Search Results - "MERELES, Derliz"

Epigallocatechin-3-gallate (EGCG) for clinical trials: more pitfalls than promises? by Mereles, Derliz, Hunstein, Werner

“…Epigallocatechin-3-gallate (EGCG), the main and most significant polyphenol in green tea, has shown numerous health promoting effects acting through different…”
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Longitudinal Left Ventricular Function for Prediction of Survival in Systemic Light-Chain Amyloidosis by Buss, Sebastian J., MD, Emami, Mostafa, BSc, Mereles, Derliz, MD, Korosoglou, Grigorios, MD, Kristen, Arnt V., MD, Voss, Andreas, PhD, Schellberg, Dieter, PhD, Zugck, Christian, MD, Galuschky, Christian, MS, Giannitsis, Evangelos, MD, Hegenbart, Ute, MD, Ho, Anthony D., MD, Katus, Hugo A., MD, Schonland, Stefan O., MD, Hardt, Stefan E., MD

“…Objectives The aim of the study was to determine whether longitudinal left ventricular (LV) function provides prognostic information in a large cohort of…”
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Reliability of Noninvasive Assessment of Systolic Pulmonary Artery Pressure by Doppler Echocardiography Compared to Right Heart Catheterization: Analysis in a Large Patient Population by Greiner, Sebastian, Jud, Andreas, Aurich, Matthias, Hess, Alexander, Hilbel, Thomas, Hardt, Stefan, Katus, Hugo A., Mereles, Derliz

“…Background Pulmonary artery pressure (PAP) is an important marker in cardiovascular disorders, being closely associated with morbidity and mortality…”
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The Symptom Complex of Familial Sinus Node Dysfunction and Myocardial Noncompaction Is Associated With Mutations in the HCN4 Channel by Schweizer, Patrick A., MD, Schröter, Julian, BSc, Greiner, Sebastian, MD, Haas, Jan, PhD, Yampolsky, Pessah, PhD, Mereles, Derliz, MD, Buss, Sebastian J., MD, Seyler, Claudia, PhD, Bruehl, Claus, PhD, Draguhn, Andreas, MD, Koenen, Michael, PhD, Meder, Benjamin, MD, Katus, Hugo A., MD, Thomas, Dierk, MD

“…Abstract Background Inherited arrhythmias were originally considered isolated electrical defects. There is growing evidence that ion channel dysfunction also…”
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Towards Personalized Cardiology: Multi-Scale Modeling of the Failing Heart by Kayvanpour, Elham, Mansi, Tommaso, Sedaghat-Hamedani, Farbod, Amr, Ali, Neumann, Dominik, Georgescu, Bogdan, Seegerer, Philipp, Kamen, Ali, Haas, Jan, Frese, Karen S, Irawati, Maria, Wirsz, Emil, King, Vanessa, Buss, Sebastian, Mereles, Derliz, Zitron, Edgar, Keller, Andreas, Katus, Hugo A, Comaniciu, Dorin, Meder, Benjamin

“…Despite modern pharmacotherapy and advanced implantable cardiac devices, overall prognosis and quality of life of HF patients remain poor. This is in part due…”
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Left ventricular mechanics assessed by two-dimensional echocardiography and cardiac magnetic resonance imaging: comparison of high-resolution speckle tracking and feature tracking by Aurich, Matthias, Keller, Marius, Greiner, Sebastian, Steen, Henning, Aus dem Siepen, Fabian, Riffel, Johannes, Katus, Hugo A, Buss, Sebastian J, Mereles, Derliz

“…Assessment of left ventricular (LV) systolic function plays a central role in cardiac imaging. Calculation of ejection fraction (EF) is the current method of…”
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Alterations in cardiac DNA methylation in human dilated cardiomyopathy by Haas, Jan, Frese, Karen S., Park, Yoon Jung, Keller, Andreas, Vogel, Britta, Lindroth, Anders M., Weichenhan, Dieter, Franke, Jennifer, Fischer, Simon, Bauer, Andrea, Marquart, Sabine, Sedaghat‐Hamedani, Farbod, Kayvanpour, Elham, Köhler, Doreen, Wolf, Nadine M., Hassel, Sarah, Nietsch, Rouven, Wieland, Thomas, Ehlermann, Philipp, Schultz, Jobst‐Hendrik, Dösch, Andreas, Mereles, Derliz, Hardt, Stefan, Backs, Johannes, Hoheisel, Jörg D., Plass, Christoph, Katus, Hugo A., Meder, Benjamin

“…Dilated cardiomyopathies (DCM) show remarkable variability in their age of onset, phenotypic presentation, and clinical course. Hence, disease mechanisms must…”
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Dilation of the Aorta Ascendens Forms Part of the Clinical Spectrum of HCN4 Mutations by Vermeer, Alexa M.C., MD, Lodder, Elisabeth M., PhD, Thomas, Dierk, MD, Duijkers, Floor A.M., MD, PhD, Marcelis, Carlo, MD, PhD, van Gorselen, Edwin O.F., MD, Fortner, Philipp, MD, Buss, Sebastian J., MD, Mereles, Derliz, MD, Katus, Hugo A., MD, Wilde, Arthur A.M., MD, PhD, Bezzina, Connie R., PhD, Boekholdt, S. Matthijs, MD, PhD, Schweizer, Patrick A., MD, Christiaans, Imke, MD, PhD

“…Dilation of the ascending aorta was detected in 20 of 26 (77%) HCN4 mutation-positive patients in whom we could obtain images with diagnostic quality…”
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Assessment of Left Ventricular Volumes with Echocardiography and Cardiac Magnetic Resonance Imaging: Real-Life Evaluation of Standard versus New Semiautomatic Methods by Aurich, Matthias, MD, André, Florian, MD, Keller, Marius, Greiner, Sebastian, MD, Hess, Alexander, MD, Buss, Sebastian J., MD, Katus, Hugo A., MD, Mereles, Derliz, MD

“…Background Routine quantitative assessment of left ventricular (LV) volumes with echocardiography is hindered by time-consuming methods requiring a manual…”
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Genomic structural variations lead to dysregulation of important coding and non‐coding RNA species in dilated cardiomyopathy by Haas, Jan, Mester, Stefan, Lai, Alan, Frese, Karen S, Sedaghat‐Hamedani, Farbod, Kayvanpour, Elham, Rausch, Tobias, Nietsch, Rouven, Boeckel, Jes‐Niels, Carstensen, Avisha, Völkers, Mirko, Dietrich, Carsten, Pils, Dietmar, Amr, Ali, Holzer, Daniel B, Martins Bordalo, Diana, Oehler, Daniel, Weis, Tanja, Mereles, Derliz, Buss, Sebastian, Riechert, Eva, Wirsz, Emil, Wuerstle, Maximilian, Korbel, Jan O, Keller, Andreas, Katus, Hugo A, Posch, Andreas E, Meder, Benjamin

“…The transcriptome needs to be tightly regulated by mechanisms that include transcription factors, enhancers, and repressors as well as non‐coding RNAs. Besides…”
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Prevalence of Intracardiac Thrombi Under Phenprocoumon, Direct Oral Anticoagulants (Dabigatran and Rivaroxaban), and Bridging Therapy in Patients With Atrial Fibrillation and Flutter by Zylla, Maura M., MD, Pohlmeier, Mara, Hess, Alexander, MD, Mereles, Derliz, MD, Kieser, Meinhard, PhD, Bruckner, Thomas, PhD, Scholz, Eberhard, MD, Zitron, Edgar, MD, Schweizer, Patrick A., MD, Katus, Hugo A., MD, Thomas, Dierk, MD

“…Direct oral anticoagulants (DOACs) are effective for stroke prevention in nonvalvular atrial fibrillation (AF). Cardioversion (CV) is frequently performed in…”
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Anterior Aortic Plane Systolic Excursion: A Novel Indicator of Transplant-Free Survival in Systemic Light-Chain Amyloidosis by Ochs, Marco M., MD, Riffel, Johannes, MD, Kristen, Arnt V., PhD, Hegenbart, Ute, PhD, Schönland, Stefan, PhD, Hardt, Stefan E., PhD, Katus, Hugo A., PhD, Mereles, Derliz, MD, Buss, Sebastian J., PhD

“…Background Anterior aortic plane systolic excursion (AAPSE) was evaluated in the present pilot study as a novel echocardiographic indicator of transplant-free…”
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Green tea halts progression of cardiac transthyretin amyloidosis: an observational report by Kristen, Arnt V., Lehrke, Stephanie, Buss, Sebastian, Mereles, Derliz, Steen, Henning, Ehlermann, Philipp, Hardt, Stefan, Giannitsis, Evangelos, Schreiner, Rupert, Haberkorn, Uwe, Schnabel, Philipp A., Linke, Reinhold P., Röcken, Christoph, Wanker, Erich E., Dengler, Thomas J., Altland, Klaus, Katus, Hugo A.

“…Background Treatment options in patients with amyloidotic transthyretin (ATTR) cardiomyopathy are limited. Epigallocatechin-3-gallate (EGCG), the most abundant…”
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Pathophysiological background and prognostic implication of systolic aortic root motion in non-ischemic dilated cardiomyopathy by Aurich, Matthias, Niemers, Matthias, Fuchs, Patrick, Greiner, Sebastian, Müller-Hennessen, Matthias, Uhlmann, Lorenz, Giannitsis, Evangelos, Ehlermann, Philipp, Meder, Benjamin, Katus, Hugo A., Mereles, Derliz

“…Recordings of aortic root movement represent one of the first accomplishments of ultrasound in medicine and mark the beginning of functional cardiac imaging…”
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Catheter ablation of atrial fibrillation in women with heart failure with preserved ejection fraction by Zylla, Maura M., Leiner, Johannes, Rahm, Ann-Kathrin, Hoffmann, Tobias, Lugenbiel, Patrick, Schweizer, Patrick, Mages, Christine, Mereles, Derliz, Kieser, Meinhard, Scholz, Eberhard, Katus, Hugo A., Frey, Norbert, Thomas, Dierk

“…BackgroundHeart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) often coincide. Female sex is associated with both increased…”
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Prognostic relevance of elevated pulmonary arterial pressure assessed non-invasively: Analysis in a large patient cohort with invasive measurements in near temporal proximity by Greiner, Sebastian, Jud, Andreas, Aurich, Matthias, Geisenberger, Christoph, Uhlmann, Lorenz, Hilbel, Thomas, Kieser, Meinhard, Katus, Hugo A, Mereles, Derliz

“…The clinical relevance of non-invasively derived pulmonary arterial pressure (PAP) by Doppler echocardiography (DE) has been questioned in the past. However,…”
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Prognosis of light chain amyloidosis: a multivariable analysis for survival prediction in patients with cardiac involvement proven by endomyocardial biopsy by Aurich, Matthias, Bucur, Julian, Vey, Johannes A, Greiner, Sebastian, aus dem Siepen, Fabian, Hegenbart, Ute, Schönland, Stefan, Katus, Hugo A, Frey, Norbert, Mereles, Derliz

“…BackgroundCardiac involvement is a main determinant of mortality in light chain (AL) amyloidosis but data on survival of patients with cardiac AL amyloidosis…”
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Functional improvement following direct interventional leaflet repair of severe tricuspid regurgitation by Volz, Martin J., Hoerbrand, Isabel, Konstandin, Mathias H., Mereles, Derliz, Weiss, Celine, Warnecke, Gregor, Frey, Norbert, Aurich, Matthias, Raake, Philip W.

“…Aims Several new percutaneous tricuspid repair systems have recently been introduced as new treatment options for severe tricuspid regurgitation (TR). Clinical…”
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A Simple, Non-Invasive Score to Predict Paroxysmal Atrial Fibrillation by Kallenberger, Stefan M, Schmid, Christian, Wiedmann, Felix, Mereles, Derliz, Katus, Hugo A, Thomas, Dierk, Schmidt, Constanze

“…Paroxysmal atrial fibrillation (pAF) is a major risk factor for stroke but remains often unobserved. To predict the presence of pAF, we developed model scores…”
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Acute Safety and 30-Day Outcome After Percutaneous Edge-to-Edge Repair of Mitral Regurgitation in Very High-Risk Patients by Pleger, Sven T., MD, Mereles, Derliz, MD, Schulz-Schönhagen, Marius, MS, Krumsdorf, Ulrike, MD, Chorianopoulos, Emmanuel, MD, Rottbauer, Wolfgang, MD, Katus, Hugo A., MD, Bekeredjian, Raffi, MD

“…Percutaneous edge-to-edge mitral valve repair using the MitraClip device has evolved as a new tool for the treatment of severe mitral valve regurgitation. This…”
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