, Pawitan, Yudi, van de Vijver, Marc J, Minn, Andy J

“…Individualization of cancer management requires prognostic markers and therapy-predictive markers. Prognostic markers assess risk of disease progression…”
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Distinct organ-specific metastatic potential of individual breast cancer cells and primary tumors by Minn, Andy J., Kang, Yibin, Serganova, Inna, Gupta, Gaorav P., Giri, Dilip D., Doubrovin, Mikhail, Ponomarev, Vladimir, Gerald, William L., Blasberg, Ronald, Massagué, Joan

“…We used bioluminescence imaging to reveal patterns of metastasis formation by human breast cancer cells in immunodeficient mice. Individual cells from a…”
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Combination anti-PD-1 and anti-CTLA-4 therapy generates waves of clonal responses that include progenitor-exhausted CD8 + T cells by Wang, Kevin, Coutifaris, Paulina, Brocks, David, Wang, Guanning, Azar, Tarek, Solis, Sabrina, Nandi, Ajeya, Anderson, Shaneaka, Han, Nicholas, Manne, Sasikanth, Kiner, Evgeny, Sachar, Chirag, Lucas, Minke, George, Sangeeth, Yan, Patrick K, Kier, Melanie W, Laughlin, Amy I, Kothari, Shawn, Giles, Josephine, Mathew, Divij, Ghinnagow, Reem, Alanio, Cecile, Flowers, Ahron, Xu, Wei, Tenney, Daniel J, Xu, Xiaowei, Amaravadi, Ravi K, Karakousis, Giorgos C, Schuchter, Lynn M, Buggert, Marcus, Oldridge, Derek, Minn, Andy J, Blank, Christian, Weber, Jeffrey S, Mitchell, Tara C, Farwell, Michael D, Herati, Ramin S, Huang, Alexander C

“…Combination checkpoint blockade with anti-PD-1 and anti-CTLA-4 antibodies has shown promising efficacy in melanoma. However, the underlying mechanism in humans…”
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Structure of Bcl-x-Bak peptide complex: recognition between regulators of apoptosis by Sattler, Michael, Nettesheim, David, Meadows, Robert P, Harlan, John E, Eberstadt, Matthias, Yoon, Ho Sup, Shuker, Suzanne B, Chang, Brian S, Minn, Andy J, Thompson, Craig B, Fesik, Stephen W

“…Heterodimerization between members of the Bcl-2 family of proteins is a key event in the regulation of programmed cell death. The molecular basis for…”
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