Search Results - "MICHIGAMI, Toshimi"

Regulatory mechanisms for the development of growth plate cartilage by Michigami, Toshimi

“…In vertebrates, most of the skeleton is formed through endochondral ossification. Endochondral bone formation is a complex process involving the mesenchymal…”
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Roles of osteocytes in phosphate metabolism by Michigami, Toshimi

“…Osteocytes are dendritic cells in the mineralized bone matrix that descend from osteoblasts. They play critical roles in controlling bone mass through the…”
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Advances in understanding of phosphate homeostasis and related disorders by Michigami, Toshimi

“…Inorganic phosphate (Pi) in the mammalian body is balanced by its influx and efflux through the intestines, kidneys, bones, and soft tissues, at which several…”
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Skeletal mineralization: mechanisms and diseases by Michigami, Toshimi

“…Skeletal mineralization is initiated in matrix vesicles (MVs), the small extracellular vesicles derived from osteoblasts and chondrocytes. Calcium and…”
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Phosphate as a Signaling Molecule and Its Sensing Mechanism by Michigami, Toshimi, Kawai, Masanobu, Yamazaki, Miwa, Ozono, Keiichi

“…In mammals, phosphate balance is maintained by influx and efflux via the intestines, kidneys, bone, and soft tissue, which involves multiple sodium/phosphate…”
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Paracrine and endocrine functions of osteocytes by Michigami, Toshimi

“…Osteocytes are dendritic-shaped cells embedded in the bone matrix and are terminally differentiated from osteoblasts. Inaccessibility due to their location has…”
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Roles of Phosphate in Skeleton by Michigami, Toshimi, Ozono, Keiichi

“…Phosphate is essential for skeletal mineralization, and its chronic deficiency leads to rickets and osteomalacia. Skeletal mineralization starts in matrix…”
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Osteocytes and the pathogenesis of hypophosphatemic rickets by Yamazaki, Miwa, Michigami, Toshimi

“…Since phosphorus is a component of hydroxyapatite, its prolonged deprivation affects bone mineralization. Fibroblast growth factor 23 (FGF23) is essential for…”
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Promising horizons in achondroplasia along with the development of new drugs by Ozono, Keiichi, Kubota, Takuo, Michigami, Toshimi

“…Achondroplasia (ACH) is a representative skeletal disorder characterized by rhizomelic shortened limbs and short stature. ACH is classified as belonging to the…”
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Nationwide survey of fibroblast growth factor 23 (FGF23)-related hypophosphatemic diseases in Japan: prevalence, biochemical data and treatment by Endo, Itsuro, Fukumoto, Seiji, Ozono, Keiichi, Namba, Noriyuki, Inoue, Daisuke, Okazaki, Ryo, Yamauchi, Mika, Sugimoto, Toshitsugu, Minagawa, Masanori, Michigami, Toshimi, Nagai, Masaki, Matsumoto, Toshio

“…A nationwide epidemiologic survey of fibroblast growth factor 23 (FGF23)-related hypophosphatemic diseases was conducted in 2010 to clarify the prevalence and…”
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Lack of PTEN in osteocytes increases circulating phosphate concentrations by decreasing intact fibroblast growth factor 23 levels by Kawai, Masanobu, Kinoshita, Saori, Ozono, Keiichi, Michigami, Toshimi

“…Fibroblast growth factor 23 (FGF23) has been centric to the regulation of phosphate (Pi) metabolism; however, the regulatory network of FGF23 in osteocytes has…”
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The Lack of Bmal1, a Core Clock Gene, in the Intestine Decreases Glucose Absorption in Mice by Onuma, Shinsuke, Kinoshita, Saori, Shimba, Shigeki, Ozono, Keiichi, Michigami, Toshimi, Kawai, Masanobu

“…Abstract The circadian clock network is an evolutionarily conserved system that regulates systemic metabolism, such as glucose homeostasis. Intestinal tissue…”
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Extracellular Phosphate, Inflammation and Cytotoxicity by Michigami, Toshimi, Yamazaki, Miwa, Razzaque, Mohammed S

“…Phosphorus is an essential nutrient that plays a crucial role in various biological processes, including cell membrane integrity, synthesis of nucleic acids,…”
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Sympathetic activation induces skeletal Fgf23 expression in a circadian rhythm-dependent manner by Kawai, Masanobu, Kinoshita, Saori, Shimba, Shigeki, Ozono, Keiichi, Michigami, Toshimi

“…The circadian clock network is well known to link food intake and metabolic outputs. Phosphorus is a pivotal nutritional factor involved in energy and skeletal…”
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Current Understanding on the Molecular Basis of Chondrogenesis by Michigami, Toshimi

“…Endochondral bone formation involves multiple steps, consisting of the condensation of undifferentiated mesenchymal cells, proliferation and hypertrophic…”
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A unique case of childhood hypophosphatasia caused by a novel heterozygous 51-bp in-frame deletion in the ALPL gene by Tachikawa, Kanako, Yamazaki, Miwa, Michigami, Toshimi

“…Hypophosphatasia (HPP) is caused by inactivating variants of the ALPL gene, which encodes tissue non-specific alkaline phosphatase (TNSALP). Among the six…”
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Growth-related skeletal changes and alterations in phosphate metabolism by Michigami, Toshimi, Tachikawa, Kanako, Yamazaki, Miwa, Nakanishi, Tatsuro, Kawai, Masanobu, Ozono, Keiichi

“…Serum inorganic phosphate (Pi) levels are higher in children than in adults; however, the underlying mechanisms remain unclear. Therefore, we herein attempted…”
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Wnt signaling in bone metabolism by Kubota, Takuo, Michigami, Toshimi, Ozono, Keiichi

“…A variety of in vivo models have increased understanding of the role of Wnt signaling in bone since mutations in the LRP5 gene were found in human bone…”
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Hypophosphatasia in Japan: ALPL Mutation Analysis in 98 Unrelated Patients by Michigami, Toshimi, Tachikawa, Kanako, Yamazaki, Miwa, Kawai, Masanobu, Kubota, Takuo, Ozono, Keiichi

“…Hypophosphatasia (HPP) is highly variable in clinical expression and is generally classified into six subtypes. Although it would be beneficial to be able to…”
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Assessment criteria for vitamin D deficiency/insufficiency in Japan: proposal by an expert panel supported by the Research Program of Intractable Diseases, Ministry of Health, Labour and Welfare, Japan, the Japanese Society for Bone and Mineral Research and the Japan Endocrine Society [Opinion] by Okazaki, Ryo, Ozono, Keiichi, Fukumoto, Seiji, Inoue, Daisuke, Yamauchi, Mika, Minagawa, Masanori, Michigami, Toshimi, Takeuchi, Yasuhiro, Matsumoto, Toshio, Sugimoto, Toshitsugu

“…Vitamin D is indispensable for the maintenance of bone and mineral health. Inadequate vitamin D action increases the risk for various musculoskeletal/mineral…”
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