Search Results - "MIKHAIL YU VYSSOKIKH"

Six Functions of Respiration: Isn’t It Time to Take Control over ROS Production in Mitochondria, and Aging Along with It? by Skulachev, Vladimir P, Vyssokikh, Mikhail Yu, Chernyak, Boris V, Mulkidjanian, Armen Y, Skulachev, Maxim V, Shilovsky, Gregory A, Lyamzaev, Konstantin G, Borisov, Vitaliy B, Severin, Fedor F, Sadovnichii, Victor A

“…Cellular respiration is associated with at least six distinct but intertwined biological functions. (1) biosynthesis of ATP from ADP and inorganic phosphate,…”
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Penetrating cation/fatty acid anion pair as a mitochondria-targeted protonophore by Severin, Fedor F, Severina, Inna I, Antonenko, Yury N, Rokitskaya, Tatiana I, Cherepanov, Dmitry A, Mokhova, Elena N, Vyssokikh, Mikhail Yu, Pustovidko, Antonina V, Markova, Olga V, Yaguzhinsky, Lev S, Korshunova, Galina A, Sumbatyan, Nataliya V, Skulachev, Maxim V, Skulachev, Vladimir P

“…A unique phenomenon of mitochondria-targeted protonophores is described. It consists in a transmembrane H⁺-conducting fatty acid cycling mediated by…”
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Macrophages from naked mole-rat possess distinct immunometabolic signatures upon polarization by Gorshkova, Ekaterina A, Gubernatorova, Ekaterina O, Dvorianinova, Ekaterina M, Yurakova, Taisiya R, Marey, Maria V, Averina, Olga A, Holtze, Susanne, Hildebrandt, Thomas B, Dmitriev, Alexey A, Drutskaya, Marina S, Vyssokikh, Mikhail Yu, Nedospasov, Sergei A

“…The naked mole-rat (NMR) is a unique long-lived rodent which is highly resistant to age-associated disorders and cancer. The immune system of NMR possesses a…”
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Prevention of cardiolipin oxidation and fatty acid cycling as two antioxidant mechanisms of cationic derivatives of plastoquinone (SkQs) by Skulachev, Vladimir P., Antonenko, Yury N., Cherepanov, Dmitry A., Chernyak, Boris V., Izyumov, Denis S., Khailova, Ludmila S., Klishin, Sergey S., Korshunova, Galina A., Lyamzaev, Konstantin G., Pletjushkina, Olga Yu, Roginsky, Vitaly A., Rokitskaya, Tatiana I., Severin, Fedor F., Severina, Inna I., Simonyan, Ruben A., Skulachev, Maxim V., Sumbatyan, Natalia V., Sukhanova, Evgeniya I., Tashlitsky, Vadim N., Trendeleva, Tatyana A., Vyssokikh, Mikhail Yu, Zvyagilskaya, Renata A.

“…The present state of the art in studies on the mechanisms of antioxidant activities of mitochondria-targeted cationic plastoquinone derivatives (SkQs) is…”
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Effects of the mitochondria-targeted antioxidant SkQ1 on lifespan of rodents by Anisimov, Vladimir N, Egorov, Maxim V, Krasilshchikova, Marina S, Lyamzaev, Konstantin G, Manskikh, Vasily N, Moshkin, Mikhail P, Novikov, Evgeny A, Popovich, Irina G, Rogovin, Konstantin A, Shabalina, Irina G, Shekarova, Olga N, Skulachev, Maxim V, Titova, Tatiana V, Vygodin, Vladimir A, Vyssokikh, Mikhail Yu, Yurova, Maria N, Zabezhinsky, Mark A, Skulachev, Vladimir P

“…The effect of the mitochondria-targeted, plastoquinone-containing antioxidant SkQ1 on the lifespan of outbred mice and of three strains of inbred mice was…”
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Adenine nucleotide translocator isoforms 1 and 2 are differently distributed in the mitochondrial inner membrane and have distinct affinities to cyclophilin D by VYSSOKIKH, Mikhail Yu, KATZ, Annette, RUECK, Alexander, WUENSCH, Christine, DÖRNER, Andrea, ZOROV, Dmitry B., BRDICZKA, Dieter

“…Different isoforms of the adenine nucleotide translocase (ANT) are expressed in a tissue-specific manner. It was assumed that ANT-1 and ANT-2 co-exist in every…”
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Enhanced ROS Production in Mitochondria from Prematurely Aging mtDNA Mutator Mice by Shabalina, Irina G., Edgar, Daniel, Gibanova, Natalia, Kalinovich, Anastasia V., Petrovic, Natasa, Vyssokikh, Mikhail Yu, Cannon, Barbara, Nedergaard, Jan

“…An increase in mitochondrial DNA (mtDNA) mutations and an ensuing increase in mitochondrial reactive oxygen species (ROS) production have been suggested to be…”
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Improved health-span and lifespan in mtDNA mutator mice treated with the mitochondrially targeted antioxidant SkQ1 by Shabalina, Irina G, Vyssokikh, Mikhail Yu, Gibanova, Natalia, Csikasz, Robert I, Edgar, Daniel, Hallden-Waldemarson, Anne, Rozhdestvenskaya, Zinaida, Bakeeva, Lora E, Vays, Valeria B, Pustovidko, Antonina V, Skulachev, Maxim V, Cannon, Barbara, Skulachev, Vladimir P, Nedergaard, Jan

“…MtDNA mutator mice exhibit marked features of premature aging. We find that these mice treated from age of ≈100 days with the mitochondria-targeted antioxidant…”
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Mitochondrial peptide Mtln contributes to oxidative metabolism in mice by Averina, Olga A., Permyakov, Oleg A., Emelianova, Mariia A., Grigoryeva, Olga O., Gulyaev, Mikhail V., Pavlova, Olga S., Mariasina, Sofia S., Frolova, Olga Yu, Kurkina, Marina V., Baydakova, Galina V., Zakharova, Ekaterina Yu, Marey, Maria V., Tsarev, Dmitry A., Tashlitsky, Vadim N., Popov, Vladimir S., Lovat, Maxim L., Polshakov, Vladimir I., Vyssokikh, Mikhail Yu, Sergiev, Petr V.

“…Mitoregulin (Mtln) is a recently identified 56 amino acid long mitochondrial peptide conserved in vertebrates. Mtln is known to enhance function of respiratory…”
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Enhanced ROS production in mitochondria from prematurely aging mtDNA mutator mice by Shabalina, Irina G., Edgar, Daniel, Gibanova, Natalia, Kalinovich, Anastasia, Petrovic, Natasa, Vyssokikh, Mikhail Yu, Cannon, Barbara, Nedergaard, Jan

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Age-Dependent Changes in the Production of Mitochondrial Reactive Oxygen Species in Human Skeletal Muscle by Vyssokikh, Mikhail Yu, Vigovskiy, Maksim A., Philippov, Vladislav V., Boroday, Yakov R., Marey, Mariya V., Grigorieva, Olga A., Vepkhvadze, Tatiana F., Kurochkina, Nadezhda S., Manukhova, Ludmila A., Efimenko, Anastasiya Yu, Popov, Daniil V., Skulachev, Vladimir P.

“…A decrease in muscle mass and its functionality (strength, endurance, and insulin sensitivity) is one of the integral signs of aging. One of the triggers of…”
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In search of novel highly active mitochondria-targeted antioxidants: Thymoquinone and its cationic derivatives by Severina, Inna I., Severin, Fedor F., Korshunova, Galina A., Sumbatyan, Natalya V., Ilyasova, Tatyana M., Simonyan, Ruben A., Rogov, Anton G., Trendeleva, Tatyana A., Zvyagilskaya, Renata A., Dugina, Vera B., Domnina, Lidia V., Fetisova, Elena K., Lyamzaev, Konstantin G., Vyssokikh, Mikhail Yu, Chernyak, Boris V., Skulachev, Maxim V., Skulachev, Vladimir P., Sadovnichii, Viktor A.

“…Since the times of the Bible, an extract of black cumin seeds was used as a medicine to treat many human pathologies. Thymoquinone (2-demethylplastoquinone…”
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Conspicuous improvement of health and life-span in mtDNA mutator mice treated with mitochondrially targeted antioxidant by Shabalina, Irina G., Vyssokikh, Mikhail Yu, Gibanova, Natalia, Csikasz, Robert I., Edgar, Daniel, Pustovidko, Antonina V., Skulachev, Maxim V., Cannon, Barbara, Skulachev, Vladimir P., Nedergaard, Jan

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An attempt to prevent senescence: A mitochondrial approach by Skulachev, Vladimir P., Anisimov, Vladimir N., Antonenko, Yuri N., Bakeeva, Lora E., Chernyak, Boris V., Erichev, Valery P., Filenko, Oleg F., Kalinina, Natalya I., Kapelko, Valery I., Kolosova, Natalya G., Kopnin, Boris P., Korshunova, Galina A., Lichinitser, Mikhail R., Obukhova, Lidia A., Pasyukova, Elena G., Pisarenko, Oleg I., Roginsky, Vitaly A., Ruuge, Enno K., Senin, Ivan I., Severina, Inna I., Skulachev, Maxim V., Spivak, Irina M., Tashlitsky, Vadim N., Tkachuk, Vsevolod A., Vyssokikh, Mikhail Yu, Yaguzhinsky, Lev S., Zorov, Dmitry B.

“…Antioxidants specifically addressed to mitochondria have been studied to determine if they can decelerate senescence of organisms. For this purpose, a project…”
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Cardiolipin: Altered content and fatty acid composition in mitochondria from mtDNA mutator mice by Vyssokikh, Mikhail Yu, Shabalina, Irina G., Trifunovic, Alexandra, Cannon, Barbara, Skulachev, Vladimir P., Nedergaard, Jan

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Oligomycin, inhibitor of the F0 part of H+-ATP-synthase, suppresses the TNF-induced apoptosis by Shchepina, Liarisa A, Pletjushkina, Olga Y, Avetisyan, Armine V, Bakeeva, Liora E, Fetisova, Elena K, Izyumov, Denis S, Saprunova, Valeria B, Vyssokikh, Mikhail Y, Chernyak, Boris V, Skulachev, Vladimir P

“…The release of cytochrome c from the intermembrane space of mitochondria into the cytosol is one of the critical events in apoptotic cell death. In the present…”
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Adenine nucleotide translocator isoforms 1 and 2 are differently distributed in the mitochondrial inner membrane and have distinct affinities to cyclophilin D by Vyssokikh, M Y, Katz, A, Rueck, A, Wuensch, C, Dörner, A, Zorov, D B, Brdiczka, D

“…Different isoforms of the adenine nucleotide translocase (ANT) are expressed in a tissue-specific manner. It was assumed that ANT-1 and ANT-2 co-exist in every…”
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Effects of lipophilic dications on planar bilayer phospholipid membrane and mitochondria by Severina, Inna I., Vyssokikh, Mikhail Yu, Pustovidko, Antonina V., Simonyan, Ruben A., Rokitskaya, Tatiana I., Skulachev, Vladimir P.

“…In this paper, we studied effects of phosphonium dications P2C5 and P2C10 on bilayer planar phospholipid membrane (BLM) and rat liver mitochondria. In line…”
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Folding and refolding of thermolabile and thermostable bacterial luciferases: the role of DnaKJ heat-shock proteins by Manukhov, Ilia V, Eroshnikov, Gennadii E, Vyssokikh, Mikhail Yu, Zavilgelsky, Gennadii B

“…Bacterial luciferases are highly suitable test substrates for the analysis of refolding of misfolded proteins, as they are structurally labile and loose…”
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The permeability transition pore induced under anaerobic conditions in mitochondria energized with ATP by Kuzminova, Alevtina E, Zhuravlyova, Anastasiya V, Vyssokikh, Mikhail Yu, Zorova, Ljubava D, Krasnikov, Boris F, Zorov, Dmitry B

“…The role of oxygen in the induction of mitochondrial permeability transitions was studied. Oxygen consumption, swelling, membrane potential and calcium…”
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