Search Results - "MERCIER, Marjorie"

Neogenesis of Lymphoid Structures and Antibody Responses Occur in Human Melanoma Metastases by CIPPONI, Arcadi, MERCIER, Marjorie, SEREMET, Teofila, BAURAIN, Jean-François, THEATE, Ivan, VAN DEN OORD, Joost, STAS, Marguerite, BOON, Thierry, COULIE, Pierre G, VAN BAREN, Nicolas

“…Lymphoid neogenesis, or the development of lymphoid structures in nonlymphoid organs, is frequently observed in chronically inflamed tissues, during the course…”
Get full text

The development of cortical connections by Price, David J., Kennedy, Henry, Dehay, Colette, Zhou, Libing, Mercier, Marjorie, Jossin, Yves, Goffinet, André M., Tissir, Fadel, Blakey, Daniel, Molnár, Zoltán

“…The cortex receives its major sensory input from the thalamus via thalamocortical axons, and cortical neurons are interconnected in complex networks by…”
Get full text

74 a-TIGIT mAb belrestotug in combination with anti-PD1 induces an immunocompetent tumor microenvironment (TME) by Cuende, Julia, Ma, Stephanie, Welsby, Iain, Rosewick, Nicolas, Wald, Noemie, Vezzu, Anais, Mercier, Marjorie, Tieppo, Paola, Claes, Bart, McGrath, Yvonne, Henau, Olivier De, Driessens, Gregory, Ceppi, Maurizio, Libouban, Marion

“…BackgroundT cell immunoglobulin and ITIM domain (TIGIT) is an immune checkpoint inhibitor expressed mainly on NK and T cell populations. Antagonist a-TIGIT…”
Get full text

Abstract 4154: EOS100850 inhibits A2A receptor signaling in human whole blood: Two pharmacodynamic assays to monitor EOS100850 activity in clinical studies by Martinoli, Chiara, Brouwer, Margreet, Houthuys, Erica, Mercier, Marjorie, Wald, Noemie, Gomes, Bruno, Crosignani, Stefano, Bodo, Veronique

“…Abstract High levels of extracellular adenosine in the tumor microenvironment promote tumor immune evasion. We and others have shown that adenosine,…”
Get full text

Restoration of T-cell Effector Function, Depletion of Tregs, and Direct Killing of Tumor Cells: The Multiple Mechanisms of Action of a-TIGIT Antagonist Antibodies by Preillon, Julie, Cuende, Julia, Rabolli, Virginie, Garnero, Lucile, Mercier, Marjorie, Wald, Noémie, Pappalardo, Angela, Denies, Sofie, Jamart, Diane, Michaux, Anne-Catherine, Pirson, Romain, Pitard, Vincent, Bagot, Martine, Prasad, Shruthi, Houthuys, Erica, Brouwer, Margreet, Marillier, Reece, Lambolez, Florence, Marchante, Joäo R, Nyawouame, Florence, Carter, Mathew J, Baron-Bodo, Véronique, Marie-Cardine, Anne, Cragg, Mark, Déchanet-Merville, Julie, Driessens, Gregory, Hoofd, Catherine

“…TIGIT is an immune checkpoint inhibitor expressed by effector CD4 and CD8 T cells, NK cells, and regulatory T cells (Tregs). Inhibition of TIGIT-ligand binding…”
Get full text

Abstract 3240: EOS884448, a high affinity fully human antibody directed against TIGIT, mediates in vitro anti-tumor activity through multiples mechanisms of action involving activation of intratumor effector cells and depletion of regulatory T cells by Cuende, Julia, Rabolli, Virginie, Nyawouame, Florence, Mercier, Marjorie, Pappalardo, Angela, Garnero, Lucile, Dechanet-Merville, Julie, Driessens, Gregory, Hoofd, Catherine

“…Abstract T cell Immunoreceptor with Ig and ITIM domains (TIGIT) is a T cell co-inhibitory receptor recently described as a key checkpoint driving tumor cell…”
Get full text

Abstract 4149: Extensive characterization of the adenosine pathway in human solid tumors gives a hint on cancer indication selection for the A2A receptor antagonist EOS100850 by Wald, Noemie, Martinoli, Chiara, Mercier, Marjorie, Hermant, Annelise, Nyawouame, Florence, Marchante, Joao, Moulin, Charlotte, Bol, Vanesa, Crosignani, Stefano, Bodo, Veronique

“…Abstract Extracellular adenosine is an immunosuppressive metabolite generated by sequential action of the two ectonucleotidases CD39 and CD73. Tissue hypoxia,…”
Get full text

Abstract 3161: Preparation of aclinical trial with a-TIGIT antagonist antibody EOS884448, which demonstrates potent preclinical activity and safe toxicology profile by Nguyen, Thi Lien-Anh, Cuende, Julia, Preillon, Julie, Garnero, Lucile, Rabolli, Virginie, Wald, Noémie, Hoofd, Catherine, Chevron, Patricia, Mercier, Marjorie, De Henau, Olivier, Bodo, Véronique, Driessens, Gregory

“…Abstract T cell Immunoreceptor with Ig and ITIM domains (TIGIT) is a co-inhibitory receptor expressed by lymphocytes, preferentially CD8+, NK, as well as by…”
Get full text

Abstract 4969: TIGIT pathway phenotyping sheds light on promising strategies to restore anti-tumor immunity by Wald, Noémie, Mercier, Marjorie, Cuende, Julia, Nyawouame, Florence, Prasad, Shruthi, Brouwer, Margreet, Houthuys, Erica, Marie-Cardine, Anne, Bagot, Martine, Driessens, Grégory, Bodo, Véronique, Hoofd, Catherine

“…Abstract TIGIT is a T cell co-inhibitory receptor recently described as a key checkpoint driving tumor cell immunosuppression. It is predominantly expressed on…”
Get full text

Plasma cells in primary melanoma. Prognostic significance and possible role of IgA by Bosisio, Francesca M, Wilmott, James S, Volders, Nathalie, Mercier, Marjorie, Wouters, Jasper, Stas, Marguerite, Blokx, Willeke AM, Massi, Daniela, Thompson, John F, Scolyer, Richard A, van Baren, Nicolas, van den Oord, Joost J

“…Melanoma is not only one of the most immunogenic cancers but also one of the most effective cancers at subverting host immunity. The role of T lymphocytes in…”
Get full text

Abstract LB-114: a-TIGIT antagonist antibody EOS884448 shows dual mechanism of action by restoration of T cell effector functions and preferential depletion of Treg by LEROY, XAVIER, Hoofd, Catherine, Cuende, Julia, Denies, Sofie, Rabolli, Virginie, Preillon, Julie, Lambolez, Florence, Prasad, Shruthi, Mercier, Marjorie, Nyawouame, Florence, Bodo, Véronique, Wald, Noémie, Driessens, Grégory, Detheux, Michel

“…Abstract T cell Immunoreceptor with Ig and ITIM domains (TIGIT) is a co-inhibitory receptor expressed by lymphocytes, preferentially CD8+ T cells, NK, as well…”
Get full text

Abstract 3278: EOS100850 potently restores adenosine A2Areceptor-dependent suppression of T cell function in the adenosine rich tumor microenvironment by Houthuys, Erica, Basilico, Paola, Bodo, Veronique, Brouwer, Margreet, Detheux, Michel, Driessens, Gregory, Gomes, Bruno, Hermant, Annelise, Hoofd, Catherine, Lambolez, Florence, Leroy, Xavier, Marillier, Reece, Martinoli, Chiara, Mercier, Marjorie, Nyawouame, Florence, Prasad, Shruthi, Scoumanne, Ariane, Crosignani, Stefano

“…Abstract Adenosine is a potent immunosuppressive metabolite that is often found elevated in the extracellular tumor microenvironment (TME). We determined…”
Get full text

Abstract 4135: A novel plasma cell-based mechanism of action of adenosine immunomodulation and A2AR antagonism by Martinoli, Chiara, Tieppo, Paola, Mercier, Marjorie, Shehade, Hussein, Wald, Noemie, Vezzu, Anais, Hermant, Annelise, Pirlot, Boris, Ma, Stephanie, Ceppi, Maurizio, McGrath, Yvonne, Rossetti, Maura

“…Abstract High levels of extracellular adenosine, often found in the tumor microenvironment (TME), promote immune suppression mainly through the A2A receptor…”
Get full text

Abstract LB189: Pharmacodynamic assessment of a-TIGIT mAb EOS-448 highlights multiple FcγR-mediated mode-of-actions in blood and tumor of patients with advanced solid tumors by Cuende, Julia, Preillon, Julie, Wald, Noemie, Mercier, Marjorie, Tieppo, Paola, Welsby, Iain, Bodo, Veronique, McGrath, Yvonne, Van Den Mooter, Tom F., Machiels, Jean-Pascal, Truong, Clarisse, De Henau, Olivier, Driessens, Gregory, Libouban, Marion

“…Abstract T cell immunoglobulin and ITIM domain (TIGIT) is an immune checkpoint inhibitor expressed mainly on NK and T cell populations which has demonstrated…”
Get full text

REVIEW ARTICLE: The development of cortical connections by Price, David J, Kennedy, Henry, Dehay, Colette, Zhou, Libing, Mercier, Marjorie, Jossin, Yves, Goffinet, Andre M, Tissir, Fadel, Blakey, Daniel, Molnar, Zoltan

“…The cortex receives its major sensory input from the thalamus via thalamocortical axons, and cortical neurons are interconnected in complex networks by…”
Get full text