Search Results - "MICHAEL IUVONE, P"

Circadian organization of the mammalian retina: From gene regulation to physiology and diseases by McMahon, Douglas G., Iuvone, P. Michael, Tosini, Gianluca

“…The retinal circadian system represents a unique structure. It contains a complete circadian system and thus the retina represents an ideal model to study…”
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Circadian rhythms, refractive development, and myopia by Chakraborty, Ranjay, Ostrin, Lisa A., Nickla, Debora L., Iuvone, P. Michael, Pardue, Machelle T., Stone, Richard A.

“…Purpose Despite extensive research, mechanisms regulating postnatal eye growth and those responsible for ametropias are poorly understood. With the marked…”
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Dopamine deficiency contributes to early visual dysfunction in a rodent model of type 1 diabetes by Aung, Moe H, Park, Han Na, Han, Moon K, Obertone, Tracy S, Abey, Jane, Aseem, Fazila, Thule, Peter M, Iuvone, P Michael, Pardue, Machelle T

“…Dopamine (DA) functions as an essential neuromodulator in the brain and retina such that disruptions in the dopaminergic system are associated with common…”
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The Retinal Circadian Clock and Photoreceptor Viability by Baba, Kenkichi, Ribelayga, Christophe P, Michael Iuvone, P, Tosini, Gianluca

“…Circadian rhythms are present in most living organisms, and these rhythms are not just a consequence of the day/night fluctuation, but rather they are…”
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Melatonin: An underappreciated player in retinal physiology and pathophysiology by Tosini, Gianluca, Baba, Kenkichi, Hwang, Christopher K., Iuvone, P. Michael

“…In the vertebrate retina, melatonin is synthesized by the photoreceptors with high levels of melatonin at night and lower levels during the day. Melatonin…”
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Pharmacology of myopia and potential role for intrinsic retinal circadian rhythms by Stone, Richard A., Pardue, Machelle T., Iuvone, P. Michael, Khurana, Tejvir S.

“…Despite the high prevalence and public health impact of refractive errors, the mechanisms responsible for ametropias are poorly understood. Much evidence now…”
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Altered ocular parameters from circadian clock gene disruptions by Stone, Richard A, McGlinn, Alice M, Chakraborty, Ranjay, Lee, Duk Cheon, Yang, Victoria, Elmasri, Ayman, Landis, Erica, Shaffer, James, Iuvone, P Michael, Zheng, Xiangzhong, Sehgal, Amita, Pardue, Machelle T

“…The pathophysiology of refractive errors is poorly understood. Myopia (nearsightedness) in particular both blurs vision and predisposes the eye to many…”
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An opsin 5–dopamine pathway mediates light-dependent vascular development in the eye by Nguyen, Minh-Thanh T., Vemaraju, Shruti, Nayak, Gowri, Odaka, Yoshinobu, Buhr, Ethan D., Alonzo, Nuria, Tran, Uyen, Batie, Matthew, Upton, Brian A., Darvas, Martin, Kozmik, Zbynek, Rao, Sujata, Hegde, Rashmi S., Iuvone, P. Michael, Van Gelder, Russell N., Lang, Richard A.

“…During mouse postnatal eye development, the embryonic hyaloid vascular network regresses from the vitreous as an adaption for high-acuity vision. This process…”
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Diurnal gene expression patterns in retina and choroid distinguish myopia progression from myopia onset by Stone, Richard A, Tobias, John W, Wei, Wenjie, Carlstedt, Xia, Zhang, Lixin, Iuvone, P Michael, Nickla, Debora L

“…The world-wide prevalence of myopia (nearsightedness) is increasing, but its pathogenesis is incompletely understood. Among many putative mechanisms,…”
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Is Retinal Dopamine Involved in the Loss of Visual Function in Retinopathy of Prematurity? by Iuvone, P Michael

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Novel Detection and Restorative Levodopa Treatment for Preclinical Diabetic Retinopathy by Motz, Cara T, Chesler, Kyle C, Allen, Rachael S, Bales, Katie L, Mees, Lukas M, Feola, Andrew J, Maa, April Y, Olson, Darin E, Thule, Peter M, Iuvone, P Michael, Hendrick, Andrew M, Pardue, Machelle T

“…Diabetic retinopathy (DR) is diagnosed clinically by directly viewing retinal vascular changes during ophthalmoscopy or through fundus photographs. However,…”
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Gnaz couples the circadian and dopaminergic system to G protein-mediated signaling in mouse photoreceptors by Vancura, Patrick, Abdelhadi, Shaima, Csicsely, Erika, Baba, Kenkichi, Tosini, Gianluca, Iuvone, P Michael, Spessert, Rainer

“…The mammalian retina harbors a circadian clockwork that regulates vision and promotes healthiness of retinal neurons, mainly through directing the rhythmic…”
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Diurnal retinal and choroidal gene expression patterns support a role for circadian biology in myopia pathogenesis by Stone, Richard A., Tobias, John W., Wei, Wenjie, Schug, Jonathan, Wang, Xia, Zhang, Lixin, Iuvone, P. Michael, Nickla, Debora L.

“…The prevalence of myopia (nearsightedness) is increasing to alarming levels, but its etiology remains poorly understood. Because both laboratory and clinical…”
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Dopamine D4 receptor activation controls circadian timing of the adenylyl cyclase 1/cyclic AMP signaling system in mouse retina by Jackson, Chad R., Chaurasia, Shyam S., Hwang, Christopher K., Michael Iuvone, P.

“…In the mammalian retina, dopamine binding to the dopamine D4 receptor (D4R) affects a light‐sensitive pool of cyclic AMP by negatively coupling to the type 1…”
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Visual Image Quality Impacts Circadian Rhythm-Related Gene Expression in Retina and in Choroid: A Potential Mechanism for Ametropias by Stone, Richard A, Wei, Wenjie, Sarfare, Shanta, McGeehan, Brendan, Engelhart, K Cameron, Khurana, Tejvir S, Maguire, Maureen G, Iuvone, P Michael, Nickla, Debora L

“…Stimulated by evidence implicating diurnal/circadian rhythms and light in refractive development, we studied the expression over 24 hours of selected clock and…”
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Circadian rhythm of contrast sensitivity is regulated by a dopamine-neuronal PAS-domain protein 2-adenylyl cyclase 1 signaling pathway in retinal ganglion cells by Hwang, Christopher K, Chaurasia, Shyam S, Jackson, Chad R, Chan, Guy C-K, Storm, Daniel R, Iuvone, P Michael

“…Spatial variation in light intensity, called spatial contrast, comprises much of the visual information perceived by mammals, and the relative ability to…”
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N-acetylserotonin activates TrkB receptor in a circadian rhythm by Jang, Sung-Wuk, Liu, Xia, Pradoldej, Sompol, Tosini, Gianluca, Chang, Qiang, Iuvone, P. Michael, Ye, Keqiang

“…Brain-derived neurotrophic factor (BDNF) is a cognate ligand for the TrkB receptor. BDNF and serotonin often function in a cooperative manner to regulate…”
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Visually-driven ocular growth in mice requires functional rod photoreceptors by Park, Han na, Jabbar, Seema B, Tan, Christopher C, Sidhu, Curran S, Abey, Jane, Aseem, Fazila, Schmid, Gregor, Iuvone, P Michael, Pardue, Machelle T

“…Proper refractive eye growth depends on several features of the visual image and requisite retinal pathways. In this study, we determined the contribution of…”
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The Circadian Clock in the Retinal Pigment Epithelium Controls the Diurnal Rhythm of Phagocytic Activity by DeVera, Christopher, Dixon, Jendayi, Chrenek, Micah A, Baba, Kenkichi, Le, Yun Z, Iuvone, P Michael, Tosini, Gianluca

“…The diurnal peak of phagocytosis by the retinal pigment epithelium (RPE) of photoreceptor outer segments (POS) is under circadian control and believed that…”
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ON pathway mutations increase susceptibility to form-deprivation myopia by Chakraborty, Ranjay, Park, Han na, Hanif, Adam M., Sidhu, Curran S., Iuvone, P. Michael, Pardue, Machelle T.

“…The ON pathway mutation in nob mice is associated with altered refractive development, and an increased susceptibility to form-deprivation (FD) myopia. In this…”
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