Search Results - "MILLS, E. J"

Efficacy and safety of statin treatment for cardiovascular disease: a network meta-analysis of 170 255 patients from 76 randomized trials by MILLS, E. J, WU, P, CHONG, G, GHEMENT, I, SINGH, S, AKL, E. A, EYAWO, O, GUYATT, G, BERWANGER, O, BRIEL, M

“…Statins represent the largest selling class of cardiovascular drug in the world. Previous randomized trials (RCTs) have demonstrated important clinical…”
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Flexible energetics of cheetah hunting strategies provide resistance against kleptoparasitism by Scantlebury, David M., Mills, Michael G. L., Wilson, Rory P., Wilson, John W., Mills, Margaret E. J., Durant, Sarah M., Bennett, Nigel C., Bradford, Peter, Marks, Nikki J., Speakman, John R.

“…Population viability is driven by individual survival, which in turn depends on individuals balancing energy budgets. As carnivores may function close to…”
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Adverse events associated with individual statin treatments for cardiovascular disease: an indirect comparison meta-analysis by Alberton, M., Wu, P., Druyts, E., Briel, M., Mills, E. J.

“…Background: Statins are the most widely prescribed drug available. Due to this reason, it is important to understand the risks involved with the drug class and…”
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Foraging behaviour of a continental shelf marine predator, the grey seal ( Halichoerus grypus ), is associated with in situ, subsurface oceanographic conditions by Nowak, B V R, Bowen, W D, Whoriskey, K, Lidgard, D C, Mills Flemming, J E, Iverson, S J

“…The heterogeneous oceanographic conditions of continental shelf ecosystems result in a three-dimensionally patchy distribution of prey available to…”
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Enhanced HTS Hit Selection via a Local Hit Rate Analysis by Posner, Bruce A, Xi, Hualin, Mills, James E. J

“…The postprocessing of high-throughput screening (HTS) results is complicated by the occurrence of false positives (inactive compounds misidentified as active…”
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Novel Amino-pyrazole Ureas with Potent In Vitro and In Vivo Antileishmanial Activity by Mowbray, Charles E, Braillard, Stéphanie, Speed, William, Glossop, Paul A, Whitlock, Gavin A, Gibson, Karl R, Mills, James E. J, Brown, Alan D, Gardner, J. Mark F, Cao, Yafeng, Hua, Wen, Morgans, Garreth L, Feijens, Pim-Bart, Matheeussen, An, Maes, Louis J

“…Visceral leishmaniasis is a severe parasitic disease that is one of the most neglected tropical diseases. Treatment options are limited, and there is an urgent…”
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Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin‑2 Receptor: Structure–Activity Relationships and Optimization by Zirimwabagabo, Jean-Olivier, Jailani, Ameera B. A, Avgoustou, Paris, Tozer, Matthew J, Gibson, Karl R, Glossop, Paul A, Mills, James E. J, Porter, Roderick A, Blaney, Paul, Wang, Ning, Skerry, Timothy M, Richards, Gareth O, Harrity, Joseph P. A

“…Class B G-protein-coupled receptors (GPCRs) remain an underexploited target for drug development. The calcitonin receptor (CTR) family is particularly…”
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Treatment of periodontal disease for glycaemic control in people with diabetes by Simpson, TC, Needleman, I, Wild, SH, Moles, DR, Mills, EJ

“…Background:  Glycaemic control is a key issue in the care of people with diabetes mellitus (DM). Some studies have suggested a bidirectional relationship…”
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Antiretroviral effects on HIV‐1 RNA, CD4 cell count and progression to AIDS or death: a meta‐regression analysis by Mills, EJ, Kelly, S, Bradley, M, Mollon, P, Cooper, C, Nachega, J

“…Objective Governments, clinicians and drug‐licensing bodies have adopted changes in CD4 cell counts and HIV‐1 RNA levels as evidence of effectiveness for new…”
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Development of a Pharmacophore Model for Histamine H3 Receptor Antagonists, Using the Newly Developed Molecular Modeling Program SLATE by De Esch, Iwan J. P, Mills, James E. J, Perkins, Tim D. J, Romeo, Giuseppe, Hoffmann, Marcel, Wieland, Kerstin, Leurs, Rob, Menge, Wiro M. P. B, Nederkoorn, Paul H. J, Dean, Philip M, Timmerman, Henk

“…New molecular modeling tools were developed to construct a qualitative pharmacophore model for histamine H3 receptor antagonists. The program SLATE superposes…”
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Discovery of a First-in-Class Potent Small Molecule Antagonist against the Adrenomedullin‑2 Receptor by Avgoustou, Paris, Jailani, Ameera B. A, Zirimwabagabo, Jean-Olivier, Tozer, Matthew J, Gibson, Karl R, Glossop, Paul A, Mills, James E. J, Porter, Roderick A, Blaney, Paul, Bungay, Peter J, Wang, Ning, Shaw, Alice P, Bigos, Kamilla J. A, Holmes, Joseph L, Warrington, Jessica I, Skerry, Timothy M, Harrity, Joseph P. A, Richards, Gareth O

“…The hormone adrenomedullin has both physiological and pathological roles in biology. As a potent vasodilator, adrenomedullin is critically important in the…”
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Marginally Specified Generalized Linear Mixed Models: A Robust Approach by Mills, J. E., Field, C. A., Dupuis, D. J.

“…Longitudinal data modeling is complicated by the necessity to deal appropriately with the correlation between observations made on the same individual…”
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Antiretroviral therapy for initial human immunodeficiency virus/AIDS treatment: critical appraisal of the evidence from over 100 randomized trials and 400 systematic reviews and meta-analyses by Kanters, S., Mills, E.J., Thorlund, K., Bucher, H.C., Ioannidis, J.P.A.

“…There have been over 100 randomized clinical trials (RCTs) of diverse regimens of antiretroviral therapy for treatment-naïve human immunodeficiency…”
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Network meta-analysis of direct-acting antivirals in combination with peginterferon-ribavirin for previously untreated patients with hepatitis C genotype 1 infection by Druyts, E, Lorenzi, M, Toor, K, Thorlund, K, Mills, E J

“…To conduct a network meta-analysis (NMA) to determine the comparative efficacy, as measured by sustained virological response (SVR), between boceprevir (BOC),…”
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Association between change in high density lipoprotein cholesterol and cardiovascular disease morbidity and mortality: systematic review and meta-regression analysis by Briel, Matthias, Ferreira-Gonzalez, Ignacio, You, John J, Karanicolas, Paul J, Akl, Elie A, Wu, Ping, Blechacz, Boris, Bassler, Dirk, Wei, Xinge, Sharman, Asheer, Whitt, Irene, Alves da Silva, Suzana, Khalid, Zahira, Nordmann, Alain J, Zhou, Qi, Walter, Stephen D, Vale, Noah, Bhatnagar, Neera, O’Regan, Christopher, Mills, Edward J, Bucher, Heiner C, Montori, Victor M, Guyatt, Gordon H

“…Objective To investigate the association between treatment induced change in high density lipoprotein cholesterol and total death, coronary heart disease…”
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How well can animals navigate? Estimating the circle of confusion from tracking data by Flemming, J. E. Mills, Field, C. A., James, M. C., Jonsen, I. D., Myers, R. A.

“…State‐space models have recently been shown to effectively model animal movement. In this paper we illustrate how such models can be used to improve our…”
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Direct-acting antiviral therapies for hepatitis C genotype 1 infection: a multiple treatment comparison meta-analysis by Cooper, C, Lester, R, Thorlund, K, Druyts, E, El Khoury, A C, Yaya, S, Mills, E J

“…New direct-acting antiviral agents for hepatitis C genotype 1 infection, boceprevir and telaprevir, offer enhanced sustained virologic response (SVR) among…”
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Promoting long term adherence to antiretroviral treatment by Mills, Edward J, Lester, Richard, Ford, Nathan

“…Patient support and community interventions are probably the best interventions…”
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Republication of Inaugural Editorial, British Journal of Orthodontics by Mills, J.R.E.

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The Use of Single-Arm Evidence In The Comparative Efficacy of Interferon-Free Antivirals for Treatment-Naïve Hepatitis C Genotype 1 by Druyts, E, Kanters, S, Toor, K, Thorlund, K, Mills, EJ

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