Search Results - "MILLER, Frederick J."

Acute cardiovascular effects of inhaled ambient particulate matter: Chemical composition-related oxidative stress, endothelin-1, blood pressure, and ST-segment changes in Wistar rats by Vincent, Renaud, Kumarathasan, Premkumari, Goegan, Patrick, Bjarnason, Stephen G., Guénette, Josée, Karthikeyan, Subramanian, Thomson, Errol M., Adamson, Ian Y., Watkinson, William P., Battistini, Bruno, Miller, Frederick J.

“…Short-term increases in particulate matter (PM) are associated with heightened morbidity and mortality from cardiovascular causes. Inhalation of PM is known to…”
Get full text

An updated analysis of respiratory tract cells at risk for formaldehyde carcinogenesis by Miller, Frederick J., Conolly, Rory B., Kimbell, Julia S.

“…Study of the mode of action (MOA) relating exposure to a given chemical with an associated adverse outcome is an iterative process with each iteration driven…”
Get full text

Estimating lung burdens based on individual particle density estimated from scanning electron microscopy and cascade impactor samples by Miller, Frederick J., Kaczmar, Swiatoslav W., Danzeisen, Ruth, Moss, Owen R.

“…Abstract Workplace air is monitored for overall dust levels and for specific components of the dust to determine compliance with occupational and workplace…”
Get full text

Requirement of a Centrosomal Activity for Cell Cycle Progression through G1 into S Phase by Hinchcliffe, Edward H., Miller, Frederick J., Cham, Matthew, Khodjakov, Alexey, Sluder, Greenfield

“…Centrosomes were microsurgically removed from BSC-1 African green monkey kidney cells before the completion of S phase. Karyoplasts (acentrosomal cells)…”
Get full text

DOSIMETRY OF PARTICLES: Critical Factors Having Risk Assessment Implications by Miller, Frederick J.

“…Species differences in the handling of particles are topics of interest for setting ambient particulate matter standards as well as for studies involving the…”
Get full text

Characterization of deposition from nasal spray devices using a computational fluid dynamics model of the human nasal passages by Kimbell, Julia S, Segal, Rebecca A, Asgharian, Bahman, Wong, Brian A, Schroeter, Jeffry D, Southall, Jeremy P, Dickens, Colin J, Brace, Geoff, Miller, Frederick J

“…Many studies suggest limited effectiveness of spray devices for nasal drug delivery due primarily to high deposition and clearance at the front of the nose…”
Get more information

Human Respiratory Tract Cancer Risks of Inhaled Formaldehyde: Dose-Response Predictions Derived From Biologically-Motivated Computational Modeling of a Combined Rodent and Human Dataset by Conolly, Rory B., Kimbell, Julia S., Janszen, Derek, Schlosser, Paul M., Kalisak, Darin, Preston, Julian, Miller, Frederick J.

“…Formaldehyde inhalation at 6 ppm and above causes nasal squamous cell carcinoma (SCC) in F344 rats. The quantitative implications of the rat tumors for human…”
Get full text

Respiratory tract lung geometry and dosimetry model for male Sprague-Dawley rats by Miller, Frederick J., Asgharian, Bahman, Schroeter, Jeffry D., Price, Owen, Corley, Richard A., Einstein, Daniel R., Jacob, Richard E., Cox, Timothy C., Kabilan, Senthil, Bentley, Timothy

“…Abstract While inhalation toxicological studies of various compounds have been conducted using a number of different strains of rats, mechanistic dosimetry…”
Get full text

The fractions of respiratory tract cells at risk in formaldehyde carcinogenesis by Miller, Frederick J., Kimbell, Julia S., Preston, R. Julian, Overton, John H., Gross, Elizabeth A., Conolly, Rory B.

“…Clonal growth modeling of carcinogenesis requires data on the number of cells at risk of becoming cancerous. We synthesized literature data to estimate the…”
Get full text

Biologically Motivated Computational Modeling of Formaldehyde Carcinogenicity in the F344 Rat by Conolly, Rory B., Kimbell, Julia S., Janszen, Derek, Schlosser, Paul M., Kalisak, Darin, Preston, Julian, Miller, Frederick J.

“…Formaldehyde inhalation at 6 ppm and above causes nasal squamous cell carcinoma (SCC) in F344 rats. The human health implications of this effect are of…”
Get full text

Dosimetric Adjustments for Interspecies Extrapolation of Inhaled Poorly Soluble Particles (PSP) by Jarabek, Annie M., Asgharian, Bahman, Miller, Frederick J.

“…Abstract Direct calculation of delivered dose in the species of interest potentially affects the magnitude of an uncertainty factor needed to address…”
Get full text

Haber’s rule: a special case in a family of curves relating concentration and duration of exposure to a fixed level of response for a given endpoint by Miller, Frederick J, Schlosser, Paul M, Janszen, Derek B

“…The concept that the product of the concentration ( C) of a substance and the length of time ( t) it is administered produces a fixed level of effect for a…”
Get full text

In memoriam Donald E. Gardner, PhD, ATS (1931-2014) by Naas, Leigh Ann Burns, Graham, Judith A, Holsapple, Michael P, Miller, Frederick J, Selgrade, Mary Jane

Get more information

Development of a rhesus monkey lung geometry model and application to particle deposition in comparison to humans by Asgharian, Bahman, Price, Owen, McClellan, Gene, Corley, Rick, Einstein, Daniel R., Jacob, Richard E., Harkema, Jack, Carey, Stephan A., Schelegle, Edward, Hyde, Dallas, Kimbell, Julia S., Miller, Frederick J.

“…The exposure-dose-response characterization of an inhalation hazard established in an animal species needs to be translated to an equivalent characterization…”
Get full text

Improvements and additions to the Multiple Path Particle Dosimetry model by Miller, Frederick J., Asgharian, Bahman, Schroeter, Jeffry D., Price, Owen

“…A little over a decade ago, the first UC Irvine dosimetry conference was held entitled “Frontiers in Aerosol Dosimetry Research”. At that time, mechanistic…”
Get full text

Dosimetry of particles in laboratory animals and humans in relationship to issues surrounding lung overload and human health risk assessment: a critical review by Miller, F J

Get full text

Dosimetry Modeling of Inhaled Formaldehyde: The Human Respiratory Tract by Overton, John H., Kimbell, Julia S., Miller, Frederick J.

“…Formaldehyde (HCHO), which has been shown to be a nasal carcinogen in rats and mice, is used widely and extensively in various manufacturing processes. Studies…”
Get full text

DOSIMETRY OF PARTICLES IN LABORATORY ANIMALS AND HUMANS IN RELATIONSHIP TO ISSUES SURROUNDING LUNG OVERLOAD AND HUMAN HEALTH RISK ASSESSMENT: A Critical Review by Miller, Frederick J.

Get full text

Analysis of Lobar Differences in Particle Deposition in the Human Lung by Subramaniam, Ravi P., Asgharian, Bahman, Freijer, Jan I., Miller, Frederick J., Anjilvel, Satish

“…Lung diseases caused by the inhalation of various particulate pollutants have often been reported to occur at specific sites in the lung with some diseases…”
Get full text

Remembering Donald E. Gardner, Ph.D., Fellow ATS (1931–2014) by Graham, Judith A., Miller, Frederick J.

Get full text