Search Results - "MERCER, W. E"

WAF1, a potential mediator of p53 tumor suppression by el-Deiry, W S, Tokino, T, Velculescu, V E, Levy, D B, Parsons, R, Trent, J M, Lin, D, Mercer, W E, Kinzler, K W, Vogelstein, B

“…The ability of p53 to activate transcription from specific sequences suggests that genes induced by p53 may mediate its biological role as a tumor suppressor…”
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Induction of WAF1/CIP1 by a p53-independent pathway by MICHIELI, P, CHEDID, M, LIN, D, PIERCE, J. H, MERCER, W. E, GIVOL, D

“…The p53-inducible gene WAF1/CIP1 encodes a M(r) 21,000 protein (p21) that has been shown to arrest cell growth by inhibition of cyclin-dependent kinases…”
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Growth arrest induced by wild-type p53 protein blocks cells prior to or near the restriction point in late G1 phase by LIN, D, SHIELDS, M. T, ULLRICH, S. J, APPELLA, E, MERCER, W. E

“…Conditional expression of wild-type (wt) p53 protein in a glioblastoma tumor cell line has been shown to be growth inhibitory. We have now more precisely…”
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Negative Growth Regulation in a Glioblastoma Tumor Cell Line that Conditionally Expresses Human Wild-Type p53 by Mercer, W. Edward, Shields, Michelle T., Amin, Mamta, Sauve, Gordon J., Appella, Ettore, Romano, Joseph W., Ullrich, Stephen J.

“…To investigate the effect that human wild-type p53 (wt-p53) expression has on cell proliferation we constructed a recombinant plasmid, pM47, in which wt-p53…”
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Ectopic expression of decorin protein core causes a generalized growth suppression in neoplastic cells of various histogenetic origin and requires endogenous p21, an inhibitor of cyclin-dependent kinases by Santra, M, Mann, D M, Mercer, E W, Skorski, T, Calabretta, B, Iozzo, R V

“…Decorin belongs to a family of secreted, small, leucine-rich proteoglycans that affect matrix assembly and cellular growth. Ectopic expression of decorin…”
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Growth Suppression Induced by Wild-Type p53 Protein is Accompanied by Selective Down-Regulation of Proliferating-Cell Nuclear Antigen Expression by Mercer, W. Edward, Shields, Michelle T., Lin, David, Appella, Ettore, Ullrich, Stephen J.

“…The p53 gene is a frequent target of mutation in a wide variety of human cancers. Previously, it was reported that conditional expression of wild-type p53…”
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Salinity Preference in the Estuarine Teleost Fish Mummichog (Fundulus heteroclitus): Halocline Behavior by Marshall, W. S., Tait, J. C., Mercer, E. W.

“…Mummichogs prefer seawater (SW) but have wide ability to acclimate to extreme temperatures and salinities. In the field, minnow trapping revealed that…”
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Mutations in the retinoblastoma-related gene RB2/p130 in primary nasopharyngeal carcinoma by CLAUDIO, P. P, HOWARD, C. M, YAN FU, CINTI, C, CALIFANO, L, MICHELI, P, MERCER, E. W, CAPUTI, M, GIORDANO, A

“…Nasopharyngeal carcinoma (NPC) is an endemic cancer in southern China and northern Africa, and its pathogenesis is not yet well defined at the molecular level…”
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The p53 tumor suppressor protein, a modulator of cell proliferation by ULLRICH, S. J, ANDERSON, C. W, MERCER, W. E, APPELLA, E

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Phosphorylation at Ser-15 and Ser-392 in Mutant p53 Molecules from Human Tumors is Altered Compared to Wild-Type p53 by Ullrich, Stephen J., Sakaguchi, Kazuyasu, Lees-Miller, Susan P., Fiscella, Michele, Mercer, W. Edward, Anderson, Carl W., Appella, Ettore

“…The product of the p53 gene suppresses cell growth and plays a critical role in suppressing development of human tumors. p53 protein binds DNA, activates…”
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Inhibition of Cellular Proliferation by Antisense Oligodeoxynucleotides to PCNA Cyclin by Jaskulski, Dariusz, DeRiel, J. Kim, Mercer, W. Edward, Calabretta, Bruno, Baserga, Renato

“…The proliferating cell nuclear antigen (PCNA or cyclin) is a nuclear protein recently identified as a cofactor of DNA polymerase $\delta $. When exponentially…”
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Role of the p53 protein in cell proliferation as studied by microinjection of monoclonal antibodies by MERCER, W. E, AVIGNOLO, C, BASERGA, R

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Microinjection of Monoclonal Antibody to Protein p53 Inhibits Serum-Induced DNA Synthesis in 3T3 Cells by Mercer, W. Edward, Nelson, Douglas, DeLeo, Albert B., Old, Lloyd J., Baserga, Renato

“…Monoclonal antibody directed against the transformation-related protein p53 was microinjected manually into the nuclei of quiescent Swiss 3T3 mouse cells. The…”
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Wild type human p53 is antiproliferative in SV40-transformed hamster cells by Mercer, W E, Amin, M, Sauve, G J, Appella, E, Ullrich, S J, Romano, J W

“…The transformation related protein p53 has been implicated in the process of normal cell proliferation and neoplastic transformation. In this study, the…”
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p53-independent induction of WAF1/CIP1 in human leukemia cells is correlated with growth arrest accompanying monocyte/macrophage differentiation by WEI ZHANG, GRASSO, L, MCCLAIN, C. D, GAMBEL, A. M, YING CHA, TRAVALI, S, DEISSEROTH, A. B, MERCER, W. E

“…The p53 tumor suppressor gene plays a role in controlling a G1 phase checkpoint. The WAF1/CIP1 gene with encodes p21WAF1/CIP1 protein, an inhibitor of…”
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Expression of the p53 protein during the cell cycle of human peripheral blood lymphocytes by Mercer, W E, Baserga, R

“…We have investigated the role of the cellular p53 protein in the induction of growth in size and cell DNA replication in human peripheral blood lymphocytes…”
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Wip1, a Novel Human Protein Phosphatase that is Induced in Response to Ionizing Radiation in a p53-Dependent Manner by Fiscella, Michele, Zhang, HongLiang, Fan, Saijun, Sakaguchi, Kazuyasu, Shen, Songfa, Mercer, W. Edward, George F. Vande Woude, O'Connor, Patrick M., Appella, Ettore

“…Exposure of mammalian cells to ionizing radiation (IR) induces a complex array of cellular responses including cell cycle arrest and/or apoptosis. IR-induced…”
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Load Regulation of the Properties of Adult Feline Cardiocytes The Role of Substrate Adhesion by Cooper, George, Mercer, W Edward, Hoober, J Kenneth, Gordon, Pamela R, Kent, Robert L, Lauva, Ines K, Marino, Thomas A

“…We have recently described rapid and reversible changes in cardiac structure, function, and composition in response to surgical load alteration in vivo. In the…”
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Expression of thymidine kinase and dihydrofolate reductase genes in mammalian ts mutants of the cell cycle by Liu, H T, Gibson, C W, Hirschhorn, R R, Rittling, S, Baserga, R, Mercer, W E

“…Thymidine kinase and dihydrofolate reductase mRNA levels and enzyme activities were determined in two temperature-sensitive cell lines, tsAF8 and ts13, that…”
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Expression of a deletion mutant of the E2F1 transcription factor in fibroblasts lengthens S phase and increases sensitivity to S phase-specific toxins by LOGAN, T. J, EVANS, D. L, MERCER, W. E, BJORNSTI, M.-A, HALL, D. J

“…To better understand how the E2F1 transcription factor contributes to the process of cell proliferation, NIH-3T3 cell lines were generated that constitutively…”
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