Search Results - "MERIGAN, THOMAS C"

Pharmacogenetics of Long-Term Responses to Antiretroviral Regimens Containing Efavirenz and/or Nelfinavir: An Adult AIDS Clinical Trials Group Study by Haas, David W., Smeaton, Laura M., Shafer, Robert W., Robbins, Gregory K., Morse, Gene D., Labbé, Line, Wilkinson, Grant R., Clifford, David B., D’Aquila, Richard T., De Gruttola, Victor, Pollard, Richard B., Merigan, Thomas C., Hirsch, Martin S., George, Alfred L., Donahue, John P., Kim, Richard B.

“…BackgroundEfavirenz and nelfinavir are metabolized by cytochrome P-450 (CYP) 2B6 and CYP2C19, respectively, with some involvement by CYP3A. Nelfinavir is a…”
Get full text

“Wide-Open” 1.3 Å Structure of a Multidrug-Resistant HIV-1 Protease as a Drug Target by Martin, Philip, Vickrey, John F., Proteasa, Gheorghe, Jimenez, Yurytzy L., Wawrzak, Zdzislaw, Winters, Mark A., Merigan, Thomas C., Kovari, Ladislau C.

“…This report examines structural changes in a highly mutated, clinical multidrug-resistant HIV-1 protease, and the crystal structure has been solved to 1.3 Å…”
Get full text

Role of Physician-Scientists in the Control of Human Immunodeficiency Virus by Merigan, Thomas C

“…Physician-scientists played many important roles in controlling human immunodeficiency virus infection (HIV). They worked in academia, government, and…”
Get full text

In vitro HIV-1 evolution in response to triple reverse transcriptase inhibitors & in silico phenotypic analysis by Rath, Barbara A, Yousef, Kaveh Pouran, Katzenstein, David K, Shafer, Robert W, Schütte, Christof, von Kleist, Max, Merigan, Thomas C

“…Effectiveness of ART regimens strongly depends upon complex interactions between the selective pressure of drugs and the evolution of mutations that allow or…”
Get full text

Multilocus genetic interactions and response to efavirenz-containing regimens: an Adult AIDS Clinical Trials Group study by Motsinger, Alison A, Ritchie, Marylyn D, Shafer, Robert W, Robbins, Gregory K, Morse, Gene D, Labbe´, Line, Wilkinson, Grant R, Clifford, David B, DʼAquila, Richard T, Johnson, Victoria A, Pollard, Richard B, Merigan, Thomas C, Hirsch, Martin S, Donahue, John P, Kim, Richard B, Haas, David W

“…OBJECTIVEFor the HIV-1 reverse transcriptase inhibitor efavirenz, variant drug transporter gene ABCB1 may predict virologic response but not plasma efavirenz…”
Get full text

Crystal Structures of a Multidrug-Resistant Human Immunodeficiency Virus Type 1 Protease Reveal an Expanded Active-Site Cavity by LOGSDON, Bradley C, VICKREY, John F, MARTIN, Philip, PROTEASA, Gheorghe, KOEPKE, Jay I, TERLECKY, Stanley R, WAWRZAK, Zdzislaw, WINTERS, Mark A, MERIGAN, Thomas C, KOVARI, Ladislau C

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Phase 2 gene therapy trial of an anti-HIV ribozyme in autologous CD34 + cells by Mitsuyasu, Ronald T, Merigan, Thomas C, Carr, Andrew, Zack, Jerome A, Winters, Mark A, Workman, Cassy, Bloch, Mark, Lalezari, Jacob, Becker, Stephen, Thornton, Lorna, Akil, Bisher, Khanlou, Homayoon, Finlayson, Robert, McFarlane, Robert, Smith, Don E, Garsia, Roger, Ma, David, Law, Matthew, Murray, John M, von Kalle, Christof, Ely, Julie A, Patino, Sharon M, Knop, Alison E, Wong, Philip, Todd, Alison V, Haughton, Margaret, Fuery, Caroline, Macpherson, Janet L, Symonds, Geoff P, Evans, Louise A, Pond, Susan M, Cooper, David A

“…The first phase 2 gene therapy trial for HIV-1 has shown some promising signs. There's a long way to go before this would be a viable approach in people with…”
Get full text

Variants Other than Aspartic Acid at Codon 69 of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Gene Affect Susceptibility to Nucleoside Analogs by WINTERS, Mark A, MERIGAN, Thomas C

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

High Degree of Interlaboratory Reproducibility of Human Immunodeficiency Virus Type 1 Protease and Reverse Transcriptase Sequencing of Plasma Samples from Heavily Treated Patients by SHAFER, Robert W, HERTOGS, Kurt, ZOLOPA, Andrew R, WARFORD, Ann, BLOOR, Stuart, BETTS, Bradley J, MERIGAN, Thomas C, HARRIGAN, Richard, LARDER, Brendon A

“…Article Usage Stats Services JCM Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Association of a Novel Human Immunodeficiency Virus Type 1 Protease Substrate Cleft Mutation, L23I, with Protease Inhibitor Therapy and In Vitro Drug Resistance by JOHNSTON, Elizabeth, WINTERS, Mark A, RHEE, Soo-Yon, MERIGAN, Thomas C, SCHIFFER, Celia A, SHAFER, Robert W

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Effect of Baseline- and Treatment-Related Factors on Immunologic Recovery After Initiation of Antiretroviral Therapy in HIV-1-Positive Subjects: Results From ACTG 384 by Gandhi, Rajesh T, Spritzler, John, Chan, Ellen, Asmuth, David M, Rodriguez, Benigno, Merigan, Thomas C, Hirsch, Martin S, Shafer, Robert W, Robbins, Gregory K, Pollard, Richard B

“…OBJECTIVE:To assess the effect of baseline- and treatment-related factors on immunologic recovery after initiation of antiretroviral therapy (ART)…”
Get full text

Pharmacokinetics of Nelfinavir and Efavirenz in Antiretroviral-Naïve, Human Immunodeficiency Virus-Infected Subjects when Administered Alone or in Combination with Nucleoside Analog Reverse Transcriptase Inhibitors by Smith, Patrick F, Robbins, Gregory K, Shafer, Robert W, Wu, Hulin, Yu, Song, Hirsch, Martin S, Merigan, Thomas C, Park, Jeong-Gun, Forrest, Alan, Fischl, Margaret A, Morse, Gene D

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Granulocyte-Macrophage Colony-Stimulating Factor Induces Modest Increases in Plasma Human Immunodeficiency Virus (HIV) Type 1 RNA Levels and CD4+ Lymphocyte Counts in Patients with Uncontrolled HIV Infection by Jacobson, Jeffrey M., Lederman, Michael M., Spritzler, John, Valdez, Hernan, Tebas, Pablo, Skowron, Gail, Wang, Rui, Jackson, J. Brooks, Fox, Lawrence, Landay, Alan, Gilbert, Mark J., O’Neil, Dorothy, Bancroft, Lynne, Al-Harthi, Lena, Jacobson, Mark A., Merigan, Thomas C.

“…BackgroundStudies have reported that plasma human immunodeficiency virus type 1 (HIV-1) RNA levels and CD4+ lymphocyte counts in HIV-infected patients improved…”
Get full text

Hydroxyurea Enhances the Activities of Didanosine, 9-[2-(Phosphonylmethoxy)ethyl]adenine, and 9-[2-(Phosphonylmethoxy)propyl]adenine against Drug-Susceptible and Drug-Resistant Human Immunodeficiency Virus Isolates by Palmer, S, Shafer, R W, Merigan, T C

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Anti-HIV type 1 activity of 3'-fluoro-3'-deoxythymidine for several different multidrug-resistant mutants by Kim, E Y, Vrang, L, Oberg, B, Merigan, T C

“…The objective of this work was to test the antiviral activity of a potent nucleoside reverse transcriptase inhibitor, 3'-fluoro-3'-deoxythymidine (FLT), on…”
Get more information

Antiviral Activity of Lamivudine in Salvage Therapy for Multidrug-Resistant HIV-1 Infection by Campbell, Thomas B., Shulman, Nancy S., Johnson, Steven C., Zolopa, Andrew R., Young, Russell K., Bushman, Lane, Fletcher, Courtney V., Lanier, E. Randall, Merigan, Thomas C., Kuritzkes, Daniel R.

“…Background. Maximum suppression of virus replication is often not achievable for persons infected with multidrug-resistant human immunodeficiency virus type 1…”
Get full text

A Trial Comparing Nucleoside Monotherapy with Combination Therapy in HIV-Infected Adults with CD4 Cell Counts from 200 to 500 per Cubic Millimeter by Hammer, Scott M, Katzenstein, David A, Hughes, Michael D, Gundacker, Holly, Schooley, Robert T, Haubrich, Richard H, Henry, W. Keith, Lederman, Michael M, Phair, John P, Niu, Manette, Hirsch, Martin S, Merigan, Thomas C

“…Zidovudine improves survival and decreases the incidence of opportunistic infections among patients with advanced infections with human immunodeficiency virus…”
Get full text

Insertions in the human immunodeficiency virus type 1 protease and reverse transcriptase genes : Clinical impact and molecular mechanisms by WINTERS, Mark A, MERIGAN, Thomas C

Get full text

Frequency of Class I HLA-Restricted Anti-HIV CD8+ T Cells in Individuals Receiving Highly Active Antiretroviral Therapy (HAART) by Gray, Clive M, Lawrence, Jody, Schapiro, Jonathan M, Altman, John D, Winters, Mark A, Crompton, Meg, Loi, Muoi, Kundu, Smriti K, Davis, Mark M, Merigan, Thomas C

“…Peptide/MHC tetrameric complexes were used to enumerate the frequency of HLA class I-restricted epitope-specific CD8+ T cells in 18 HLA-A*0201 HIV type…”
Get full text

Treatment of Human Immunodeficiency Virus Infection with Saquinavir, Zidovudine, and Zalcitabine by Collier, Ann C, Coombs, Robert W, Schoenfeld, David A, Bassett, Roland L, Timpone, Joseph, Baruch, Alice, Jones, Michelle, Facey, Karen, Whitacre, Caroline, McAuliffe, Vincent J, Friedman, Harvey M, Merigan, Thomas C, Reichman, Richard C, Hooper, Carol, Corey, Lawrence

“…Antiretroviral therapy is associated with delayed progression of disease and prolonged survival in patients with advanced human immunodeficiency virus (HIV)…”
Get full text