Search Results - "MINAKER, Sean"

ARID1A regulates R-loop associated DNA replication stress by Tsai, Shuhe, Fournier, Louis-Alexandre, Chang, Emily Yun-Chia, Wells, James P, Minaker, Sean W, Zhu, Yi Dan, Wang, Alan Ying-Hsu, Wang, Yemin, Huntsman, David G, Stirling, Peter C

“…ARID1A is a core DNA-binding subunit of the BAF chromatin remodeling complex, and is lost in up to 7% of all cancers. The frequency of ARID1A loss increases in…”
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Cystine/glutamate antiporter xCT (SLC7A11) facilitates oncogenic RAS transformation by preserving intracellular redox balance by Lim, Jonathan K. M., Delaidelli, Alberto, Minaker, Sean W., Zhang, Hai-Feng, Colovic, Milena, Yang, Hua, Negri, Gian Luca, von Karstedt, Silvia, Lockwood, William W., Schaffer, Paul, Leprivier, Gabriel, Sorensen, Poul H.

“…The RAS family of proto-oncogenes are among the most commonly mutated genes in human cancers and predict poor clinical outcome. Several mechanisms underlying…”
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R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants by Stirling, Peter C, Chan, Yujia A, Minaker, Sean W, Aristizabal, Maria J, Barrett, Irene, Sipahimalani, Payal, Kobor, Michael S, Hieter, Philip

“…Genome instability via RNA:DNA hybrid-mediated R loops has been observed in mutants involved in various aspects of transcription and RNA processing. The…”
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A nuclear proteome localization screen reveals the exquisite specificity of Gpn2 in RNA polymerase biogenesis by Minaker, Sean W., Kofoed, Megan C., Hieter, Philip, Stirling, Peter C.

“…The GPN proteins are a conserved family of GTP-binding proteins that are involved in the assembly and subsequent import of RNA polymerase II and III. In this…”
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An E4 Ligase Facilitates Polyubiquitination of Plant Immune Receptor Resistance Proteins in Arabidopsis by Huang, Yan, Minaker, Sean, Roth, Charlotte, Huang, Shuai, Hieter, Philip, Lipka, Volker, Wiermer, Marcel, Li, Xin

“…Proteins with nucleotide binding and leucine-rich repeat domains (NLRs) serve as immune receptors in animals and plants that recognize pathogens and activate…”
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Biogenesis of RNA polymerases II and III requires the conserved GPN small GTPases in Saccharomyces cerevisiae by Minaker, Sean W, Filiatrault, Megan C, Ben-Aroya, Shay, Hieter, Philip, Stirling, Peter C

“…The GPN proteins are a poorly characterized and deeply evolutionarily conserved family of three paralogous small GTPases, Gpn1, 2, and 3. The founding member,…”
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Saccharomyces cerevisiae genetics predicts candidate therapeutic genetic interactions at the mammalian replication fork by van Pel, Derek M, Stirling, Peter C, Minaker, Sean W, Sipahimalani, Payal, Hieter, Philip

“…The concept of synthetic lethality has gained popularity as a rational guide for predicting chemotherapeutic targets based on negative genetic interactions…”
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PDTM-02. STRESS GRANULES ARE INDUCED BY OXIDATIVE STRESS IN PEDIATRIC BRAIN TUMORS AND PREDICT POOR OUTCOME by Delaidelli, Alberto, Luca Negri, Gian, Cho, Brian, Minaker, Sean, El Naggar, Amal, Hukin, Juliette, Yip, Stephen, Santi, Mariarita, Maris, John, Sorensen, Poul

“…Abstract BACKGROUND/OBJECTIVES: Brain tumors represent the most common and aggressive pediatric cancer type, underscoring a dire need for novel therapeutic…”
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Pharmacological differentiation of the P2X7 receptor and the maitotoxin-activated cationic channel by LUNDY, Paul M, NELSON, Peggy, LEI MI, FREW, Robert, MINAKER, Sean, VAIR, Cory, SAWYER, Thomas W

“…The ATP-P2X(7) receptor subtype and a maitotoxin-activated ion channel were studied to determine factors which identify them as separate entities in the…”
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Pharmacological differentiation of the P2X 7 receptor and the maitotoxin-activated cationic channel by Lundy, Paul M., Nelson, Peggy, Mi, Lei, Frew, Robert, Minaker, Sean, Vair, Cory, Sawyer, Thomas W.

“…The ATP-P2X 7 receptor subtype and a maitotoxin-activated ion channel were studied to determine factors which identify them as separate entities in the control…”
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