Search Results - "MICHALSKI, Nicolas"

Mapping the Fine-Scale Organization and Plasticity of the Brain Vasculature by Kirst, Christoph, Skriabine, Sophie, Vieites-Prado, Alba, Topilko, Thomas, Bertin, Paul, Gerschenfeld, Gaspard, Verny, Florine, Topilko, Piotr, Michalski, Nicolas, Tessier-Lavigne, Marc, Renier, Nicolas

“…The cerebral vasculature is a dense network of arteries, capillaries, and veins. Quantifying variations of the vascular organization across individuals, brain…”
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Stiffness and tension gradients of the hair cell's tip-link complex in the mammalian cochlea by Tobin, Mélanie, Chaiyasitdhi, Atitheb, Michel, Vincent, Michalski, Nicolas, Martin, Pascal

“…Sound analysis by the cochlea relies on frequency tuning of mechanosensory hair cells along a tonotopic axis. To clarify the underlying biophysical mechanism,…”
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BMP signaling specifies the development of a large and fast CNS synapse by Xiao, Le, Michalski, Nicolas, Kronander, Elin, Gjoni, Enida, Genoud, Christel, Knott, Graham, Schneggenburger, Ralf

“…The calyx of Held synapse in the auditory brainstem is an unusually large and fast synapse. Using genome-wide screening and conditional deletion in mice, Xiao…”
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Control of exocytosis by synaptotagmins and otoferlin in auditory hair cells by Beurg, Maryline, Michalski, Nicolas, Safieddine, Saaid, Bouleau, Yohan, Schneggenburger, Ralf, Chapman, Edwin R, Petit, Christine, Dulon, Didier

“…In pre-hearing mice, vesicle exocytosis at cochlear inner hair cell (IHC) ribbon synapses is triggered by spontaneous Ca(2+) spikes. At the onset of hearing,…”
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Defect in the gene encoding the EAR/EPTP domain-containing protein TSPEAR causes DFNB98 profound deafness by DELMAGHANI, Sedigheh, AGHAIE, Asadollah, MICHALSKI, Nicolas, BONNET, Crystel, WEIL, Dominique, PETIT, Christine

“…We report a consanguineous Iranian family affected by congenital profound sensorineural deafness segregating in an autosomal recessive mode. Auditory tests…”
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Otoferlin acts as a Ca2+ sensor for vesicle fusion and vesicle pool replenishment at auditory hair cell ribbon synapses by Michalski, Nicolas, Goutman, Juan D, Auclair, Sarah Marie, Boutet de Monvel, Jacques, Tertrais, Margot, Emptoz, Alice, Parrin, Alexandre, Nouaille, Sylvie, Guillon, Marc, Sachse, Martin, Ciric, Danica, Bahloul, Amel, Hardelin, Jean-Pierre, Sutton, Roger Bryan, Avan, Paul, Krishnakumar, Shyam S, Rothman, James E, Dulon, Didier, Safieddine, Saaid, Petit, Christine

“…Hearing relies on rapid, temporally precise, and sustained neurotransmitter release at the ribbon synapses of sensory cells, the inner hair cells (IHCs). This…”
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Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction by Libé-Philippot, Baptiste, Michel, Vincent, de Monvel, Jacques Boutet, Le Gal, Sébastien, Dupont, Typhaine, Avan, Paul, Métin, Christine, Michalski, Nicolas, Petit, Christine

“…Many genetic forms of congenital deafness affect the sound reception antenna of cochlear sensory cells, the hair bundle. The resulting sensory deprivation…”
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An organotypic slice culture to study the formation of calyx of Held synapses in-vitro by Kronander, Elin, Michalski, Nicolas, Lebrand, Cécile, Hornung, Jean-Pierre, Schneggenburger, Ralf

“…The calyx of Held, a large axo-somatic relay synapse containing hundreds of presynaptic active zones, is possibly the largest nerve terminal in the mammalian…”
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Stereocilin connects outer hair cell stereocilia to one another and to the tectorial membrane by Verpy, Elisabeth, Leibovici, Michel, Michalski, Nicolas, Goodyear, Richard J., Houdon, Carine, Weil, Dominique, Richardson, Guy P., Petit, Christine

“…Stereocilin is defective in a recessive form of deafness, DFNB16. We studied the distribution of stereocilin in the developing and mature mouse inner ear and…”
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Usher type 1G protein sans is a critical component of the tip-link complex, a structure controlling actin polymerization in stereocilia by Caberlotto, Elisa, Michel, Vincent, Foucher, Isabelle, Bahloul, Amel, Goodyear, Richard J, Pepermans, Elise, Michalski, Nicolas, Perfettini, Isabelle, Alegria-Prévot, Olinda, Chardenoux, Sébastien, Do Cruzeiro, Marcio, Hardelin, Jean-Pierre, Richardson, Guy P, Avan, Paul, Weil, Dominique, Petit, Christine

“…The mechanotransducer channels of auditory hair cells are gated by tip-links, oblique filaments that interconnect the stereocilia of the hair bundle. Tip-links…”
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Spontaneous Mouse Behavior in Presence of Dissonance and Acoustic Roughness by Postal, Olivier, Dupont, Typhaine, Bakay, Warren, Dominique, Noémi, Petit, Christine, Michalski, Nicolas, Gourévitch, Boris

“…According to a novel hypothesis (Arnal et al., 2015, Current Biology 25:2051-2056), auditory roughness, or temporal envelope modulations between 30 and 150 Hz,…”
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Detecting Central Auditory Processing Disorders in Awake Mice by Dejean, Camille, Dupont, Typhaine, Verpy, Elisabeth, Gonçalves, Noémi, Coqueran, Sabrina, Michalski, Nicolas, Pucheu, Sylvie, Bourgeron, Thomas, Gourévitch, Boris

“…Mice are increasingly used as models of human-acquired neurological or neurodevelopmental conditions, such as autism, schizophrenia, and Alzheimer’s disease…”
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The SNARE protein SNAP-25 is required for normal exocytosis at auditory hair cell ribbon synapses by Calvet, Charlotte, Peineau, Thibault, Benamer, Najate, Cornille, Maxence, Lelli, Andrea, Plion, Baptiste, Lahlou, Ghizlène, Fanchette, Julia, Nouaille, Sylvie, Boutet de Monvel, Jacques, Estivalet, Amrit, Jean, Philippe, Michel, Vincent, Sachse, Martin, Michalski, Nicolas, Avan, Paul, Petit, Christine, Dulon, Didier, Safieddine, Saaid

“…Hearing depends on fast and sustained calcium-dependent synaptic vesicle fusion at the ribbon synapses of cochlear inner hair cells (IHCs). The implication of…”
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Myosin XVa and whirlin, two deafness gene products required for hair bundle growth, are located at the stereocilia tips and interact directly by Delprat, Benjamin, Michel, Vincent, Goodyear, Richard, Yamasaki, Yasuhiro, Michalski, Nicolas, El-Amraoui, Aziz, Perfettini, Isabelle, Legrain, Pierre, Richardson, Guy, Hardelin, Jean-Pierre, Petit, Christine

“…Defects in myosin XVa and the PDZ domain-containing protein, whirlin, underlie deafness in humans and mice. Hair bundles of mutant mice defective for either…”
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Central auditory deficits associated with genetic forms of peripheral deafness by Michalski, Nicolas, Petit, Christine

“…Since the 1990s, the study of inherited hearing disorders, mostly those detected at birth, in the prelingual period or in young adults, has led to the…”
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Genes Involved in the Development and Physiology of Both the Peripheral and Central Auditory Systems by Michalski, Nicolas, Petit, Christine

“…The genetic approach, based on the study of inherited forms of deafness, has proven to be particularly effective for deciphering the molecular mechanisms…”
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Genetics of auditory mechano-electrical transduction by Michalski, Nicolas, Petit, Christine

“…The hair bundles of cochlear hair cells play a central role in the auditory mechano-electrical transduction (MET) process. The identification of MET components…”
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Characterizing subcutaneous cortical auditory evoked potentials in mice by Postal, Olivier, Bakay, Warren, Dupont, Typhaine, Buck, Alexa, Élodie Daoud, Petit, Christine, Michalski, Nicolas, Gourévitch, Boris

“…Auditory Brainstem Responses (ABRs) are a reliably robust measure of auditory thresholds in the mammalian hearing system and can be used to determine deficits…”
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Single-cell transcriptomic profiling of the mouse cochlea: An atlas for targeted therapies by Jean, Philippe, Wong Jun Tai, Fabienne, Singh-Estivalet, Amrit, Lelli, Andrea, Scandola, Cyril, Megharba, Sébastien, Schmutz, Sandrine, Roux, Solène, Mechaussier, Sabrina, Sudres, Muriel, Mouly, Enguerran, Heritier, Anne-Valérie, Bonnet, Crystel, Mallet, Adeline, Novault, Sophie, Libri, Valentina, Petit, Christine, Michalski, Nicolas

“…Functional molecular characterization of the cochlea has mainly been driven by the deciphering of the genetic architecture of sensorineural deafness. As a…”
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Ultrarare heterozygous pathogenic variants of genes causing dominant forms of early-onset deafness underlie severe presbycusis by Boucher, Sophie, Tai, Fabienne Wong Jun, Delmaghani, Sedigheh, Lelli, Andrea, Singh-Estivalet, Amrit, Dupont, Typhaine, Niasme-Grare, Magali, Michel, Vincent, Wolff, Nicolas, Bahloul, Amel, Bouyacoub, Yosra, Bouccara, Didier, Fraysse, Bernard, Deguine, Olivier, Collet, Lionel, Thai-Van, Hung, Ionescu, Eugen, Kemeny, Jean-Louis, Giraudet, Fabrice, Lavieille, Jean-Pierre, Devèze, Arnaud, Roudevitch-Pujol, Anne-Laure, Vincent, Christophe, Renard, Christian, Franco-Vidal, Valérie, Thibult-Apt, Claire, Darrouzet, Vincent, Bizaguett, Eric, Coez, Arnaud, Aschard, Hugues, Michalski, Nicolas, Lefevre, Gaëlle M., Aubois, Anne, Avan, Paul, Bonnet, Crystel, Petit, Christine

“…Presbycusis, or age-related hearing loss (ARHL), is a major public health issue. About half the phenotypic variance has been attributed to genetic factors…”
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