Search Results - "MERLINI, Lucio"

Total Synthesis of the Natural Product Benzo[j]fluoranthene-4,9-diol: An Approach to the Synthesis of Oxygenated Benzo[j]fluoranthenes by Lahore, Santosh, Narkhede, Umesh, Merlini, Lucio, Dallavalle, Sabrina

“…A synthetic sequence to the benzo[j]fluoranthene nucleus is described. Crucial steps of the procedure include a Suzuki coupling between appropriately…”
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Natural and semisynthetic azaphilones as a new scaffold for Hsp90 inhibitors by Musso, Loana, Dallavalle, Sabrina, Merlini, Lucio, Bava, Adriana, Nasini, Gianluca, Penco, Sergio, Giannini, Giuseppe, Giommarelli, Chiara, De Cesare, Andrea, Zuco, Valentina, Vesci, Loredana, Pisano, Claudio, Dal Piaz, Fabrizio, De Tommasi, Nunziatina, Zunino, Franco

“…A series of mold metabolites of Ascomycetes, structurally belonging to the class of azaphilones, were found to inhibit the heat shock protein Hsp90. In…”
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Preclinical profile of antitumor activity of a novel hydrophilic camptothecin, ST1968 by Pisano, Claudio, De Cesare, Michelandrea, Beretta, Giovanni Luca, Zuco, Valentina, Pratesi, Graziella, Penco, Sergio, Vesci, Loredana, Foderà, Rosanna, Ferrara, Fabiana Fosca, Guglielmi, Mario Berardino, Carminati, Paolo, Dallavalle, Sabrina, Morini, Gabriella, Merlini, Lucio, Orlandi, Augusto, Zunino, Franco

“…ST1968 is a novel hydrophilic camptothecin (CPT) derivative of the 7-oxyiminomethyl series. Because ST1968 retained ability to form remarkably stable cleavable…”
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Synthesis and Antifungal Activity of a Series of N-Substituted [2-(2,4-Dichlorophenyl)-3-(1,2,4-triazol-1-yl)]propylamines by Arnoldi, Anna, Dallavalle, Sabrina, Merlini, Lucio, Musso, Loana, Farina, Gandolfina, Moretti, Maddalena, Jayasinghe, Lalith

“…A series of N-mono- or N,N-disubstituted [2-(2,4-dichlorophenyl-3-(1,2,4-triazol-1-yl)]propylamines and…”
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Optimized Synthesis and Enhanced Efficacy of Novel Triplex-Forming Camptothecin Derivatives Based on Gimatecan by Vekhoff, Pierre, Halby, Ludovic, Oussedik, Kahina, Dallavalle, Sabrina, Merlini, Lucio, Mahieu, Christine, Lansiaux, Amélie, Bailly, Christian, Boutorine, Alexandre, Pisano, Claudio, Giannini, Giuseppe, Alloatti, Domenico, Arimondo, Paola B

“…Sequence-specific camptothecins are useful tools to inhibit specifically gene expression. The camptothecins are attached to the 3′ end of triplex-forming…”
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Current status and perspectives in the development of camptothecins by Zunino, Franco, Dallavalleb, Sabrina, Laccabuea, Diletta, Berettaa, Giovanni, Merlinib, Lucio, Pratesi, Graziella

“…Camptothecins are cytotoxic agents with a wide spectrum of antitumor activity. The unique mechanism of action, the impressive preclinical efficacy and the…”
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Monatin, Its Stereoisomers and Derivatives: Modeling the Sweet Taste Chemoreception Mechanism by Bassoli, Angela, Borgonovo, Gigliola, Busnelli, Gilberto, Morini, Gabriella, Merlini, Lucio

“…The sweet natural compound monatin 1 has two stereogenic centers, and the 2S,4S absolute configuration has been attributed previously to the natural isomer…”
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Pattern of Antitumor Activity of a Novel Camptothecin, ST1481, in a Large Panel of Human Tumor Xenografts by PRATESI, Graziella, DE CESARE, Michelandrea, VESCI, Loredana, ZUNINO, Franco, CARENINI, Nives, PEREGO, Paola, RIGHETTI, Sabina C, CUCCO, Carla, MERLINI, Lucio, PISANO, Claudio, PENCO, Sergio, CARMINATI, Paolo

“…Purpose: ST1481 is the lead compound of a novel series of 7-modified camptothecins, the 7-oxyimino methyl derivatives, characterized by potent topoisomerase I…”
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Structure elucidation of clavilactone D: an inhibitor of protein tyrosine kinases by Merlini, Lucio, Nasini, Gianluca, Scaglioni, Leonardo, Cassinelli, Giuliana, Lanzi, Cinzia

“…Clavilactones D and E were isolated from an agar culture of the Basidiomycetous fungus Clitocybe clavipes, and their structure was elucidated by 1 H - and 13 C…”
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Synthesis of photoactivable inhibitors of osteoclast vacuolar ATPase by Biasotti, Barbara, Dallavalle, Sabrina, Merlini, Lucio, Farina, Carlo, Gagliardi, Stefania, Parini, Carlo, Belfiore, Pietro

“…Amides of (2 Z,4 E)-5-[(5,6-dichloroindol-2-yl)]-2-methoxy- N-[3-[4-[3-(carboxymethoxy)phenyl)] piperazin-1-yl]propyl]-2,4-pentadienamide ( 1) and of…”
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A New 3,4-seco-Lupane Derivative from Lasianthus gardneri by Dallavalle, Sabrina, Jayasinghe, Lalith, Kumarihamy, B. M. M, Merlini, Lucio, Musso, Loana, Scaglioni, Leonardo

“…A new seco-ring A lupane triterpene derivative (1), along with lupenone, lupeol, β-sitosterol, ursolic acid, and stigmasterol 3-O-β-d-glucoside, were isolated…”
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7-Azaindole-1-carboxamides as a new class of PARP-1 inhibitors by Cincinelli, Raffaella, Musso, Loana, Merlini, Lucio, Giannini, Giuseppe, Vesci, Loredana, Milazzo, Ferdinando M., Carenini, Nives, Perego, Paola, Penco, Sergio, Artali, Roberto, Zunino, Franco, Pisano, Claudio, Dallavalle, Sabrina

“…[Display omitted] 7-Azaindole-1-carboxamides were designed as a new class of PARP-1 inhibitors. The compounds displayed a variable pattern of target inhibition…”
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Abstract 3096: Host antitumor immune response activated by Dual POLA1-HDAC11 inhibitors endowed with a large spectrum of antitumor activity by Pisano, Claudio, Merlini, Lucio, Penco, Sergio, Cincinelli, Raffaella, Darwiche, Nadine, Guglielmi, Mario B., Porta, Ilaria La, Pizzulo, Maddalena, Prosperi, Federica, Signorino, Giacomo, Colelli, Fabiana, Cardile, Francesco, Focareta, Laura, Fucci, Alessandra, D'Andrea, Egildo L., Riccio, Assunta, Dallavalle, Sabrina

“…Abstract Small molecule modulators of chromatin modifying enzymes became the focus of drug discovery efforts, because of their direct antitumor effects, such…”
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Synthesis and topoisomerase I inhibitory activity of a novel diazaindeno[2,1-b]phenanthrene analogue of Lamellarin D by Cananzi, Salvatore, Merlini, Lucio, Artali, Roberto, Beretta, Giovanni Luca, Zaffaroni, Nadia, Dallavalle, Sabrina

“…A novel 5-oxa-6a,8-diazaindeno[2,1-b]phenanthren-7-one scaffold was designed and synthesized as an active analogue of the cytotoxic marine alkaloid Lamellarin…”
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Enantioselective total synthesis and absolute configuration of the alleged structure of crassinervic acid by Chakor, Jyotsna N., Merlini, Lucio, Dallavalle, Sabrina

“…An enantioselective synthesis of the structure reported for the natural antifungal compound, (−)-crassinervic acid ( 1), has been achieved starting from…”
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Abstract 4848: Preclinical antitumor activity of novel DNA polymerase 1 (POLA1) inhibitors by Pisano, Claudio, Merlini, Lucio, Penco, Sergio, Cincinelli, Raffaella, Darwiche, Nadine, Guglielmi, Mario B., Porta, Ilaria La, Signorino, Giacomo, Rubis, Gabriele De, Colelli, Fabiana, Cardile, Francesco, Fucci, Alessandra, D'Andrea, Egildo L., Dallavalle, Sabrina

“…Abstract The anti-proliferative and pro-apoptotic effects of Retinoid-Related Molecules (RRMs) are described as independent from Retinoids' receptors-mediated…”
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Design, synthesis, and evaluation of biphenyl-4-yl-acrylohydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors by Dallavalle, Sabrina, Cincinelli, Raffaella, Nannei, Raffaella, Merlini, Lucio, Morini, Gabriella, Penco, Sergio, Pisano, Claudio, Vesci, Loredana, Barbarino, Marcella, Zuco, Valentina, De Cesare, Michelandrea, Zunino, Franco

“…A series of hydroxamic acid-based histone deacetylase (HDAC) inhibitors were designed on the basis of a model of the HDAC2 binding site and synthesized. They…”
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Abstract 4195: MIR002: a new POLA1 inhibitor endowed with a large spectrum of antitumor activity by Pisano, Claudio, Merlini, Lucio, Penco, Sergio, Cincinelli, Raffaella, Darwiche, Nadine, Guglielmi, Mario B., Esposito, Antonietta, Porta, Ilaria La, Signorino, Giacomo, Rubis, Gabriele De, Colelli, Fabiana, Cardile, Francesco, Fucci, Alessandra, D'Andrea, Egildo L., Dallavalle, Sabrina

“…Abstract A recent work from Han et al. disclosed DNA polymerase 1 alpha (POLA1) as the key target for the anti-cancer effects of CD437, a molecule belonging to…”
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First total synthesis of topopyrone C by Gattinoni, Sonia, Merlini, Lucio, Dallavalle, Sabrina

“…The first synthesis of topopyrone C, a natural compound and inhibitor of Topoisomerase I, has been carried out by Marschalk alkylation of…”
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Synthesis of (+)-Spirolaxine Methyl Ether by Nannei, Raffaella, Dallavalle, Sabrina, Merlini, Lucio, Bava, Adriana, Nasini, Gianluca

“…A short and efficient synthesis of (+)-spirolaxine methyl ether, a metabolite of the fungus Sporotrichum laxum with inhibitory activity against Helicobacter…”
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