Search Results - "MILLER, V. A"

Next-generation sequencing reveals frequent consistent genomic alterations in small cell undifferentiated lung cancer by Ross, J S, Wang, K, Elkadi, O R, Tarasen, A, Foulke, L, Sheehan, C E, Otto, G A, Palmer, G, Yelensky, R, Lipson, D, Chmielecki, J, Ali, S M, Elvin, J, Morosini, D, Miller, V A, Stephens, P J

“…Small cell lung cancer (SCLC) carries a poor prognosis, and the systemic therapies currently used as treatments are only modestly effective, as demonstrated by…”
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Next-generation sequencing of adrenocortical carcinoma reveals new routes to targeted therapies by Ross, J S, Wang, K, Rand, J V, Gay, L, Presta, M J, Sheehan, C E, Ali, S M, Elvin, J A, Labrecque, E, Hiemstra, C, Buell, J, Otto, G A, Yelensky, R, Lipson, D, Morosini, D, Chmielecki, J, Miller, V A, Stephens, P J

“…Adrenocortical carcinoma (ACC) carries a poor prognosis and current systemic cytotoxic therapies result in only modest improvement in overall survival. In this…”
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Glucocorticoid-mediated BIM induction and apoptosis are regulated by Runx2 and c-Jun in leukemia cells by Heidari, N, Miller, A V, Hicks, M A, Marking, C B, Harada, H

“…Glucocorticoids (GCs) are common components of many chemotherapeutic regimens for lymphoid malignancies. GC-induced apoptosis involves an intrinsic…”
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Efficacy of Cytotoxic Agents against Human Tumor Xenografts Is Markedly Enhanced By Coadministration of ZD1839 (Iressa), an Inhibitor of EGFR Tyrosine Kinase by SIROTNAK, Francis M, ZAKOWSKI, Maureen F, MILLER, Vincent A, SCHER, Howard I, KRIS, Mark G

“…The blockade of epidermal growth factor receptor (EGFR) function with monoclonal antibodies has major antiproliferative effects against human tumors in vivo …”
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Time Synchronization in Satellite Quantum Key Distribution by Miller, A. V.

“…Time synchronization is one of the most crucial issues that must be addressed in developing quantum key distribution (QKD) systems. It not only lets the…”
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Tumor mutational burden is predictive of response to immune checkpoint inhibitors in MSI-high metastatic colorectal cancer by Schrock, A.B., Ouyang, C., Sandhu, J., Sokol, E., Jin, D., Ross, J.S., Miller, V.A., Lim, D., Amanam, I., Chao, J., Catenacci, D., Cho, M., Braiteh, F., Klempner, S.J., Ali, S.M., Fakih, M.

“…Microsatellite instability (MSI) is a biomarker for response to immune checkpoint inhibitors (ICPIs). PD-1 inhibitors in metastatic colorectal carcinoma (mCRC)…”
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Migraine Headaches and Sleep Disturbances in Children by Miller, V.A., Palermo, T.M., Powers, S.W., Scher, M.S., Hershey, A.D.

“…Objective.—The aim of the present study was to investigate the prevalence of sleep disturbances in children with migraine headaches and to describe individual…”
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Solute transport through the integrated groundwater-stream system of a catchment by Lindgren, G. A., Destouni, G., Miller, A. V.

“…We present a coupled groundwater‐stream model of catchment‐scale solute transport, using a Lagrangian stochastic advective‐sorptive travel time approach. We…”
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Initial clinical trial of a selective retinoid X receptor ligand, LGD1069 by Miller, V A, Benedetti, F M, Rigas, J R, Verret, A L, Pfister, D G, Straus, D, Kris, M G, Crisp, M, Heyman, R, Loewen, G R, Truglia, J A, Warrell, Jr, R P

“…The retinoid response is mediated by nuclear receptors, including retinoic acid receptors (RARs) and retinoid "X" receptors (RXRs). All-trans retinoic acid…”
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Comparative Genomic Profiling of Refractory and Metastatic Penile and Nonpenile Cutaneous Squamous Cell Carcinoma: Implications for Selection of Systemic Therapy by Jacob, Joseph M, Ferry, Elizabeth K, Gay, Laurie M, Elvin, Julia A, Vergilio, Jo-Anne, Ramkissoon, Shakti, Severson, Eric, Necchi, Andrea, Killian, J Keith, Ali, Siraj M, Schrock, Alexa B, Liu, Nick W, Chung, J, Miller, V A, Stephens, P J, Welsh, A, Corona, Robert J, Ross, Jeffrey S, Bratslavsky, Gennady

“…Metastatic penile squamous cell carcinoma is an aggressive malignancy with limited treatment options. We compared the potential therapy impacting genomic…”
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Genomic alterations in head and neck squamous cell carcinoma determined by cancer gene-targeted sequencing by Chung, C.H., Guthrie, V.B., Masica, D.L., Tokheim, C., Kang, H., Richmon, J., Agrawal, N., Fakhry, C., Quon, H., Subramaniam, R.M., Zuo, Z., Seiwert, T., Chalmers, Z.R., Frampton, G.M., Ali, S.M., Yelensky, R., Stephens, P.J., Miller, V.A., Karchin, R., Bishop, J.A.

“…To determine genomic alterations in head and neck squamous cell carcinoma (HNSCC) using formalin-fixed, paraffin-embedded (FFPE) tumors obtained through…”
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"Pulsatile" high-dose weekly erlotinib for CNS metastases from EGFR mutant non-small cell lung cancer by Grommes, Christian, Oxnard, Geoffrey R., Kris, Mark G., Miller, Vincent A., Pao, William, Holodny, Andrei I., Clarke, Jennifer L., Lassman, Andrew B.

“…Erlotinib is effective for epidermal growth factor receptor (EGFR) mutant lung cancer, but CNS penetration at standard daily dosing is limited. We previously…”
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Inhibiting MEK in MAPK pathway-activated myeloma by Heuck, C J, Jethava, Y, Khan, R, van Rhee, F, Zangari, M, Chavan, S, Robbins, K, Miller, S E, Matin, A, Mohan, M, Ali, S M, Stephens, P J, Ross, J S, Miller, V A, Davies, F, Barlogie, B, Morgan, G

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Hybrid capture-based genomic profiling of circulating tumor DNA from patients with estrogen receptor-positive metastatic breast cancer by Chung, J.H., Pavlick, D., Hartmaier, R., Schrock, A.B., Young, L., Forcier, B., Ye, P., Levin, M.K., Goldberg, M., Burris, H., Gay, L.M., Hoffman, A.D., Stephens, P.J., Frampton, G.M., Lipson, D.M., Nguyen, D.M., Ganesan, S., Park, B.H., Vahdat, L.T., Leyland-Jones, B., Mughal, T.I., Pusztai, L., O’Shaughnessy, J., Miller, V.A., Ross, J.S., Ali, S.M.

“…Genomic changes that occur in breast cancer during the course of disease have been informed by sequencing of primary and metastatic tumor tissue. For patients…”
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Comprehensive genomic profiling of anal squamous cell carcinoma reveals distinct genomically defined classes by Chung, J.H., Sanford, E., Johnson, A., Klempner, S.J., Schrock, A.B., Palma, N.A., Erlich, R.L., Frampton, G.M., Chalmers, Z.R., Vergilio, J., Rubinson, D.A., Sun, J.X., Chmielecki, J., Yelensky, R., Suh, J.H., Lipson, D., George, T.J., Elvin, J.A., Stephens, P.J., Miller, V.A., Ross, J.S., Ali, S.M.

“…Squamous cell cancers of the anal canal (ASCC) are increasing in frequency and lack effective therapies for advanced disease. Although an association with…”
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High-speed OH chemiluminescence imaging of ignition through a shock tube end-wall by Troutman, V. A., Strand, C. L., Campbell, M. F., Tulgestke, A. M., Miller, V. A., Davidson, D. F., Hanson, R. K.

“…A high-speed OH* chemiluminescence imaging diagnostic was developed to image the structure and homogeneity of combustion events behind reflected shock waves in…”
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Patient-derived xenotransplants can recapitulate the genetic driver landscape of acute leukemias by Wang, K, Sanchez-Martin, M, Wang, X, Knapp, K M, Koche, R, Vu, L, Nahas, M K, He, J, Hadler, M, Stein, E M, Tallman, M S, Donahue, A L, Frampton, G M, Lipson, D, Roels, S, Stephens, P J, Sanford, E M, Brennan, T, Otto, G A, Yelensky, R, Miller, V A, Kharas, M G, Levine, R L, Ferrando, A, Armstrong, S A, Krivtsov, A V

“…Genomic studies have identified recurrent somatic mutations in acute leukemias. However, current murine models do not sufficiently encompass the genomic…”
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Comprehensive genomic profiling of epithelial ovarian cancer by next generation sequencing-based diagnostic assay reveals new routes to targeted therapies by Ross, J.S, Ali, S.M, Wang, K, Palmer, G, Yelensky, R, Lipson, D, Miller, V.A, Zajchowski, D, Shawver, L.K, Stephens, P.J

“…Abstract Objective Targeted next generation sequencing (NGS) was evaluated for its ability to identify unanticipated targetable genomic alterations (GA) for…”
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Docetaxel in the management of advanced non-small cell lung cancer by Miller, V A

“…Following encouraging phase I trials in non-small cell lung cancer, the semisynthetic taxoid docetaxel has been extensively studied in the phase 11 setting,…”
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Identification of genomic markers of sensitivity and resistance to checkpoint inhibitors in non-small cell lung cancer in a real world clinico-genomic database by Murugesan, K., Li, G., Kaushik, G., Singal, G., Miller, V.A., Frampton, G.M., Albacker, L.A.

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