Search Results - "MICHEL, Beat"

Epigenetically-driven anatomical diversity of synovial fibroblasts guides joint-specific fibroblast functions by Frank-Bertoncelj, Mojca, Trenkmann, Michelle, Klein, Kerstin, Karouzakis, Emmanuel, Rehrauer, Hubert, Bratus, Anna, Kolling, Christoph, Armaka, Maria, Filer, Andrew, Michel, Beat A., Gay, Renate E., Buckley, Christopher D., Kollias, George, Gay, Steffen, Ospelt, Caroline

“…A number of human diseases, such as arthritis and atherosclerosis, include characteristic pathology in specific anatomical locations. Here we show…”
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Performance of the new ACR/EULAR classification criteria for systemic sclerosis in clinical practice by Jordan, Suzana, Maurer, Britta, Toniolo, Martin, Michel, Beat, Distler, Oliver

“…The preliminary classification criteria for SSc lack sensitivity for mild/early SSc patients, therefore, the new ACR/EULAR classification criteria for SSc were…”
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Interleukin-6 Modulates the Expression of the Bone Morphogenic Protein Receptor Type II Through a Novel STAT3–microRNA Cluster 17/92 Pathway by Brock, Matthias, Trenkmann, Michelle, Gay, Renate E, Michel, Beat A, Gay, Steffen, Fischler, Manuel, Ulrich, Silvia, Speich, Rudolf, Huber, Lars C

“…Dysregulated expression of bone morphogenetic protein receptor type II (BMPR2) is a pathogenetic hallmark of pulmonary hypertension. Downregulation of BMPR2…”
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Association of circulating miR-223 and miR-16 with disease activity in patients with early rheumatoid arthritis by Filková, Mária, Aradi, Borbala, Senolt, Ladislav, Ospelt, Caroline, Vettori, Serena, Mann, Heřman, Filer, Andrew, Raza, Karim, Buckley, Christopher D, Snow, Martyn, Vencovský, Jiří, Pavelka, Karel, Michel, Beat A, Gay, Renate E, Gay, Steffen, Jüngel, Astrid

“…Identification of parameters for early diagnosis and treatment response would be beneficial for patients with early rheumatoid arthritis (ERA) to prevent…”
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Epigenome analysis reveals TBX5 as a novel transcription factor involved in the activation of rheumatoid arthritis synovial fibroblasts by Karouzakis, Emmanuel, Trenkmann, Michelle, Gay, Renate E, Michel, Beat A, Gay, Steffen, Neidhart, Michel

“…In this study, we analyzed the methylation status of human promoters in rheumatoid arthritis synovial fibroblasts (RASF). Differentially methylated genes…”
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Expression and Regulation of PIWIL-Proteins and PIWI-Interacting RNAs in Rheumatoid Arthritis by Pleštilová, Lenka, Neidhart, Michel, Russo, Giancarlo, Frank-Bertoncelj, Mojca, Ospelt, Caroline, Ciurea, Adrian, Kolling, Christoph, Gay, Renate E, Michel, Beat A, Vencovský, Jiří, Gay, Steffen, Jüngel, Astrid

“…The PIWIL (P-element induced wimpy testis like protein) subfamily of argonaute proteins is essential for Piwi-interacting RNA (piRNA) biogenesis and their…”
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Vascular endothelial growth factor aggravates fibrosis and vasculopathy in experimental models of systemic sclerosis by Maurer, Britta, Distler, Alfiya, Suliman, Yossra A, Gay, Renate E, Michel, Beat A, Gay, Steffen, Distler, Jörg H W, Distler, Oliver

“…High levels of vascular endothelial growth factor (VEGF), a key angiogenic factor, are present in patients with systemic sclerosis (SSc), but its role in the…”
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Protection from lethal Gram-negative bacterial sepsis by targeting Toll-like receptor 4 by Roger, Thierry, Froidevaux, Céline, Le Roy, Didier, Reymond, Marlies Knaup, Chanson, Anne-Laure, Mauri, Davide, Burns, Kim, Riederer, Beat Michel, Akira, Shizuo, Calandra, Thierry

“…Toll-like receptor 4 (TLR4), the signal-transducing molecule of the LPS receptor complex, plays a fundamental role in the sensing of LPS from Gram-negative…”
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Impaired response to treatment with tumour necrosis factor α inhibitors in smokers with axial spondyloarthritis by Ciurea, Adrian, Scherer, Almut, Weber, Ulrich, Exer, Pascale, Bernhard, Jürg, Tamborrini, Giorgio, Riek, Myriam, Müller, Rüdiger B, Weiss, Bettina, Nissen, Michael J, Kissling, Rudolf, Michel, Beat A, Finckh, Axel

“…To investigate the impact of smoking on the response to treatment with a first tumour necrosis factor inhibitor (TNFi) in patients with axial spondyloarthritis…”
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RheumaTool, a novel clinical decision support system for the diagnosis of rheumatic diseases, and its first validation in a retrospective chart analysis by Alder, Hannes, Marx, Christian, Steurer, Johann, Wertli, Maria, Korner-Nievergelt, Pius, Tamborrini, Giorgio, Langenegger, Thomas, Eichholzer, Andrina, Andor, Michael, Krebs, Andreas, Michel, Beat, Wildi, Lukas

“…RheumaTool is a clinical decision support system designed to support the diagnostic process in rheumatology by presenting a differential diagnosis list after…”
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Protein Tyrosine Phosphatase Nonreceptor Type 2: An Important Regulator of lnterleukin‐6 Production in Rheumatoid Arthritis Synovial Fibroblasts by Aradi, Borbala, Kato, Masaru, Filkova, Maria, Karouzakis, Emmanuel, Klein, Kerstin, Scharl, Michael, Kolling, Christoph, Michel, Beat A., Gay, Renate E., Buzas, Edit I., Gay, Steffen, Jüngel, Astrid

“…Objective To investigate the role of protein tyrosine phosphatase nonreceptor type 2 (PTPN2) in the pathogenesis of rheumatoid arthritis (RA). Methods Synovial…”
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Transcription Factor Fos-Related Antigen-2 Induces Progressive Peripheral Vasculopathy in Mice Closely Resembling Human Systemic Sclerosis by MAURER, Britta, BUSCH, Nicole, JÜNGEL, Astrid, PILECKYTE, Margarita, GAY, Renate E, MICHEL, Beat A, SCHETT, Georg, GAY, Steffen, DISTLER, Jörg, DISTLER, Oliver

“…Microvascular damage is one of the first pathological changes in systemic sclerosis. In this study, we investigated the role of Fos-related antigen-2 (Fra-2),…”
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The long-term impact of early treatment of rheumatoid arthritis on radiographic progression: a population-based cohort study by KYBURZ, Diego, GABAY, Cem, MICHEL, Beat A, FINCKH, Axel

“…To measure the long-term rate of radiographic progression in a cohort of patients treated early vs late with conventional DMARDs. The long-term rate of…”
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Fra-2 transgenic mice as a novel model of pulmonary hypertension associated with systemic sclerosis by Maurer, Britta, Reich, Nicole, Juengel, Astrid, Kriegsmann, Jörg, Gay, Renate E, Schett, Georg, Michel, Beat A, Gay, Steffen, Distler, Jörg H W, Distler, Oliver

“…Systemic sclerosis-associated pulmonary arterial hypertension differs from idiopathic pulmonary arterial hypertension with respect to histopathology, treatment…”
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Pathological reorganization of NMDA receptors subunits and postsynaptic protein PSD-95 distribution in Alzheimer's disease by Leuba, Genevieve, Vernay, Andre, Kraftsik, Rudolf, Tardif, Eric, Riederer, Beat Michel, Savioz, Armand

“…In Alzheimer's disease (AD), synaptic alterations play a major role and are often correlated with cognitive changes. In order to better understand synaptic…”
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Citrullination enhances the pro-inflammatory response to fibrin in rheumatoid arthritis synovial fibroblasts by Sanchez-Pernaute, Olga, Filkova, Maria, Gabucio, Antonio, Klein, Martin, Maciejewska-Rodrigues, Hanna, Ospelt, Caroline, Brentano, Fabia, Michel, Beat A, Gay, Renate E, Herrero-Beaumont, Gabriel, Gay, Steffen, Neidhart, Michel, Juengel, Astrid

“…Fibrin deposits are characteristic of the synovial tissues in rheumatoid arthritis (RA). Once citrullinated, fibrin becomes an autoantigen and is thought to…”
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Expression and function of EZH2 in synovial fibroblasts: epigenetic repression of the Wnt inhibitor SFRP1 in rheumatoid arthritis by Trenkmann, Michelle, Brock, Matthias, Gay, Renate E, Kolling, Christoph, Speich, Rudolf, Michel, Beat A, Gay, Steffen, Huber, Lars C

“…To study the expression, regulation and function of the histone methyltransferase enhancer of zeste homologue 2 (EZH2) in synovial fibroblasts (SF) from…”
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Smoking induces transcription of the heat shock protein system in the joints by Ospelt, Caroline, Camici, Giovanni G, Engler, Anna, Kolling, Christoph, Vogetseder, Alexander, Gay, Renate E, Michel, Beat A, Gay, Steffen

“…Smoking increases the risk of developing rheumatoid arthritis (RA) and worsens the course of the disease. In the current study we analysed whether smoking can…”
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Interdisciplinary rehabilitation after whiplash injury: An observational prospective 5 years outcome study by Haiduk, Philipp, Benz, Thomas, Lehmann, Susanne, Gysi-Klaus, Francoise, Aeschlimann, André, Michel, Beat A., Angst, Felix

“…Whiplash injury associated disorders (WAD) cause high costs for public health care. Neck pain is number 16 on the global prevalence lists for the 50 most…”
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Prognostic Factors for Pain Relief and Functional Improvement in Chronic Pain After Inpatient Rehabilitation by Fuss, Isabelle, Angst, Felix, Lehmann, Susanne, Michel, Beat A, Aeschlimann, André

“…OBJECTIVE:To determine the factors associated with pain relief and improved physical functioning in chronic pain patients during outpatient management in the…”
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