Search Results - "MINANA, Belén"

Synonymous Mutations Frequently Act as Driver Mutations in Human Cancers by Supek, Fran, Miñana, Belén, Valcárcel, Juan, Gabaldón, Toni, Lehner, Ben

“…Synonymous mutations change the sequence of a gene without directly altering the sequence of the encoded protein. Here, we present evidence that these “silent”…”
Get full text

Reduced fidelity of branch point recognition and alternative splicing induced by the anti-tumor drug spliceostatin A by Corrionero, Anna, Miñana, Belén, Valcárcel, Juan

“…Spliceostatin A (SSA) is a stabilized derivative of a Pseudomonas bacterial fermentation product that displays potent anti-proliferative and anti-tumor…”
Get full text

Combinatorial Genetics Reveals a Scaling Law for the Effects of Mutations on Splicing by Baeza-Centurion, Pablo, Miñana, Belén, Schmiedel, Jörn M., Valcárcel, Juan, Lehner, Ben

“…Despite a wealth of molecular knowledge, quantitative laws for accurate prediction of biological phenomena remain rare. Alternative pre-mRNA splicing is an…”
Get full text

The complete local genotype–phenotype landscape for the alternative splicing of a human exon by Julien, Philippe, Miñana, Belén, Baeza-Centurion, Pablo, Valcárcel, Juan, Lehner, Ben

“…The properties of genotype–phenotype landscapes are crucial for understanding evolution but are not characterized for most traits. Here, we present a >95%…”
Get full text

Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks by Sebestyén, Endre, Singh, Babita, Miñana, Belén, Pagès, Amadís, Mateo, Francesca, Pujana, Miguel Angel, Valcárcel, Juan, Eyras, Eduardo

“…Alternative splicing is regulated by multiple RNA-binding proteins and influences the expression of most eukaryotic genes. However, the role of this process in…”
Get full text

The Ewing Sarcoma Protein Regulates DNA Damage-Induced Alternative Splicing by Paronetto, Maria Paola, Miñana, Belén, Valcárcel, Juan

“…The Ewing sarcoma (EWS) protein is a member of the TET (TLS/EWS/TAF15) family of RNA- and DNA-binding proteins whose expression is altered in cancer. We report…”
Get full text

Mutations primarily alter the inclusion of alternatively spliced exons by Baeza-Centurion, Pablo, Miñana, Belén, Valcárcel, Juan, Lehner, Ben

“…Genetic analyses and systematic mutagenesis have revealed that synonymous, non-synonymous and intronic mutations frequently alter the inclusion levels of…”
Get full text

Genotoxic stress inhibits Ewing sarcoma cell growth by modulating alternative pre-mRNA processing of the RNA helicase DHX9 by Fidaleo, Marco, Svetoni, Francesca, Volpe, Elisabetta, Miñana, Belén, Caporossi, Daniela, Paronetto, Maria Paola

“…Alternative splicing plays a key role in the DNA damage response and in cancer. Ewing Sarcomas (ES) are aggressive tumors caused by different chromosomal…”
Get full text

Argonaute-1 binds transcriptional enhancers and controls constitutive and alternative splicing in human cells by Alló, Mariano, Agirre, Eneritz, Bessonov, Sergey, Bertucci, Paola, Acuña, Luciana Gómez, Buggiano, Valeria, Bellora, Nicolás, Singh, Babita, Petrillo, Ezequiel, Blaustein, Matías, Miñana, Belén, Dujardin, Gwendal, Pozzi, Berta, Pelisch, Federico, Bechara, Elías, Agafonov, Dmitry E., Srebrow, Anabella, Lührmann, Reinhard, Valcárcel, Juan, Eyras, Eduardo, Kornblihtt, Alberto R.

“…Significance Argonaute proteins are well characterized factors in posttranscriptional gene silencing, the process by which small RNAs trigger mRNA degradation…”
Get full text

Systems analysis identifies melanoma-enriched pro-oncogenic networks controlled by the RNA binding protein CELF1 by Cifdaloz, Metehan, Osterloh, Lisa, Graña, Osvaldo, Riveiro-Falkenbach, Erica, Ximénez-Embún, Pilar, Muñoz, Javier, Tejedo, Cristina, Calvo, Tonantzin G., Karras, Panagiotis, Olmeda, David, Miñana, Belén, Gómez-López, Gonzalo, Cañon, Estela, Eyras, Eduardo, Guo, Haihong, Kappes, Ferdinand, Ortiz-Romero, Pablo L., Rodríguez-Peralto, Jose L., Megías, Diego, Valcárcel, Juan, Soengas, María S.

“…Melanomas are well-known for their altered mRNA expression profiles. Yet, the specific contribution of mRNA binding proteins (mRBPs) to melanoma development…”
Get full text

Functional Network Analysis Reveals the Relevance of SKIIP in the Regulation of Alternative Splicing by p38 SAPK by Carbonell, Caterina, Ulsamer, Arnau, Vivori, Claudia, Papasaikas, Panagiotis, Böttcher, René, Joaquin, Manel, Miñana, Belén, Tejedor, Juan Ramón, de Nadal, Eulàlia, Valcárcel, Juan, Posas, Francesc

“…Alternative splicing is a prevalent mechanism of gene regulation that is modulated in response to a wide range of extracellular stimuli. Stress-activated…”
Get full text

Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis by Hentze, Matthias W, Custodio, Ángel O, Miñana, Belén, Andrews, Nancy C, Roy, Cindy N, Muckenthaler, Martina, deGraaf, Jos, Montross, Lynne K

“…Individuals with hereditary hemochromatosis suffer from systemic iron overload due to duodenal hyperabsorption. Most cases arise from a founder mutation in HFE…”
Get full text

Distinction between Asymptomatic Monoclonal B-cell Lymphocytosis with Cyclin D1 Overexpression and Mantle Cell Lymphoma: From Molecular Profiling to Flow Cytometry by ESPINET, Blanca, FERRER, Ana, LUNO, Elisa, COLLADO, Rosa, NAVARRO, José Tomás, DE LA BANDA, Esmeralda, ABRISQUETA, Pau, ARENILLAS, Leonor, SERRANO, Cristina, LLORETA, Josep, MINANA, Belén, CERUTTI, Andrea, BELLOSILLO, Beatriz, FLORENSA, Lourdes, ORFAO, Alberto, SANZ, Ferran, SOLE, Francesc, DOMINGUEZ-SOLA, David, SERRANO, Sergio, NONELL, Lara, SALAR, Antonio, FERNANDEZ-RODRIGUEZ, Concepción, PUIGDECANET, Eulàlia, GIMENO, Javier, GARCIA-GARCIA, Mar, VELA, Maria Carmen

“…According to current diagnostic criteria, mantle cell lymphoma (MCL) encompasses the usual, aggressive variants and rare, nonnodal cases with monoclonal…”
Get full text

Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2) by Galy, Bruno, Ferring, Dunja, Minana, Belen, Bell, Oliver, Janser, Heinz G., Muckenthaler, Martina, Schümann, Klaus, Hentze, Matthias W.

“…Iron regulatory protein 2 (IRP2)-deficient mice have been reported to suffer from late-onset neurodegeneration by an unknown mechanism. We report that young…”
Get full text

Distinct regulatory programs establish widespread sex-specific alternative splicing in Drosophila melanogaster by Hartmann, Britta, Castelo, Robert, Miñana, Belén, Peden, Erin, Blanchette, Marco, Rio, Donald C, Singh, Ravinder, Valcárcel, Juan

“…In Drosophila melanogaster, female-specific expression of Sex-lethal (SXL) and Transformer (TRA) proteins controls sex-specific alternative splicing and/or…”
Get full text

Mutational Analysis of Progesterone Receptor Functional Domains in Stable Cell Lines Delineates Sets of Genes Regulated by Different Mechanisms by Quiles, Ignacio, Millán-Ariño, Lluís, Subtil-Rodríguez, Alicia, Miñana, Belén, Spinedi, Nora, Ballaré, Cecilia, Beato, Miguel, Jordan, Albert

“…Steroid hormone receptors act directly in the nucleus on the chromatin organization and transcriptional activity of several promoters. Furthermore, they have…”
Get full text

CPEB1 coordinates alternative 3′-UTR formation with translational regulation by Bava, Felice-Alessio, Eliscovich, Carolina, Ferreira, Pedro G., Miñana, Belen, Ben-Dov, Claudia, Guigó, Roderic, Valcárcel, Juan, Méndez, Raúl

“…CPEB1 is known to regulate cytoplasmic polyadenylation, and is now shown to have a second function in the nucleus; it associates with the cleavage and…”
Get full text

Partially degraded RNA from bladder washing is a suitable sample for studying gene expression profiles in bladder cancer by Mengual, Lourdes, Burset, Moisès, Ars, Elisabet, Ribal, María José, Lozano, Juan José, Minana, Belén, Sumoy, Lauro, Alcaraz, Antonio

“…To determine the impact of different levels of RNA degradation on gene expression measurements and to ascertain if the gene expression profile obtained from…”
Get full text

Corrigendum: Large-scale analysis of genome and transcriptome alterations in multiple tumors unveils novel cancer-relevant splicing networks by Sebestyén, Endre, Singh, Babita, Miñana, Belén, Pagès, Amadís, Mateo, Francesca, Pujana, Miguel Angel, Valcárcel, Juan, Eyras, Eduardo

Get full text

Partially degraded RNA from bladder washing is a suitable sample for studying gene expression profiles in bladder cancer. Commentary by MENGUAL, Lourdes, BURSET, Moisès, ARS, Elisabet, RIBAL, Maria José, LOZANO, Juan José, MINANA, Belén, SUMOY, Lauro, ALCARAZ, Antonio, ROUPRET, Morgan

Get full text