Search Results - "MICHALOPOULOS, George K"

Hepatostat: Liver regeneration and normal liver tissue maintenance by Michalopoulos, George K.

“…In contrast to all other organs, liver‐to‐body‐weight ratio needs to be maintained always at 100% of what is required for body homeostasis. Adjustment of liver…”
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Liver regeneration: biological and pathological mechanisms and implications by Michalopoulos, George K., Bhushan, Bharat

“…The liver is the only solid organ that uses regenerative mechanisms to ensure that the liver-to-bodyweight ratio is always at 100% of what is required for body…”
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Liver regeneration by Michalopoulos, George K.

“…Liver regeneration after partial hepatectomy is a very complex and well‐orchestrated phenomenon. It is carried out by the participation of all mature liver…”
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Role of epidermal growth factor receptor in liver injury and lipid metabolism: Emerging new roles for an old receptor by Bhushan, Bharat, Michalopoulos, George K.

“…Epidermal growth factor receptor (EGFR) is conventionally known to play a crucial role in hepatocyte proliferation, liver regeneration and is also associated…”
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Targeting genomic rearrangements in tumor cells through Cas9-mediated insertion of a suicide gene by Chen, Zhang-Hui, Yu, Yan P, Zuo, Ze-Hua, Nelson, Joel B, Michalopoulos, George K, Monga, Satdatshan, Liu, Silvia, Tseng, George, Luo, Jian-Hua

“…Insertion of the sequence encoding herpes simplex virus 1 thymidine kinase at the breakpoints of fusion genes in cancer cells causes cell death and regression…”
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Pharmacologic Inhibition of Epidermal Growth Factor Receptor Suppresses Nonalcoholic Fatty Liver Disease in a Murine Fast‐Food Diet Model by Bhushan, Bharat, Banerjee, Swati, Paranjpe, Shirish, Koral, Kelly, Mars, Wendy M., Stoops, John W., Orr, Anne, Bowen, William C., Locker, Joseph, Michalopoulos, George K.

“…Epidermal growth factor receptor (EGFR) is a critical regulator of hepatocyte proliferation and liver regeneration. Our recent work indicated that EGFR can…”
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Combined systemic elimination of MET and epidermal growth factor receptor signaling completely abolishes liver regeneration and leads to liver decompensation by Paranjpe, Shirish, Bowen, William C., Mars, Wendy M., Orr, Anne, Haynes, Meagan M., DeFrances, Marie C., Liu, Silvia, Tseng, George C., Tsagianni, Anastasia, Michalopoulos, George K.

“…Receptor tyrosine kinases MET and epidermal growth factor receptor (EGFR) are critically involved in initiation of liver regeneration. Other cytokines and…”
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Correction: Conditional Genetic Elimination of Hepatocyte Growth Factor in Mice Compromises Liver Regeneration after Partial Hepatectomy by Nejak-Bowen, Kari, Orr, Anne, Bowen, Jr, William C, Michalopoulos, George K

“…[This corrects the article DOI: 10.1371/journal.pone.0059836.]…”
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TCPOBOP‐Induced Hepatomegaly and Hepatocyte Proliferation are Attenuated by Combined Disruption of MET and EGFR Signaling by Bhushan, Bharat, Stoops, John W., Mars, Wendy M., Orr, Anne, Bowen, William C., Paranjpe, Shirish, Michalopoulos, George K.

“…TCPOBOP (1,4‐Bis [2‐(3,5‐Dichloropyridyloxy)] benzene) is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and…”
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Phosphorylated Ezrin (Thr567) Regulates Hippo Pathway and Yes-Associated Protein (Yap) in Liver by Xue, Yuhua, Bhushan, Bharat, Mars, Wendy M., Bowen, William, Tao, Junyan, Orr, Anne, Stoops, John, Yu, Yanping, Luo, Jianhua, Duncan, Andrew W., Michalopoulos, George K.

“…The activation of CD81 [the portal of entry of hepatitis C virus (HCV)] by agonistic antibody results in phosphorylation of Ezrin via Syk kinase and is…”
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Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations by Affo, Silvia, Nair, Ajay, Brundu, Francesco, Ravichandra, Aashreya, Bhattacharjee, Sonakshi, Matsuda, Michitaka, Chin, LiKang, Filliol, Aveline, Wen, Wen, Song, Xinhua, Decker, Aubrianna, Worley, Jeremy, Caviglia, Jorge Matias, Yu, Lexing, Yin, Deqi, Saito, Yoshinobu, Savage, Thomas, Wells, Rebecca G., Mack, Matthias, Zender, Lars, Arpaia, Nicholas, Remotti, Helen E., Rabadan, Raul, Sims, Peter, Leblond, Anne-Laure, Weber, Achim, Riener, Marc-Oliver, Stockwell, Brent R., Gaublomme, Jellert, Llovet, Josep M., Kalluri, Raghu, Michalopoulos, George K., Seki, Ekihiro, Sia, Daniela, Chen, Xin, Califano, Andrea, Schwabe, Robert F.

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Synthesis of IL-6 by hepatocytes is a normal response to common hepatic stimuli by Norris, Callie A, He, Mu, Kang, Liang-I, Ding, Michael Qi, Radder, Josiah E, Haynes, Meagan M, Yang, Yu, Paranjpe, Shirish, Bowen, William C, Orr, Anne, Michalopoulos, George K, Stolz, Donna B, Mars, Wendy M

“…Exogenous interleukin 6 (IL-6), synthesized at the initiation of the acute phase response, is considered responsible for signaling hepatocytes to produce acute…”
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Liver Regeneration after Partial Hepatectomy: Critical Analysis of Mechanistic Dilemmas by Michalopoulos, George K

“…Liver regeneration after partial hepatectomy is one of the most studied models of cell, organ, and tissue regeneration. The complexity of the signaling…”
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Conditional genetic elimination of hepatocyte growth factor in mice compromises liver regeneration after partial hepatectomy by Nejak-Bowen, Kari, Orr, Anne, Bowen, Jr, William C, Michalopoulos, George K

“…Hepatocyte growth factor (HGF) has been shown to be indispensable for liver regeneration because it serves as a main mitogenic stimulus driving hepatocytes…”
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Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells by Han, Chang, Michalopoulos, George K., Wu, Tong

“…Recent evidence indicates that cyclooxygenase‐2 (COX‐2) and epidermal growth factor receptor (EGFR) are involved in hepatocarcinogenesis. This study was…”
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A mouse model of accelerated liver aging caused by a defect in DNA repair by Gregg, Siobhán Q., Gutiérrez, Verónica, Rasile Robinson, Andria, Woodell, Tyler, Nakao, Atsunori, Ross, Mark A., Michalopoulos, George K., Rigatti, Lora, Rothermel, Carrie E., Kamileri, Irene, Garinis, George A., Beer Stolz, Donna, Niedernhofer, Laura J.

“…The liver changes with age, leading to an impaired ability to respond to hepatic insults and increased incidence of liver disease in the elderly. Therefore,…”
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Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas by Luo, Jian‐Hua, Ren, Baoguo, Keryanov, Sergei, Tseng, George C., Rao, Uma N. M., Monga, Satdarshan P., Strom, Steven, Demetris, Anthony J., Nalesnik, Michael, Yu, Yan P., Ranganathan, Sarangarajan, Michalopoulos, George K.

“…This study analyzed gene expression patterns and global genomic alterations in hepatocellular carcinomas (HCC), hepatoblastomas (HPBL), tissue adjacent to HCC…”
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Enhanced liver regeneration following changes induced by hepatocyte‐specific genetic ablation of integrin‐linked kinase by Apte, Udayan, Gkretsi, Vasiliki, Bowen, William C., Mars, Wendy M., Luo, Jian‐Hua, Donthamsetty, Shashikiran, Orr, Ann, Monga, Satdarshan P.S., Wu, Chuanyue, Michalopoulos, George K.

“…Following liver regeneration after partial hepatectomy, liver grows back precisely to its original mass and does not exceed it. The mechanism regulating this…”
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Mechanocrine signaling, Yap, HB-EGF and liver regeneration by Michalopoulos, George K

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Antagonizing Activin A/p15INK4b Signaling as Therapeutic Strategy for Liver Disease by Mekala, Sowmya, Rai, Ravi, Reed, Samantha Loretta, Bowen, Bill, Michalopoulos, George K., Locker, Joseph, Raeman, Reben, Oertel, Michael

“…Background/Aim: Activin A is involved in the pathogenesis of human liver diseases, but its therapeutic targeting is not fully explored. Here, we tested the…”
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