Search Results - "MIFSUD, J"

Antivirals targeting the polymerase complex of influenza viruses by Mifsud, Edin J., Hayden, Frederick G., Hurt, Aeron C.

“…Current influenza antivirals have limitations with regard to their effectiveness and the potential emergence of resistance. Encouragingly, several new…”
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Innate Immune Responses to Influenza Virus Infections in the Upper Respiratory Tract by Mifsud, Edin J, Kuba, Miku, Barr, Ian G

“…The innate immune system is the host's first line of immune defence against any invading pathogen. To establish an infection in a human host the influenza…”
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Telehealth Interventions in Head and Neck Cancer Patients: A Systematic Review by Caputo, Mathew P., Rodriguez, Carmen S., Padhya, Tapan A., Mifsud, Matthew J.

“…Head and neck cancer (HNC) and its treatments often result in adverse effects that impair a patient's quality of life. Although intensive rehabilitative…”
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Evaluating the fitness of PA/I38T-substituted influenza A viruses with reduced baloxavir susceptibility in a competitive mixtures ferret model by Lee, Leo Yy, Zhou, Jie, Koszalka, Paulina, Frise, Rebecca, Farrukee, Rubaiyea, Baba, Keiko, Miah, Shahjahan, Shishido, Takao, Galiano, Monica, Hashimoto, Takashi, Omoto, Shinya, Uehara, Takeki, Mifsud, Edin J, Collinson, Neil, Kuhlbusch, Klaus, Clinch, Barry, Wildum, Steffen, Barclay, Wendy S, Hurt, Aeron C

“…Baloxavir is approved in several countries for the treatment of uncomplicated influenza in otherwise-healthy and high-risk patients. Treatment-emergent viruses…”
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Baloxavir treatment of ferrets infected with influenza A(H1N1)pdm09 virus reduces onward transmission by Lee, Leo Yi Yang, Zhou, Jie, Frise, Rebecca, Goldhill, Daniel H, Koszalka, Paulina, Mifsud, Edin J, Baba, Kaoru, Noda, Takahiro, Ando, Yoshinori, Sato, Kenji, Yuki, Aoe-Ishikawa, Shishido, Takao, Uehara, Takeki, Wildum, Steffen, Zwanziger, Elke, Collinson, Neil, Kuhlbusch, Klaus, Clinch, Barry, Hurt, Aeron C, Barclay, Wendy S

“…Influenza viruses cause seasonal outbreaks and pose a continuous pandemic threat. Although vaccines are available for influenza control, their efficacy varies…”
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Links between recognition and degradation of cytoplasmic viral RNA in innate immune response by Oshiumi, Hiroyuki, Mifsud, Edin J., Daito, Takuji

“…Summary Recognition and degradation of viral RNA are essential for antiviral innate immune responses. Cytoplasmic viral RNA is recognized by retinoic…”
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Adjuvant radiotherapy versus concurrent chemoradiotherapy for the management of high-risk salivary gland carcinomas by Mifsud, Matthew J., Tanvetyanon, Tawee, Mccaffrey, Judith C., Otto, Kristen J., Padhya, Tapan A., Kish, Julie, Trotti, Andy M., Harrison, Louis B., Caudell, Jimmy J.

“…Background Given the aggressive behavior of advanced salivary malignancies, the purpose of the current study was to explore the utility of adjuvant…”
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Intranasal Administration of the TLR2 Agonist Pam2Cys Provides Rapid Protection against Influenza in Mice by Tan, Amabel C. L, Mifsud, Edin J, Zeng, Weiguang, Edenborough, Kathryn, McVernon, Jodie, Brown, Lorena E, Jackson, David C

“…The protective role played by the innate immune system during early stages of infection suggests that compounds which stimulate innate responses could be used…”
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A variable-fidelity aerodynamic model using proper orthogonal decomposition by Mifsud, M. J., MacManus, D. G., Shaw, S.T.

“…Summary A variable‐fidelity aerodynamic model based on proper orthogonal decomposition (POD) of an ensemble of computational fluid dynamics (CFD) solutions at…”
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Assessing the fitness of a dual-antiviral drug resistant human influenza virus in the ferret model by Stannard, Harry L., Mifsud, Edin J., Wildum, Steffen, Brown, Sook Kwan, Koszalka, Paulina, Shishido, Takao, Kojima, Satoshi, Omoto, Shinya, Baba, Keiko, Kuhlbusch, Klaus, Hurt, Aeron C., Barr, Ian G.

“…Influenza antivirals are important tools in our fight against annual influenza epidemics and future influenza pandemics. Combinations of antivirals may reduce…”
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Inactivated Influenza Vaccine That Provides Rapid, Innate-Immune-System-Mediated Protection and Subsequent Long-Term Adaptive Immunity by Chua, Brendon Y, Wong, Chinn Yi, Mifsud, Edin J, Edenborough, Kathryn M, Sekiya, Toshiki, Tan, Amabel C L, Mercuri, Francesca, Rockman, Steve, Chen, Weisan, Turner, Stephen J, Doherty, Peter C, Kelso, Anne, Brown, Lorena E, Jackson, David C

“…The continual threat to global health posed by influenza has led to increased efforts to improve the effectiveness of influenza vaccines for use in epidemics…”
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A high-fidelity low-cost aerodynamic model using proper orthogonal decomposition by Mifsud, M. J., Shaw, S. T., MacManus, D. G.

“…In this paper a high‐fidelity aerodynamic model is presented for use in parametric studies of weapon aerodynamics. The method employs a reduced‐order model…”
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Extracellular Vesicles Including Exosomes Regulate Innate Immune Responses to Hepatitis B Virus Infection by Kouwaki, Takahisa, Fukushima, Yoshimi, Daito, Takuji, Sanada, Takahiro, Yamamoto, Naoki, Mifsud, Edin J., Leong, Chean Ring, Tsukiyama-Kohara, Kyoko, Kohara, Michinori, Matsumoto, Misako, Seya, Tsukasa, Oshiumi, Hiroyuki

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Extracellular Vesicles Including Exosomes Regulate Innate Immune Responses to Hepatitis B Virus Infection by Kouwaki, Takahisa, Fukushima, Yoshimi, Daito, Takuji, Sanada, Takahiro, Yamamoto, Naoki, Mifsud, Edin J, Leong, Chean Ring, Tsukiyama-Kohara, Kyoko, Kohara, Michinori, Matsumoto, Misako, Seya, Tsukasa, Oshiumi, Hiroyuki

“…The innate immune system is essential for controlling viral infection. Hepatitis B virus (HBV) persistently infects human hepatocytes and causes hepatocellular…”
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Epidemiology of repeat influenza infection in Queensland, Australia, 2005–2017 by Price, Olivia, Birrell, Frances A., Mifsud, Edin J., Sullivan, Sheena G.

“…Natural infection with the influenza virus is believed to generate cross-protective immunity across both types and subtypes. However, less is known about the…”
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Reply to Letter to the Editor regarding “Diabetes mellitus in major head and neck cancer surgery: Systematic review and meta‐analysis” by Mhaskar, Rahul, Caputo, Mathew P., Mifsud, Matthew J.

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TLR Agonists as Modulators of the Innate Immune Response and Their Potential as Agents Against Infectious Disease by Mifsud, Edin J, Tan, Amabel C L, Jackson, David C

“…Immunotherapies that can either activate or suppress innate immune responses are being investigated as treatments against infectious diseases and the pathology…”
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Diabetes mellitus in major head and neck cancer surgery: Systematic review and meta‐analysis by Caputo, Mathew P., Shabani, Sepehr, Mhaskar, Rahul, McMullen, Caitlin, Padhya, Tapan A., Mifsud, Matthew J.

“…Background Diabetes mellitus (DM) is a risk factor for surgical complications and a common comorbidity in the setting of head and neck (H&N) cancer. Our…”
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Prophylaxis of ferrets with nitazoxanide and oseltamivir combinations is more effective at reducing the impact of influenza a virus infection compared to oseltamivir monotherapy by Mifsud, Edin J., Tilmanis, Danielle, Oh, Ding Yuan, Ming-Kay Tai, Celeste, Rossignol, Jean-Francois, Hurt, Aeron C.

“…Combination therapy is an alternative approach to reduce viral shedding and improve clinical outcomes following influenza virus infections. In this study we…”
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Inactivated whole virus particle vaccine with potent immunogenicity and limited IL-6 induction is ideal for influenza by Sekiya, Toshiki, Mifsud, Edin J, Ohno, Marumi, Nomura, Naoki, Sasada, Mayumi, Fujikura, Daisuke, Daito, Takuji, Shingai, Masashi, Ohara, Yuki, Nishimura, Tomohiro, Endo, Masafumi, Mitsumata, Ryotarou, Ikeda, Tomio, Hatanaka, Hironori, Kitayama, Hiroki, Motokawa, Kenji, Sobue, Tomoyoshi, Suzuki, Saori, Itoh, Yasushi, Brown, Lorena E, Ogasawara, Kazumasa, Kino, Yoichiro, Kida, Hiroshi

“…In contrast to current ether- or detergent-disrupted “split” vaccines (SVs) for influenza, inactivated whole influenza virus particle vaccines (WPVs) retain…”
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