Search Results - "METZ, Stefan W"

Noncoding Flavivirus RNA Displays RNA Interference Suppressor Activity in Insect and Mammalian Cells by SCHNETTLER, Esther, STERKEN, Mark G, LEUNG, Jason Y, METZ, Stefan W, GEERTSEMA, Corinne, GOTDBACH, Rob W, VLAK, Just M, KOHL, Alain, KHROMYKH, Alexander A, PIJLMAN, Gorben P

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Dengue virus-like particles mimic the antigenic properties of the infectious dengue virus envelope by Metz, Stefan W, Thomas, Ashlie, White, Laura, Stoops, Mark, Corten, Markus, Hannemann, Holger, de Silva, Aravinda M

“…The 4 dengue serotypes (DENV) are mosquito-borne pathogens that are associated with severe hemorrhagic disease. DENV particles have a lipid bilayer envelope…”
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Oligomeric state of the ZIKV E protein defines protective immune responses by Metz, Stefan W., Thomas, Ashlie, Brackbill, Alex, Forsberg, John, Miley, Michael J., Lopez, Cesar A., Lazear, Helen M., Tian, Shaomin, de Silva, Aravinda M.

“…The current leading Zika vaccine candidates in clinical testing are based on live or killed virus platforms, which have safety issues, especially in pregnant…”
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In Vitro Assembly and Stabilization of Dengue and Zika Virus Envelope Protein Homo-Dimers by Metz, Stefan W., Gallichotte, Emily N., Brackbill, Alex, Premkumar, Lakshmanane, Miley, Michael J., Baric, Ralph, de Silva, Aravinda M.

“…Zika virus (ZIKV) and the 4 dengue virus (DENV) serotypes are mosquito-borne Flaviviruses that are associated with severe neuronal and hemorrhagic syndromes…”
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Role of Zika Virus Envelope Protein Domain III as a Target of Human Neutralizing Antibodies by Gallichotte, Emily N, Young, Ellen F, Baric, Thomas J, Yount, Boyd L, Metz, Stefan W, Begley, Matthew C, de Silva, Aravinda M, Baric, Ralph S

“…Zika virus (ZIKV) is a flavivirus that is structurally highly similar to the related viruses, dengue virus (DENV), West Nile virus, and yellow fever virus…”
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Nanoparticle delivery of a tetravalent E protein subunit vaccine induces balanced, type-specific neutralizing antibodies to each dengue virus serotype by Metz, Stefan W, Thomas, Ashlie, Brackbill, Alex, Xianwen, Yi, Stone, Michele, Horvath, Katie, Miley, Michael J, Luft, Chris, DeSimone, Joseph M, Tian, Shaomin, de Silva, Aravinda M

“…Dengue virus (DENV) is the causative agent of dengue fever and dengue hemorrhagic shock syndrome. Dengue vaccine development is challenging because of the need…”
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Precisely Molded Nanoparticle Displaying DENV-E Proteins Induces Robust Serotype-Specific Neutralizing Antibody Responses by Metz, Stefan W, Tian, Shaomin, Hoekstra, Gabriel, Yi, Xianwen, Stone, Michelle, Horvath, Katie, Miley, Michael J, DeSimone, Joseph, Luft, Chris J, de Silva, Aravinda M

“…Dengue virus (DENV) is the causative agent of dengue fever and dengue hemorrhagic fever. The virus is endemic in over 120 countries, causing over 350 million…”
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Selecting the optimal Tet-On system for doxycycline-inducible gene expression in transiently transfected and stably transduced mammalian cells by Das, Atze T., Zhou, Xue, Metz, Stefan W., Vink, Monique A., Berkhout, Ben

“…The doxycycline (dox)‐inducible Tet‐On system is widely used to control gene expression in mammalian cells. This system is based on the bacterial Tet operon,…”
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Functional processing and secretion of Chikungunya virus E1 and E2 glycoproteins in insect cells by Metz, Stefan W, Geertsema, Corinne, Martina, Byron E, Andrade, Paulina, Heldens, Jacco G, van Oers, Monique M, Goldbach, Rob W, Vlak, Just M, Pijlman, Gorben P

“…Chikungunya virus (CHIKV) is a mosquito-borne, arthrogenic Alphavirus that causes large epidemics in Africa, South-East Asia and India. Recently, CHIKV has…”
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Progress and Works in Progress: Update on Flavivirus Vaccine Development by Collins, Matthew H., Metz, Stefan W.

“…Most areas of the globe are endemic for at least one flavivirus, putting billions at risk for infection. This diverse group of viral pathogens causes a range…”
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Effective chikungunya virus-like particle vaccine produced in insect cells by Metz, Stefan W, Gardner, Joy, Geertsema, Corinne, Le, Thuy T, Goh, Lucas, Vlak, Just M, Suhrbier, Andreas, Pijlman, Gorben P

“…The emerging arthritogenic, mosquito-borne chikungunya virus (CHIKV) causes severe disease in humans and represents a serious public health threat in countries…”
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Low temperature-dependent salmonid alphavirus glycoprotein processing and recombinant virus-like particle formation by Metz, Stefan W, Feenstra, Femke, Villoing, Stephane, van Hulten, Marielle C, van Lent, Jan W, Koumans, Joseph, Vlak, Just M, Pijlman, Gorben P

“…Pancreas disease (PD) and sleeping disease (SD) are important viral scourges in aquaculture of Atlantic salmon and rainbow trout. The etiological agent of PD…”
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Immunological implications of diverse production approaches for Chikungunya virus-like particle vaccines by Thompson, Danielle, Metz, Stefan W., Abad, Carmen, Beaty, Shannon, Warfield, Kelly

“…•Chikungunya virus (CHIKV) is a mosquito-borne pathogen capable of causing explosive, disruptive epidemics.•CHIKV infection causes acute febrile illness…”
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Dengue Vaccines: The Promise and Pitfalls of Antibody-Mediated Protection by Martinez, David R., Metz, Stefan W., Baric, Ralph S.

“…More than 390 million human dengue virus (DENV) infections occur each year, worldwide. Dengvaxia, a live-virus tetravalent vaccine from Sanofi Pasteur, was…”
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Focused dengue vaccine development: outwitting nature's design by Kudlacek, Stephan T, Metz, Stefan W

“…ABSTRACT The four DENV serotypes are mosquito-borne pathogens that belong to the Flavivirus genus. These viruses present a major global health burden, being…”
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Production of Chikungunya Virus-Like Particles and Subunit Vaccines in Insect Cells by Metz, Stefan W, Pijlman, Gorben P

“…Chikungunya virus is a reemerging human pathogen that causes debilitating arthritic disease in humans. Like dengue and Zika virus, CHIKV is transmitted by…”
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Dimerization of Dengue Virus E Subunits Impacts Antibody Function and Domain Focus by Thomas, Ashlie, Thiono, Devina J, Kudlacek, Stephan T, Forsberg, John, Premkumar, Lakshmanane, Tian, Shaomin, Kuhlman, Brian, de Silva, Aravinda M, Metz, Stefan W

“…Dengue virus (DENV) is responsible for the most prevalent and significant arthropod-borne viral infection of humans. The leading DENV vaccines are based on…”
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Physiological temperatures reduce dimerization of dengue and Zika virus recombinant envelope proteins by Kudlacek, Stephan T., Premkumar, Lakshmanane, Metz, Stefan W., Tripathy, Ashutosh, Bobkov, Andrey A., Payne, Alexander Matthew, Graham, Stephen, Brackbill, James A., Miley, Michael J., de Silva, Aravinda M., Kuhlman, Brian

“…The spread of dengue (DENV) and Zika virus (ZIKV) is a major public health concern. The primary target of antibodies that neutralize DENV and ZIKV is the…”
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Optimization of Surface Display of DENV2 E Protein on a Nanoparticle to Induce Virus Specific Neutralizing Antibody Responses by Coffman, Jason E, Metz, Stefan W, Brackbill, Alex, Paul, Molly, Miley, Michael J, DeSimone, Joseph, Luft, J. Christopher, de Silva, Aravinda, Tian, Shaomin

“…The dengue virus (DENV) causes over 350 million infections, resulting in ∼25,000 deaths per year globally. An effective dengue vaccine requires generation of…”
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Arbovirus vaccines; opportunities for the baculovirus-insect cell expression system by Metz, Stefan W., Pijlman, Gorben P.

“…[Display omitted] ► We describe medically important arboviruses from the families Togaviridae, Flaviviridae, Bunyaviridae and Reoviridae. ► Vaccine development…”
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