Search Results - "MILLARD, RONALD W"

Cardiomyocyte protection by GATA-4 gene engineered mesenchymal stem cells is partially mediated by translocation of miR-221 in microvesicles by Yu, Bin, Gong, Min, Wang, Yigang, Millard, Ronald W, Pasha, Zeeshan, Yang, Yueting, Ashraf, Muhammad, Xu, Meifeng

“…microRNAs (miRs), a novel class of small non-coding RNAs, are involved in cell proliferation, differentiation, development, and death. In this study, we found…”
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Exosomes Secreted from CXCR4 Overexpressing Mesenchymal Stem Cells Promote Cardioprotection via Akt Signaling Pathway following Myocardial Infarction by Xu, Meifeng, Millard, Ronald W., Wen, Zhili, Wang, Yigang, Zhao, Tiejun, Wang, Yuhua, Liang, Jialiang, Paul, Christian, Huang, Wei, Cai, Wenfeng, Ma, Ruilian, Kang, Kai, Kim, Ha Won

“…Background and Objective. Exosomes secreted from mesenchymal stem cells (MSC) have demonstrated cardioprotective effects. This study examined the role of…”
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MicroRNA-377 regulates mesenchymal stem cell-induced angiogenesis in ischemic hearts by targeting VEGF by Wen, Zhili, Huang, Wei, Feng, Yuliang, Cai, Wenfeng, Wang, Yuhua, Wang, Xiaohong, Liang, Jialiang, Wani, Mashhood, Chen, Jing, Zhu, Pin, Chen, Ji-Mei, Millard, Ronald W, Fan, Guo-Chang, Wang, Yigang

“…MicroRNAs have been appreciated in various cellular functions, including the regulation of angiogenesis. Mesenchymal-stem-cells (MSCs) transplanted to the MI…”
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Clusterin/Akt Up-Regulation Is Critical for GATA-4 Mediated Cytoprotection of Mesenchymal Stem Cells against Ischemia Injury by Yu, Bin, Yang, Yueting, Liu, Huan, Gong, Min, Millard, Ronald W, Wang, Yi-Gang, Ashraf, Muhammad, Xu, Meifeng

“…Clusterin (Clu) is a stress-responding protein with multiple biological functions. Our preliminary microarray studies show that clusterin was prominently…”
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Protein kinase G1 α overexpression increases stem cell survival and cardiac function after myocardial infarction by Wang, Linlin, Pasha, Zeeshan, Wang, Shuyun, Li, Ning, Feng, Yuliang, Lu, Gang, Millard, Ronald W, Ashraf, Muhammad

“…We hypothesized that overexpression of cGMP-dependent protein kinase type 1α (PKG1α) could mimic the effect of tadalafil on the survival of bone marrow derived…”
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Ultrastructural features of ischemic tissue following application of a bio-membrane based progenitor cardiomyocyte patch for myocardial infarction repair by Chang, Dehua, Wen, Zhili, Wang, Yuhua, Cai, Wenfeng, Wani, Mashhood, Paul, Christian, Okano, Teruo, Millard, Ronald W, Wang, Yigang

“…Implantation of cell-sheets into damaged regions of the heart after myocardial infarction (MI) has been shown to improve heart function. However, the tissue…”
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Reduced Collagen Deposition in Infarcted Myocardium Facilitates Induced Pluripotent Stem Cell Engraftment and Angiomyogenesis for Improvement of Left Ventricular Function by Dai, Bo, MD, PhD, Huang, Wei, MD, PhD, Xu, Meifeng, MD, PhD, Millard, Ronald W., PhD, Gao, Mei Hua, PhD, Hammond, H. Kirk, PhD, Menick, Donald R., PhD, Ashraf, Muhammad, PhD, Wang, Yigang, MD, PhD

“…Objectives The purpose of this study was to assess the effect of scar tissue composition on engraftment of progenitor cells into infarcted myocardium…”
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Suicide gene reveals the myocardial neovascularization role of mesenchymal stem cells overexpressing CXCR4 (MSC(CXCR4)) by Liang, Jialiang, Huang, Wei, Yu, Xiyong, Ashraf, Atif, Wary, Kishore K, Xu, Meifeng, Millard, Ronald W, Ashraf, Muhammad, Wang, Yigang

“…Our previous studies indicated that MSC(CXCR4) improved cardiac function after myocardial infarction (MI). This study was aimed to investigate the specific…”
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Mesenchymal stem cells release exosomes that transfer miRNAs to endothelial cells and promote angiogenesis by Gong, Min, Yu, Bin, Wang, Jingcai, Wang, Yigang, Liu, Min, Paul, Christian, Millard, Ronald W, Xiao, De-Sheng, Ashraf, Muhammad, Xu, Meifeng

“…Mesenchymal stem cells (MSCs) have been found to benefit patients with a variety of ischemic diseases via promoting angiogenesis. It is also well established…”
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Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells by Wang, Xiaohong, Huang, Wei, Liu, Guansheng, Cai, Wenfeng, Millard, Ronald W, Wang, Yigang, Chang, Jiang, Peng, Tianqing, Fan, Guo-Chang

“…Abstract Exosomes, nano-vesicles naturally released from living cells, have been well recognized to play critical roles in mediating cell-to-cell…”
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Metabolomics by Millard, Ronald W., PhD, Rosevear, Paul R., PhD

“…(1) have selected a porcine model as a control. Because they evaluated patient data in retrospective and prospective study components, this animal model is a…”
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Molecular strategy to reduce in vivo collagen barrier promotes entry of NCX1 positive inducible pluripotent stem cells (iPSC(NCX¹⁺)) into ischemic (or injured) myocardium by Huang, Wei, Dai, Bo, Wen, Zhili, Millard, Ronald W, Yu, Xi-Yong, Luther, Kristin, Xu, Meifeng, Zhao, Ting C, Yang, Huang-Tian, Qi, Zhihua, Lasance, Kathleen, Ashraf, Muhammad, Wang, Yigang

“…The purpose of this study was to assess the effect of collagen composition on engraftment of progenitor cells within infarcted myocardium. We previously…”
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Impaired baroreflex function in mice overexpressing alpha-synuclein by Fleming, Sheila M, Jordan, Maria C, Mulligan, Caitlin K, Masliah, Eliezer, Holden, John G, Millard, Ronald W, Chesselet, Marie-Françoise, Roos, Kenneth P

“…Cardiovascular autonomic dysfunction, such as orthostatic hypotension consequent to baroreflex failure and cardiac sympathetic denervation, is frequently…”
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Functional and Anatomical Diagnosis of Coronary Artery Stenoses by Sinha Roy, Abhijit, Ph.D, Back, Martin R., M.D, Khoury, Saeb F., M.D, Schneeberger, Eric W., M.D, Back, Lloyd H., Ph.D, Velury, Vijaya V., M.D, Millard, Ronald W., Ph.D, Banerjee, Rupak K., Ph.D

“…Background Functional/physiological evaluation of coronary artery stenoses may be more important than anatomical measurements of severity. Optimization of…”
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Blockade of senescence‐associated microRNA‐195 in aged skeletal muscle cells facilitates reprogramming to produce induced pluripotent stem cells by Kondo, Hideyuki, Kim, Ha Won, Wang, Lei, Okada, Motoi, Paul, Christian, Millard, Ronald W., Wang, Yigang

“…Summary The low reprogramming efficiency in cells from elderly patients is a challenge that must be overcome. Recently, it has been reported that…”
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Exosomes secreted from GATA-4 overexpressing mesenchymal stem cells serve as a reservoir of anti-apoptotic microRNAs for cardioprotection by Yu, Bin, Kim, Ha Won, Gong, Min, Wang, Jingcai, Millard, Ronald W, Wang, Yigang, Ashraf, Muhammad, Xu, Meifeng

“…Abstract Background Exosomes play an important role in intercellular signaling and exert regulatory function by carrying bioactive molecules. This study…”
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Enhanced mesenchymal stem cell survival induced by GATA-4 overexpression is partially mediated by regulation of the miR-15 family by Yu, Bin, Gong, Min, He, Zhisong, Wang, Yi-Gang, Millard, Ronald W., Ashraf, Muhammad, Xu, Meifeng

“…We reported previously that pre-programming mesenchymal stem cells with the GATA-4 gene increases significantly cell survival in an ischemic environment. In…”
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Genetically manipulated progenitor cell sheet with diprotin A improves myocardial function and repair of infarcted hearts by Zhang, Dongsheng, Huang, Wei, Dai, Bo, Zhao, Tiemin, Ashraf, Atif, Millard, Ronald W, Ashraf, Muhammad, Wang, Yigang

“…We postulated that the combination of overexpression of CXCR4 in mesenchymal stem cells (MSC) with diprotin A would enhance MSC recruitment and penetration…”
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Heterogeneity of adult masseter muscle satellite cells with cardiomyocyte differentiation potential by Huang, Wei, Liang, Jialiang, Feng, Yuliang, Jia, Zhanfeng, Jiang, Lin, Cai, Wenfeng, Paul, Christian, Gu, Jianguo G., Stambrook, Peter J., Millard, Ronald W., Zhu, Xiao-Lan, Zhu, Ping, Wang, Yigang

“…Although resident cardiac stem cells have been reported, regeneration of functional cardiomyocytes (CMs) remains a challenge. The present study identifies an…”
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Suicide gene-mediated sequencing ablation revealed the potential therapeutic mechanism of induced pluripotent stem cell-derived cardiovascular cell patch post-myocardial infarction by Wang, Yuhua, Huang, Wei, Liang, Jialiang, Wen, Zhili, Chang, Dehua, Kang, Kai, Wang, Jiapeng, Xu, Meifeng, Millard, Ronald W, Wang, Yigang

“…This study is designed to assess the protective cardiac effects after myocardial infarction (MI) of (i) cardiovascular progenitor cells (PC) differentiated…”
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