Search Results - "MILLER, DUANE"

Tubulin Inhibitor-Based Antibody-Drug Conjugates for Cancer Therapy by Chen, Hao, Lin, Zongtao, Arnst, Kinsie E, Miller, Duane D, Li, Wei

“…Antibody-drug conjugates (ADCs) are a class of highly potent biopharmaceutical drugs generated by conjugating cytotoxic drugs with specific monoclonal…”
Get full text

Molecular interactions at the colchicine binding site in tubulin: An X-ray crystallography perspective by Wang, Jiaxing, Miller, Duane D., Li, Wei

“…•Colchicine binding site inhibitors (CBSIs) emerge as new generations of tubulin inhibitors.•CBSIs are less susceptible to multidrug resistance than…”
Get full text

An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site by Lu, Yan, Chen, Jianjun, Xiao, Min, Li, Wei, Miller, Duane D.

“…Tubulin dynamics is a promising target for new chemotherapeutic agents. The colchicine binding site is one of the most important pockets for potential tubulin…”
Get full text

CaFe2O4 oxygen carrier characterization during the partial oxidation of coal in the chemical looping gasification application by Miller, Duane D., Siriwardane, Ranjani

“…[Display omitted] •Coal CLG with Ca ferrite evaluated using DFT/Raman spectroscopy/XRD.•Oxygen ion diffusion-controlled regime occurred at the Fe octahedral…”
Get full text

Interaction of manganese with aluminosilicate support during high temperature (1100 °C) chemical looping combustion of the Fe-Mn-based oxygen carrier by Miller, Duane D., Smith, Mark, Shekhawat, Dushyant

“…[Display omitted] Investigation of the redox reactivity of mixed-metal oxides in Chemical-Looping Combustion (CLC) can improve our understanding of the…”
Get full text

Diallyl Sulfide: Potential Use in Novel Therapeutic Interventions in Alcohol, Drugs, and Disease Mediated Cellular Toxicity by Targeting Cytochrome P450 2E1 by Rao, P S S, Midde, Narasimha M, Miller, Duane D, Chauhan, Subhash, Kumar, Anil, Kumar, Santosh

“…Diallyl sulfide (DAS) and other organosulfur compounds are chief constituents of garlic. These compounds have many health benefits, as they are very efficient…”
Get more information

Recent Progress on Tubulin Inhibitors with Dual Targeting Capabilities for Cancer Therapy by Shuai, Wen, Wang, Guan, Zhang, Yiwen, Bu, Faqian, Zhang, Sicheng, Miller, Duane D, Li, Wei, Ouyang, Liang, Wang, Yuxi

“…Microtubules play a crucial role in multiple cellular functions including mitosis, cell signaling, and organelle trafficking, which makes the microtubule an…”
Get full text

Development of Fe-based oxygen carrier using spent FCC catalyst as support for high temperature chemical looping combustion by Miller, Duane D., Smith, Mark, Shekhawat, Dushyant

“…[Display omitted] Chemical looping combustion is based on the transfer of oxygen from air to fuel by means of an oxygen carrier using a metal oxide. This study…”
Get full text

Interaction of Methane with Calcium Ferrite in the Chemical Looping Partial Oxidation Application: Experimental and DFT Study by Miller, Duane D, Riley, Jarrett, Siriwardane, Ranjani

“…Experimental studies using mass spectroscopy, thermogravimetric analysis, in situ X-ray diffraction (XRD), and theoretical density functional theory…”
Get full text

Recent Advances in Elucidating Paclitaxel Resistance Mechanisms in Non-small Cell Lung Cancer and Strategies to Overcome Drug Resistance by Cui, Hongmei, Arnst, Kinsie, Miller, Duane D, Li, Wei

“…Paclitaxel (PTX) is a first-line drug for late-stage non-small cell lung cancer (NSCLC) patients who do not benefit from targeted therapy or immunotherapy…”
Get more information

Current advances of tubulin inhibitors as dual acting small molecules for cancer therapy by Arnst, Kinsie E, Banerjee, Souvik, Chen, Hao, Deng, Shanshan, Hwang, Dong‐Jin, Li, Wei, Miller, Duane D

“…Microtubule (MT)‐targeting agents are highly successful drugs as chemotherapeutic agents, and this is attributed to their ability to target MT dynamics and…”
Get full text

Current Advances of Tubulin Inhibitors in Nanoparticle Drug Delivery and Vascular Disruption/Angiogenesis by Banerjee, Souvik, Hwang, Dong-Jin, Li, Wei, Miller, Duane D

“…Extensive research over the last decade has resulted in a number of highly potent tubulin polymerization inhibitors acting either as microtubule stabilizing…”
Get full text

Orally available tubulin inhibitor VERU-111 enhances antitumor efficacy in paclitaxel-resistant lung cancer by Mahmud, Foyez, Deng, Shanshan, Chen, Hao, Miller, Duane D., Li, Wei

“…Lung cancer is the most common cause of cancer associated mortality. Chemotherapeutic agents, such as paclitaxel, are important treatment options but drug…”
Get full text

Discovery of 4‑Aryl-2-benzoyl-imidazoles as Tubulin Polymerization Inhibitor with Potent Antiproliferative Properties by Xiao, Min, Ahn, Sunjoo, Wang, Jin, Chen, Jianjun, Miller, Duane. D, Dalton, James T, Li, Wei

“…A series of 4-aryl-2-benzoyl-imidazoles were designed and synthesized based on our previously reported 2-aryl-4-benzoyl-imidazole (ABI) derivatives. The new…”
Get full text

Orally Bioavailable Androgen Receptor Degrader, Potential Next-Generation Therapeutic for Enzalutamide-Resistant Prostate Cancer by Ponnusamy, Suriyan, He, Yali, Hwang, Dong-Jin, Thiyagarajan, Thirumagal, Houtman, Rene, Bocharova, Vera, Sumpter, Bobby G, Fernandez, Elias, Johnson, Daniel, Du, Ziyun, Pfeffer, Lawrence M, Getzenberg, Robert H, McEwan, Iain J, Miller, Duane D, Narayanan, Ramesh

“…Androgen receptor (AR)-targeting prostate cancer drugs, which are predominantly competitive ligand-binding domain (LBD)-binding antagonists, are inactivated by…”
Get full text

Non-Musculoskeletal Benefits of Vitamin D beyond the Musculoskeletal System by Zhang, Sicheng, Miller, Duane D, Li, Wei

“…Vitamin D, a fat-soluble prohormone, is endogenously synthesized in response to sunlight or taken from dietary supplements. Since vitamin D receptors are…”
Get full text

Unraveling the Structure and Binding Energy of Adsorbed CO2/H2O on Amine Sorbents by Miller, Duane D, Yu, Jie, Chuang, Steven S. C

“…One critical issue in the design of amine-based sorbents and solvents for next-generation CO2 capture technology is the effect of H2O on the behavior of…”
Get full text

Advances in the understanding of androgen receptor structure and function and in the development of next-generation AR-targeted therapeutics by Effah, Wendy, Khalil, Marjana, Hwang, Dong-Jin, Miller, Duane D., Narayanan, Ramesh

“…[Display omitted] •The incidence of prostate cancer is 50% higher and mortality is two times higher in American black men than in American white men.•AR has…”
Get full text

Fluidized-bed and fixed-bed reactor testing of methane chemical looping combustion with MgO-promoted hematite by Miller, Duane D., Siriwardane, Ranjani, Poston, James

“…•Mg-promoted hematite showed better performance than hematite for methane CLC.•Stable reaction performance was observed during cyclic CH4 CLC fluidized bed…”
Get full text

Heterocyclic-Fused Pyrimidines as Novel Tubulin Polymerization Inhibitors Targeting the Colchicine Binding Site: Structural Basis and Antitumor Efficacy by Banerjee, Souvik, Arnst, Kinsie E, Wang, Yuxi, Kumar, Gyanendra, Deng, Shanshan, Yang, Lei, Li, Guo-bo, Yang, Jinliang, White, Stephen W, Li, Wei, Miller, Duane D

“…We report the design, synthesis, and biological evaluation of heterocyclic-fused pyrimidines as tubulin polymerization inhibitors targeting the colchicine…”
Get full text