Search Results - "MESTER, Jan"
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Frondoside A inhibits human breast cancer cell survival, migration, invasion and the growth of breast tumor xenografts
Published in European journal of pharmacology (01-10-2011)“…Breast cancer is a major challenge for pharmacologists to develop new drugs to improve the survival of cancer patients. Frondoside A is a triterpenoid…”
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Captopril as a Potential Inhibitor of Lung Tumor Growth and Metastasis
Published in Annals of the New York Academy of Sciences (01-09-2008)“…Lung cancer is the most common form of cancer in the world, and 90% of patients die from their disease. The angiotensin converting enzyme (ACE) inhibitors are…”
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Estrogen Induction of the Cyclin D1 Promoter: Involvement of a cAMP Response-Like Element
Published in Proceedings of the National Academy of Sciences - PNAS (28-09-1999)“…Estrogens induce cell proliferation in target tissues by stimulating progression through the G1phase of the cell cycle. Induction of cyclin D1 expression is a…”
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Ligand-free estrogen receptor activity complements IGF1R to induce the proliferation of the MCF-7 breast cancer cells
Published in BMC cancer (16-07-2012)“…Ligand-dependent activation of the estrogen receptor (ER) as well as of the insulin-like growth factor type 1 (IGF1R) induces the proliferation of luminal…”
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Structure, Synthesis, and Molecular Cloning of Dermaseptins B, a Family of Skin Peptide Antibiotics
Published in The Journal of biological chemistry (12-06-1998)“…Analysis of antimicrobial activities that are present in the skin secretions of the South American frogPhyllomedusa bicolor revealed six polycationic…”
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Direct Inhibition of the Expression of Cyclin D1 Gene by Sodium Butyrate
Published in Biochemical and biophysical research communications (04-12-1996)“…In the mouse fibroblasts BP-A31 as well as in the human epidermoid carcinoma cells KB-3-1, both cyclin D1 mRNA and protein contents decreased rapidly during…”
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p21WAF1/CIP1 Selectively Controls the Transcriptional Activity of Estrogen Receptor α
Published in Molecular and Cellular Biology (01-03-2005)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Sodium Butyrate Induces G2 Arrest in the Human Breast Cancer Cells MDA-MB-231 and Renders Them Competent for DNA Rereplication
Published in Experimental cell research (15-03-1999)“…When exposed to sodium butyrate (NaBut), exponentially growing cells accumulate in G1 and G2 phases of the cell cycle. In the human breast cancer cell line…”
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B-ind1, a Novel Mediator of Rac1 Signaling Cloned from Sodium Butyrate-treated Fibroblasts
Published in The Journal of biological chemistry (09-06-2000)“…Sodium butyrate is a multifunctional agent known to inhibit cell proliferation and to induce differentiation by modulating transcription. We have performed…”
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Akt2 knock-down reveals its contribution to human lung cancer cell proliferation, growth, motility, invasion and endothelial cell tube formation
Published in Scientific reports (03-08-2015)“…The Akt/PKB serine/threonine protein kinase consists of three isoforms: Akt-1, −2 and −3. Their overexpression has been detected in human cancers, but their…”
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Partial Primary Deficiency of Insulin-Like Growth Factor (IGF)-I Activity Associated with IGF1 Mutation Demonstrates Its Critical Role in Growth and Brain Development
Published in The journal of clinical endocrinology and metabolism (01-10-2009)“…Context: IGF-I is essential for fetal and postnatal development. Only three IGF1 defects leading to dramatic loss of binding to its type 1 receptor, IGF-1R,…”
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The c-kit tyrosine kinase inhibitor STI571 for colorectal cancer therapy
Published in Cancer research (Chicago, Ill.) (01-09-2002)“…The c-kit tyrosine kinase inhibitor STI571 exhibits a substantial therapeutic activity in patients with chronic myeloid leukemia and gastrointestinal stromal…”
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Geldanamycin, an inhibitor of the chaperone activity of HSP90, induces MAPK‐independent cell cycle arrest
Published in International journal of cancer (01-05-2004)“…The effects of GA, an ansamycin antibiotic in development as a lead anticancer drug, were studied in mouse BP‐A31 fibroblasts and in human cancer‐derived cell…”
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Cellular effects of purvalanol A: A specific inhibitor of cyclin‐dependent kinase activities
Published in International journal of cancer (20-02-2002)“…We have studied the effects of purvalanol A on the cell cycle progression, proliferation and viability. In synchronized cells, purvalanol A induced a…”
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Indirect participation of Hsp90 in the regulation of the cyclin E turnover
Published in Biochemical pharmacology (15-01-2009)“…Cyclin E is the Cdk2-regulatory subunit required for the initiation of DNA replication at the G1/S transition. It accumulates in late G1 phase and gets rapidly…”
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Mitogenic Activity of Estrogens in Human Breast Cancer Cells Does Not Rely on Direct Induction of Mitogen-Activated Protein Kinase/Extracellularly Regulated Kinase or Phosphatidylinositol 3-Kinase
Published in Molecular endocrinology (Baltimore, Md.) (01-11-2004)“…We have addressed the question of rapid, nongenomic mechanisms that may be involved in the mitogenic action of estrogens in hormone-dependent breast cancer…”
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p21 super(WAF1/CIP1) Selectively Controls the Transcriptional Activity of Estrogen Receptor alpha
Published in Molecular and cellular biology (15-03-2005)“…Estrogen receptors (ER) are ligand-dependent transcription factors that regulate growth, differentiation, and maintenance of cellular functions in a wide…”
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Partial Primary Deficiency of Insulin-Like Growth Factor (IGF)-I Activity Associated with IGF1 Mutation Demonstrates Its Critical Role in Growth and Brain Development
Published in Molecular endocrinology (Baltimore, Md.) (01-11-2009)“…ABSTRACT Context IGF-I is essential for fetal and postnatal development. Only three IGF1 defects leading to dramatic loss of binding to its type 1 receptor,…”
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