Synthesis, NMR, DFT and antimicrobial studies of Zn(II) complexes with N-benzyloxycarbonyl-S-alanine

In this study, the first complexes of Zn(II) with the N-benzyl-oxycarbonyl-S-alaninato ligand (N-Boc-S-ala) were synthesized. The new complexes were characterized by elemental analysis, conductometric measurements, IR, 1H-NMR, 13C-NMR and 2D-NMR spectroscopy. On the basis of the experimental data, t...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of the Serbian Chemical Society Vol. 73; no. 8-9; pp. 815 - 824
Main Authors:	DRAGANA M. MITIC, DJENANA U. MIODRAGOVIC, DUSAN M. SLADIC, ZELJKO J. VITNIK, ZORAN M. MIODRAGOVIC, KATARINA K. ANDJELKOVIC, MILANKA Dj. RADULOVIC, NENAD O. JURANIC
Format:	Journal Article
Language:	English
Published:	Serbian Chemical Society 01-01-2008
Subjects:	antimicrobial activity DFT N-benzyloxycarbonyl-S-alanine NMR Zn(II) complexes
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	In this study, the first complexes of Zn(II) with the N-benzyl-oxycarbonyl-S-alaninato ligand (N-Boc-S-ala) were synthesized. The new complexes were characterized by elemental analysis, conductometric measurements, IR, 1H-NMR, 13C-NMR and 2D-NMR spectroscopy. On the basis of the experimental data, tetrahedral geometry of the Zn(II) complexes was proposed. A very good agreement between the NMR and DFT calculated data was obtained. Investigation of antimicrobial activity of the newly synthesized complexes was also performed. It was established that [Zn(N-Boc-S-ala)2] was selective and acts only on Candida albicans.
ISSN:	0352-5139
DOI:	10.2298/JSC0809815M