Search Results - "MINKO, Tamara"

Recent Developments on Therapeutic and Diagnostic Approaches for COVID-19 by Majumder, Joydeb, Minko, Tamara

“…The ongoing pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has made a serious…”
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Nanotechnology approaches for inhalation treatment of lung diseases by Kuzmov, Andriy, Minko, Tamara

“…Local administration of therapeutics by inhalation for treatment of lung diseases has the ability to deliver drugs, nucleic acids and peptides specifically to…”
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Nanotherapeutics for Nose-to-Brain Drug Delivery: An Approach to Bypass the Blood Brain Barrier by Lee, David, Minko, Tamara

“…Treatment of neurodegenerative diseases or other central nervous system (CNS) disorders has always been a significant challenge. The nature of the blood-brain…”
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Pharmacokinetics of inhaled nanotherapeutics for pulmonary delivery by Shen, Andrew M., Minko, Tamara

“…Pulmonary delivery of lipid-based nanotherapeutics by inhalation presents an advantageous alternative to oral and intravenous routes of administration that…”
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Nanostructured lipid carriers as multifunctional nanomedicine platform for pulmonary co-delivery of anticancer drugs and siRNA by Taratula, Oleh, Kuzmov, Andriy, Shah, Milin, Garbuzenko, Olga B., Minko, Tamara

“…We developed, synthesized, and tested a multifunctional nanostructured lipid nanocarrier-based system (NLCS) for efficient delivery of an anticancer drug and…”
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Multifunctional Lipid-Based Nanoparticles for Codelivery of Anticancer Drugs and siRNA for Treatment of Non-Small Cell Lung Cancer with Different Level of Resistance and EGFR Mutations by Majumder, Joydeb, Minko, Tamara

“…Resistance to chemotherapy, enhanced proliferation, invasion, angiogenesis, and metastasis (RPIAM) represent major obstacles that limit the efficacy of cancer…”
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Metastatic and triple-negative breast cancer: challenges and treatment options by Al-Mahmood, Sumayah, Sapiezynski, Justin, Garbuzenko, Olga B., Minko, Tamara

“…The major current conventional types of metastatic breast cancer (MBC) treatments include surgery, radiation, hormonal therapy, chemotherapy, or immunotherapy…”
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Multifunctional Triblock Nanocarrier (PAMAM-PEG-PLL) for the Efficient Intracellular siRNA Delivery and Gene Silencing by Patil, Mahesh L, Zhang, Min, Minko, Tamara

“…A novel triblock poly(amido amine)-poly(ethylene glycol)-poly-l-lysine (PAMAM-PEG-PLL) nanocarrier was designed, synthesized, and evaluated for the delivery of…”
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Co-delivery of Doxorubicin and Bcl-2 siRNA by Mesoporous Silica Nanoparticles Enhances the Efficacy of Chemotherapy in Multidrug-Resistant Cancer Cells by Chen, Alex M., Zhang, Min, Wei, Dongguang, Stueber, Dirk, Taratula, Oleh, Minko, Tamara, He, Huixin

“…Co‐delivery of Doxorubicin and siRNAs by mesoporous silica nanoparticles into multidrug‐resistance cancer cells with minimal premature release significantly…”
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Development of Liposomal Vesicles for Osimertinib Delivery to EGFR Mutation—Positive Lung Cancer Cells by Skupin-Mrugalska, Paulina, Minko, Tamara

“…Osimertinib (OSI, AZD9291), is a third-generation, irreversible tyrosine kinase inhibitor (TKI) of the epidermal growth factor receptor (EGFR) that selectively…”
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Shape effects of filaments versus spherical particles in flow and drug delivery by Geng, Yan, Dalhaimer, Paul, Discher, Dennis E, Cai, Shenshen, Tsai, Richard, Tewari, Manorama, Minko, Tamara

“…Interaction of spherical particles with cells and within animals has been studied extensively, but the effects of shape have received little attention. Here we…”
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Co-delivery of siRNA and an anticancer drug for treatment of multidrug-resistant cancer by Saad, Maha, Garbuzenko, Olga B, Minko, Tamara

“…To develop a novel nanomedicine approach for the treatment of multidrug-resistant (MDR) cancer by combining an anticancer drug and suppressors of cellular…”
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Innovative strategy for treatment of lung cancer: targeted nanotechnology-based inhalation co-delivery of anticancer drugs and siRNA by Taratula, Oleh, Garbuzenko, Olga B., Chen, Alex M., Minko, Tamara

“…A tumor targeted mesoporous silica nanoparticles (MSN)-based drug delivery system (DDS) was developed for inhalation treatment of lung cancer. The system was…”
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LHRH-Targeted Drug Delivery Systems for Cancer Therapy by Li, Xiaoning, Taratula, Oleh, Taratula, Olena, Schumann, Canan, Minko, Tamara

“…Targeted delivery of therapeutic and diagnostic agents to cancer sites has significant potential to improve the therapeutic outcome of treatment while…”
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Nanotechnology-Based Strategy for Enhancing Therapeutic Efficacy in Pancreatic Cancer: Receptor-Targeted Drug Delivery by Somatostatin Analog by Gu, Xin, Majumder, Joydeb, Taratula, Olena, Kuzmov, Andriy, Garbuzenko, Olga, Pogrebnyak, Natalia, Minko, Tamara

“…A novel nanotechnology-based drug delivery system (DDS) targeted at pancreatic cancer cells was developed, characterized, and tested. The system consisted of…”
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Stem cell-based gene therapy activated using magnetic hyperthermia to enhance the treatment of cancer by Yin, Perry T, Shah, Shreyas, Pasquale, Nicholas J, Garbuzenko, Olga B, Minko, Tamara, Lee, Ki-Bum

“…Abstract Stem cell-based gene therapies, wherein stem cells are genetically engineered to express therapeutic molecules, have shown tremendous potential for…”
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Nanotechnology-Based RNA Vaccines: Fundamentals, Advantages and Challenges by Pozharov, Vitaly P, Minko, Tamara

“…Over the past decades, many drugs based on the use of nanotechnology and nucleic acids have been developed. However, until recently, most of them remained at…”
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In Vivo Evaluation of Nose-to-Brain Delivery of Liposomal Donepezil, Memantine, and BACE-1 siRNA for Alzheimer's Disease Therapy by Lee, David, Shen, Andrew M, Shah, Milin, Garbuzenko, Olga B, Minko, Tamara

“…Our study took an innovative approach by evaluating, in vivo, the efficacy of intranasal (IN) administration of liposomal formulations of donepezil, memantine,…”
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Inhibition of lung tumor growth by complex pulmonary delivery of drugs with oligonucleotides as suppressors of cellular resistance by Garbuzenko, Olga B, Saad, Maha, Pozharov, Vitaly P, Reuhl, Kenneth R, Mainelis, Gediminas, Minko, Tamara

“…Development of cancer cell resistance, low accumulation of therapeutic drug in the lungs, and severe adverse treatment side effects represent main obstacles to…”
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Synergistic antitumor effect of liposomal-based formulations of olaparib and topotecan in primary epithelial ovarian cancer cells by Romaniuk-Drapala, Aleksandra, Skupin-Mrugalska, Paulina, Garbuzenko, Olga, Hatefi, Arash, Minko, Tamara

“…Olaparib is a PARP inhibitor inducing synthetic lethality in tumors with deficient homologous recombination (HRD) caused by BRCA1/2 mutations. The FDA has…”
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