Search Results - "MICHELS, Sebastian"

Clinical and Pathological Characteristics of KEAP1 - and NFE2L2 -Mutated Non-Small Cell Lung Carcinoma (NSCLC) by Frank, Rieke, Scheffler, Matthias, Merkelbach-Bruse, Sabine, Ihle, Michaela A, Kron, Anna, Rauer, Michael, Ueckeroth, Frank, König, Katharina, Michels, Sebastian, Fischer, Rieke, Eisert, Anna, Fassunke, Jana, Heydt, Carina, Serke, Monika, Ko, Yon-Dschun, Gerigk, Ulrich, Geist, Thomas, Kaminsky, Britta, Heukamp, Lukas C, Clement-Ziza, Mathieu, Büttner, Reinhard, Wolf, Jürgen

“…and mutations are associated with impaired prognosis in a variety of cancers and with squamous cell carcinoma formation in non-small cell lung cancer (NSCLC)…”
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Alternative polyadenylation transcriptome-wide association study identifies APA-linked susceptibility genes in brain disorders by Cui, Ya, Arnold, Frederick J., Peng, Fanglue, Wang, Dan, Li, Jason Sheng, Michels, Sebastian, Wagner, Eric J., La Spada, Albert R., Li, Wei

“…Alternative polyadenylation (APA) plays an essential role in brain development; however, current transcriptome-wide association studies (TWAS) largely overlook…”
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Genetic Heterogeneity of MET-Aberrant NSCLC and Its Impact on the Outcome of Immunotherapy by Kron, Anna, Scheffler, Matthias, Heydt, Carina, Ruge, Lea, Schaepers, Carsten, Eisert, Anna-Kristina, Merkelbach-Bruse, Sabine, Riedel, Richard, Nogova, Lucia, Fischer, Rieke Nila, Michels, Sebastian, Abdulla, Diana S Y, Koleczko, Sophia, Fassunke, Jana, Schultheis, Anne M, Kron, Florian, Ueckeroth, Frank, Wessling, Gabriele, Sueptitz, Juliane, Beckers, Frank, Braess, Jan, Panse, Jens, Grohé, Christian, Hamm, Michael, Kabitz, Hans-Joachim, Kambartel, Kato, Kaminsky, Britta, Krueger, Stefan, Schulte, Clemens, Lorenz, Joachim, Lorenzen, Johann, Meister, Wolfram, Meyer, Andreas, Kappes, Jutta, Reinmuth, Niels, Schaaf, Bernhard, Schulte, Wolfgang, Serke, Monika, Buettner, Reinhard, Wolf, Jürgen

“…Robust data on the outcome of MET-aberrant NSCLC with nontargeted therapies are limited, especially in consideration of the heterogeneity of MET-amplified…”
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Mutational spectrum of acquired resistance to reversible versus irreversible EGFR tyrosine kinase inhibitors by Wagener-Ryczek, Svenja, Heydt, Carina, Süptitz, Juliane, Michels, Sebastian, Falk, Markus, Alidousty, Christina, Fassunke, Jana, Ihle, Michaela Angelika, Tiemann, Markus, Heukamp, Lukas, Wolf, Jürgen, Büttner, Reinhard, Merkelbach-Bruse, Sabine

“…Over the past years, EGFR tyrosine kinase inhibitors (TKI) revolutionized treatment response. 1st-generation (reversible) EGFR TKI and later the 2nd…”
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Comparison of in Situ and Extraction-Based Methods for the Detection of ROS1 Rearrangements in Solid Tumors by Heydt, Carina, Ruesseler, Vanessa, Pappesch, Roberto, Wagener, Svenja, Haak, Anja, Siebolts, Udo, Riedel, Richard, Michels, Sebastian, Wolf, Juergen, Schultheis, Anne M., Rehker, Jan, Buettner, Reinhard, Merkelbach-Bruse, Sabine

“…Clinical data confirmed that patients with ROS1 rearrangement are sensitive to specific inhibitors. Therefore, reliable detection of ROS1 rearrangements is…”
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Next-generation lung cancer pathology: Development and validation of diagnostic and prognostic algorithms by Kludt, Carina, Wang, Yuan, Ahmad, Waleed, Bychkov, Andrey, Fukuoka, Junya, Gaisa, Nadine, Kühnel, Mark, Jonigk, Danny, Pryalukhin, Alexey, Mairinger, Fabian, Klein, Franziska, Schultheis, Anne Maria, Seper, Alexander, Hulla, Wolfgang, Brägelmann, Johannes, Michels, Sebastian, Klein, Sebastian, Quaas, Alexander, Büttner, Reinhard, Tolkach, Yuri

“…Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors. In this study, we develop a clinically useful computational pathology platform…”
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ROS1 rearrangements in lung adenocarcinoma: prognostic impact, therapeutic options and genetic variability by Scheffler, Matthias, Schultheis, Anne, Teixido, Cristina, Michels, Sebastian, Morales-Espinosa, Daniela, Viteri, Santiago, Hartmann, Wolfgang, Merkelbach-Bruse, Sabine, Fischer, Rieke, Schildhaus, Hans-Ulrich, Fassunke, Jana, Sebastian, Martin, Serke, Monika, Kaminsky, Britta, Randerath, Winfried, Gerigk, Ulrich, Ko, Yon-Dschun, Krüger, Stefan, Schnell, Roland, Rothe, Achim, Kropf-Sanchen, Cornelia, Heukamp, Lukas, Rosell, Rafael, Büttner, Reinhard, Wolf, Jürgen

“…While recent data show that crizotinib is highly effective in patients with ROS1 rearrangement, few data is available about the prognostic impact, the…”
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A natural history comparison of SOD1-mutant patients with amyotrophic lateral sclerosis between Chinese and German populations by Tang, Lu, Dorst, Johannes, Chen, Lu, Liu, Xiaolu, Ma, Yan, Günther, Kornelia, Michels, Sebastian, Müller, Kathrin, Freischmidt, Axel, Weishaupt, Jochen H, Fan, Dongsheng, Ludolph, Albert C

“…Table S2, Fig. Because of the significant relationship between diagnostic delay and early and late progression rate (see definition in Additional file 2:…”
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SRC Signaling Is Crucial in the Growth of Synovial Sarcoma Cells by MICHELS, Sebastian, TRAUTMANN, Marcel, WURST, Peter, HEUKAMP, Lukas, PENZEL, Roland, LARSSON, Olle, KAWAI, Akira, TANAKA, Shinya, SONOBE, Hiroshi, SCHIRMACHER, Peter, MECHTERSHEIMER, Gunhild, WARDELMANN, Eva, SIEVERS, Elisabeth, BÜTTNER, Reinhard, HARTMANN, Wolfgang, KINDLER, Dagmar, HUSS, Sebastian, RENNER, Marcus, FRIEDRICHS, Nicolaus, KIRFEL, Jutta, STEINER, Susanne, ENDL, Elmar

“…Synovial sarcoma is a soft-tissue malignancy characterized by a reciprocal t(X;18) translocation encoding a chimeric transcriptional modifier. Several receptor…”
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Safety and efficacy of immunoadsorption versus plasma exchange in steroid-refractory relapse of multiple sclerosis and clinically isolated syndrome: A randomised, parallel-group, controlled trial by Dorst, Johannes, Fangerau, Tanja, Taranu, Daniela, Eichele, Pia, Dreyhaupt, Jens, Michels, Sebastian, Schuster, Joachim, Ludolph, Albert C, Senel, Makbule, Tumani, Hayrettin

“…Plasma exchange (PE) constitutes the standard therapy for steroid-refractory relapse in multiple sclerosis and clinically isolated syndrome. Immunoadsorption…”
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18F-FDG PET/CT: an unexpected case of Huntington's disease by Michels, Sebastian, Buchholz, Hans-Georg, Rosar, Florian, Heinrich, Isabel, Hoffmann, Manuela A, Schweiger, Susann, Tüscher, Oliver, Schreckenberger, Mathias

“…Huntington's disease (HD) is a rare, genetic neurodegenerative disorder often presenting with emotional, cognitive and behavioral abnormalities before…”
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Overcoming EGFRG724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors by Fassunke, Jana, Müller, Fabienne, Keul, Marina, Michels, Sebastian, Dammert, Marcel A., Schmitt, Anna, Plenker, Dennis, Lategahn, Jonas, Heydt, Carina, Brägelmann, Johannes, Tumbrink, Hannah L., Alber, Yannic, Klein, Sebastian, Heimsoeth, Alena, Dahmen, Ilona, Fischer, Rieke N., Scheffler, Matthias, Ihle, Michaela A., Priesner, Vanessa, Scheel, Andreas H., Wagener, Svenja, Kron, Anna, Frank, Konrad, Garbert, Katia, Persigehl, Thorsten, Püsken, Michael, Haneder, Stefan, Schaaf, Bernhard, Rodermann, Ernst, Engel-Riedel, Walburga, Felip, Enriqueta, Smit, Egbert F., Merkelbach-Bruse, Sabine, Reinhardt, H. Christian, Kast, Stefan M., Wolf, Jürgen, Rauh, Daniel, Büttner, Reinhard, Sos, Martin L.

“…The emergence of acquired resistance against targeted drugs remains a major clinical challenge in lung adenocarcinoma patients. In a subgroup of these patients…”
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Sorafenib and everolimus in patients with advanced solid tumors and KRAS‐mutated NSCLC: A phase I trial with early pharmacodynamic FDG‐PET assessment by Nogova, Lucia, Mattonet, Christian, Scheffler, Matthias, Taubert, Max, Gardizi, Masyar, Sos, Martin L., Michels, Sebastian, Fischer, Rieke N., Limburg, Meike, Abdulla, Diana S.Y., Persigehl, Thorsten, Kobe, Carsten, Merkelbach‐Bruse, Sabine, Franklin, Jeremy, Backes, Heiko, Schnell, Roland, Behringer, Dirk, Kaminsky, Britta, Eichstaedt, Martina, Stelzer, Christoph, Kinzig, Martina, Sörgel, Fritz, Tian, Yingying, Junge, Lisa, Suleiman, Ahmed A., Frechen, Sebastian, Rokitta, Dennis, Ouyang, Dongsheng, Fuhr, Uwe, Buettner, Reinhard, Wolf, Jürgen

“…Background Treatment of patients with solid tumors and KRAS mutations remains disappointing. One option is the combined inhibition of pathways involved in…”
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Image quality analysis of 44Sc on two preclinical PET scanners: a comparison to 68Ga by Rosar, Florian, Buchholz, Hans-Georg, Michels, Sebastian, Hoffmann, Manuela A., Piel, Markus, Waldmann, Christopher M., Rösch, Frank, Reuss, Stefan, Schreckenberger, Mathias

“…Background 44 Sc has been increasingly investigated as a potential alternative to 68 Ga in the development of tracers for positron emission tomography (PET)…”
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Overcoming EGFR G724S-mediated osimertinib resistance through unique binding characteristics of second-generation EGFR inhibitors by Fassunke, Jana, Müller, Fabienne, Keul, Marina, Michels, Sebastian, Dammert, Marcel A, Schmitt, Anna, Plenker, Dennis, Lategahn, Jonas, Heydt, Carina, Brägelmann, Johannes, Tumbrink, Hannah L, Alber, Yannic, Klein, Sebastian, Heimsoeth, Alena, Dahmen, Ilona, Fischer, Rieke N, Scheffler, Matthias, Ihle, Michaela A, Priesner, Vanessa, Scheel, Andreas H, Wagener, Svenja, Kron, Anna, Konrad, Frank, Garbert, Katia, Persigehl, Thorsten, Püsken, Michael, Haneder, Stefan, Schaaf, Bernhard, Rodermann, Ernst, Engel-Riedel, Walburga, Felip, Enriqueta, Smit, Egbert F, Merkelbach-Bruse, Sabine, Reinhardt, H Christian, Kast, Stefan M, Wolf, Jürgen, Rauh, Daniel, Büttner, Reinhard, Sos, Martin L

“…The emergence of acquired resistance against targeted drugs remains a major clinical challenge in lung adenocarcinoma patients. In a subgroup of these patients…”
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ALKG1269A mutation as a potential mechanism of acquired resistance to crizotinib in an ALK-rearranged inflammatory myofibroblastic tumor by Michels, Sebastian Y. F., Scheel, Andreas H., Wündisch, Thomas, Heuckmann, Johannes M., Menon, Roopika, Puesken, Michael, Kobe, Carsten, Pasternack, Helen, Heydt, Carina, Scheffler, Matthias, Fischer, Rieke, Schultheis, Anne M., Merkelbach-Bruse, Sabine, Heukamp, Lukas, Büttner, Reinhard, Wolf, Jürgen

“…Inflammatory myofibroblastic tumors are rare mesenchymal neoplasms frequently harboring oncogenic chromosomal rearrangements, most commonly, involving the ALK…”
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Genetic heterogeneity of KRAS -mutated NSCLC: Co-occurrence of potentially targetable aberrations and evolutionary background by Scheffler, Matthias, Ihle, Michaela A., Hein, Rebecca, Merkelbach-Bruse, Sabine, Braegelmann, Johannes, Scheel, Andreas H., Michels, Sebastian Yves Friedrich, Ueckeroth, Frank, Eisert, Anna, Gogl, Leonie, Frank, Rieke, Fischer, Rieke Nila, Koleczko, Sophia, Schaepers, Carsten, Kostenko, Anna, Kron, Florian, Hellmich, Martin, Sos, Martin L., Buettner, Reinhard, Wolf, Juergen

“…Abstract only…”
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Comprehensive genomic profiles of small cell lung cancer by George, Julie, Lim, Jing Shan, Jang, Se Jin, Cun, Yupeng, Ozretić, Luka, Kong, Gu, Leenders, Frauke, Lu, Xin, Fernández-Cuesta, Lynnette, Bosco, Graziella, Müller, Christian, Dahmen, Ilona, Jahchan, Nadine S., Park, Kwon-Sik, Yang, Dian, Karnezis, Anthony N., Vaka, Dedeepya, Torres, Angela, Wang, Maia Segura, Korbel, Jan O., Menon, Roopika, Chun, Sung-Min, Kim, Deokhoon, Wilkerson, Matt, Hayes, Neil, Engelmann, David, Pützer, Brigitte, Bos, Marc, Michels, Sebastian, Vlasic, Ignacija, Seidel, Danila, Pinther, Berit, Schaub, Philipp, Becker, Christian, Altmüller, Janine, Yokota, Jun, Kohno, Takashi, Iwakawa, Reika, Tsuta, Koji, Noguchi, Masayuki, Muley, Thomas, Hoffmann, Hans, Schnabel, Philipp A., Petersen, Iver, Chen, Yuan, Soltermann, Alex, Tischler, Verena, Choi, Chang-min, Kim, Yong-Hee, Massion, Pierre P., Zou, Yong, Jovanovic, Dragana, Kontic, Milica, Wright, Gavin M., Russell, Prudence A., Solomon, Benjamin, Koch, Ina, Lindner, Michael, Muscarella, Lucia A., la Torre, Annamaria, Field, John K., Jakopovic, Marko, Knezevic, Jelena, Castaños-Vélez, Esmeralda, Roz, Luca, Pastorino, Ugo, Brustugun, Odd-Terje, Lund-Iversen, Marius, Thunnissen, Erik, Köhler, Jens, Schuler, Martin, Botling, Johan, Sandelin, Martin, Sanchez-Cespedes, Montserrat, Salvesen, Helga B., Achter, Viktor, Lang, Ulrich, Bogus, Magdalena, Schneider, Peter M., Zander, Thomas, Ansén, Sascha, Hallek, Michael, Wolf, Jürgen, Vingron, Martin, Yatabe, Yasushi, Travis, William D., Nürnberg, Peter, Reinhardt, Christian, Perner, Sven, Heukamp, Lukas, Büttner, Reinhard, Haas, Stefan A., Brambilla, Elisabeth, Peifer, Martin, Sage, Julien, Thomas, Roman K.

“…We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest human cancers. In nearly all the tumours analysed we found bi-allelic…”
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Safety and Effectiveness of Long-term Intravenous Administration of Edaravone for Treatment of Patients With Amyotrophic Lateral Sclerosis by Witzel, Simon, Maier, André, Steinbach, Robert, Grosskreutz, Julian, Koch, Jan C, Sarikidi, Anastasia, Petri, Susanne, Günther, René, Wolf, Joachim, Hermann, Andreas, Prudlo, Johannes, Cordts, Isabell, Lingor, Paul, Löscher, Wolfgang N, Kohl, Zacharias, Hagenacker, Tim, Ruckes, Christian, Koch, Birgit, Spittel, Susanne, Günther, Kornelia, Michels, Sebastian, Dorst, Johannes, Meyer, Thomas, Ludolph, Albert C

“…Intravenous edaravone is approved as a disease-modifying drug for patients with amyotrophic lateral sclerosis (ALS), but evidence for efficacy is limited to…”
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K-ras Mutation Subtypes in NSCLC and Associated Co-occuring Mutations in Other Oncogenic Pathways by Scheffler, Matthias, Ihle, Michaela A, Hein, Rebecca, Merkelbach-Bruse, Sabine, Scheel, Andreas H, Siemanowski, Janna, Brägelmann, Johannes, Kron, Anna, Abedpour, Nima, Ueckeroth, Frank, Schüller, Merle, Koleczko, Sophia, Michels, Sebastian, Fassunke, Jana, Pasternack, Helen, Heydt, Carina, Serke, Monika, Fischer, Rieke, Schulte, Wolfgang, Gerigk, Ulrich, Nogova, Lucia, Ko, Yon-Dschun, Abdulla, Diana S Y, Riedel, Richard, Kambartel, Karl-Otto, Lorenz, Joachim, Sauerland, Imke, Randerath, Winfried, Kaminsky, Britta, Hagmeyer, Lars, Grohé, Christian, Eisert, Anna, Frank, Rieke, Gogl, Leonie, Schaepers, Carsten, Holzem, Alessandra, Hellmich, Martin, Thomas, Roman K, Peifer, Martin, Sos, Martin L, Büttner, Reinhard, Wolf, Jürgen

“…Although KRAS mutations in NSCLC have been considered mutually exclusive driver mutations for a long time, there is now growing evidence that KRAS-mutated…”
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