Efficiency and biocompatibility of antimicrobial textile material of broad spectrum activity

The subject of this article is to study the behavior of the antimicrobial textile material. The material is in the form of plaster wound dressing which is consisting of a nonwoven textile base containing polypropylene (PP)/viscose, a polymer carrier, and an antimicrobial active substance. The polyme...

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Bibliographic Details
Published in:	Journal of applied polymer science Vol. 120; no. 3; pp. 1459 - 1467
Main Authors:	SIMOVIC, Ljiljana M, KUNDRIC, Petar D. S, KOSTIC, Mirjana M, TASIC, Goran M, KOJIC, Zvezdana Z, MILAKOVIE, Branko D, MEDOMC, Adela H
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 05-05-2011 Wiley Wiley Subscription Services, Inc
Subjects:	Applied sciences biocompatibility Biological and medical sciences biological applications of polymers drug delivery system Exact sciences and technology Fibers and threads Forms of application and semi-finished materials Materials science Medical sciences Polymer industry, paints, wood Polymers polysaccharides Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Technology of polymers Technology. Biomaterials. Equipments Biological properties polysaccharides Artificial fiber Gentamicin Propylene polymer Cellulose hydrate Synthetic fiber Experimental study In vitro biological applications of polymers Antimicrobial agent Bactericidal effect In vivo Dressing Antibiotic Concentration effect Biocompatibility Olefin polymer Oside polymer Biomaterial Non woven material Chitosan drug delivery system
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Summary:	The subject of this article is to study the behavior of the antimicrobial textile material. The material is in the form of plaster wound dressing which is consisting of a nonwoven textile base containing polypropylene (PP)/viscose, a polymer carrier, and an antimicrobial active substance. The polymer carrier is the polysaccharide D-glucosamine (chitosan), and the active antimicrobial substance is antibiotic gentamicin sulfate. The amount of gentamicin sulfate immobilized into the polymer matrix of the polymer carrier was 0.15-0.20 mg/cm² or 2.0-2.5% of the mass of the nonwoven textile material. The antimicrobial textile material has been studied in vitro and in vivo conditions through the efficiency of the antimicrobial effects on different kinds of pathogenic microorganisms, as well as the biocompatibility in preclinical research. The results of these experiments indicate that all bioactive textile materials were biocidal in vitro for all pathogenic test organisms. Good biocompatibility, the existence of the correlation between the in vitro and in vivo results, concerning efficiency, qualifies these antimicrobial biomaterials for clinical use.
Bibliography:	http://dx.doi.org/10.1002/app.33235 istex:121C423E75D0164672AA5A143BA5105A03269211 Ministry of Science of the Republic Serbia ark:/67375/WNG-175872CS-G ArticleID:APP33235 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0021-8995 1097-4628 1097-4628
DOI:	10.1002/app.33235