Search Results - "MESSNER, B."

DIA-NN: neural networks and interference correction enable deep proteome coverage in high throughput by Demichev, Vadim, Messner, Christoph B., Vernardis, Spyros I., Lilley, Kathryn S., Ralser, Markus

“…We present an easy-to-use integrated software suite, DIA-NN, that exploits deep neural networks and new quantification and signal correction strategies for the…”
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Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection by Messner, Christoph B, Demichev, Vadim, Wendisch, Daniel, Michalick, Laura, White, Matthew, Freiwald, Anja, Textoris-Taube, Kathrin, Vernardis, Spyros I, Egger, Anna-Sophia, Kreidl, Marco, Ludwig, Daniela, Kilian, Christiane, Agostini, Federica, Zelezniak, Aleksej, Thibeault, Charlotte, Pfeiffer, Moritz, Hippenstiel, Stefan, Hocke, Andreas, von Kalle, Christof, Campbell, Archie, Hayward, Caroline, Porteous, David J, Marioni, Riccardo E, Langenberg, Claudia, Lilley, Kathryn S, Kuebler, Wolfgang M, Mülleder, Michael, Drosten, Christian, Suttorp, Norbert, Witzenrath, Martin, Kurth, Florian, Sander, Leif Erik, Ralser, Markus

“…The COVID-19 pandemic is an unprecedented global challenge, and point-of-care diagnostic classifiers are urgently required. Here, we present a platform for…”
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LINE-1 induces hTERT and ensures telomere maintenance in tumour cell lines by Aschacher, T, Wolf, B, Enzmann, F, Kienzl, P, Messner, B, Sampl, S, Svoboda, M, Mechtcheriakova, D, Holzmann, K, Bergmann, M

“…A hallmark of cancer cells is an activated telomere maintenance mechanism, which allows prolonged survival of the malignant cells. In more than 80% of tumours,…”
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Cysteine and iron accelerate the formation of ribose-5-phosphate, providing insights into the evolutionary origins of the metabolic network structure by Piedrafita, Gabriel, Varma, Sreejith J, Castro, Cecilia, Messner, Christoph B, Szyrwiel, Lukasz, Griffin, Julian L, Ralser, Markus

“…The structure of the metabolic network is highly conserved, but we know little about its evolutionary origins. Key for explaining the early evolution of…”
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Machine Learning Predicts the Yeast Metabolome from the Quantitative Proteome of Kinase Knockouts by Zelezniak, Aleksej, Vowinckel, Jakob, Capuano, Floriana, Messner, Christoph B, Demichev, Vadim, Polowsky, Nicole, Mülleder, Michael, Kamrad, Stephan, Klaus, Bernd, Keller, Markus A, Ralser, Markus

“…A challenge in solving the genotype-to-phenotype relationship is to predict a cell's metabolome, believed to correlate poorly with gene expression. Using…”
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Inorganic sulfur fixation via a new homocysteine synthase allows yeast cells to cooperatively compensate for methionine auxotrophy by Yu, Jason S L, Heineike, Benjamin M, Hartl, Johannes, Aulakh, Simran K, Correia-Melo, Clara, Lehmann, Andrea, Lemke, Oliver, Agostini, Federica, Lee, Cory T, Demichev, Vadim, Messner, Christoph B, Mülleder, Michael, Ralser, Markus

“…The assimilation, incorporation, and metabolism of sulfur is a fundamental process across all domains of life, yet how cells deal with varying sulfur…”
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Persistent complement dysregulation with signs of thromboinflammation in active Long Covid by Cervia-Hasler, Carlo, Brüningk, Sarah C, Hoch, Tobias, Fan, Bowen, Muzio, Giulia, Thompson, Ryan C, Ceglarek, Laura, Meledin, Roman, Westermann, Patrick, Emmenegger, Marc, Taeschler, Patrick, Zurbuchen, Yves, Pons, Michele, Menges, Dominik, Ballouz, Tala, Cervia-Hasler, Sara, Adamo, Sarah, Merad, Miriam, Charney, Alexander W, Puhan, Milo, Brodin, Petter, Nilsson, Jakob, Aguzzi, Adriano, Raeber, Miro E, Messner, Christoph B, Beckmann, Noam D, Borgwardt, Karsten, Boyman, Onur

“…Long Covid is a debilitating condition of unknown etiology. We performed multimodal proteomics analyses of blood serum from COVID-19 patients followed up to 12…”
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Global analysis of cytosine and adenine DNA modifications across the tree of life by Varma, Sreejith Jayasree, Calvani, Enrica, Grüning, Nana-Maria, Messner, Christoph B, Grayson, Nicholas, Capuano, Floriana, Mülleder, Michael, Ralser, Markus

“…Interpreting the function and metabolism of enzymatic DNA modifications requires both position-specific and global quantities. Sequencing-based techniques that…”
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Apoptosis and necrosis: two different outcomes of cigarette smoke condensate-induced endothelial cell death by Messner, B, Frotschnig, S, Steinacher-Nigisch, A, Winter, B, Eichmair, E, Gebetsberger, J, Schwaiger, S, Ploner, C, Laufer, G, Bernhard, D

“…Cigarette smoking is one of the most important and preventable risk factors for atherosclerosis. However, because of the complex composition of cigarette…”
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Vein graft thrombi, a niche for smooth muscle cell colonization – a hypothesis to explain the asymmetry of intimal hyperplasia by Blaas, I., Heinz, K., Würtinger, P., Türkcan, A., Tepeköylü, C., Grimm, M., Doppler, C., Danzl, K., Messner, B., Bernhard, D.

“…Essentials Vein graft failure is the most frequent late onset complication of coronary artery bypass grafting. Cuff technique‐based interposition mouse model…”
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Metabolomic profiling of ascending thoracic aortic aneurysms and dissections – Implications for pathophysiology and biomarker discovery by Doppler, C, Arnhard, K, Dumfarth, J, Heinz, K, Danzl, K, Messner, B, Stern, C, Bernhard, D

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Mass spectrometry‐based high‐throughput proteomics and its role in biomedical studies and systems biology by Messner, Christoph B., Demichev, Vadim, Wang, Ziyue, Hartl, Johannes, Kustatscher, Georg, Mülleder, Michael, Ralser, Markus

“…There are multiple reasons why the next generation of biological and medical studies require increasing numbers of samples. Biological systems are dynamic, and…”
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Cellular control of protein levels: A systems biology perspective by Munro, Victoria, Kelly, Van, Messner, Christoph B., Kustatscher, Georg

“…How cells regulate protein levels is a central question of biology. Over the past decades, molecular biology research has provided profound insights into the…”
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A proteomic survival predictor for COVID-19 patients in intensive care by Demichev, Vadim, Tober-Lau, Pinkus, Nazarenko, Tatiana, Lemke, Oliver, Kaur Aulakh, Simran, Whitwell, Harry J, Röhl, Annika, Freiwald, Anja, Mittermaier, Mirja, Szyrwiel, Lukasz, Ludwig, Daniela, Correia-Melo, Clara, Lippert, Lena J, Helbig, Elisa T, Stubbemann, Paula, Olk, Nadine, Thibeault, Charlotte, Grüning, Nana-Maria, Blyuss, Oleg, Vernardis, Spyros, White, Matthew, Messner, Christoph B, Joannidis, Michael, Sonnweber, Thomas, Klein, Sebastian J, Pizzini, Alex, Wohlfarter, Yvonne, Sahanic, Sabina, Hilbe, Richard, Schaefer, Benedikt, Wagner, Sonja, Machleidt, Felix, Garcia, Carmen, Ruwwe-Glösenkamp, Christoph, Lingscheid, Tilman, Bosquillon de Jarcy, Laure, Stegemann, Miriam S, Pfeiffer, Moritz, Jürgens, Linda, Denker, Sophy, Zickler, Daniel, Spies, Claudia, Edel, Andreas, Müller, Nils B, Enghard, Philipp, Zelezniak, Aleksej, Bellmann-Weiler, Rosa, Weiss, Günter, Campbell, Archie, Hayward, Caroline, Porteous, David J, Marioni, Riccardo E, Uhrig, Alexander, Zoller, Heinz, Löffler-Ragg, Judith, Keller, Markus A, Tancevski, Ivan, Timms, John F, Zaikin, Alexey, Hippenstiel, Stefan, Ramharter, Michael, Müller-Redetzky, Holger, Witzenrath, Martin, Suttorp, Norbert, Lilley, Kathryn, Mülleder, Michael, Sander, Leif Erik, Kurth, Florian, Ralser, Markus

“…Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as…”
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Ultra-fast proteomics with Scanning SWATH by Messner, Christoph B., Demichev, Vadim, Bloomfield, Nic, Yu, Jason S. L., White, Matthew, Kreidl, Marco, Egger, Anna-Sophia, Freiwald, Anja, Ivosev, Gordana, Wasim, Fras, Zelezniak, Aleksej, Jürgens, Linda, Suttorp, Norbert, Sander, Leif Erik, Kurth, Florian, Lilley, Kathryn S., Mülleder, Michael, Tate, Stephen, Ralser, Markus

“…Accurate quantification of the proteome remains challenging for large sample series and longitudinal experiments. We report a data-independent acquisition…”
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The proteomic landscape of genome-wide genetic perturbations by Messner, Christoph B., Demichev, Vadim, Muenzner, Julia, Aulakh, Simran K., Barthel, Natalie, Röhl, Annika, Herrera-Domínguez, Lucía, Egger, Anna-Sophia, Kamrad, Stephan, Hou, Jing, Tan, Guihong, Lemke, Oliver, Calvani, Enrica, Szyrwiel, Lukasz, Mülleder, Michael, Lilley, Kathryn S., Boone, Charles, Kustatscher, Georg, Ralser, Markus

“…Functional genomic strategies have become fundamental for annotating gene function and regulatory networks. Here, we combined functional genomics with…”
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Nonenzymatic gluconeogenesis-like formation of fructose 1,6-bisphosphate in ice by Messner, Christoph B., Driscoll, Paul C., Piedrafita, Gabriel, De Volder, Michael F. L., Ralser, Markus

“…The evolutionary origins of metabolism, in particular the emergence of the sugar phosphates that constitute glycolysis, the pentose phosphate pathway, and the…”
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Natural proteome diversity links aneuploidy tolerance to protein turnover by Muenzner, Julia, Trébulle, Pauline, Agostini, Federica, Zauber, Henrik, Messner, Christoph B., Steger, Martin, Kilian, Christiane, Lau, Kate, Barthel, Natalie, Lehmann, Andrea, Textoris-Taube, Kathrin, Caudal, Elodie, Egger, Anna-Sophia, Amari, Fatma, De Chiara, Matteo, Demichev, Vadim, Gossmann, Toni I., Mülleder, Michael, Liti, Gianni, Schacherer, Joseph, Selbach, Matthias, Berman, Judith, Ralser, Markus

“…Accessing the natural genetic diversity of species unveils hidden genetic traits, clarifies gene functions and allows the generalizability of laboratory…”
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Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan by Correia-Melo, Clara, Kamrad, Stephan, Tengölics, Roland, Messner, Christoph B., Trebulle, Pauline, Townsend, StJohn, Jayasree Varma, Sreejith, Freiwald, Anja, Heineike, Benjamin M., Campbell, Kate, Herrera-Dominguez, Lucía, Kaur Aulakh, Simran, Szyrwiel, Lukasz, Yu, Jason S.L., Zelezniak, Aleksej, Demichev, Vadim, Mülleder, Michael, Papp, Balázs, Alam, Mohammad Tauqeer, Ralser, Markus

“…Metabolism is deeply intertwined with aging. Effects of metabolic interventions on aging have been explained with intracellular metabolism, growth control, and…”
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A time-resolved proteomic and prognostic map of COVID-19 by Demichev, Vadim, Tober-Lau, Pinkus, Lemke, Oliver, Nazarenko, Tatiana, Thibeault, Charlotte, Whitwell, Harry, Röhl, Annika, Freiwald, Anja, Szyrwiel, Lukasz, Ludwig, Daniela, Correia-Melo, Clara, Aulakh, Simran Kaur, Helbig, Elisa T, Stubbemann, Paula, Lippert, Lena J, Grüning, Nana-Maria, Blyuss, Oleg, Vernardis, Spyros, White, Matthew, Messner, Christoph B, Joannidis, Michael, Sonnweber, Thomas, Klein, Sebastian J, Pizzini, Alex, Wohlfarter, Yvonne, Sahanic, Sabina, Hilbe, Richard, Schaefer, Benedikt, Wagner, Sonja, Mittermaier, Mirja, Machleidt, Felix, Garcia, Carmen, Ruwwe-Glösenkamp, Christoph, Lingscheid, Tilman, Bosquillon de Jarcy, Laure, Stegemann, Miriam S, Pfeiffer, Moritz, Jürgens, Linda, Denker, Sophy, Zickler, Daniel, Enghard, Philipp, Zelezniak, Aleksej, Campbell, Archie, Hayward, Caroline, Porteous, David J, Marioni, Riccardo E, Uhrig, Alexander, Müller-Redetzky, Holger, Zoller, Heinz, Löffler-Ragg, Judith, Keller, Markus A, Tancevski, Ivan, Timms, John F, Zaikin, Alexey, Hippenstiel, Stefan, Ramharter, Michael, Witzenrath, Martin, Suttorp, Norbert, Lilley, Kathryn, Mülleder, Michael, Sander, Leif Erik, Ralser, Markus, Kurth, Florian

“…COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection to severe organ damage and death. We characterized the…”
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