Search Results - "METZ, D. C."

Review article: dual delayed release formulation of dexlansoprazole MR, a novel approach to overcome the limitations of conventional single release proton pump inhibitor therapy by METZ, D. C., VAKILY, M., DIXIT, T., MULFORD, D.

“…Summary Background  Proton pump inhibitors (PPIs) provide the most effective pharmacotherapy for treating acid‐related disorders. However, PPIs do not…”
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Proton pump inhibitors: are they overutilised in clinical practice and do they pose significant risk? by Heidelbaugh, J J, Metz, D C, Yang, Y-X

“…Proton pump inhibitors are highly effective acid suppressants with decades of use highlighting positive outcomes in millions of patients worldwide, and they…”
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Clinical trial: dexlansoprazole MR, a proton pump inhibitor with dual delayed‐release technology, effectively controls symptoms and prevents relapse in patients with healed erosive oesophagitis by METZ, D. C., HOWDEN, C. W., PEREZ, M. C., LARSEN, L., O’NEIL, J., ATKINSON, S. N.

“…Summary Background  Dexlansoprazole MR heals all grades of erosive oesophagitis (EO). Aim  To assess efficacy and safety of dexlansoprazole MR in maintaining…”
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Safety profile of dexlansoprazole MR, a proton pump inhibitor with a novel dual delayed release formulation: global clinical trial experience by PEURA, D. A., METZ, D. C., DABHOLKAR, A. H., PARIS, M. M., YU, P., ATKINSON, S. N.

“…Summary Background  Dexlansoprazole MR is a dual delayed release formulation of dexlansoprazole, an enantiomer of lansoprazole. Aim  To assess safety of…”
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Lansoprazole regimens that sustain intragastric pH >6.0: an evaluation of intermittent oral and continuous intravenous infusion dosages by METZ, D. C., AMER, F., HUNT, B., VAKILY, M., KUKULKA, M. J., SAMRA, N.

“…Summary Background  Orally and intravenously administered proton pump inhibitors have been shown to reduce rebleeding rates, surgery and transfusion…”
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Three‐year oral pantoprazole administration is effective for patients with Zollinger–Ellison syndrome and other hypersecretory conditions by METZ, D. C., COMER, G. M., SOFFER, E., FORSMARK, C. E., CRYER, B., CHEY, W., PISEGNA, J. R.

“…Summary Background Zollinger–Ellison syndrome and idiopathic hypersecretion are gastrointestinal hypersecretory conditions requiring long‐term maintenance…”
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Dose–response evaluation of the antisecretory effect of continuous infusion intravenous lansoprazole regimens over 48 h by HOWDEN, C. W., METZ, D. C., HUNT, B., VAKILY, M., KUKULKA, M., AMER, F., SAMRA, N.

“…Summary Background  Attainment of intragastric pH < 6.0 may require high‐dose continuously infused proton pump therapy. Aim  To assess the pharmacokinetic and…”
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Alginate therapy is effective treatment for GERD symptoms: a systematic review and meta-analysis by Leiman, D. A., Riff, B. P., Morgan, S., Metz, D. C., Falk, G. W., French, B., Umscheid, C. A., Lewis, J. D.

“…SUMMARY In patients with gastroesophageal reflux disease (GERD) and erosive esophagitis, treatment with proton pump inhibitors (PPIs) is highly effective…”
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Clinical presentation and disease course of patients with esophagogastric junction outflow obstruction by Lynch, K. L., Yang, Y.-X., Metz, D. C., Falk, G. W.

“…SUMMARY Esophagogastric junction outflow obstruction, characterized by preserved peristalsis in conjunction with an elevated integrated relaxation pressure,…”
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Commentary: netazepide for gastric acid suppression - another kid on the block? by Metz, D. C.

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Alginate therapy is effective treatment for gastroesophageal reflux disease symptoms: a systematic review and meta-analysis by Leiman, D. A., Riff, B. P., Morgan, S., Metz, D. C., Falk, G. W., French, B., Umscheid, C. A., Lewis, J. D.

“…SUMMARY In patients with gastroesophageal reflux disease (GERD) and erosive esophagitis, treatment with proton pump inhibitors (PPIs) is highly effective…”
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Determinants of metastatic rate and survival in patients with Zollinger-Ellison syndrome: a prospective long-term study by Weber, H C, Venzon, D J, Lin, J T, Fishbein, V A, Orbuch, M, Strader, D B, Gibril, F, Metz, D C, Fraker, D L, Norton, J A

“…It is unclear whether tumor location, size, or the presence of multiple endocrine neoplasia type 1 (MEN-1) alters metastatic rate and survival in patients with…”
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Comparison of the effects of intravenously and orally administered esomeprazole on acid output in patients with symptoms of gastro‐oesophageal reflux disease by METZ, D. C., MINER, P. B., HEUMAN, D. M., CHEN, Y., SOSTEK, M.

“…Summary Background : Intravenous esomeprazole may be beneficial for patients who cannot take oral medications. Aim : To compare intravenous esomeprazole with…”
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Intravenous and oral lansoprazole are equivalent in suppressing stimulated acid output in patient volunteers with erosive oesophagitis by Kovacs, T. O. G., Lee, C. Q., Chiu, Y.‐L., Pilmer, B. L., Metz, D. C.

“…Summary Background : Some patients requiring acid suppression may be unable to take oral medications. Aim : To compare the gastric acid inhibition effects of…”
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Intravenous pantoprazole rapidly controls gastric acid hypersecretion in patients with Zollinger–Ellison syndrome by Lew, Edward A., Pisegna, Joseph R., Starr, Julie A., Soffer, Elaine F., Forsmark, Christopher, Modlin, Irvin M., Walsh, John H., Beg, Mirza, Bochenek, Wieslaw, Metz, David C.

“…Background & Aims: Parenteral control of gastric acid hypersecretion in conditions such as Zollinger–Ellison syndrome (ZES) or idiopathic gastric acid…”
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Pantoprazole maintenance therapy prevents relapse of erosive oesophagitis by Metz, D. C., Bochenek, W. J.

“…Summary Objectives : To compare the safety and efficacy of pantoprazole with ranitidine for the maintenance of endoscopically documented healed (grade 0 or 1)…”
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A randomized controlled crossover study comparing synthetic porcine and human secretins with biologically derived porcine secretin to diagnose Zollinger–Ellison Syndrome by Metz, D. C., Buchanan, M., Purich, E., Fein, S.

“…Background: Although biologically‐derived porcine secretin is approved for the diagnosis of Zollinger–Ellison Syndrome, it is no longer available in the United…”
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Pantoprazole provides rapid and sustained symptomatic relief in patients treated for erosive oesophagitis by Bochenek, W. J., Mack, M. E., Fraga, P. D., Metz, D. C.

“…Summary Background : Effective symptom control is a primary concern of most heartburn suffers. Aim : To compare the safety and efficacy of pantoprazole,…”
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Postprandial oesophageal integrated acidity is a reliable predictor of gastro‐oesophageal reflux disease by Shih, G. L., Brensinger, C. M., Katzka, D. A., Metz, D. C.

“…Summary Background : Measurement of oesophageal acid exposure parameters postprandially has been shown to distinguish gastro‐oesophageal reflux disease…”
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Radiographically diagnosed antral gastritis: findings in patients with and without Helicobacter pylori infection by DHEER, S, LEVINE, M. S, REDFERN, R. O, METZ, D. C, RUBESIN, S. E, LAUFER, I

“…The purpose of this study was to characterize the radiographic findings of antral gastritis and to determine whether there are differences in the appearance of…”
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