Search Results - "MEULENBELT, Ingrid"

Osteoarthritis as a disease of the cartilage pericellular matrix by Guilak, Farshid, Nims, Robert J., Dicks, Amanda, Wu, Chia-Lung, Meulenbelt, Ingrid

“…Osteoarthritis is a painful joint disease characterized by progressive degeneration of the articular cartilage as well as associated changes to the subchondral…”
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Cartilage from human-induced pluripotent stem cells: comparison with neo-cartilage from chondrocytes and bone marrow mesenchymal stromal cells by Rodríguez Ruiz, Alejandro, Dicks, Amanda, Tuerlings, Margo, Schepers, Koen, van Pel, Melissa, Nelissen, Rob G. H. H., Freund, Christian, Mummery, Christine L., Orlova, Valeria, Guilak, Farshid, Meulenbelt, Ingrid, Ramos, Yolande F. M.

“…Cartilage has little intrinsic capacity for repair, so transplantation of exogenous cartilage cells is considered a realistic option for cartilage…”
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The role of epigenetics in osteoarthritis: current perspective by Ramos, Yolande F.M, Meulenbelt, Ingrid

“…PURPOSE OF REVIEWThe purpose of this review is to provide an update of recent advances in the established role of different layers of epigenetic control…”
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Genes involved in the osteoarthritis process identified through genome wide expression analysis in articular cartilage; the RAAK study by Ramos, Yolande F M, den Hollander, Wouter, Bovée, Judith V M G, Bomer, Nils, van der Breggen, Ruud, Lakenberg, Nico, Keurentjes, J Christiaan, Goeman, Jelle J, Slagboom, P Eline, Nelissen, Rob G H H, Bos, Steffan D, Meulenbelt, Ingrid

“…Identify gene expression profiles associated with OA processes in articular cartilage and determine pathways changing during the disease process. Genome wide…”
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Identification and characterization of two consistent osteoarthritis subtypes by transcriptome and clinical data integration by Coutinho de Almeida, Rodrigo, Mahfouz, Ahmed, Mei, Hailiang, Houtman, Evelyn, den Hollander, Wouter, Soul, Jamie, Suchiman, Eka, Lakenberg, Nico, Meessen, Jennifer, Huetink, Kasper, Nelissen, Rob G H H, Ramos, Yolande F M, Reinders, Marcel, Meulenbelt, Ingrid

“…Abstract Objective To identify OA subtypes based on cartilage transcriptomic data in cartilage tissue and characterize their underlying pathophysiological…”
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Integrative epigenomics, transcriptomics and proteomics of patient chondrocytes reveal genes and pathways involved in osteoarthritis by Steinberg, Julia, Ritchie, Graham R. S., Roumeliotis, Theodoros I., Jayasuriya, Raveen L., Clark, Matthew J., Brooks, Roger A., Binch, Abbie L. A., Shah, Karan M., Coyle, Rachael, Pardo, Mercedes, Le Maitre, Christine L., Ramos, Yolande F. M., Nelissen, Rob G. H. H., Meulenbelt, Ingrid, McCaskie, Andrew W., Choudhary, Jyoti S., Wilkinson, J. Mark, Zeggini, Eleftheria

“…Osteoarthritis (OA) is a common disease characterized by cartilage degeneration and joint remodeling. The underlying molecular changes underpinning disease…”
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Elucidating mechano-pathology of osteoarthritis: transcriptome-wide differences in mechanically stressed aged human cartilage explants by Houtman, Evelyn, Tuerlings, Margo, Riechelman, Janne, Suchiman, Eka H. E. D, van der Wal, Robert J. P, Nelissen, Rob G. H. H, Mei, Hailiang, Ramos, Yolande F. M, Coutinho de Almeida, Rodrigo, Meulenbelt, Ingrid

“…Abstract Background Failing of intrinsic chondrocyte repair after mechanical stress is known as one of the most important initiators of osteoarthritis…”
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DNA Methylation in Osteoarthritis by den Hollander, Wouter, Meulenbelt, Ingrid

“…Osteoarthritis (OA) is a prevalent disease of articular joints and primarily characterized by degradation and calcification of articular cartilage. Presently,…”
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Identification and systematic annotation of tissue-specific differentially methylated regions using the Illumina 450k array by Slieker, Roderick C, Bos, Steffan D, Goeman, Jelle J, Bovée, Judith Vmg, Talens, Rudolf P, van der Breggen, Ruud, Suchiman, H Eka D, Lameijer, Eric-Wubbo, Putter, Hein, van den Akker, Erik B, Zhang, Yanju, Jukema, J Wouter, Slagboom, P Eline, Meulenbelt, Ingrid, Heijmans, Bastiaan T

“…DNA methylation has been recognized as a key mechanism in cell differentiation. Various studies have compared tissues to characterize epigenetically regulated…”
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Transcriptional Associations of Osteoarthritis‐Mediated Loss of Epigenetic Control in Articular Cartilage by den Hollander, Wouter, Ramos, Yolande F. M., Bomer, Nils, Elzinga, Stefan, van der Breggen, Ruud, Lakenberg, Nico, de Dijcker, Wesley J., Suchiman, H. Eka D., Duijnisveld, Bouke J., Houwing‐Duistermaat, Jeanine J., Slagboom, P. Eline, Bos, Steffan D., Nelissen, Rob G. H. H., Meulenbelt, Ingrid

“…Objective To identify osteoarthritis (OA) progression–modulating pathways in articular cartilage and their respective regulatory epigenetic and genetic…”
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Identified senescence endotypes in aged cartilage are reflected in the blood metabolome by Boone, Ilja, Tuerlings, Margo, Coutinho de Almeida, Rodrigo, Lehmann, Johannes, Ramos, Yolande, Nelissen, Rob, Slagboom, Eline, de Keizer, Peter, Meulenbelt, Ingrid

“…Heterogeneous accumulation of senescent cells expressing the senescence-associated secretory phenotype (SASP) affects tissue homeostasis which leads to…”
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The role of DNA methylation in chondrogenesis of human iPSCs as a stable marker of cartilage quality by Hajmousa, Ghazaleh, de Almeida, Rodrigo Coutinho, Bloks, Niek, Ruiz, Alejandro Rodríguez, Bouma, Marga, Slieker, Roderick, Kuipers, Thomas B, Nelissen, Rob G H H, Ito, Keita, Freund, Christian, Ramos, Yolande F M, Meulenbelt, Ingrid

“…Lack of insight into factors that determine purity and quality of human iPSC (hiPSC)-derived neo-cartilage precludes applications of this powerful technology…”
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Characterizing the secretome of licensed hiPSC-derived MSCs by Ramos, Yolande F M, Tertel, Tobias, Shaw, Georgina, Staubach, Simon, de Almeida, Rodrigo Coutinho, Suchiman, Eka, Kuipers, Thomas B, Mei, Hailiang, Barry, Frank, Murphy, Mary, Giebel, Bernd, Meulenbelt, Ingrid

“…Although mesenchymal stromal cells (MSCs) from primary tissues have been successfully applied in the clinic, their expansion capabilities are limited and…”
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The effect of forced exercise on knee joints in Dio2(-/-) mice: type II iodothyronine deiodinase-deficient mice are less prone to develop OA-like cartilage damage upon excessive mechanical stress by Bomer, Nils, Cornelis, Frederique M F, Ramos, Yolande F M, den Hollander, Wouter, Storms, Lies, van der Breggen, Ruud, Lakenberg, Nico, Slagboom, P Eline, Meulenbelt, Ingrid, Lories, Rik J L

“…To further explore deiodinase iodothyronine type 2 (DIO2) as a therapeutic target in osteoarthritis (OA) by studying the effects of forced mechanical loading…”
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Radiographic endophenotyping in hip osteoarthritis improves the precision of genetic association analysis by Panoutsopoulou, Kalliope, Thiagarajah, Shankar, Zengini, Eleni, Day-Williams, Aaron G, Ramos, Yolande Fm, Meessen, Jennifer Mta, Huetink, Kasper, Nelissen, Rob Ghh, Southam, Lorraine, Rayner, N William, Doherty, Michael, Meulenbelt, Ingrid, Zeggini, Eleftheria, Wilkinson, J Mark

“…Osteoarthritis (OA) has a strong genetic component but the success of previous genome-wide association studies (GWAS) has been restricted due to insufficient…”
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Hyper-physiologic mechanical cues, as an osteoarthritis disease-relevant environmental perturbation, cause a critical shift in set points of methylation at transcriptionally active CpG sites in neo-cartilage organoids by Bloks, Niek G C, Dicks, Amanda, Harissa, Zainab, Nelissen, Rob G H H, Hajmousa, Ghazaleh, Ramos, Yolande F M, de Almeida, Rodrigo Coutinho, Guilak, Farshid, Meulenbelt, Ingrid

“…Osteoarthritis (OA) is a complex, age-related multifactorial degenerative disease of diarthrodial joints marked by impaired mobility, joint stiffness, pain,…”
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Identification of DIO2 as a new susceptibility locus for symptomatic osteoarthritis by Meulenbelt, Ingrid, Min, Josine L., Bos, Steffan, Riyazi, Naghmeh, Houwing-Duistermaat, Jeanine J., van der Wijk, Henk-Jan, Kroon, Herman M., Nakajima, Masahiro, Ikegawa, Shiro, Uitterlinden, André G., van Meurs, Joyce B.J., van der Deure, Wendy M., Visser, Theo J., Seymour, Albert B., Lakenberg, Nico, van der Breggen, Ruud, Kremer, Dennis, van Duijn, Cornelia M., Kloppenburg, Margreet, Loughlin, John, Slagboom, P. Eline

“…Osteoarthritis [MIM 165720] is a common late-onset articular joint disease for which no pharmaceutical intervention is available to attenuate the cartilage…”
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A Damaging COL6A3 Variant Alters the MIR31HG-Regulated Response of Chondrocytes in Neocartilage Organoids to Hyperphysiologic Mechanical Loading by Bloks, Niek Gc, Harissa, Zainab, Mazzini, Giorgia, Adkar, Shaunak S, Dicks, Amanda R, Hajmousa, Ghazaleh, Steward, Nancy, Koning, Roman I, Mulder, Aat, de Koning, Berend B R, Kloppenburg, Margreet, de Almeida, Rodrigo Coutinho, Ramos, Yolande Fm, Guilak, Farshid, Meulenbelt, Ingrid

“…The pericellular matrix (PCM), with its hallmark proteins collagen type VI (COLVI) and fibronectin (FN), surrounds chondrocytes and is critical in transducing…”
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Circulating MicroRNAs Highly Correlate to Expression of Cartilage Genes Potentially Reflecting OA Susceptibility-Towards Identification of Applicable Early OA Biomarkers by Ramos, Yolande F M, Coutinho de Almeida, Rodrigo, Lakenberg, Nico, Suchiman, Eka, Mei, Hailiang, Kloppenburg, Margreet, Nelissen, Rob G H H, Meulenbelt, Ingrid

“…To identify and validate circulating micro RNAs (miRNAs) that mark gene expression changes in articular cartilage early in osteoarthritis (OA) pathophysiology…”
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The first international workshop on the epigenetics of osteoarthritis by Meulenbelt, Ingrid M, Bhutani, Nidhi, den Hollander, Wouter, Gay, Steffen, Oppermann, Udo, Reynard, Louise N, Skelton, Andrew J, Young, David A, Beier, Frank, Loughlin, John

“…Osteoarthritis (OA) is a major clinical problem across the world, in part due to the lack of disease-modifying drugs resulting, to a significant degree, from…”
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