Search Results - "MIKUS, G"

Morphine-6-glucuronide is responsible for the analgesic effect after morphine administration: a quantitative review of morphine, morphine-6-glucuronide, and morphine-3-glucuronide by Klimas, R., Mikus, G.

“…Morphine-6-glucuronide (M6G) is a strong µ-receptor agonist with higher affinity than morphine itself. It has been suggested that M6G contributes to the…”
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The NTCP‐inhibitor Myrcludex B: Effects on Bile Acid Disposition and Tenofovir Pharmacokinetics by Blank, A, Eidam, A, Haag, M, Hohmann, N, Burhenne, J, Schwab, M, Graaf, SFJ, Meyer, MR, Maurer, HH, Meier, K, Weiss, J, Bruckner, T, Alexandrov, A, Urban, S, Mikus, G, Haefeli, WE

“…Myrcludex B acts as a hepatitis B and D virus entry inhibitor blocking the sodium taurocholate cotransporting polypeptide (SLC10A1). We investigated the…”
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Determining the Time Course of CYP3A Inhibition by Potent Reversible and Irreversible CYP3A Inhibitors Using A Limited Sampling Strategy by Katzenmaier, S, Markert, C, Riedel, K-D, Burhenne, J, Haefeli, W E, Mikus, G

“…We established a new limited sampling strategy to assess CYP3A activity and evaluated the time course of reversible (voriconazole) and irreversible (ritonavir)…”
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A Nanogram Dose of the CYP3A Probe Substrate Midazolam to Evaluate Drug Interactions by Halama, B, Hohmann, N, Burhenne, J, Weiss, J, Mikus, G, Haefeli, W E

“…The objective of the study was to establish an in vivo method for assessing cytochrome P450 3A (CYP3A) activity using therapeutically inert nanogram doses of…”
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European Pain Federation position paper on appropriate opioid use in chronic pain management by O'Brien, T., Christrup, L.L., Drewes, A.M., Fallon, M.T., Kress, H.G., McQuay, H.J., Mikus, G., Morlion, B.J., Perez‐Cajaraville, J., Pogatzki‐Zahn, E., Varrassi, G., Wells, J.C.D.

“…Poorly controlled pain is a global public health issue. The personal, familial and societal costs are immeasurable. Only a minority of European patients have…”
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Relative contribution of morphine and morphine-6-glucuronide to the analgesic effect after morphine administration by Mikus, G., Klimas, R.

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Contribution of oxycodone and its metabolites to the analgesic effect by Mikus, G., Klimas, R.

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Preclinical characterization of CPL302-253, a selective inhibitor of PI3Kδ, as the candidate for the inhalatory treatment and prevention of Asthma by Gunerka, Paweł, Gala, Kamila, Banach, Martyna, Dominowski, Jakub, Hucz-Kalitowska, Joanna, Mulewski, Krzysztof, Hajnal, Agnes, Mikus, Endre G., Smuga, Damian, Zagozda, Marcin, Dubiel, Krzysztof, Pieczykolan, Jerzy, Zygmunt, Beata M., Wieczorek, Maciej

“…Asthma is a common chronic inflammatory disease. Although effective asthma therapies are available, part of asthmatic population do not respond to these…”
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Higher chlorzoxazone clearance in obese children compared with nonobese peers by Gade, C., Dalhoff, K., Petersen, T. S., Riis, T., Schmeltz, C., Chabanova, E., Christensen, H. R., Mikus, G., Burhenne, J., Holm, J. C., Holst, H.

“…Aims To test the in vivo activity of Cytochrome P450 (CYP) 2E1 in obese children vs. nonobese children, aged 11–18 years. Secondly, whether the activity of…”
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Steady-state pharmacokinetics and metabolism of voriconazole in patients by Geist, Marcus J P, Egerer, Gerlinde, Burhenne, Jürgen, Riedel, Klaus-Dieter, Weiss, Johanna, Mikus, Gerd

“…Voriconazole exhibits non-linear pharmacokinetics in adults and is said to be mainly metabolized by CYP2C19 and CYP3A4 to voriconazole-N-oxide. The aim of this…”
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No alteration of Cyp3A4 activity after major hepatectomy in the early postoperative period – A prospective before-after study by Jedamzik, J., Mühlbacher, J., Fitschek, F., Schwarz, C., Burhenne, J., Asenbaum, U., Kaczirek, K., Mikus, G.

“…The impact of major liver resection (LR) on the detoxifying function of the remaining liver tissue as represented by CYP3A activity has yet to be assessed…”
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Response to "Can CYP3A Activity Be Evaluated for Drug Interaction Using a Nanogram Dose of Probe Drug?": Evaluation of CYP3A Activity With Microdoses of Midazolam by Hohmann, N, Halama, B, Siller, N, Mikus, G, Haefeli, W E

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Potent cytochrome P450 2C19 genotype-related interaction between voriconazole and the cytochrome P450 3A4 inhibitor ritonavir by Mikus, Gerd, Schöwel, Verena, Drzewinska, Magdalena, Rengelshausen, Jens, Ding, Reinhard, Riedel, Klaus‐Dieter, Burhenne, Jürgen, Weiss, Johanna, Thomsen, Torben, Haefeli, Walter E.

“…Objectives Cytochrome P450 (CYP) 2C19 and CYP3A4 are the major enzymes responsible for voriconazole elimination. Because the activity of CYP2C19 is under…”
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Cytochrome P450-3A Phenotyping Using Midazolam Is Not Altered by OATP1B1 Polymorphisms by Ziesenitz, V C, Weiss, J, Haefeli, W E, Mikus, G

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CYP2C9 Polymorphism is not a Major Determinant of Bosentan Exposure in Healthy Volunteers by Markert, C, Burhenne, J, Weiss, J, Mikus, G, Haefeli, WE

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Effect of Simultaneous Induction and Inhibition of CYP3A by St John's Wort and Ritonavir on CYP3A Activity by Hafner, V, Jäger, M, Matthée, A‐K, Ding, R, Burhenne, J, Haefeli, W E, Mikus, G

“…We aimed to assess the effect of coadministration and withdrawal of a potent cytochrome P450 3A (CYP3A) inhibitor (ritonavir) and a potent CYP3A inducer (St…”
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Opposite effects of short-term and long-term St John's wort intake on voriconazole pharmacokinetics by Rengelshausen, Jens, Banfield, Maria, Riedel, Klaus‐Dieter, Burhenne, Jürgen, Weiss, Johanna, Thomsen, Torben, Walter‐Sack, Ingeborg, Haefeli, Walter E., Mikus, Gerd

“…Objectives Constituents of St John's wort (SJW) in vivo induce the cytochrome P450 (CYP) isozymes 3A4, 2C9, and 2C19 but in vitro were shown to inhibit them…”
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Candida infections in the elderly by Hof, H, Mikus, G

“…Candida infections of the skin, mucous membranes as well as of internal organs may be more frequent and more serious in the elderly. There are several…”
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Combination of the Hepatitis B/D Entry Inhibitor Myrcludex B and Tenofovir: Assessment of the Effect on Plasma Bile Acid Profiles and Tenofovir Pharmacokinetics by Blank, A, Eidam, A, Haag, M, Hohmann, N, Burhenne, J, Witt, L, Meyer, M, Schwab, M, Mikus, G, Alexandrov, A, Urban, S, Haefeli, W.E

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Management of chronic pain using extended release tilidine : Quality of life and implication of comedication on tilidine metabolism by Wolfert, C, Merbach, M, Stammler, G, Emrich, O, Meid, A D, Burhenne, J, Blank, A, Mikus, G

“…The synthetic opioid tilidine is often used in chronic pain treatment. However, the activation via metabolism in patients with concomitant medication and…”
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