Search Results - "MIKKOLA, L"

Early inductive events in ectodermal appendage morphogenesis by Biggs, Leah C., Mikkola, Marja L.

“…•The vertebrate ectoderm gives rise to a wide variety of organs known as ectodermal appendages.•Ectodermal appendage development is guided by…”
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Molecular aspects of hypohidrotic ectodermal dysplasia by Mikkola, Marja L.

“…Hypohidrotic (anhidrotic) ectodermal dysplasia (HED) is a congenital syndrome characterized by sparse hair, oligodontia, and reduced sweating. It is caused by…”
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Early epithelial signaling center governs tooth budding morphogenesis by Ahtiainen, Laura, Uski, Isa, Thesleff, Irma, Mikkola, Marja L

“…During organogenesis, cell fate specification and patterning are regulated by signaling centers, specialized clusters of morphogen-expressing cells. In many…”
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Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles by Huh, Sung-Ho, Närhi, Katja, Lindfors, Päivi H, Häärä, Otso, Yang, Lu, Ornitz, David M, Mikkola, Marja L

“…In hair follicle development, a placode-derived signal is believed to induce formation of the dermal condensation, an essential component of ectodermal organs…”
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TNF superfamily in skin appendage development by Mikkola, Marja L

“…Abstract The development of skin appendages such as hairs, teeth, and mammary glands is regulated by signaling molecules of the Wnt, FGF, TGFβ, and Hedgehog…”
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Replaying evolutionary transitions from the dental fossil record by Harjunmaa, Enni, Seidel, Kerstin, Häkkinen, Teemu, Renvoisé, Elodie, Corfe, Ian J., Kallonen, Aki, Zhang, Zhao-Qun, Evans, Alistair R., Mikkola, Marja L., Salazar-Ciudad, Isaac, Klein, Ophir D., Jernvall, Jukka

“…The evolutionary relationships of extinct species are ascertained primarily through the analysis of morphological characters. Character inter-dependencies can…”
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Transcriptomic landscape of early hair follicle and epidermal development by Sulic, Ana-Marija, Das Roy, Rishi, Papagno, Verdiana, Lan, Qiang, Saikkonen, Riikka, Jernvall, Jukka, Thesleff, Irma, Mikkola, Marja L.

“…Morphogenesis of ectodermal organs, such as hair, tooth, and mammary gland, starts with the formation of local epithelial thickenings, or placodes, but it…”
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On the difficulty of increasing dental complexity by Harjunmaa, Enni, Kallonen, Aki, Voutilainen, Maria, Hämäläinen, Keijo, Mikkola, Marja L., Jernvall, Jukka

“…Activation of EDA and activin A signalling, and inhibition of SHH signalling pathways together increase the number of cusps on cultured mouse cheek teeth,…”
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Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation by Biggs, Leah C, Mäkelä, Otto Jm, Myllymäki, Satu-Marja, Das Roy, Rishi, Närhi, Katja, Pispa, Johanna, Mustonen, Tuija, Mikkola, Marja L

“…Mesenchymal condensation is a critical step in organogenesis, yet the underlying molecular and cellular mechanisms remain poorly understood. The hair follicle…”
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Genetic basis of skin appendage development by Mikkola, Marja L.

“…Morphogenesis of hair follicles, teeth, and mammary glands depends on inductive epithelial–mesenchymal interactions mediated by a conserved set of signalling…”
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Inactivation of IL11 Signaling Causes Craniosynostosis, Delayed Tooth Eruption, and Supernumerary Teeth by Nieminen, Pekka, Morgan, Neil V., Fenwick, Aimée L., Parmanen, Satu, Veistinen, Lotta, Mikkola, Marja L., van der Spek, Peter J., Giraud, Andrew, Judd, Louise, Arte, Sirpa, Brueton, Louise A., Wall, Steven A., Mathijssen, Irene M.J., Maher, Eamonn R., Wilkie, Andrew O.M., Kreiborg, Sven, Thesleff, Irma

“…Craniosynostosis and supernumerary teeth most often occur as isolated developmental anomalies, but they are also separately manifested in several malformation…”
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FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells by Nguyen, Minh Binh, Cohen, Idan, Kumar, Vinod, Xu, Zijian, Bar, Carmit, Dauber-Decker, Katherine L., Tsai, Pai-Chi, Marangoni, Pauline, Klein, Ophir D., Hsu, Ya-Chieh, Chen, Ting, Mikkola, Marja L., Ezhkova, Elena

“…Merkel cells are innervated mechanosensory cells responsible for light-touch sensations. In murine dorsal skin, Merkel cells are located in touch domes and…”
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Directional Cell Migration, but Not Proliferation, Drives Hair Placode Morphogenesis by Ahtiainen, Laura, Lefebvre, Sylvie, Lindfors, Päivi H., Renvoisé, Elodie, Shirokova, Vera, Vartiainen, Maria K., Thesleff, Irma, Mikkola, Marja L.

“…Epithelial reorganization involves coordinated changes in cell shapes and movements. This restructuring occurs during formation of placodes, ectodermal…”
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Mesenchyme instructs growth while epithelium directs branching in the mouse mammary gland by Lan, Qiang, Trela, Ewelina, Lindström, Riitta, Satta, Jyoti Prabha, Kaczyńska, Beata, Christensen, Mona M, Holzenberger, Martin, Jernvall, Jukka, Mikkola, Marja L

“…The mammary gland is a unique organ that undergoes dynamic alterations throughout a female's reproductive life, making it an ideal model for developmental,…”
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Toward a universal measure of robustness across model organs and systems by Jernvall, Jukka, Di-Poï, Nicolas, Mikkola, Marja L, Kratochwil, Claudius F

“…The development of an individual must be capable of resisting the harmful effects of internal and external perturbations. This capacity, called robustness, can…”
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p63 regulates multiple signalling pathways required for ectodermal organogenesis and differentiation by Laurikkala, Johanna, Mikkola, Marja L, James, Martyn, Tummers, Mark, Mills, Alea A, Thesleff, Irma

“…Heterozygous germline mutations in p63 , a transcription factor of the p53 family, result in abnormal morphogenesis of the skin and its associated structures,…”
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Ectodysplasin regulates activator-inhibitor balance in murine tooth development through Fgf20 signaling by Häärä, Otso, Harjunmaa, Enni, Lindfors, Päivi H, Huh, Sung-Ho, Fliniaux, Ingrid, Åberg, Thomas, Jernvall, Jukka, Ornitz, David M, Mikkola, Marja L, Thesleff, Irma

“…Uncovering the origin and nature of phenotypic variation within species is the first step in understanding variation between species. Mouse models with altered…”
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Genetic parameters for carcass weight, conformation and fat in five beef cattle breeds by Kause, A., Mikkola, L., Strandén, I., Sirkko, K.

“…Profitability of beef production can be increased by genetically improving carcass traits. To construct breeding value evaluations for carcass traits,…”
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Ectodysplasin regulates hormone-independent mammary ductal morphogenesis via NF-κB by Voutilainen, Maria, Lindfors, Päivi H, Lefebvre, Sylvie, Ahtiainen, Laura, Fliniaux, Ingrid, Rysti, Elisa, Murtoniemi, Marja, Schneider, Pascal, Schmidt-Ullrich, Ruth, Mikkola, Marja L

“…Ductal growth of the mammary gland occurs in two distinct stages. The first round of branching morphogenesis occurs during embryogenesis, and the second round…”
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Ectodysplasin and Wnt pathways are required for salivary gland branching morphogenesis by Häärä, Otso, Fujimori, Sayumi, Schmidt-Ullrich, Ruth, Hartmann, Christine, Thesleff, Irma, Mikkola, Marja L

“…The developing submandibular salivary gland (SMG) is a well-studied model for tissue interactions and branching morphogenesis. Its development shares similar…”
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