Search Results - "MICHELSEN, Kathrin S"

Chronic intestinal inflammation alters hippocampal neurogenesis by Zonis, Svetlana, Pechnick, Robert N, Ljubimov, Vladimir A, Mahgerefteh, Michael, Wawrowsky, Kolja, Michelsen, Kathrin S, Chesnokova, Vera

“…Adult neurogenesis in the subgranular zone of the hippocampus is involved in learning, memory, and mood control. Decreased hippocampal neurogenesis elicits…”
Get full text

Constitutive TL1A (TNFSF15) expression on lymphoid or myeloid cells leads to mild intestinal inflammation and fibrosis by Shih, David Q, Barrett, Robert, Zhang, Xiaolan, Yeager, Nicole, Koon, Hon Wai, Phaosawasdi, Piangwarin, Song, Yahui, Ko, Brian, Wong, Michelle H, Michelsen, Kathrin S, Martins, Gislaine, Pothoulakis, Charalabos, Targan, Stephan R

“…TL1A is a member of the TNF superfamily and its expression is increased in the mucosa of inflammatory bowel disease patients. Moreover, a subset of Crohn's…”
Get full text

Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer by Lowe, Emily L, Crother, Timothy R, Rabizadeh, Shervin, Hu, Bing, Wang, Hanlin, Chen, Shuang, Shimada, Kenichi, Wong, Michelle H, Michelsen, Kathrin S, Arditi, Moshe

“…Inflammatory bowel disease (IBD) is a disorder of chronic inflammation with increased susceptibility to colorectal cancer. The etiology of IBD is unclear but…”
Get full text

HMGB1 mediates endogenous TLR2 activation and brain tumor regression by Curtin, James F, Liu, Naiyou, Candolfi, Marianela, Xiong, Weidong, Assi, Hikmat, Yagiz, Kader, Edwards, Matthew R, Michelsen, Kathrin S, Kroeger, Kurt M, Liu, Chunyan, Muhammad, A K M Ghulam, Clark, Mary C, Arditi, Moshe, Comin-Anduix, Begonya, Ribas, Antoni, Lowenstein, Pedro R, Castro, Maria G

“…Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor that carries a 5-y survival rate of 5%. Attempts at eliciting a clinically relevant…”
Get full text

Lack of Toll-Like Receptor 4 or Myeloid Differentiation Factor 88 Reduces Atherosclerosis and Alters Plaque Phenotype in Mice Deficient in Apolipoprotein E by Michelsen, Kathrin S., Wong, Michelle H., Shah, Prediman K., Zhang, Wenxuan, Yano, Juliana, Doherty, Terence M., Akira, Shizuo, Rajavashisth, Tripathi B., Arditi, Moshe, Ignarro, Louis J.

“…Toll-like receptors (TLRs) and the downstream adaptor molecule myeloid differentiation factor 88 (MyD88) play an essential role in the innate immune responses…”
Get full text

Toll-like receptor 7 protects against intestinal inflammation and restricts the development of colonic tissue-resident memory CD8 + T cells by Hamade, Hussein, Tsuda, Masato, Oshima, Naoki, Stamps, Dalton T, Wong, Michelle H, Stamps, Jasmine T, Thomas, Lisa S, Salumbides, Brenda C, Jin, Caroline, Nunnelee, Jordan S, Dhall, Deepti, Targan, Stephan R, Michelsen, Kathrin S

“…The maintenance of intestinal homeostasis depends on a complex interaction between the immune system, intestinal epithelial barrier, and microbiota. Alteration…”
Get full text

Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis by Fukata, Masayuki, Michelsen, Kathrin S, Eri, Rajaraman, Thomas, Lisa S, Hu, Bing, Lukasek, Katie, Nast, Cynthia C, Lechago, Juan, Xu, Ruliang, Naiki, Yoshikazu, Soliman, Antoine, Arditi, Moshe, Abreu, Maria T

“…Inflammatory bowel disease (IBD) arises from a dysregulated mucosal immune response to luminal bacteria. Toll-like receptor (TLR)4 recognizes LPS and…”
Get more information

Platelet-activating factor induces TLR4 expression in intestinal epithelial cells: implication for the pathogenesis of necrotizing enterocolitis by Soliman, Antoine, Michelsen, Kathrin S, Karahashi, Hisae, Lu, Jing, Meng, Fan Jing, Qu, Xiaowu, Crother, Timothy R, Rabizadeh, Shervin, Chen, Shuang, Caplan, Michael S, Arditi, Moshe, Jilling, Tamas

“…Necrotizing enterocolitis (NEC) is a leading cause of morbidity and mortality in neonatal intensive care units, however its pathogenesis is not completely…”
Get full text

BATF3 Protects Against Metabolic Syndrome and Maintains Intestinal Epithelial Homeostasis by Hamade, Hussein, Stamps, Jasmine T, Stamps, Dalton T, More, Shyam K, Thomas, Lisa S, Blackwood, Anna Y, Lahcene, Nawele L, Castanon, Sofi L, Salumbides, Brenda C, Shimodaira, Yosuke, Goodridge, Helen S, Targan, Stephan R, Michelsen, Kathrin S

“…The intestinal immune system and microbiota are emerging as important contributors to the development of metabolic syndrome, but the role of intestinal…”
Get full text

Mycobacterium Tuberculosis Heat Shock Proteins Use Diverse Toll-like Receptor Pathways to Activate Pro-inflammatory Signals by Bulut, Yonca, Michelsen, Kathrin S., Hayrapetian, Linda, Naiki, Yoshikazu, Spallek, Ralf, Singh, Mahavir, Arditi, Moshe

“…Although the Toll-like receptors used by Mycobacterium tuberculosis membrane and secreted factors are known, the pathways activated by M. tuberculosis heat…”
Get full text

TLR Signaling: An Emerging Bridge from Innate Immunity to Atherogenesis by Michelsen, Kathrin S, Doherty, Terence M, Shah, Prediman K, Arditi, Moshe

“…Chronic inflammation and disordered lipid metabolism represent hallmarks of atherosclerosis. Considerable evidence suggests that innate immune defense…”
Get full text

Failure of the Anti-Inflammatory Parasitic Worm Product ES-62 to Provide Protection in Mouse Models of Type I Diabetes, Multiple Sclerosis, and Inflammatory Bowel Disease by Doonan, James, Thomas, David, Wong, Michelle H, Ramage, Hazel J, Al-Riyami, Lamyaa, Lumb, Felicity E, Bell, Kara S, Fairlie-Clarke, Karen J, Suckling, Colin J, Michelsen, Kathrin S, Jiang, Hui-Rong, Cooke, Anne, Harnett, Margaret M, Harnett, William

“…Parasitic helminths and their isolated secreted products show promise as novel treatments for allergic and autoimmune conditions in humans. Foremost amongst…”
Get full text

IBD-associated TL1A gene (TNFSF15) haplotypes determine increased expression of TL1A protein by Michelsen, Kathrin S, Thomas, Lisa S, Taylor, Kent D, Yu, Qi T, Mei, Ling, Landers, Carol J, Derkowski, Carrie, McGovern, Dermot P B, Rotter, Jerome I, Targan, Stephan R

“…The recently identified member of the TNF superfamily TL1A (TNFSF15) increases IFN-gamma production by T cells in peripheral and mucosal CCR9+ T cells. TL1A…”
Get full text

Human Intestinal Epithelial Cells Are Broadly Unresponsive to Toll-Like Receptor 2-Dependent Bacterial Ligands: Implications for Host-Microbial Interactions in the Gut by Melmed, Gil, Thomas, Lisa S, Lee, Nahee, Tesfay, Samuel Y, Lukasek, Katie, Michelsen, Kathrin S, Zhou, Yuehua, Hu, Bing, Arditi, Moshe, Abreu, Maria T

“…Intestinal epithelial cells (IEC) interact with a high density of Gram-positive bacteria and are active participants in mucosal immune responses. Recognition…”
Get full text

The TNF family member TL1A induces IL‐22 secretion in committed human Th17 cells via IL‐9 induction by Thomas, Lisa S., Targan, Stephan R., Tsuda, Masato, Yu, Qi T., Salumbides, Brenda C., Haritunians, Talin, Mengesha, Emebet, McGovern, Dermot P.B., Michelsen, Kathrin S.

“…Mechanism identified by which TL1A differentially regulates the expression of TH17 effector cytokines IL‐17 and IL‐22, in human TH17 cells. TL1A contributes to…”
Get full text

Blood-brain barrier invasion by group B Streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid by Doran, Kelly S, Engelson, Erin J, Khosravi, Arya, Maisey, Heather C, Fedtke, Iris, Equils, Ozlem, Michelsen, Kathrin S, Arditi, Moshe, Peschel, Andreas, Nizet, Victor

“…Group B streptococci (GBSs) are the leading cause of neonatal meningitis. GBSs enter the CNS by penetrating the blood-brain barrier (BBB), which consists of…”
Get full text

Lipopolysaccharide-Induced Apoptosis in Transformed Bovine Brain Endothelial Cells and Human Dermal Microvessel Endothelial Cells: The Role of JNK by Karahashi, Hisae, Michelsen, Kathrin S, Arditi, Moshe

“…Stimulation of transformed bovine brain endothelial cells (TBBEC) with LPS leads to apoptosis while human microvessel endothelial cells (HMEC) need the…”
Get full text

Toll-like receptors and innate immunity in gut homeostasis and pathology by Michelsen, Kathrin S, Arditi, Moshe

“…PURPOSE OF REVIEWImmune responses to commensal bacteria and resulting chronic inflammation are hallmarks of inflammatory bowel disease. Considerable evidence…”
Get full text

Chlamydial Heat Shock Protein 60 Activates Macrophages and Endothelial Cells Through Toll-Like Receptor 4 and MD2 in a MyD88-Dependent Pathway by Bulut, Yonca, Faure, Emmanuelle, Thomas, Lisa, Karahashi, Hisae, Michelsen, Kathrin S, Equils, Ozlem, Morrison, Sandra G, Morrison, Richard P, Arditi, Moshe

“…Active inflammation and NF-kappaB activation contribute fundamentally to atherogenesis and plaque disruption. Accumulating evidence has implicated specific…”
Get full text

Inflammation-independent TL1A-mediated intestinal fibrosis is dependent on the gut microbiome by Jacob, Noam, Jacobs, Jonathan P., Kumagai, Kotaro, Ha, Connie W.Y., Kanazawa, Yoshitake, Lagishetty, Venu, Altmayer, Katherine, Hamill, Ariel M., Von Arx, Aimee, Sartor, R. Balfour, Devkota, Suzanne, Braun, Jonathan, Michelsen, Kathrin S., Targan, Stephan R., Shih, David Q.

Get full text