Search Results - "MICHELE, T. M"

Functional connectivity in the basal ganglia network differentiates PD patients from controls by Szewczyk-Krolikowski, Konrad, Menke, Ricarda A.L, Rolinski, Michal, Duff, Eugene, Salimi-Khorshidi, Gholamreza, Filippini, Nicola, Zamboni, Giovanna, Hu, Michele T.M, Mackay, Clare E

“…OBJECTIVE:To examine functional connectivity within the basal ganglia network (BGN) in a group of cognitively normal patients with early Parkinson disease (PD)…”
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Mitochondrial dysfunction and increased glycolysis in prodromal and early Parkinson's blood cells by Smith, Amy M., Depp, Constanze, Ryan, Brent J., Johnston, Geoffrey I., Alegre‐Abarrategui, Javier, Evetts, Samuel, Rolinski, Michal, Baig, Fahd, Ruffmann, Claudio, Simon, Anna Katharina, Hu, Michele T. M., Wade‐Martins, Richard

“…ABSTRACT Background: Although primarily a neurodegenerative process, there is increasing awareness of peripheral disease mechanisms in Parkinson's disease. To…”
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Prioritizing Construction Risks Using Fuzzy AHP in Brazilian Public Enterprises by Beltrão, Leandro M. P, Carvalho, Michele T. M

“…AbstractRisks capable of impacting project objectives are intrinsic to the construction industry. Effective risk analysis has key importance to professionals…”
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Predictors of cognitive impairment in an early stage Parkinson's disease cohort by Hu, Michele T. M., Szewczyk-Królikowski, Konrad, Tomlinson, Paul, Nithi, Kannan, Rolinski, Michal, Murray, Clara, Talbot, Kevin, Ebmeier, Klaus P., Mackay, Clare E., Ben-Shlomo, Yoav

“…ABSTRACT The impact of Parkinson's disease (PD) dementia is substantial and has major functional and socioeconomic consequences. Early prediction of future…”
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Visual short-term memory deficits associated with GBA mutation and Parkinson's disease by ZOKAEI, Nahid, MCNEILL, Alisdair, HUSAIN, Masud, PROUKAKIS, Christos, BEAVAN, Michelle, JARMAN, Paul, KORLIPARA, Prasad, HUGHES, Derralynn, MEHTA, Atul, HU, Michele T. M, SCHAPIRA, Anthony H. V

“…Individuals with mutation in the lysosomal enzyme glucocerebrosidase (GBA) gene are at significantly high risk of developing Parkinson's disease with cognitive…”
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Sleep Disturbance as Potential Risk and Progression Factor for Parkinson's Disease by Bohnen, Nicolaas I, Hu, Michele T M

“…Sleep disturbances are common and a major source of disability in Parkinson's disease (PD). Primary and secondary insomnia, rapid eye movement sleep behavior…”
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Genome‐Wide Association Studies of Cognitive and Motor Progression in Parkinson's Disease by Tan, Manuela M.X., Lawton, Michael A., Jabbari, Edwin, Reynolds, Regina H., Iwaki, Hirotaka, Blauwendraat, Cornelis, Kanavou, Sofia, Pollard, Miriam I., Hubbard, Leon, Malek, Naveed, Grosset, Katherine A., Marrinan, Sarah L., Bajaj, Nin, Barker, Roger A., Burn, David J., Bresner, Catherine, Foltynie, Thomas, Wood, Nicholas W., Williams‐Gray, Caroline H., Hardy, John, Nalls, Michael A., Singleton, Andrew B., Williams, Nigel M., Ben‐Shlomo, Yoav, Hu, Michele T.M., Grosset, Donald G., Shoai, Maryam, Morris, Huw R.

“…ABSTRACT Background There are currently no treatments that stop or slow the progression of Parkinson's disease (PD). Case–control genome‐wide association…”
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Challenges in the reproducibility of clinical studies with resting state fMRI: An example in early Parkinson's disease by Griffanti, Ludovica, Rolinski, Michal, Szewczyk-Krolikowski, Konrad, Menke, Ricarda A., Filippini, Nicola, Zamboni, Giovanna, Jenkinson, Mark, Hu, Michele T.M., Mackay, Clare E.

“…Resting state fMRI (rfMRI) is gaining in popularity, being easy to acquire and with promising clinical applications. However, rfMRI studies, especially those…”
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Prodromal Parkinsonism and Neurodegenerative Risk Stratification in REM Sleep Behavior Disorder by Barber, Thomas R, Lawton, Michael, Rolinski, Michal, Evetts, Samuel, Baig, Fahd, Ruffmann, Claudio, Gornall, Aimie, Klein, Johannes C, Lo, Christine, Dennis, Gary, Bandmann, Oliver, Quinnell, Timothy, Zaiwalla, Zenobia, Ben-Shlomo, Yoav, Hu, Michele T M

“…Rapid eye movement (REM) sleep behavior disorder (RBD) is the most specific marker of prodromal alpha-synucleinopathies. We sought to delineate the baseline…”
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Network Analysis of the CSF Proteome Characterizes Convergent Pathways of Cellular Dysfunction in ALS by Thompson, Alexander G, Gray, Elizabeth, Charles, Philip D, Hu, Michele T M, Talbot, Kevin, Fischer, Roman, Kessler, Benedikt M, Turner, Martin R

“…Amyotrophic lateral sclerosis is a clinical syndrome with complex biological determinants, but which in most cases is characterized by TDP-43 pathology. The…”
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Genetic meta-analysis of levodopa induced dyskinesia in Parkinson’s disease by Martinez-Carrasco, Alejandro, Real, Raquel, Lawton, Michael, Iwaki, Hirotaka, Tan, Manuela M. X., Wu, Lesley, Williams, Nigel M., Carroll, Camille, Hu, Michele T. M., Grosset, Donald G., Hardy, John, Ryten, Mina, Foltynie, Tom, Ben-Shlomo, Yoav, Shoai, Maryam, Morris, Huw R.

“…The genetic basis of levodopa-induced-dyskinesia (LiD) is poorly understood, and there have been few well-powered genome-wide studies. We performed a…”
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Validation of conversion between mini-mental state examination and montreal cognitive assessment by Lawton, Michael, Kasten, Meike, May, Margaret T., Mollenhauer, Brit, Schaumburg, Martina, Liepelt-Scarfone, Inga, Maetzler, Walter, Vollstedt, Eva-Juliane, Hu, Michele T.M., Berg, Daniela, Ben-Shlomo, Yoav

“…ABSTRACT Introduction Harmonizing data across cohorts is important for validating findings or combining data in meta‐analyses. We replicate and validate a…”
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Delineating nonmotor symptoms in early Parkinson's disease and first-degree relatives by Baig, Fahd, Lawton, Michael, Rolinski, Michal, Ruffmann, Claudio, Nithi, Kannan, Evetts, Samuel G., Fernandes, Hugo R., Ben-Shlomo, Yoav, Hu, Michele T.M

“…ABSTRACT Nonmotor symptoms (NMS) are an important prodromal feature of Parkinson's disease (PD). However, their frequency, treatment rates, and impact on…”
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Comprehensive Analysis of Familial Parkinsonism Genes in Rapid‐Eye‐Movement Sleep Behavior Disorder by Mufti, Kheireddin, Rudakou, Uladzislau, Yu, Eric, Krohn, Lynne, Ruskey, Jennifer A., Asayesh, Farnaz, Laurent, Sandra B., Spiegelman, Dan, Arnulf, Isabelle, Hu, Michele T.M., Montplaisir, Jacques Y., Gagnon, Jean‐François, Desautels, Alex, Dauvilliers, Yves, Gigli, Gian Luigi, Valente, Mariarosaria, Janes, Francesco, Högl, Birgit, Stefani, Ambra, Holzknecht, Evi, Šonka, Karel, Kemlink, David, Oertel, Wolfgang, Janzen, Annette, Plazzi, Giuseppe, Antelmi, Elena, Figorilli, Michela, Puligheddu, Monica, Mollenhauer, Brit, Trenkwalder, Claudia, Sixel‐Döring, Friederike, Cochen De Cock, Valérie, Monaca, Christelle Charley, Heidbreder, Anna, Ferini‐Strambi, Luigi, Dijkstra, Femke, Viaene, Mineke, Abril, Beatriz, Boeve, Bradley F., Postuma, Ronald B., Rouleau, Guy A., Gan‐Or, Ziv

“…ABSTRACT Background There is only partial overlap in the genetic background of isolated rapid‐eye‐movement sleep behavior disorder (iRBD) and Parkinson's…”
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Detection of REM sleep behaviour disorder by automated polysomnography analysis by Cooray, Navin, Andreotti, Fernando, Lo, Christine, Symmonds, Mkael, Hu, Michele T.M., De Vos, Maarten

“…•REM sleep behaviour disorder (RBD) detection benefits from an ensemble of metrics that incorporate sleep architecture.•RBD detection remains successful using…”
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Montelukast, a Leukotriene Receptor Antagonist, for the Treatment of Persistent Asthma in Children Aged 2 to 5 Years by Knorr, Barbara, Franchi, Luis M, Bisgaard, Hans, Vermeulen, Jan Hendrik, LeSouef, Peter, Santanello, Nancy, Michele, Theresa M, Reiss, Theodore F, Nguyen, Ha H, Bratton, Donna L

“…The greatest prevalence of asthma is in preschool children; however, the clinical utility of asthma therapy for this age group is limited by a narrow…”
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Developing and validating Parkinson’s disease subtypes and their motor and cognitive progression by Lawton, Michael, Ben-Shlomo, Yoav, May, Margaret T, Baig, Fahd, Barber, Thomas R, Klein, Johannes C, Swallow, Diane M A, Malek, Naveed, Grosset, Katherine A, Bajaj, Nin, Barker, Roger A, Williams, Nigel, Burn, David J, Foltynie, Thomas, Morris, Huw R, Wood, Nicholas W, Grosset, Donald G, Hu, Michele T M

“…ObjectivesTo use a data-driven approach to determine the existence and natural history of subtypes of Parkinson’s disease (PD) using two large independent…”
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Basal ganglia dysfunction in idiopathic REM sleep behaviour disorder parallels that in early Parkinson's disease by Rolinski, Michal, Griffanti, Ludovica, Piccini, Paola, Roussakis, Andreas A, Szewczyk-Krolikowski, Konrad, Menke, Ricarda A, Quinnell, Timothy, Zaiwalla, Zenobia, Klein, Johannes C, Mackay, Clare E, Hu, Michele T M

“…SEE POSTUMA DOI101093/AWW131 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Resting state functional magnetic resonance imaging dysfunction within the basal…”
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The clinical management of sarcoidosis. A 50-year experience at the Johns Hopkins Hospital by Johns, C J, Michele, T M

“…Sarcoidosis is an enigmatic disease with extremely variable manifestations in pattern, severity and course. Since Longcope and Freiman's descriptive monograph…”
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Alpha‐synuclein RT‐QuIC in the CSF of patients with alpha‐synucleinopathies by Fairfoul, Graham, McGuire, Lynne I., Pal, Suvankar, Ironside, James W., Neumann, Juliane, Christie, Sharon, Joachim, Catherine, Esiri, Margaret, Evetts, Samuel G., Rolinski, Michal, Baig, Fahd, Ruffmann, Claudio, Wade‐Martins, Richard, Hu, Michele T. M., Parkkinen, Laura, Green, Alison J. E.

“…We have developed a novel real‐time quaking‐induced conversion RT‐QuIC‐based assay to detect alpha‐synuclein aggregation in brain and cerebrospinal fluid from…”
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