Search Results - "MILLHOLLAND, John"

Translational precision medicine: an industry perspective by Hartl, Dominik, de Luca, Valeria, Kostikova, Anna, Laramie, Jason, Kennedy, Scott, Ferrero, Enrico, Siegel, Richard, Fink, Martin, Ahmed, Sohail, Millholland, John, Schuhmacher, Alexander, Hinder, Markus, Piali, Luca, Roth, Adrian

“…In the era of precision medicine, digital technologies and artificial intelligence, drug discovery and development face unprecedented opportunities for product…”
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BRAF -Mutant Transcriptional Subtypes Predict Outcome of Combined BRAF, MEK, and EGFR Blockade with Dabrafenib, Trametinib, and Panitumumab in Patients with Colorectal Cancer by Middleton, Gary, Yang, Yiqun, Campbell, Catarina D, André, Thierry, Atreya, Chloe E, Schellens, Jan H M, Yoshino, Takayuki, Bendell, Johanna C, Hollebecque, Antoine, McRee, Autumn J, Siena, Salvatore, Gordon, Michael S, Tabernero, Josep, Yaeger, Rona, O'Dwyer, Peter J, De Vos, Filip, Van Cutsem, Eric, Millholland, John M, Brase, Jan C, Rangwala, Fatima, Gasal, Eduard, Corcoran, Ryan B

“…The influence of the transcriptional and immunologic context of mutations on therapeutic outcomes with targeted therapy in cancer has not been well defined…”
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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma by Weng, Andrew P, Millholland, John M, Yashiro-Ohtani, Yumi, Arcangeli, Marie Laure, Lau, Arthur, Wai, Carol, Del Bianco, Cristina, Rodriguez, Carlos G, Sai, Hong, Tobias, John, Li, Yueming, Wolfe, Michael S, Shachaf, Cathy, Felsher, Dean, Blacklow, Stephen C, Pear, Warren S, Aster, Jon C

“…Human acute T-cell lymphoblastic leukemias and lymphomas (T-ALL) are commonly associated with gain-of-function mutations in Notch1 that contribute to T-ALL…”
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Targeting P-selectin and interleukin-1β in mice with sickle cell disease: effects on vaso-occlusion, liver injury and organ iron deposition by Gotardo, Érica M. F., Torres, Lidiane S., Zaidan, Bruna Cunha, Gushiken, Lucas F. S., Brito, Pâmela L., Leonardo, Flavia C., Pellizzon, Claudia H., Millholland, John, Agoulnik, Sergei, Kovarik, Jiri, Costa, Fernando F., Conran, Nicola

“…Continuous vaso-occlusive and inflammatory processes cause extensive end-organ damage in adults with sickle cell disease (SCD), and there is little evidence…”
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A Simplified, Noninvasive Stool DNA Test for Colorectal Cancer Detection by ITZKOWITZ, Steven, BRAND, Randall, PASZAT, Lawrence, BERGER, Barry M, JANDORF, Lina, DURKEE, Kris, MILLHOLLAND, John, RABENECK, Linda, SCHROY, Paul C, SONTAG, Stephen, JOHNSON, David, MARKOWITZ, Sanford

“…As a noninvasive colorectal cancer (CRC) screening test, a multi-marker first generation stool DNA (sDNA V 1.0) test is superior to guaiac-based fecal occult…”
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Targeting the IL1β Pathway for Cancer Immunotherapy Remodels the Tumor Microenvironment and Enhances Antitumor Immune Responses by Diwanji, Rohan, O'Brien, Neil A, Choi, Jiyoung E, Nguyen, Beverly, Laszewski, Tyler, Grauel, Angelo L, Yan, Zheng, Xu, Xin, Wu, Jincheng, Ruddy, David A, Piquet, Michelle, Pelletier, Marc R, Savchenko, Alexander, Charette, LaSalette, Rodrik-Outmezguine, Vanessa, Baum, Jason, Millholland, John M, Wong, Connie C, Martin, Anne-Marie, Dranoff, Glenn, Pruteanu-Malinici, Iulian, Cremasco, Viviana, Sabatos-Peyton, Catherine, Jayaraman, Pushpa

“…High levels of IL1β can result in chronic inflammation, which in turn can promote tumor growth and metastasis. Inhibition of IL1β could therefore be a…”
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An end is in sight: a perspective on PCR as an endpoint for Chagas disease treatment trials by Hochberg, Natasha S., Rao, Srinivasa P. S., Angyalosi, Gerhild, Zhao, Xiaojun, Carballo, Leticia, Demacq, Caroline, Braud-Perez, Sofia, Wieser, Daniela, Casas, JP, Millholland, John, Ngo, Debby

“…Novel therapies for chronic indeterminate Chagas disease (CICD) are needed, but trials are limited by the absence of tests to detect infection and early…”
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Detection of low frequency FGFR3 mutations in the urine of bladder cancer patients using next-generation deep sequencing by Millholland, John M, Li, Shuqiang, Fernandez, Cecilia A, Shuber, Anthony P

“…Biological fluid-based noninvasive biomarker assays for monitoring and diagnosing disease are clinically powerful. A major technical hurdle for developing…”
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Nuclear ferritin in corneal epithelial cells: tissue–specific nuclear transport and protection from UV–damage by Linsenmayer, Thomas F., Cai, Cindy X., Millholland, John M., Beazley, Kelly E., Fitch, John M.

“…We have identified the heavy chain of ferritin as a developmentally regulated nuclear protein of embryonic chicken corneal epithelial cells. The nuclear…”
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Ferritoid, a Tissue-specific Nuclear Transport Protein for Ferritin in Corneal Epithelial Cells by Millholland, John M, Fitch, John M, Cai, Cindy X, Gibney, Eileen P, Beazley, Kelly E, Linsenmayer, Thomas F

“…Previously we reported that ferritin in corneal epithelial (CE) cells is a nuclear protein that protects DNA from UV damage. Since ferritin is normally…”
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A noninvasive multi-analyte diagnostic assay: combining protein and DNA markers to stratify bladder cancer patients by Fernandez, Cecilia A, Millholland, John M, Zwarthoff, Ellen C, Feldman, Adam S, Karnes, R Jeffrey, Shuber, Anthony P

“…The authors recently reported the development of a noninvasive diagnostic assay using urinary matrix metalloproteinases (MMPs) as monitors of disease-free…”
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T1098 Improved Non-Invasive Stool DNA (SDNA) Test to Screen for Colorectal Cancer (CRC): Validation of High Sensitivity and Specificity by Itzkowitz, Steven H, Brand, Randall, Jandorf, Lina, Rabeneck, Linda, Schroy, Paul C, Sontag, Stephen J, Johnson, David A, Markowitz, Sanford, Millholland, John M, Durkee, Kristine H, Paszat, Lawrence, Berger, Barry M

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Neutralization of IL-1β and P-Selectin Inhibition Attenuate Organ Injury in Mice with Sickle Cell Disease by Gotardo, Erica M.F., Gushiken, Lucas F.S., Brito, Pamela L, Leonardo, Flavia C., Torres, Lidiane S., Agoulnik, Sergei, Kovarik, Jiri, Bruederle, Andreas, Millholland, John, Costa, Fernando Ferreira, Conran, Nicola

“…Advances in the clinical management of sickle cell disease (SCD) have significantly improved the life expectancy of patients. However, aging in SCD is…”
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P-Selectin Blockage Potentiates the Inhibiting Effects of Inflammasome Cytokine Neutralization on Leukocyte Recruitment in an In Vivo Model of Acute Sickle Cell Vaso-Occlusion by Gotardo, Erica M.F., Torres, Lidiane S., Gushiken, Lucas F.S., Brito, Pamela L., Leonardo, Flavia C., Agoulnik, Sergei, Kovarik, Jiri, Bruederle, Andreas, Millholland, John, Vitaliti, Alessandra, Förster, Irmgard, Costa, Fernando Ferreira, Conran, Nicola

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Immune infiltration and angiogenesis as markers of outcome in the post-nephrectomy setting: Transcriptomic data from patients receiving placebo on a randomized phase III trial (PROTECT) by Hakimi, A. Ari, Voss, Martin H, Kuo, Fengshen, Silagy, Andrew W., Marker, Mahtab, Reising, Albert, Millholland, John, Chan, Timothy An-thy, Russo, Paul, Motzer, Robert J.

“…Abstract only 5082 Background: Defined stromal and immune features of the tumor microenvironment (TME) have proven relevant for outcomes with systemic therapy…”
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PD49-01 THERAPY-RELEVANT GENE SIGNATURES IN THE HIGH RISK LOCALIZED RENAL CELL CARCINOMA SETTING: TRANSCRIPTOMIC DATA FROM PATIENTS RECEIVING PLACEBO ON A RANDOMIZED PHASE 3 TRIAL (PROTECT) by Rappold, Phillip, Silagy, Andrew W., Kuo, Fengshen, Marker, Mahtab, Reising, Albert, Millholland, John, Russo, Paul, Coleman, Jonathan, Voss, Martin H., Chan, Timothy A., Motzer, Robert J, Hakimi, A. Ari

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Therapy-relevant gene signatures in the high risk localized renal cell carcinoma setting: Transcriptomic data from patients receiving placebo on a randomized phase III trial (PROTECT) by Rappold, Phillip M., Silagy, Andrew W., Kuo, Fengshen, Marker, Mahtab, Reising, Albert, Millholland, John, Russo, Paul, Coleman, Jonathan, Voss, Martin H., Chan, Timothy A., Motzer, Robert J., Hakimi, A. Ari

“…Abstract only 353 Background: Transcriptomic profiling of the renal cell carcinoma (RCC) tumor microenvironment (TME) has revealed gene signatures predictive…”
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The requirement for Notch signaling at the beta-selection checkpoint in vivo is absolute and independent of the pre-T cell receptor by Maillard, Ivan, Tu, LiLi, Sambandam, Arivazhagan, Yashiro-Ohtani, Yumi, Millholland, John, Keeshan, Karen, Shestova, Olga, Xu, Lanwei, Bhandoola, Avinash, Pear, Warren S

“…Genetic inactivation of Notch signaling in CD4(-)CD8(-) double-negative (DN) thymocytes was previously shown to impair T cell receptor (TCR) gene rearrangement…”
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Abstract 5640: Targeting tumor-promoting inflammation (TPI) via the IL-1βpathway for cancer immunotherapy by Jayaraman, Pushpa, Rodrik-Outmezguine, Vanessa, Millholland, John, O'Brien, Neil, Wong, Connie, Diwanji, Rohan, Wang, Muchun, Choi, Elizabeth, Linnartz, Ronald, Rose, Kristine, Pelletier, Marc, Savchenko, Alexander, Luo, Tong, Rezek, Valerie, Kitchen, Scott, Baum, Jason, Sabatos-Peyton, Catherine, Martin, Anne-Marie, Dranoff, Glenn

“…Introduction: TPI is a hallmark of cancer and plays a pivotal role in tumor initiation, development, progression, and invasiveness. High levels of…”
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Abstract C103: Targeting IL-1β pathway for cancer immunotherapy by Jayaraman, Pushpa, Millholland, John, O’Brien, Neil, Wong, Connie, Diwanji, Rohan, Wang, Muchun, Choi, Elizabeth, Linnartz, Ronald, Rose, Kristine, Rodrik-Outmezguine, Vanessa, Pelletier, Marc, Savchenko, Alexander, Luo, Tong, Rezek, Valerie, Kitchen, Scott, Baum, Jason, Sabatos-Peyton, Catherine, Martin, Anne-Marie, Dranoff, Glenn

“…Introduction: Inflammation is a hallmark of cancer wherein diverse immune cells exert either pro- or antitumor properties and affect therapeutic resistance…”
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