Search Results - "MILLER, Shyra J"

MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors by Jessen, Walter J, Miller, Shyra J, Jousma, Edwin, Wu, Jianqiang, Rizvi, Tilat A, Brundage, Meghan E, Eaves, David, Widemann, Brigitte, Kim, Mi-Ok, Dombi, Eva, Sabo, Jessica, Hardiman Dudley, Atira, Niwa-Kawakita, Michiko, Page, Grier P, Giovannini, Marco, Aronow, Bruce J, Cripe, Timothy P, Ratner, Nancy

“…Neurofibromatosis type 1 (NF1) patients develop benign neurofibromas and malignant peripheral nerve sheath tumors (MPNST). These incurable peripheral nerve…”
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A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor by Ratner, Nancy, Miller, Shyra J.

“…Key Points The neurofibromatosis type 1 (NF1) research community has identified the NF1 gene and has developed mouse models of plexiform neurofibroma, optic…”
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Neuregulin 1-erbB Signaling Is Necessary for Normal Myelination and Sensory Function by Chen, Suzhen, Velardez, Miguel Omar, Warot, Xavier, Yu, Zhao-Xue, Miller, Shyra J, Cros, Didier, Corfas, Gabriel

“…To investigate the role of erbB signaling in the interactions between peripheral axons and myelinating Schwann cells, we generated transgenic mice expressing a…”
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Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues by MILLER, Shyra J, RANGWALA, Fatima, MAUTNER, Victor, UPADHYAYA, Meena, MUIR, David, WALLACE, Margaret, HAGEN, Jussara, QUELLE, Dawn E, WATSON, Mark A, PERRY, Arie, GUTMANN, David H, RATNER, Nancy, WILLIAMS, Jon, ACKERMAN, Peter, KONG, Sue, JEGGA, Anil G, KAISER, Sergio, ARONOW, Bruce J, FRAHM, Silke, KLUWE, Lan

“…Malignant peripheral nerve sheath tumors (MPNST) are highly invasive soft tissue sarcomas that arise within the peripheral nerve and frequently metastasize. To…”
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Role for the epidermal growth factor receptor in neurofibromatosis-related peripheral nerve tumorigenesis by Ling, Benjamin C., Wu, Jianqiang, Miller, Shyra J., Monk, Kelly R., Shamekh, Rania, Rizvi, Tilat A., DeCourten-Myers, Gabrielle, Vogel, Kristine S., DeClue, Jeffrey E., Ratner, Nancy

“…Benign neurofibromas and malignant peripheral nerve sheath tumors are serious complications of neurofibromatosis type 1. The epidermal growth factor receptor…”
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Oncolytic HSV and Erlotinib Inhibit Tumor Growth and Angiogenesis in a Novel Malignant Peripheral Nerve Sheath Tumor Xenograft Model by Mahller, Yonatan Y, Vaikunth, Sachin S, Currier, Mark A, Miller, Shyra J, Ripberger, Maria C, Hsu, Ya-Hsuan, Mehrian-Shai, Ruty, Collins, Margaret H, Crombleholme, Timothy M, Ratner, Nancy, Cripe, Timothy P

“…Malignant peripheral nerve sheath tumors (MPNSTs), driven in part by hyperactive Ras and epidermal growth factor receptor (EGFR) signaling, are often…”
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Gene Expression Analysis Identifies Potential Biomarkers of Neurofibromatosis Type 1 Including Adrenomedullin by HUMMEL, Trent R, JESSEN, Walter J, SCHORRY, Elizabeth K, RATNER, Nancy, MILLER, Shyra J, KLUWE, Lan, MAUTNER, Victor F, WALLACE, Margaret R, LAZARO, Conxi, PAGE, Grier P, WORLEY, Paul F, ARONOW, Bruce J

“…Plexiform neurofibromas (pNF) are Schwann cell tumors found in a third of individuals with neurofibromatosis type 1 (NF1). pNF can undergo transformation to…”
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Ras-Driven Transcriptome Analysis Identifies Aurora Kinase A as a Potential Malignant Peripheral Nerve Sheath Tumor Therapeutic Target by PATEL, Ami V, EAVES, David, MILLER, Shyra J, RATNER, Nancy, JESSEN, Walter J, RIZVI, Tilat A, ECSEDY, Jeffrey A, QIAN, Mark G, ARONOW, Bruce J, PERENTESIS, John P, SERRA, Eduard, CRIPE, Timothy P

“…Patients with neurofibromatosis type 1 (NF1) develop malignant peripheral nerve sheath tumors (MPNST), which are often inoperable and do not respond well to…”
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Brain Lipid Binding Protein in Axon-Schwann Cell Interactions and Peripheral Nerve Tumorigenesis by Miller, Shyra J., Li, Hongzhen, Rizvi, Tilat A., Huang, Yuan, Johansson, Gunnar, Bowersock, Jason, Sidani, Amer, Vitullo, John, Vogel, Kristine, Parysek, Linda M., DeClue, Jeffrey E., Ratner, Nancy

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Integrative genomic analyses of neurofibromatosis tumours identify SOX9 as a biomarker and survival gene by Miller, Shyra J., Jessen, Walter J., Mehta, Tapan, Hardiman, Atira, Sites, Emily, Kaiser, Sergio, Jegga, Anil G., Li, Hua, Upadhyaya, Meena, Giovannini, Marco, Muir, David, Wallace, Margaret R., Lopez, Eva, Serra, Eduard, Nielsen, G. Petur, Lazaro, Conxi, Stemmer‐Rachamimov, Anat, Page, Grier, Aronow, Bruce J., Ratner, Nancy

“…Understanding the biological pathways critical for common neurofibromatosis type 1 (NF1) peripheral nerve tumours is essential, as there is a lack of tumour…”
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The N-terminal Region of Neuregulin Isoforms Determines the Accumulation of Cell Surface and Released Neuregulin Ectodomain by Wang, Jay Y., Miller, Shyra J., Falls, Douglas L.

“…Two neuregulin-1 isoforms highly expressed in the nervous system are the type III neuregulin III-β1a and the type I neuregulin I-β1a. The sequence of these two…”
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MAF mediates crosstalk between Ras-MAPK and mTOR signaling in NF1 by Brundage, M E, Tandon, P, Eaves, D W, Williams, J P, Miller, S J, Hennigan, R H, Jegga, A, Cripe, T P, Ratner, N

“…Mutations in the neurofibromatosis type 1 ( NF1 ) tumor suppressor gene are common in cancer and can cause resistance to therapy. Using transcriptome analysis…”
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Oral 1821-3 - Ras signaling and NO in oligodendrocytes modulate permeability of the blood–brain barrier by Titus-Mitchell, Haley, Rizvi, Tilat A., Mayes, Debra A., Miller, Shyra J., Ratner, Nancy

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Ras signaling and NO in oligodendrocytes modulate permeability of the blood–brain barrier by Titus-Mitchell, Haley, Rizvi, Tilat A., Mayes, Debra A., Miller, Shyra J., Ratner, Nancy

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Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis by Miller, S J, Lan, Z D, Hardiman, A, Wu, J, Kordich, J J, Patmore, D M, Hegde, R S, Cripe, T P, Cancelas, J A, Collins, M H, Ratner, N

“…Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas without effective therapeutics. Bioinformatics was used to identify potential…”
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Model systems for neurofibroma and malignant peripheral nerve sheath tumor by Ratner, Nancy, Miller, Shyra J.

“…Although clinically benign, neurofibromas that form in type 1 neurofibromatosis (NF1) require surgical removal when disfiguring or causing morbidity. Surgery…”
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A 1-Mb Physical Map and PAC Contig of the Imprinted Domain in 11p15.5 That Contains TAPA1 and the BWSCR1/WT2 Region by Reid, Laura H., Davies, Chris, Cooper, Paul R., Crider-Miller, Shyra J., Sait, Sheila N.J., Nowak, Norma J., Evans, Glen, Stanbridge, Eric J., dejong, Pieter, Shows, Thomas B., Weissman, Bernard E., Higgins, Michael J.

“…We have constructed a 1-Mb contig in human chromosomal band 11p15.5, a region implicated in the etiology of several embryonal tumors, including Wilms tumor,…”
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Identification of candidate pediatric tumor suppressor genes on human chromosome 11P15.5 by Crider-Miller, Shyra J

“…The positional cloning approach to disease gene identification has made a significant impact in the search for tumor suppressor genes. Several lines of…”
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Novel Transcribed Sequences within the BWS/WT2 Region in 11p15.5: Tissue-Specific Expression Correlates with Cancer Type by Crider-Miller, Shyra J., Reid, Laura H., Higgins, Michael J., Nowak, Norma J., Shows, Thomas B., Futreal, P.Andrew, Weissman, Bernard E.

“…Chromosome band 11p15.5 has proven to be an intriguing area of the human genome. Various studies have linked alterations in this region to growth-related…”
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Genomic organization of the human p57KIP2 gene and its analysis in the G401 Wilms' tumor assay by REID, L. H, CRIDER-MILLER, S. J, WEST, A, LEE, M.-H, MASSAGUE, J, WEISSMAN, B. E

“…The p57KIP2 gene encodes an inhibitor of cyclin-dependent kinase activity, which negatively regulates cell cycle progression. The human p57 gene is located in…”
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