Search Results - "MINER, P. B"

Randomised clinical trial: the safety and efficacy of AST‐120 in non‐constipating irritable bowel syndrome – a double‐blind, placebo‐controlled study by Tack, J. F., Miner, P. B., Fischer, L., Harris, M. S.

“…Aliment Pharmacol Ther 2011; 34: 868–877 Summary Background  There is a need for safe and effective treatment options for irritable bowel syndrome (IBS)…”
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A Phase II dose ranging, double‐blind, placebo‐controlled study of alicaforsen enema in subjects with acute exacerbation of mild to moderate left‐sided ulcerative colitis by VAN DEVENTER, S. J. H., WEDEL, M. K., BAKER, B. F., XIA, S., CHUANG, E., MINER, P. B.

“…Summary Background Alicaforsen is an antisense oligonucleotide designed to inhibit expression of human intercellular adhesion molecule 1. Previous clinical…”
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Safety and efficacy of two dose formulations of alicaforsen enema compared with mesalazine enema for treatment of mild to moderate left‐sided ulcerative colitis: a randomized, double‐blind, active‐controlled trial by MINER, P. B., WEDEL, M. K., XIA, S., BAKER, B. F.

“…Summary Background Alicaforsen is an antisense oligonucleotide inhibitor of intercellular adhesion molecule 1 protein expression with activity in subjects with…”
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Intragastric acidity and omeprazole exposure during dosing with either PA32540 (enteric‐coated aspirin 325 mg + immediate‐release omeprazole 40 mg) or enteric‐coated aspirin 325 mg + enteric‐coated omeprazole 40 mg – a randomised, phase 1, crossover study by Miner, P. B., Fort, J. G., Zhang, Y.

“…Summary Background Aspirin therapy is associated with adverse upper gastrointestinal effects. PA32540 is a coordinated‐delivery tablet containing…”
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Prucalopride induces high‐amplitude propagating contractions in the colon of patients with chronic constipation: a randomized study by Miner, P. B., Camilleri, M., Burton, D., Achenbach, H., Wan, H., Dragone, J., Mellgard, B.

“…Background This study compared prucalopride, a selective, prokinetic, 5‐HT4 receptor agonist, with polyethylene glycol 3350 + electrolytes (PEG3350), an…”
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Bioavailability and therapeutic activity of alicaforsen (ISIS 2302) administered as a rectal retention enema to subjects with active ulcerative colitis by MINER, P. B., GEARY, R. S., MATSON, J., CHUANG, E., XIA, S., BAKER, B. F., WEDEL, M. K.

“…Summary Background Alicaforsen is a phosphorothioate‐modified antisense oligodeoxynucleotide designed to sequence‐specifically reduce intercellular adhesion…”
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Review article: physiologic and clinical effects of proton pump inhibitors on non‐acidic and acidic gastro‐oesophageal reflux by MINER, P. B.

“…Summary The control of oesophageal acid exposure through gastric acid inhibition, as the basis for gastro‐oesophageal reflux disease (GERD) treatment, arose…”
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Comparison of gastric pH with omeprazole magnesium 20.6 mg (Prilosec OTC) o.m. famotidine 10 mg (Pepcid AC) b.d. and famotidine 20 mg b.d. over 14 days of treatment by MINER, P. B., ALLGOOD, L. D., GRENDER, J. M.

“…Summary Background The onset of acid inhibition for proton pump inhibitors is slower than with H2RAs and generally considered to be at a steady‐state after 5…”
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Failure of a motilin receptor agonist (ABT‐229) to relieve the symptoms of functional dyspepsia in patients with and without delayed gastric emptying: a randomized double‐blind placebo‐controlled trial by Talley, N. J., Verlinden, M., Snape, W., Beker, J. A., Ducrotte, P., Dettmer, A., Brinkhoff, H., Eaker, E., Ohning, G., Miner, P. B, Mathias, J. R, Fumagalli, I., Staessen, D., Mack, R. J.

“…Introduction: Motilin‐receptor agonists are prokinetics; whether they relieve the symptoms of functional dyspepsia is unknown. We aimed to test the efficacy of…”
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Intragastric acid control in non‐steroidal anti‐inflammatory drug users: comparison of esomeprazole, lansoprazole and pantoprazole by GOLDSTEIN, J. L., MINER, P. B., SCHLESINGER, P. K., LIU, S., SILBERG, D. G.

“…Summary Background  Studies to date have not directly compared the pharmacodynamic efficacies of different proton pump inhibitors in controlling intragastric…”
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Omeprazole‐Mg 20.6 mg is superior to lansoprazole 15 mg for control of gastric acid: a comparison of over‐the‐counter doses of proton pump inhibitors by MINER, P. B., MCKEAN, L. A., GIBB, R. D., ERASALA, G. N., RAMSEY, D. L., MCRORIE, J. W.

“…Aliment Pharmacol Ther 31, 846–851 Summary Background  Over‐the‐counter (OTC) proton pump inhibitors (PPIs) relieve heartburn by decreasing the production of…”
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Intravenous esomeprazole 40 mg vs. intravenous lansoprazole 30 mg for controlling intragastric acidity in healthy adults by PISEGNA, J. R., SOSTEK, M. B., MONYAK, J. T., MINER, P. B.

“…Summary Background  Intravenous (IV) formulations of proton pump inhibitors are effective for patients in whom oral therapy is not appropriate. Aim  To compare…”
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Psyllium is superior to docusate sodium for treatment of chronic constipation by MCRORIE, J. W, DAGGY, B. P, MOREL, J. G, DIERSING, P. S, MINER, P. B, ROBINSON, M

“…Background: Stool softening is a physician’s first step in the management of chronic constipation. Aim: To compare stool softening (stool water content) and…”
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Effect of naproxen on gastric acid secretion and gastric pH by RODRIGUEZ‐STANLEY, S., REDINGER, N., MINER, P. B.

“…Summary Background The mechanisms for the non‐steroidal anti‐inflammatory drug‐induced inflammation in the stomach are unclear. Aims To determine if naproxen…”
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The effects of capsaicin on reflux, gastric emptying and dyspepsia by RODRIGUEZ-STANLEY, S, COLLINGS, K. L, ROBINSON, M, OWEN, W, MINER, P. B

“…Aims: To evaluate capsaicin’s effects on heartburn, dyspepsia, gastric acidity and emptying, and gastro‐oesophageal reflux, and to test the hypothesis that…”
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A single dose of ranitidine 150 mg modulates oesophageal acid sensitivity in patients with functional heartburn by Rodriguez‐Stanley, S., Ciociola, A. A., Zubaidi, S., Proskin, H. M., Miner, P. B.

“…Summary Background : The rapid onset and symptomatic response to histamine‐2 receptor antagonists prior to the pharmacological effect on acid secretion…”
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Meal‐stimulated gastric acid secretion and integrated gastric acidity in gastro‐oesophageal reflux disease by Gardner, J. D., Sloan, S., Miner, P. B., Robinson, M.

“…Summary Background : No current methods exist to determine meal‐stimulated gastric acid secretion in humans under conditions that approximate those of daily…”
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Esophageal hypersensitivity may be a major cause of heartburn by Rodriguez-Stanley, Sheila, Robinson, Malcolm, Earnest, David L, Greenwood-Van Meerveld, Beverley, Miner, Philip B

“…Little is known about esophageal nociceptive thresholds in chronic heartburn sufferers with normal clinical findings. The aim of this study was to evaluate and…”
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Frequency analyses of gastric pH in control and gastro‐oesophageal reflux disease subjects treated with a proton‐pump inhibitor by Gardner, J. D., Sloan, S., Robinson, M., Miner Jr, P. B.

“…Summary Background : We are unaware of any solid theoretical or pathophysiological basis for selecting pH 4 or any other pH value to assess gastric acidity…”
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The effects of changing temperature correction factors on measures of acidity calculated from gastric and oesophageal pH recordings by GARDNER, J. D., YOUNG, W., SLOAN, S., ROBINSON, M., MINER, P. B.

“…Summary Background  Recently, Medtronic notified customers that new correction factors should be used for their Slimline and Zinetics24 single‐use,…”
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