Search Results - "MILLIGAN, Laura"

Regulation of the RNAPII Pool Is Integral to the DNA Damage Response by Tufegdžić Vidaković, Ana, Mitter, Richard, Kelly, Gavin P., Neumann, Michelle, Harreman, Michelle, Rodríguez-Martínez, Marta, Herlihy, Anna, Weems, Juston C., Boeing, Stefan, Encheva, Vesela, Gaul, Liam, Milligan, Laura, Tollervey, David, Conaway, Ronald C., Conaway, Joan W., Snijders, Ambrosius P., Stewart, Aengus, Svejstrup, Jesper Q.

“…In response to transcription-blocking DNA damage, cells orchestrate a multi-pronged reaction, involving transcription-coupled DNA repair, degradation of RNA…”
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Strand‐specific, high‐resolution mapping of modified RNA polymerase II by Milligan, Laura, Huynh‐Thu, Vân A, Delan‐Forino, Clémentine, Tuck, Alex, Petfalski, Elisabeth, Lombraña, Rodrigo, Sanguinetti, Guido, Kudla, Grzegorz, Tollervey, David

“…Reversible modification of the RNAPII C‐terminal domain links transcription with RNA processing and surveillance activities. To better understand this, we…”
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A Yeast Exosome Cofactor, Mpp6, Functions in RNA Surveillance and in the Degradation of Noncoding RNA Transcripts by Milligan, Laura, Decourty, Laurence, Saveanu, Cosmin, Rappsilber, Juri, Ceulemans, Hugo, Jacquier, Alain, Tollervey, David

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H19 antisense RNA can up-regulate Igf2 transcription by activation of a novel promoter in mouse myoblasts by Tran, Van Giang, Court, Franck, Duputié, Anne, Antoine, Etienne, Aptel, Nathalie, Milligan, Laura, Carbonell, Françoise, Lelay-Taha, Marie-Noëlle, Piette, Jacques, Weber, Michaël, Montarras, Didier, Pinset, Christian, Dandolo, Luisa, Forné, Thierry, Cathala, Guy

“…It was recently shown that a long non-coding RNA (lncRNA), that we named the 91H RNA (i.e. antisense H19 transcript), is overexpressed in human breast tumours…”
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RNA polymerase II stalling at pre-mRNA splice sites is enforced by ubiquitination of the catalytic subunit by Milligan, Laura, Sayou, Camille, Tuck, Alex, Auchynnikava, Tatsiana, Reid, Jane Ea, Alexander, Ross, Alves, Flavia de Lima, Allshire, Robin, Spanos, Christos, Rappsilber, Juri, Beggs, Jean D, Kudla, Grzegorz, Tollervey, David

“…Numerous links exist between co-transcriptional RNA processing and the transcribing RNAPII. In particular, pre-mRNA splicing was reported to be associated with…”
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Retrospective Analysis: Most Common Diagnoses Seen in a Primary Care Clinic and Corresponding Occupational Therapy Interventions by Vanwinkle, Makenzie, Milligan, Laura, Trembath, Felicia, Dahl-Popolizio, Sue

“…Background: The literature supports occupational therapy (OT) on primary care (PC) interprofessional teams; however, due to uncertainty regarding the role of,…”
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A Nuclear Surveillance Pathway for mRNAs with Defective Polyadenylation by Milligan, Laura, Torchet, Claire, Allmang, Christine, Shipman, Tracey, Tollervey, David

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Processing of 3′-Extended Read-Through Transcripts by the Exosome Can Generate Functional mRNAs by Torchet, Claire, Bousquet-Antonelli, Cecile, Milligan, Laura, Thompson, Emma, Kufel, Joanna, Tollervey, David

“…Strains carrying rna14.1 and rna15.2 mutations are defective in pre-mRNA 3′ cleavage, polyadenylation, and transcription termination. Long extended…”
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Depletion of the Yeast Nuclear Exosome Subunit Rrp6 Results in Accumulation of Polyadenylated RNAs in a Discrete Domain within the Nucleolus by Carneiro, Tiago, Carvalho, Célia, Braga, José, Rino, José, Milligan, Laura, Tollervey, David, Carmo-Fonseca, Maria

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Effectiveness and safety of high‐dose cyclophosphamide as salvage therapy for high‐risk multiple myeloma and plasma cell leukemia refractory to new biological agents by Rivell, Guillermo L., Brunson, Chris Y., Milligan, Laura, Stuart, Robert K., Costa, Luciano J.

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Outcomes of 10-day decitabine with venetoclax for AML by Coltoff, Alexander, Baratam, Praneeth, Green, Kimberly Michelle, Davis, James A., Smith, Deidra, Gaffney, Kelly, Dougherty, Elizabeth, Milligan, Laura

“…7022 Background: Venetoclax (VEN) + a hypomethylating agent (HMA) has improved outcomes for patients with acute myeloid leukemia (AML). VIALE-A showed improved…”
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Abstract 342: Sub-group of HER2-negative breast cancer patients with hyperactive RAS network signaling identified: Dynamic pathway activity test identifies patients that may benefit from PI3K/mTOR or PI3K/mTOR/BCL inhibitors by Khan, Salmaan, Sen, Adrish, Kuzmicki, Catherine, MacNeil, Ian, Broege, Aaron, Mutka, Sarah, Brass, Kelly, McCracken, Ky, Milligan, Laura, Kotke, Katja, Sullivan, Brian, Laing, Lance

“…Abstract Background: Dysregulated signaling through GPCRs is implicated in oncogenic RAS signaling in breast cancer (BC). The complex regulatory mechanisms…”
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Outcomes of AML Patients Undergoing Reduced Intensity Allogeneic Stem Cell Transplantation with Adverse Risk Disease By European Leukemianet Classification: A Single Center Retrospective Analysis by Chiad, Zane, Alsfeld, Clark, Collins, Robert, Randolph, Brion, Nahhas, Georges, Stuart, Robert K., Neppalli, Amarendra K., Greenwell, Irl Brian, Edwards, Kathy, Milligan, Laura, Pearce, Lauren, Hess, Brian T.

“…Background: Acute myeloid leukemia (AML) is the most common acute leukemia in adults with a median age at diagnosis of close to 70 years. (Juliusson G, et al…”
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A Selective Inverse Agonist for Central Cannabinoid Receptor Inhibits Mitogen-activated Protein Kinase Activation Stimulated by Insulin or Insulin-like Growth Factor 1 by Bouaboula, Monsif, Perrachon, Sylvie, Milligan, Laura, Canat, Xavier, Rinaldi-Carmona, Murielle, Portier, Marielle, Barth, Francis, Calandra, Bernard, Pecceu, Florence, Lupker, Johannes, Maffrand, Jean-Pierre, Le Fur, Gérard, Casellas, Pierre

“…In the present study, we showed that Chinese hamster ovary (CHO) cells transfected with human central cannabinoid receptor (CB1) exhibit high constitutive…”
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Extensive tissue-specific variation of allelic methylation in the Igf2 gene during mouse fetal development: relation to expression and imprinting by Weber, Michaël, Milligan, Laura, Delalbre, Annie, Antoine, Etienne, Brunel, Claude, Cathala, Guy, Forné, Thierry

“…The imprinted Igf2 gene is active only on the paternal allele in most tissues. Its imprinting involves a cis-acting imprinting-control region (ICR) located…”
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Most Patients with Core Binding Factor AML Require Hematopoietic Stem Cell Transplantation for Long-Term Survival: Long Term Follow-up of a Cohort of Unselected Patients by Adams, Betsy R., McElligott, Kevin, Milligan, Laura, Costa, Luciano J, Stuart, Robert K

“…Abstract 4560 About 15% of acute myelogenous leukemia (AML) patients will have disruption of the core binding factor (CBF) transcription factor as indicated by…”
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A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. Evidence for a new model of receptor/ligand interactions by Bouaboula, M, Perrachon, S, Milligan, L, Canat, X, Rinaldi-Carmona, M, Portier, M, Barth, F, Calandra, B, Pecceu, F, Lupker, J, Maffrand, J P, Le Fur, G, Casellas, P

“…In the present study, we showed that Chinese hamster ovary (CHO) cells transfected with human central cannabinoid receptor (CB1) exhibit high constitutive…”
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Eosinophil-rich CD30+ lymphoproliferative disorder of the oral mucosa: A form of traumatic eosinophilic granuloma by ALOBEID, Bachir, PAN, Lang-Xing, MILLIGAN, Laura, BUDEL, Leo, FRIZZERA, Glauco

“…We describe 3 patients who had oral mucosal lesions with features of traumatic eosinophilic granuloma (TEG) and containing CD30+ atypical cells. In 1 patient,…”
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Inactivation of cleavage factor I components Rna14p and Rna15p induces sequestration of small nucleolar ribonucleoproteins at discrete sites in the nucleus by Carneiro, Tiago, Carvalho, Célia, Braga, José, Rino, José, Milligan, Laura, Tollervey, David, Carmo-Fonseca, Maria

“…Small nucleolar RNAs (snoRNAs) associate with specific proteins forming small nucleolar ribonucleoprotein (snoRNP) particles, which are essential for ribosome…”
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Expression of Kaposi's Sarcoma-Associated Herpesvirus G Protein-Coupled Receptor Monocistronic and Bicistronic Transcripts in Primary Effusion Lymphomas by Nador, Roland G., Milligan, Laura L., Flore, Ornella, Wang, Xiao, Arvanitakis, Leandros, Knowles, Daniel M., Cesarman, Ethel

“…Kaposi's sarcoma-associated herpesvirus (KSHV/HHV-8) encodes a G protein-coupled receptor (vGPCR) in open reading frame (ORF) 74, which is homologous to human…”
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