Search Results - "MINER, J. N"

Glucocorticoid receptor-cAMP response element-binding protein interaction and the response of the phosphoenolpyruvate carboxykinase gene to glucocorticoids by IMAI, E, MINER, J. N, MITCHELL, J. A, YAMAMOTO, K. R, GRANNER, D. K

“…The phosphoenolpyruvate carboxykinase (PEPCK) gene encodes the rate-limiting enzyme in gluconeogenesis. Glucocorticoids enhance PEPCK gene expression through a…”
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Nonsteroidal Selective Glucocorticoid Modulators:  the Effect of C-5 Alkyl Substitution on the Transcriptional Activation/Repression Profile of 2,5-Dihydro-10-methoxy-2,2,4-trimethyl-1H-[1]benzopyrano[3,4-f]quinolines by Elmore, Steven W, Coghlan, Michael J, Anderson, David D, Pratt, John K, Green, Brian E, Wang, Alan X, Stashko, Michael A, Lin, Chun W, Tyree, Curtis M, Miner, Jeffery N, Jacobson, Peer B, Wilcox, Denise M, Lane, Benjamin C

“…The preparation and characterization of a series of selective glucocorticoid receptor modulators are described. The preliminary structure−activity relationship…”
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The basic region of AP-1 specifies glucocorticoid receptor activity at a composite response element by MINER, J. N, YAMAMOTO, K. R

“…Unrelated factors collaborate at composite response elements to confer novel patterns of transcriptional regulation. For example, AP-1 and glucocorticoid…”
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The growth plate sparing effects of the selective glucocorticoid receptor modulator, AL-438 by Owen, H.C., Miner, J.N., Ahmed, S.F., Farquharson, C.

“…Long-term use of glucocorticoids (GC) can cause growth retardation in children due to their actions on growth plate chondrocytes. AL-438, a non-steroidal…”
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The Search for Safer Glucocorticoid Receptor Ligands by Rosen, Jonathan, Miner, Jeffrey N

“…Steroidal glucocorticoids are commonly used due to their powerful antiinflammatory activity. However, despite their excellent efficacy, severe side effects…”
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A Novel Antiinflammatory Maintains Glucocorticoid Efficacy with Reduced Side Effects by Coghlan, Michael J, Jacobson, Peer B, Lane, Ben, Nakane, Masaki, Lin, Chun Wei, Elmore, Steven W, Kym, Philip R, Luly, Jay R, Carter, George W, Turner, Russell, Tyree, Curtis M, Hu, Junlian, Elgort, Marc, Rosen, Jon, Miner, Jeffrey N

“…Glucocorticoids (GCs) are commonly used to treat inflammatory disease; unfortunately, the long-term use of these steroids leads to a large number of…”
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DNA sequences that regulate expression of a vaccinia virus late gene (L65) and interact with a DNA-binding protein from infected cells by MINER, J. N, HRUBY, D. E

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Transcription Factor Interactions: Selectors of Positive or Negative Regulation from a Single DNA Element by Diamond, Marc I., Miner, Jeffrey N., Yoshinaga, Steven K., Yamamoto, Keith R.

“…The mechanism by which a single factor evokes opposite regulatory effects from a specific DNA sequence is not well understood. In this study, a 25-base pair…”
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Molecular dissection of cis-acting regulatory elements from 5'-proximal regions of a vaccinia virus late gene cluster by MINER, J. N, WEINRICH, S. L, HRUBY, D. E

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Regulatory crosstalk at composite response elements by Miner, J N, Yamamoto, K R

“…Transcriptional regulatory factors from different families interact with each other when bound to DNA at composite response elements. This level of…”
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Glucocorticoid Receptor Transcriptional Activity Determined by Spacing of Receptor and Nonreceptor DNA Sites by Pearce, David, Matsui, William, Miner, Jeffrey N., Yamamoto, Keith R.

“…The glucocorticoid receptor (GR) displays distinct modes of regulation when bound at glucocorticoid response elements (GREs) bearing different binding…”
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Vaccinia virus: a versatile tool for molecular biologists by Miner, J N, Hruby, D E

“…Continued advances in genetic engineering have made possible the high-level expression of correctly processed cellular, viral and bacterial polypeptides. This…”
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Determinants of promoter-specific activity by glucocorticoid receptor by Guido, E C, Delorme, E O, Clemm, D L, Stein, R B, Rosen, J, Miner, J N

“…Glucocorticoid receptor (GR) is expressed at essentially equal levels in almost all tissues and cell types. Remarkably, glucocorticoids themselves regulate…”
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Joints in the regulatory lattice: composite regulation by steroid receptor-AP1 complexes by Miner, J N, Diamond, M I, Yamamoto, K R

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Discovery and characterization of verinurad, a potent and specific inhibitor of URAT1 for the treatment of hyperuricemia and gout by Tan, Philip K., Liu, Sha, Gunic, Esmir, Miner, Jeffrey N.

“…Gout is caused by elevated serum urate levels, which can be treated using inhibitors of the uric acid transporter, URAT1. Here, we characterize verinurad…”
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Drug discovery and the intracellular receptor family by Miner, Jeffrey N, Tyree, Curtis M

“…Drug discovery using intracellular receptors (IRs) as targets presents its own set of unique complications and advantages. The natural ligands for these…”
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Pharmacodynamic, pharmacokinetic and tolerability evaluation of concomitant administration of lesinurad and febuxostat in gout patients with hyperuricaemia by Fleischmann, Roy, Kerr, Bradley, Yeh, Li-Tain, Suster, Matt, Shen, Zancong, Polvent, Elizabeth, Hingorani, Vijay, Quart, Barry, Manhard, Kimberly, Miner, Jeffrey N, Baumgartner, Scott

“…The aim of this study was to evaluate the pharmacodynamics (PDs), pharmacokinetics (PKs) and safety of lesinurad (selective uric acid reabsorption inhibitor)…”
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Rifampicin prevents virosome localization of L65, an essential vaccinia virus polypeptide by Miner, J N, Hruby, D E

“…In contrast to its irreversible effect on the Escherichia coliRNA polymerase beta-subunit, the antibiotic rifampicin reversibly inhibits vaccinia virus…”
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The relationship between ferritin and urate levels and risk of gout by Fatima, Tahzeeb, McKinney, Cushla, Major, Tanya J, Stamp, Lisa K, Dalbeth, Nicola, Iverson, Cory, Merriman, Tony R, Miner, Jeffrey N

“…Ferritin positively associates with serum urate and an interventional study suggests that iron has a role in triggering gout flares. The objective of this…”
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No association between ATP-binding cassette transporter G2 rs2231142 (Q141K) and urate-lowering response to febuxostat by Stamp, Lisa K, Topless, Ruth, Miner, Jeffrey N, Dalbeth, Nicola, Merriman, Tony

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