Search Results - "MILLS, Richard J"

Development of a human cardiac organoid injury model reveals innate regenerative potential by Voges, Holly K, Mills, Richard J, Elliott, David A, Parton, Robert G, Porrello, Enzo R, Hudson, James E

“…The adult human heart possesses a limited regenerative potential following an ischemic event, and undergoes a number of pathological changes in response to…”
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Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway by Mills, Richard J., Parker, Benjamin L., Quaife-Ryan, Gregory A., Voges, Holly K., Needham, Elise J., Bornot, Aurelie, Ding, Mei, Andersson, Henrik, Polla, Magnus, Elliott, David A., Drowley, Lauren, Clausen, Maryam, Plowright, Alleyn T., Barrett, Ian P., Wang, Qing-Dong, James, David E., Porrello, Enzo R., Hudson, James E.

“…We have previously developed a high-throughput bioengineered human cardiac organoid (hCO) platform, which provides functional contractile tissue with…”
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Bioengineering adult human heart tissue: How close are we? by Mills, Richard J., Hudson, James E.

“…Human pluripotent stem cells (hPSCs) have extensive applications in fundamental biology, regenerative medicine, disease modelling, and drug…”
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Induction of Human iPSC-Derived Cardiomyocyte Proliferation Revealed by Combinatorial Screening in High Density Microbioreactor Arrays by Titmarsh, Drew M., Glass, Nick R., Mills, Richard J., Hidalgo, Alejandro, Wolvetang, Ernst J., Porrello, Enzo R., Hudson, James E., Cooper-White, Justin J.

“…Inducing cardiomyocyte proliferation in post-mitotic adult heart tissue is attracting significant attention as a therapeutic strategy to regenerate the heart…”
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Proteome-wide systems genetics identifies UFMylation as a regulator of skeletal muscle function by Molendijk, Jeffrey, Blazev, Ronnie, Mills, Richard J, Ng, Yaan-Kit, Watt, Kevin I, Chau, Daryn, Gregorevic, Paul, Crouch, Peter J, Hilton, James B W, Lisowski, Leszek, Zhang, Peixiang, Reue, Karen, Lusis, Aldons J, Hudson, James E, James, David E, Seldin, Marcus M, Parker, Benjamin L

“…Improving muscle function has great potential to improve the quality of life. To identify novel regulators of skeletal muscle metabolism and function, we…”
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Generation of vascularized human cardiac organoids for 3D in vitro modeling by Voges, Holly K., Mills, Richard J., Porrello, Enzo R., Hudson, James E.

“…Here, we provide a protocol for next-generation human cardiac organoid modeling containing markers of vascularized tissues. We describe steps for cardiac…”
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Lateral spacing of adhesion peptides influences human mesenchymal stem cell behaviour by Frith, Jessica E, Mills, Richard J, Cooper-White, Justin J

“…Mesenchymal stem cells (MSCs) have attracted great interest in recent years for tissue engineering and regenerative medicine applications due to their ease of…”
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Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest by Mills, Richard J., Titmarsh, Drew M., Koenig, Xaver, Parker, Benjamin L., Ryall, James G., Quaife-Ryan, Gregory A., Voges, Holly K., Hodson, Mark P., Ferguson, Charles, Drowley, Lauren, Plowright, Alleyn T., Needham, Elise J., Wang, Qing-Dong, Gregorevic, Paul, Xin, Mei, Thomas, Walter G., Parton, Robert G., Nielsen, Lars K., Launikonis, Bradley S., James, David E., Elliott, David A., Porrello, Enzo R., Hudson, James E.

“…The mammalian heart undergoes maturation during postnatal life to meet the increased functional requirements of an adult. However, the key drivers of this…”
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Belantamab mafodotin concentration–QTc relationships in patients with relapsed or refractory multiple myeloma from the DREAMM‐1 and ‐2 studies by Jewell, Roxanne C., Mills, Richard J., Farrell, Colm, Visser, Sandra A. G.

“…Aims To evaluate relationships between plasma concentrations of belantamab mafodotin, total monoclonal antibody, and its payload and changes in…”
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There’s No I in Team: Cellular Crosstalk Enhances In Vitro Cardiac Maturation by Mills, Richard J., Hudson, James E.

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Aripiprazole Lauroxil: Pharmacokinetic Profile of This Long-Acting Injectable Antipsychotic in Persons With Schizophrenia by Hard, Marjie L, Mills, Richard J, Sadler, Brian M, Turncliff, Ryan Z, Citrome, Leslie

“…Aripiprazole lauroxil is an extended-release prodrug of aripiprazole for intramuscular injection, approved for schizophrenia treatment. We developed a…”
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β-Catenin drives distinct transcriptional networks in proliferative and nonproliferative cardiomyocytes by Quaife-Ryan, Gregory A, Mills, Richard J, Lavers, George, Voges, Holly K, Vivien, Celine J, Elliott, David A, Ramialison, Mirana, Hudson, James E, Porrello, Enzo R

“…The inability of the adult mammalian heart to regenerate represents a fundamental barrier in heart failure management. By contrast, the neonatal heart retains…”
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Development of a human skeletal micro muscle platform with pacing capabilities by Mills, Richard J., Parker, Benjamin L., Monnot, Pauline, Needham, Elise.J, Vivien, Celine J., Ferguson, Charles, Parton, Robert G., James, David E., Porrello, Enzo R., Hudson, James E.

“…Three dimensional engineered culture systems are powerful tools to rapidly expand our knowledge of human biology and identify novel therapeutic targets for…”
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Effect of geometric challenges on cell migration by Mills, Richard J, Frith, Jessica E, Hudson, James E, Cooper-White, Justin J

“…Cellular infiltration and colonization of three-dimensional (3D) porous scaffolds is influenced by many factors. One of the major factors is the internal…”
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Sex-Specific Control of Human Heart Maturation by the Progesterone Receptor by Sim, Choon Boon, Phipson, Belinda, Ziemann, Mark, Rafehi, Haloom, Mills, Richard J., Watt, Kevin I., Abu-Bonsrah, Kwaku D., Kalathur, Ravi K.R., Voges, Holly K., Dinh, Doan T., ter Huurne, Menno, Vivien, Celine J., Kaspi, Antony, Kaipananickal, Harikrishnan, Hidalgo, Alejandro, Delbridge, Leanne M.D., Robker, Rebecca L., Gregorevic, Paul, dos Remedios, Cristobal G., Lal, Sean, Piers, Adam T., Konstantinov, Igor E., Elliott, David A., El-Osta, Assam, Oshlack, Alicia, Hudson, James E., Porrello, Enzo R.

“…Despite in-depth knowledge of the molecular mechanisms controlling embryonic heart development, little is known about the signals governing postnatal…”
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NKX2-5 regulates human cardiomyogenesis via a HEY2 dependent transcriptional network by Anderson, David J., Kaplan, David I., Bell, Katrina M., Koutsis, Katerina, Haynes, John M., Mills, Richard J., Phelan, Dean G., Qian, Elizabeth L., Leitoguinho, Ana Rita, Arasaratnam, Deevina, Labonne, Tanya, Ng, Elizabeth S., Davis, Richard P., Casini, Simona, Passier, Robert, Hudson, James E., Porrello, Enzo R., Costa, Mauro W., Rafii, Arash, Curl, Clare L., Delbridge, Lea M., Harvey, Richard P., Oshlack, Alicia, Cheung, Michael M., Mummery, Christine L., Petrou, Stephen, Elefanty, Andrew G., Stanley, Edouard G., Elliott, David A.

“…Congenital heart defects can be caused by mutations in genes that guide cardiac lineage formation. Here, we show deletion of NKX2-5 , a critical component of…”
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Platelet-derived growth factor-AB improves scar mechanics and vascularity after myocardial infarction by Thavapalachandran, Sujitha, Grieve, Stuart M, Hume, Robert D, Le, Thi Yen Loan, Raguram, Kalyan, Hudson, James E, Pouliopoulos, Jim, Figtree, Gemma A, Dye, Rafael P, Barry, Anthony M, Brown, Paula, Lu, Juntang, Coffey, Sean, Kesteven, Scott H, Mills, Richard J, Rashid, Fairooj N, Taran, Elena, Kovoor, Pramesh, Thomas, Liza, Denniss, Alan Robert, Kizana, Eddy, Asli, Naisana S, Xaymardan, Munira, Feneley, Michael P, Graham, Robert M, Harvey, Richard P, Chong, James J H

“…Therapies that target scar formation after myocardial infarction (MI) could prevent ensuing heart failure or death from ventricular arrhythmias. We have…”
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Pharmacokinetic Profile of a 2-Month Dose Regimen of Aripiprazole Lauroxil: A Phase I Study and a Population Pharmacokinetic Model by Hard, Marjie L., Mills, Richard J., Sadler, Brian M., Wehr, Angela Y., Weiden, Peter J., von Moltke, Lisa

“…Background Aripiprazole lauroxil (AL) is a long-acting injectable medication approved for the treatment of schizophrenia. Current AL regimens are 441 mg,…”
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Limited oxygen in standard cell culture alters metabolism and function of differentiated cells by Tan, Joycelyn, Virtue, Sam, Norris, Dougall M, Conway, Olivia J, Yang, Ming, Bidault, Guillaume, Gribben, Christopher, Lugtu, Fatima, Kamzolas, Ioannis, Krycer, James R, Mills, Richard J, Liang, Lu, Pereira, Conceição, Dale, Martin, Shun-Shion, Amber S, Baird, Harry JM, Horscroft, James A, Sowton, Alice P, Ma, Marcella, Carobbio, Stefania, Petsalaki, Evangelia, Murray, Andrew J, Gershlick, David C, Nathan, James A, Hudson, James E, Vallier, Ludovic, Fisher-Wellman, Kelsey H, Frezza, Christian, Vidal-Puig, Antonio, Fazakerley, Daniel J

“…The in vitro oxygen microenvironment profoundly affects the capacity of cell cultures to model physiological and pathophysiological states. Cell culture is…”
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Vascular cells improve functionality of human cardiac organoids by Voges, Holly K., Foster, Simon R., Reynolds, Liam, Parker, Benjamin L., Devilée, Lynn, Quaife-Ryan, Gregory A., Fortuna, Patrick R.J., Mathieson, Ellen, Fitzsimmons, Rebecca, Lor, Mary, Batho, Christopher, Reid, Janice, Pocock, Mark, Friedman, Clayton E., Mizikovsky, Dalia, Francois, Mathias, Palpant, Nathan J., Needham, Elise J., Peralta, Marina, Monte-Nieto, Gonzalo del, Jones, Lynelle K., Smyth, Ian M., Mehdiabadi, Neda R., Bolk, Francesca, Janbandhu, Vaibhao, Yao, Ernestene, Harvey, Richard P., Chong, James J.H., Elliott, David A., Stanley, Edouard G., Wiszniak, Sophie, Schwarz, Quenten, James, David E., Mills, Richard J., Porrello, Enzo R., Hudson, James E.

“…Crosstalk between cardiac cells is critical for heart performance. Here we show that vascular cells within human cardiac organoids (hCOs) enhance their…”
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