Search Results - "MIKECZ, K."

Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5–hyaluronan complexes in articular cartilages by Plaas, A., Ph.D, Osborn, B., M.S, Yoshihara, Y., M.D., Ph.D, Bai, Y., M.S, Bloom, T., M.D, Nelson, F., M.D, Mikecz, K., M.D., Ph.D, Sandy, J.D., Ph.D

“…Summary Objective Human osteoarthritis (OA) is characterized by aggrecanase-mediated depletion of cartilage aggrecan. We have examined the abundance, location…”
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Synoviocyte inflammatory responses to calcium pyrophosphate dihydrate crystals involves CD14 and TLR-4 by Scanzello, C.R, Nair, A, Margolis, A, Mikecz, K, Finnegan, A

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Oral glucosamine modulates the response of the liver and lymphocytes of the mesenteric lymph nodes in a papain-induced model of joint damage and repair by Panicker, S, Borgia, J, Fhied, C, Mikecz, K, Oegema, T.R

“…Summary Objectives To assess whether glucosamine (GlcN), an oral supplement commonly taken to relieve the symptoms of osteoarthritis, modulates the immune and…”
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Proteoglycan Aggrecan Conducting T Cell Activation and Apoptosis in a Murine Model of Rheumatoid Arthritis by Olasz, K., Hanyecz, A., Tarjanyi, O., Németh, Pèter, Mikecz, K., Glant, T. T., Boldizsar, F.

“…Rheumatoid arthritis (RA) is a systemic autoimmune disease and its targeting of the joints indicates the presence of a candidate autoantigen(s) in synovial…”
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Osteoarthritis-like damage of cartilage in the temporomandibular joints in mice with autoimmune inflammatory arthritis by Ghassemi-Nejad, S, Kobezda, T, Rauch, T.A, Matesz, C, Glant, T.T, Mikecz, K

“…Summary Objective To study temporomandibular joint (TMJ) involvement in an autoimmune murine model of rheumatoid arthritis (RA), a disease characterized by…”
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T cell receptor (TCR) signal strength controls arthritis severity in proteoglycan‐specific TCR transgenic mice by Olasz, K., Boldizsar, F., Kis‐Toth, K., Tarjanyi, O., Hegyi, A., van Eden, W., Rauch, T. A., Mikecz, K., Glant, T. T.

“…Summary T cell receptor transgenic (TCR‐Tg) mice specific for the arthritogenic 5/4E8 epitope in the G1 domain of cartilage proteoglycan were generated and…”
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A longitudinal study on an autoimmune murine model of ankylosing spondylitis by Bárdos, T, Szabó, Z, Czipri, M, Vermes, C, Tunyogi-Csapó, M, Urban, R M, Mikecz, K, Glant, T T

“…Background: Proteoglycan aggrecan (PG)-induced arthritis (PGIA) is the only systemic autoimmune murine model which affects the axial skeleton, but no studies…”
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Disease-promoting and -protective genomic loci on mouse chromosomes 3 and 19 control the incidence and severity of autoimmune arthritis by Glant, T T, Adarichev, V A, Boldizsar, F, Besenyei, T, Laszlo, A, Mikecz, K, Rauch, T A

“…Proteoglycan (PG)-induced arthritis (PGIA) is a murine model of rheumatoid arthritis. Arthritis-prone BALB/c mice are 100% susceptible, whereas the major…”
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Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis by Mikecz, K, Brennan, F R, Kim, J H, Glant, T T

“…A ubiquitous cell adhesion receptor, CD44, preferentially binds hyaluronan, a polysaccharide macromolecule that is present in most extracellular matrices…”
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26 SYNOVIAL FLUID FROM PATIENTS WITH OSTEOARTHRITIS AND MENISCAL INJURY MODULATES THE RESPONSE OF FIBROBLAST-LIKE SYNOVIOCYTES TO TLR-2 AND TLR-4 LIGANDS VIA SOLUBLE CD14 by Scanzello, C.R, Nair, A, Kanda, V, Bush-Joseph, C, Verma, N, Chubinskaya, S, Mikecz, K, Malfait, A.-M, Crow, M.K, Spear, G.T, Finnegan, A

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Antibody-Induced Shedding of CD44 from Adherent Cells Is Linked to the Assembly of the Cytoskeleton by Shi, Mei, Dennis, Kathryn, Peschon, Jacques J, Chandrasekaran, Raman, Mikecz, Katalin

“…CD44 is a widely expressed integral membrane glycoprotein that serves as a specific adhesion receptor for the extracellular matrix glycosaminoglycan…”
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Orthopaedic implant related metal toxicity in terms of human lymphocyte reactivity to metal-protein complexes produced from cobalt-base and titanium-base implant alloy degradation by Hallab, N J, Mikecz, K, Vermes, C, Skipor, A, Jacobs, J J

“…Metal toxicity from sources such as orthopaedic implants was investigated in terms of immune system hyper-reactivity to metal implant alloy degradation…”
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Impaired Fas Signaling Pathway Is Involved in Defective T Cell Apoptosis in Autoimmune Murine Arthritis by Zhang, Jian, Bardos, Tamas, Mikecz, Katalin, Finnegan, Alison, Glant, Tibor T

“…Proteoglycan (PG)-induced arthritis (PGIA) is a novel autoimmune murine model for rheumatoid arthritis induced by immunization with cartilage PG in susceptible…”
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Congenic strains displaying similar clinical phenotype of arthritis represent different immunologic models of inflammation by Adarichev, V A, Vegvari, A, Szabo, Z, Kis-Toth, K, Mikecz, K, Glant, T T

“…Proteoglycan (PG)-induced arthritis (PGIA) is an autoimmune inflammatory disease controlled by multiple genes in the murine genome. BALB/c × DBA/2 congenic…”
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Complex pattern of Th1 and Th2 activation with a preferential increase of autoreactive Th1 cells in BALB/c mice with proteoglycan (aggrecan)‐induced arthritis by Holló, K., Glant, T. T., Garzó, M., Finnegan, A., Mikecz, K., Buzás, E.

“…The central role of CD4+ T cells and the balance between T helper (Th) subpopulations in the pathogenesis of autoimmune diseases have been extensively studied…”
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A Genome Scan Using a Novel Genetic Cross Identifies New Susceptibility Loci and Traits in a Mouse Model of Rheumatoid Arthritis by Otto, Jeffrey M, Chandrasekeran, Raman, Vermes, Csaba, Mikecz, Katalin, Finnegan, Alison, Rickert, Sarah E, Enders, Jill T, Glant, Tibor T

“…Proteoglycan-induced arthritis (PGIA) is a murine model for rheumatoid arthritis (RA) both in terms of its pathology and its genetics. PGIA can only be induced…”
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Spontaneous Thymocyte Apoptosis Is Regulated by a Mitochondrion-Mediated Signaling Pathway by Zhang, Jian, Mikecz, Katalin, Finnegan, Alison, Glant, Tibor T

“…Most thymocytes that have not successfully rearranged their TCR genes or that express a receptor with subthreshold avidity for self-Ag/MHC enter a default…”
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Continuous nasal administration of antigen is critical to maintain tolerance in adoptively transferred autoimmune arthritis in SCID mice by BÁRDOS, T., CZIPRI, M., VERMES, C., ZHANG, J., MIKECZ, K., GLANT, T. T.

“…SUMMARY Mucosal tolerance is a natural mechanism that prevents immunological reactions to antigens by altering the activity of immune cells of pathogenic…”
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Citrullinated Aggrecan Epitopes as Targets of Autoreactive CD4+ T Cells in Patients With Rheumatoid Arthritis by Rims, Cliff, Uchtenhagen, Hannes, Kaplan, Mariana J., Carmona‐Rivera, Carmelo, Carlucci, Philip, Mikecz, Katalin, Markovics, Adrienn, Carlin, Jeffrey, Buckner, Jane H., James, Eddie A.

“…Objective Recognition of citrullinated antigens such as vimentin, fibrinogen, and α‐enolase is associated with rheumatoid arthritis (RA). Emerging data suggest…”
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Disease-associated qualitative and quantitative trait loci in proteoglycan-induced arthritis and collagen-induced arthritis by Glant, T T, Adarichev, V A, Nesterovitch, A B, Szanto, S, Oswald, J P, Jacobs, J J, Firneisz, G, Zhang, J, Finnegan, A, Mikecz, K

“…Two autoimmune murine models--proteoglycan (aggrecan)-induced arthritis (PGIA) and collagen-induced arthritis (CIA)--were developed in parent strains, F1 and…”
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