Search Results - "MESTECKY, Jiri"

Antibody-dependent passive protection of mucosal surfaces by Mestecky, Jiri

“…Extensive experiments performed mostly in a variety of animal models convincingly demonstrated the protective effect of polyclonal or monoclonal antibodies…”
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Mucosal Immunity in COVID-19: A Neglected but Critical Aspect of SARS-CoV-2 Infection by Russell, Michael W, Moldoveanu, Zina, Ogra, Pearay L, Mestecky, Jiri

“…The mucosal immune system is the largest component of the entire immune system, having evolved to provide protection at the main sites of infectious threat:…”
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Mucosal immunity: The missing link in comprehending SARS-CoV-2 infection and transmission by Russell, Michael W., Mestecky, Jiri

“…SARS-CoV-2 is primarily an airborne infection of the upper respiratory tract, which on reaching the lungs causes the severe acute respiratory disease,…”
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Role of IgA1 protease-producing bacteria in SARS-CoV-2 infection and transmission: a hypothesis by Russell, Michael W, Kilian, Mogens, Mestecky, Jiri

“…Secretory (S) IgA antibodies against severe acute respiratory syndrome (SARS)-CoV-2 are induced in saliva and upper respiratory tract (URT) secretions by…”
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Enhancing oral vaccine potency by targeting intestinal M cells by Azizi, Ali, Kumar, Ashok, Diaz-Mitoma, Francisco, Mestecky, Jiri

“…The immune system in the gastrointestinal tract plays a crucial role in the control of infection, as it constitutes the first line of defense against mucosal…”
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Galactose-Deficient IgA1 B cells in the Circulation of IgA Nephropathy Patients Carry Preferentially Lambda Light Chains and Mucosal Homing Receptors by Zachova, Katerina, Jemelkova, Jana, Kosztyu, Petr, Ohyama, Yukako, Takahashi, Kazuo, Zadrazil, Josef, Orsag, Jiri, Matousovic, Karel, Galuszkova, Dana, Petejova, Nadezda, Mestecky, Jiri, Raska, Milan

“…IgA nephropathy (IgAN) primary glomerulonephritis is characterized by the deposition of circulating immune complexes composed of polymeric IgA1 molecules with…”
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Mucosal immunoglobulins by Woof, Jenny M., Mestecky, Jiri

“…Due to their vast surface area, the mucosal surfaces of the body represent a major site of potential attack by invading pathogens. The secretions that bathe…”
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The Origin and Activities of IgA1-Containing Immune Complexes in IgA Nephropathy by Knoppova, Barbora, Reily, Colin, Maillard, Nicolas, Rizk, Dana V, Moldoveanu, Zina, Mestecky, Jiri, Raska, Milan, Renfrow, Matthew B, Julian, Bruce A, Novak, Jan

“…IgA nephropathy (IgAN) is the most common primary glomerulonephritis, frequently leading to end-stage renal disease, as there is no disease-specific therapy…”
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IgA Glycosylation and IgA Immune Complexes in the Pathogenesis of IgA Nephropathy by Novak, Jan, PhD, Julian, Bruce A., MD, Tomana, Milan, PhD, Mestecky, Jiri, MD, PhD

“…Summary Circulating immune complexes containing aberrantly glycosylated IgA1 play a pivotal role in the pathogenesis of IgA nephropathy (IgAN). A portion of…”
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IgA Nephropathy: Pleiotropic impact of Epstein-Barr virus infection on immunopathogenesis and racial incidence of the disease by Mestecky, Jiri, Julian, Bruce A, Raska, Milan

“…IgA nephropathy (IgAN) is an autoimmune disease in which poorly galactosylated IgA1 is the antigen recognized by naturally occurring anti-glycan antibodies,…”
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Two Cells, One Antibody: The Discovery of the Cellular Origins and Transport of Secretory IgA by Kaetzel, Charlotte S, Mestecky, Jiri, Johansen, Finn-Eirik

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IgA nephropathy: molecular mechanisms of the disease by Mestecky, Jiri, Raska, Milan, Julian, Bruce A, Gharavi, Ali G, Renfrow, Matthew B, Moldoveanu, Zina, Novak, Lea, Matousovic, Karel, Novak, Jan

“…Studies of molecular and cellular interactions involved in the pathogenesis of IgA nephropathy have revealed the autoimmune nature of this most common primary…”
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Perspectives on Mucosal Vaccines: Is Mucosal Tolerance a Barrier? by Mestecky, Jiri, Russell, Michael W, Elson, Charles O

“…Mucosal administration of Ags induces specific Abs in external secretions and systemic unresponsiveness termed oral or mucosal tolerance. The dominant response…”
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Aberrant IgA1 Glycosylation Is Inherited in Familial and Sporadic IgA Nephropathy by GHARAVI, Ali G, MOLDOVEANU, Zina, WYATT, Robert J, BARKER, Catherine V, WOODFORD, Susan Y, LIFTON, Richard P, MESTECKY, Jiri, NOVAK, Jan, JULIAN, Bruce A

“…IgA nephropathy (IgAN) is a complex trait determined by genetic and environmental factors. Most IgAN patients exhibit a characteristic undergalactosylation of…”
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Glycosylation of IgA1 and pathogenesis of IgA nephropathy by Novak, Jan, Julian, Bruce A., Mestecky, Jiri, Renfrow, Matthew B.

“…IgA nephropathy, described in 1968 as IgA-IgG immune-complex disease, is an autoimmune disease. Galactose-deficient IgA1 is recognized by unique…”
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Glycosylation Patterns of HIV-1 gp120 Depend on the Type of Expressing Cells and Affect Antibody Recognition by Raska, Milan, Takahashi, Kazuo, Czernekova, Lydie, Zachova, Katerina, Hall, Stacy, Moldoveanu, Zina, Elliott, Matt C., Wilson, Landon, Brown, Rhubell, Jancova, Dagmar, Barnes, Stephen, Vrbkova, Jana, Tomana, Milan, Smith, Phillip D., Mestecky, Jiri, Renfrow, Matthew B., Novak, Jan

“…Human immunodeficiency virus type 1 (HIV-1) entry is mediated by the interaction between a variably glycosylated envelope glycoprotein (gp120) and host-cell…”
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Secretory IgA N-glycans contribute to the protection against E. coli O55 infection of germ-free piglets by Raskova Kafkova, Leona, Brokesova, Diana, Krupka, Michal, Stehlikova, Zuzana, Dvorak, Jiri, Coufal, Stepan, Fajstova, Alena, Srutkova, Dagmar, Stepanova, Katerina, Hermanova, Petra, Stepankova, Renata, Uberall, Ivo, Skarda, Jozef, Novak, Zdenek, Vannucci, Luca, Tlaskalova-Hogenova, Helena, Jiraskova Zakostelska, Zuzana, Sinkora, Marek, Mestecky, Jiri, Raska, Milan

“…Mucosal surfaces are colonized by highly diverse commensal microbiota. Coating with secretory IgA (SIgA) promotes the survival of commensal bacteria while it…”
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Role of Epstein-Barr Virus in Pathogenesis and Racial Distribution of IgA Nephropathy by Zachova, Katerina, Kosztyu, Petr, Zadrazil, Josef, Matousovic, Karel, Vondrak, Karel, Hubacek, Petr, Julian, Bruce A, Moldoveanu, Zina, Novak, Zdenek, Kostovcikova, Klara, Raska, Milan, Mestecky, Jiri

“…IgA nephropathy (IgAN) is the dominant type of primary glomerulonephritis worldwide. However, IgAN rarely affects African Blacks and is uncommon in African…”
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The Neonatal Fc receptor (FcRn) enhances human immunodeficiency virus type 1 (HIV-1) transcytosis across epithelial cells by Gupta, Sandeep, Gach, Johannes S, Becerra, Juan C, Phan, Tran B, Pudney, Jeffrey, Moldoveanu, Zina, Joseph, Sarah B, Landucci, Gary, Supnet, Medalyn Jude, Ping, Li-Hua, Corti, Davide, Moldt, Brian, Hel, Zdenek, Lanzavecchia, Antonio, Ruprecht, Ruth M, Burton, Dennis R, Mestecky, Jiri, Anderson, Deborah J, Forthal, Donald N

“…The mechanisms by which human immunodeficiency virus type 1 (HIV-1) crosses mucosal surfaces to establish infection are unknown. Acidic genital secretions of…”
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Differences in serum IgA responses to HIV-1 gp41 in elite controllers compared to viral suppressors on highly active antiretroviral therapy by Nabi, Rafiq, Moldoveanu, Zina, Wei, Qing, Golub, Elizabeth T, Durkin, Helen G, Greenblatt, Ruth M, Herold, Betsy C, Nowicki, Marek J, Kassaye, Seble, Cho, Michael W, Pinter, Abraham, Landay, Alan L, Mestecky, Jiri, Kozlowski, Pamela A

“…Mechanisms responsible for natural control of human immunodeficiency type 1 (HIV) replication in elite controllers (EC) remain incompletely defined. To…”
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