Search Results - "MILLER, Alyson A"

Obesity and neuroinflammation: A pathway to cognitive impairment by Miller, Alyson A, Spencer, Sarah J

“…Abstract Obesity is a growing problem worldwide and is associated with a range of comorbidities, including cognitive dysfunction. In this review we will…”
Get full text

COPD and stroke: are systemic inflammation and oxidative stress the missing links? by Austin, Victoria, Crack, Peter J, Bozinovski, Steven, Miller, Alyson A, Vlahos, Ross

“…Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow limitation and loss of lung function, and is currently the third largest…”
Get more information

CNS border-associated macrophages in the homeostatic and ischaemic brain by Gerganova, Gabriela, Riddell, Alexandra, Miller, Alyson A.

“…CNS border-associated macrophages (BAMs) are a small population of specialised macrophages localised in the choroid plexus, meningeal and perivascular spaces…”
Get full text

SDMA as a marker and mediator in cerebrovascular disease by Riddell, Alexandra, Flynn, Arun, Bergugnat, Hugo, Dowsett, Laura B, Miller, Alyson A

“…Symmetric dimethylarginine (SDMA) is a methylated derivative of arginine, generated by all cells as a by-product of cellular metabolism and eliminated via the…”
Get more information

Cigarette smoke extract exacerbates hyperpermeability of cerebral endothelial cells after oxygen glucose deprivation and reoxygenation by Bernard, Ashton, Ku, Jacqueline M., Vlahos, Ross, Miller, Alyson A.

“…Cigarette smoking is a risk factor for stroke and is linked to stroke severity. Previous studies have shown that cigarette smoke extract (CSE) triggers…”
Get full text

Direct angiotensin AT2 receptor stimulation using a novel AT2 receptor agonist, compound 21, evokes neuroprotection in conscious hypertensive rats by McCarthy, Claudia A, Vinh, Antony, Miller, Alyson A, Hallberg, Anders, Alterman, Mathias, Callaway, Jennifer K, Widdop, Robert E

“…In this study, the neuroprotective effect of a novel nonpeptide AT2R agonist, C21, was examined in a conscious model of stroke to verify a class effect of AT2R…”
Get full text

Microglial regulation of satiety and cognition by De Luca, Simone N., Miller, Alyson A., Sominsky, Luba, Spencer, Sarah J.

“…Microglia have been known for decades as key immune cells that shape the central nervous system (CNS) during development and respond to brain pathogens and…”
Get full text

Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE-/- mice by Judkins, Courtney P, Diep, Henry, Broughton, Brad R S, Mast, Anja E, Hooker, Elizabeth U, Miller, Alyson A, Selemidis, Stavros, Dusting, Gregory J, Sobey, Christopher G, Drummond, Grant R

“…The Nox family NADPH oxidases are reactive oxygen species (ROS)-generating enzymes that are strongly implicated in atherogenesis. However, no studies have…”
Get more information

Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries by Broughton, Brad R S, Miller, Alyson A, Sobey, Christopher G

“…Recent studies have identified that the novel membrane estrogen receptor, G protein-coupled receptor 30 (GPR30), is present in blood vessels. However, the…”
Get more information

Nox2 oxidase activity accounts for the oxidative stress and vasomotor dysfunction in mouse cerebral arteries following ischemic stroke by De Silva, T Michael, Brait, Vanessa H, Drummond, Grant R, Sobey, Christopher G, Miller, Alyson A

“…Post-ischemic oxidative stress and vasomotor dysfunction in cerebral arteries may increase the likelihood of cognitive impairment and secondary stroke…”
Get full text

Vascular dysfunction in cerebrovascular disease: mechanisms and therapeutic intervention by Miller, Alyson A, Budzyn, Klaudia, Sobey, Christopher G

“…The endothelium plays a crucial role in the control of vascular homoeostasis through maintaining the synthesis of the vasoprotective molecule NO* (nitric…”
Get more information

Protective actions of des-acylated ghrelin on brain injury and blood-brain barrier disruption after stroke in mice by Ku, Jacqueline M, Taher, Mohammadali, Chin, Kai Yee, Barsby, Tom, Austin, Victoria, Wong, Connie H Y, Andrews, Zane B, Spencer, Sarah J, Miller, Alyson A

“…The major ghrelin forms, acylated ghrelin and des-acylated ghrelin, are novel gastrointestinal hormones. Moreover, emerging evidence indicates that these…”
Get more information

Hydrogen sulfide protects endothelial nitric oxide function under conditions of acute oxidative stress in vitro by Al-Magableh, Mohammad R., Kemp-Harper, Barbara K., Ng, Hooi H., Miller, Alyson A., Hart, Joanne L.

“…The aim of this study was to examine the ability of H 2 S, released from NaHS to protect vascular endothelial function under conditions of acute oxidative…”
Get full text

NADPH Oxidase Activity and Function Are Profoundly Greater in Cerebral Versus Systemic Arteries by Miller, Alyson A, Drummond, Grant R, Schmidt, Harald H.H.W, Sobey, Christopher G

“…Recent studies suggest that the superoxide generating enzyme NADPH oxidase may play a functional role in regulating cerebral vascular tone. We tested whether…”
Get full text

Importance of NOX1 for angiotensin II-induced cerebrovascular superoxide production and cortical infarct volume following ischemic stroke by Jackman, Katherine A, Miller, Alyson A, Drummond, Grant R, Sobey, Christopher G

“…Abstract Angiotensin II (Ang II) receptor blockade is beneficial in stroke, possibly due to attenuation of vascular oxidative stress. Mice genetically targeted…”
Get full text

Endogenous ghrelin's role in hippocampal neuroprotection after global cerebral ischemia: does endogenous ghrelin protect against global stroke? by Kenny, Rachel, Cai, Guohui, Bayliss, Jacqueline A, Clarke, Melanie, Choo, Yuen Ling, Miller, Alyson A, Andrews, Zane B, Spencer, Sarah J

“…Ghrelin is a gastrointestinal hormone with a well-characterized role in feeding and metabolism. Recent evidence suggests that ghrelin may also be…”
Get more information

NADPH oxidase activity is higher in cerebral versus systemic arteries of four animal species: role of Nox2 by Miller, Alyson A, Drummond, Grant R, De Silva, T Michael, Mast, Anja E, Hickey, Haruyo, Williams, John P, Broughton, Brad R S, Sobey, Christopher G

“…We previously reported that NADPH oxidase activity is greater in intracranial cerebral versus systemic arteries of the rat. Here, we first tested whether NADPH…”
Get more information

Stroke Increases G Protein-Coupled Estrogen Receptor Expression in the Brain of Male but Not Female Mice by Broughton, Brad R.S., Brait, Vanessa H., Guida, Elizabeth, Lee, Seyoung, Arumugam, Thiruma V., Gardiner-Mann, Chantelle V., Miller, Alyson A., Tang, Sung-Chun, Drummond, Grant R., Sobey, Christopher G.

“…The novel estrogen receptor, G protein-coupled estrogen receptor (GPER, previously named GPR30), is widely distributed throughout the male and female brain…”
Get full text

Endothelial Cell Mineralocorticoid Receptors Regulate Deoxycorticosterone/Salt-Mediated Cardiac Remodeling and Vascular Reactivity But Not Blood Pressure by RICKARD, Amanda J, MORGAN, James, CHRISSOBOLIS, Sophocles, MILLER, Alyson A, SOBEY, Christopher G, YOUNG, Morag J

“…Recent studies have identified novel pathological roles for mineralocorticoid receptors (MR) in specific cell types in cardiovascular disease. The mechanisms…”
Get full text

Ischaemic stroke in mice induces lung inflammation but not acute lung injury by Austin, Victoria, Ku, Jacqueline M., Miller, Alyson A, Vlahos, Ross

“…Stroke is a major cause of death worldwide and ischemic stroke is the most common subtype accounting for approximately 80% of all cases. Pulmonary…”
Get full text