Search Results - "MH Tomasson"

EFFICACY AND SAFETY OF ELRANATAMAB (PF-06863135), A B-CELL MATURATION ANTIGEN (BCMA)-CD3 BISPECIFIC ANTIBODY, IN PATIENTS WITH RELAPSED OR REFRACTORY MULTIPLE MYELOMA by M Solh, NJ Bahlis, NS Raje, CL Costello, B Dholaria, MY Levy, MH Tomasson, H Dube, MA Damore, HK Lon, C Basu, A Skoura, EM Chan, S Trudel, A Jakubowiak, MP Chu, C Gasparetto, A Dalovisio, M Sebag, AM Lesokhin

“…Objectives: Elranatamab (PF-06863135) is a humanized bispecific monoclonal antibody (IgG2a) that targets BCMA, a member of the tumor necrosis factor receptor…”
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Induction of myeloproliferative disease in mice by tyrosine kinase fusion oncogenes does not require granulocyte-macrophage colony-stimulating factor or interleukin-3 by Tomasson, Michael H., Williams, Ifor R., Li, Shaoguang, Kutok, Jeffrey, Cain, Danielle, Gillessen, Silke, Dranoff, Glenn, Van Etten, Richard A., Gilliland, D. Gary

“…Tyrosine kinase fusion oncogenes that occur as a result of chromosomal translocations have been shown to activate proliferative and antiapoptotic pathways in…”
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The epoxyketone-based proteasome inhibitors carfilzomib and orally bioavailable oprozomib have anti-resorptive and bone-anabolic activity in addition to anti-myeloma effects by Hurchla, M A, Garcia-Gomez, A, Hornick, M C, Ocio, E M, Li, A, Blanco, J F, Collins, L, Kirk, C J, Piwnica-Worms, D, Vij, R, Tomasson, M H, Pandiella, A, San Miguel, J F, Garayoa, M, Weilbaecher, K N

“…Proteasome inhibitors (PIs), namely bortezomib, have become a cornerstone therapy for multiple myeloma (MM), potently reducing tumor burden and inhibiting…”
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c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations by Luo, Hui, Li, Qing, O'Neal, Julie, Kreisel, Friederike, Le Beau, Michelle M., Tomasson, Michael H.

“…Ectopic expression of c-Myc (Myc) in most primary cell types results in programmed cell death, and malignant transformation cannot occur without additional…”
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An Activated Receptor Tyrosine Kinase, TEL/PDGFβR, Cooperates with AML1/ETO to Induce Acute Myeloid Leukemia in Mice by Grisolano, Jay L., O'Neal, Julie, Cain, Jennifer, Tomasson, Michael H.

“…The t(8;21)(q22;q22) translocation, occurring in 40% of patients with acute myeloid leukemia (AML) of the FAB-M2 subtype (AML with maturation), results in…”
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A Murine Model of CML Blast Crisis Induced by Cooperation between BCR/ABL and NUP98/HOXA9 by Dash, Ajeeta B., Williams, Ifor R., Kutok, Jeffery L., Tomasson, Michael H., Anastasiadou, Ema, Lindahl, Kathleen, Li, Shaoguang, Van Etten, Richard A., Borrow, Julian, Housman, David, Druker, Brian, Gilliland, D. Gary

“…Constitutive activation of tyrosine kinases, such as the BCR/ABL fusion associated with t(9;22)(q34;q22), is a hallmark of chronic myeloid leukemia (CML)…”
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Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes by Schwaller, Juerg, Frantsve, Julie, Aster, Jon, Williams, Ifor R., Tomasson, Michael H., Ross, Theodora S., Peeters, Pieter, Van Rompaey, Luc, Van Etten, Richard A., Ilaria Jr, Robert, Marynen, Peter, Gilliland, D.Gary

“…Recent reports have demonstrated fusion of the TEL gene on 12p13 to the JAK2 gene on 9p24 in human leukemias. Three variants have been identified that fuse the…”
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The TEL/Platelet-Derived Growth Factor β Receptor (PDGFβ R) Fusion in Chronic Myelomonocytic Leukemia is a Transforming Protein that Self-Associates and Activates PDGFβ R Kinase-Dependent Signaling Pathways by Carroll, Martin, Tomasson, Michael H., Barker, George F., Golub, Todd R., Gilliland, D. Gary

“…The TEL/PDGFβ R fusion protein is the product of the t (5;12) translocation in patients with chronic myelomonocytic leukemia. The TEL/PDGFβ R is an unusual…”
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Fatal myeloproliferation, induced in mice by TEL/PDGFβR expression, depends on PDGFβR tyrosines 579/581 by Tomasson, Michael H., Sternberg, David W., Williams, Ifor R., Carroll, Martin, Cain, Danielle, Aster, Jon C., Ilaria, Robert L., Etten, Richard A. Van, Gilliland, D. Gary

“…The t(5;12)(q33;p13) translocation associated with chronic myelomonocytic leukemia (CMML) generates a TEL/PDGFβR fusion gene. Here, we used a murine bone…”
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Interleukin 3 and granulocyte-macrophage colony-stimulating factor are not required for induction of chronic myeloid leukemia-like myeloproliferative disease in mice by BCR/ABL by Li, Shaoguang, Gillessen, Silke, Tomasson, Michael H., Dranoff, Glenn, Gilliland, D. Gary, Van Etten, Richard A.

“…Primitive hematopoietic progenitors from some patients with Philadelphia chromosome (Ph)–positive chronic myeloid leukemia (CML) express aberrant transcripts…”
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TEL/PDGFβR Induces Hematologic Malignancies in Mice That Respond to a Specific Tyrosine Kinase Inhibitor by Tomasson, Michael H., Williams, Ifor R., Hasserjian, Robert, Udomsakdi, Chirayu, McGrath, Shannon M., Schwaller, Juerg, Druker, Brian, Gilliland, D. Gary

“…The TEL/PDGFβR fusion protein is expressed as the consequence of a recurring t(5;12) translocation associated with chronic myelomonocytic leukemia (CMML)…”
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The TEL/PDGFβR fusion in chronic myelomonocytic leukemia signals through STAT5-dependent and STAT5-independent pathways by Sternberg, David W., Tomasson, Michael H., Carroll, Martin, Curley, David P., Barker, George, Caprio, Michael, Wilbanks, Alyson, Kazlauskas, Andrius, Gilliland, D. Gary

“…The TEL/PDGFβR gene, which encodes a fusion protein containing the ETS-family member TEL fused to the protein-tyrosine kinase domain of the platelet-derived…”
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The activity and toxicity of low dose clofarabine against relapsed or refractory myeloma by Uy, GL, Tomasson, MH, Ruddell, A, DiPersio, JF, Vij, R

“…Eight patients with refractory multiple myeloma were treated with clofarabine 4 mg/m2/day on days 1-5 of a 28 day cycle. No objective evidence of anti-myeloma…”
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Complete remission of TEL-PDGFRB–induced myeloproliferative disease in mice by receptor tyrosine kinase inhibitor SU11657 by Cain, Jennifer A., Grisolano, Jay L., Laird, A. Douglas, Tomasson, Michael H.

“…The TEL-PDGFRB fusion oncogene is associated with chronic myelomonocytic leukemia (CMML) and results in the expression of a constitutively active tyrosine…”
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Intrinsic Human Immunodeficiency Virus Type 1 Resistance of Hematopoietic Stem Cells Despite Coreceptor Expression by Shen, H, Cheng, T, Preffer, F I, Dombkowski, D, Tomasson, M H, Golan, D E, Yang, O, Hofmann, W, Sodroski, J G, Luster, A D, Scadden, D T

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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