Search Results - "MERCER, Julian F. B"

Localization of copper and copper transporters in the human brain by Davies, Katherine M, Hare, Dominic J, Cottam, Veronica, Chen, Nicholas, Hilgers, Leon, Halliday, Glenda, Mercer, Julian F B, Double, Kay L

“…Disturbances in brain copper result in rare and severe neurological disorders and may play a role in the pathogenesis and progression of multiple…”
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Copper accumulation by cultured astrocytes by Scheiber, Ivo F., Mercer, Julian F.B., Dringen, Ralf

“…To study copper transport in brain astrocytes, we have used astrocyte-rich primary cultures as model system. Cells in these cultures contained a basal copper…”
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Missense Mutations in the Copper Transporter Gene ATP7A Cause X-Linked Distal Hereditary Motor Neuropathy by Kennerson, Marina L., Nicholson, Garth A., Kaler, Stephen G., Kowalski, Bartosz, Mercer, Julian F.B., Tang, Jingrong, Llanos, Roxana M., Chu, Shannon, Takata, Reinaldo I., Speck-Martins, Carlos E., Baets, Jonathan, Almeida-Souza, Leonardo, Fischer, Dirk, Timmerman, Vincent, Taylor, Philip E., Scherer, Steven S., Ferguson, Toby A., Bird, Thomas D., De Jonghe, Peter, Feely, Shawna M.E., Shy, Michael E., Garbern, James Y.

“…Distal hereditary motor neuropathies comprise a clinically and genetically heterogeneous group of disorders. We recently mapped an X-linked form of this…”
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Altered intracellular localization and valosin-containing protein (p97 VCP) interaction underlie ATP7A-related distal motor neuropathy by LING YI, DONSANTE, Anthony, KENNERSON, Marina L, MERCER, Julian F. B, GARBERN, James Y, KALER, Stephen G

“…ATP7A is a P-type ATPase that regulates cellular copper homeostasis by activity at the trans-Golgi network (TGN) and plasma membrane (PM), with the location…”
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Metabolism and functions of copper in brain by Scheiber, Ivo F, Mercer, Julian F B, Dringen, Ralf

“…Copper is an important trace element that is required for essential enzymes. However, due to its redox activity, copper can also lead to the generation of…”
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Copper Transporter ATP7A Protects Against Endothelial Dysfunction in Type 1 Diabetic Mice by Regulating Extracellular Superoxide Dismutase by SUDHAHAR, Varadarajan, URAO, Norifumi, OSHIKAWA, Jin, MCKINNEY, Ronald D, LIANOS, Roxana M, MERCER, Julian F. B, USHIO-FUKAI, Masuko, FUKAI, Tohru

“…Oxidative stress and endothelial dysfunction contribute to vascular complication in diabetes. Extracellular superoxide dismutase (SOD3) is one of the key…”
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Copper metabolism of astrocytes by Dringen, Ralf, Scheiber, Ivo F, Mercer, Julian F B

“…This short review will summarize the current knowledge on the uptake, storage, and export of copper ions by astrocytes and will address the potential roles of…”
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Neuronal expression of copper transporter 1 in rat dorsal root ganglia: association with platinum neurotoxicity by Liu, Johnson J., Jamieson, Stephen M. F., Subramaniam, Joshuan, Ip, Virginia, Jong, Nancy N., Mercer, Julian F. B., McKeage, Mark J.

“…Purpose We report the neuronal expression of copper transporter 1 (CTR1) in rat dorsal root ganglia (DRG) and its association with the neurotoxicity of…”
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Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells by Hardman, Belinda, Michalczyk, Agnes, Greenough, Mark, Camakaris, James, Mercer, Julian F B, Ackland, M Leigh

“…Copper deficiency during pregnancy results in early embryonic death and foetal structural abnormalities including skeletal, pulmonary and cardiovascular…”
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Differential Expression of ATP7A, ATP7B and CTR1 in Adult Rat Dorsal Root Ganglion Tissue by Ip, Virginia, Liu, Johnson J, Mercer, Julian FB, McKeage, Mark J

“…Background: ATP7A, ATP7B and CTR1 are metal transporting proteins that control the cellular disposition of copper and platinum drugs, but their expression in…”
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Copper-dependent Interaction of Dynactin Subunit p62 with the N Terminus of ATP7B but Not ATP7A by Lim, Chris M., Cater, Michael A., Mercer, Julian F.B., La Fontaine, Sharon

“…The P-type ATPase affected in Wilson disease, ATP7B, is a key liver protein required to regulate and maintain copper homeostasis. When hepatocytes are exposed…”
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Lack of ceruloplasmin expression alters aspects of copper transport to the fetus and newborn, as determined in mice by Chu, Yu-Ling, Sauble, Eric N., Cabrera, Anthony, Roth, Aleeza, Leigh Ackland, M., Mercer, Julian F. B., Linder, Maria C.

“…Copper transport and accumulation were studied in virgin and lactating C57BL/6 mice, with and without expression of ceruloplasmin (Cp), to assess the…”
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Chronological changes in tissue copper, zinc and iron in the toxic milk mouse and effects of copper loading by Allen, Katrina J, Buck, Nicole E, Cheah, Daphne M Y, Gazeas, Sophie, Bhathal, Prithi, Mercer, Julian F B

“…The toxic milk (tx) mouse is a rodent model for Wilson disease, an inherited disorder of copper overload. Here we assessed the effect of copper accumulation in…”
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Copper comes of age in Melbourne by Mercer, Julian F. B, Camakaris, James

“…When we were asked to produce articles for this volume, it seemed appropriate to us to co-author an article on the history and impact of copper research in…”
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Heterozygous tx mice have an increased sensitivity to copper loading: Implications for Wilson's disease carriers by Cheah, Daphne M. Y, Deal, Yolanda J, Wright, Paul F. A, Buck, Nicole E, Chow, Chung Wo, Mercer, Julian F. B, Allen, Katrina J

“…Wilson's disease carriers constitute 1% of the human population. It is unknown whether Wilson's disease carriers are at increased susceptibility to copper…”
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Effects of ATP7A overexpression in mice on copper transport and metabolism in lactation and gestation by Wadwa, Jarrod, Chu, Yu‐Hsiang, Nguyen, Nhu, Henson, Thomas, Figueroa, Alyssa, Llanos, Roxana, Ackland, Margaret Leigh, Michalczyk, Agnes, Fullriede, Hendrik, Brennan, Grant, Mercer, Julian F. B., Linder, Maria C.

“…Placentae and mammary epithelial cells are unusual in robustly expressing two copper “pumps”, ATP7A and B, raising the question of their individual roles in…”
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Role of Glutaredoxin1 and Glutathione in Regulating the Activity of the Copper-transporting P-type ATPases, ATP7A and ATP7B by Singleton, William C.J., McInnes, Kelly T., Cater, Michael A., Winnall, Wendy R., McKirdy, Ross, Yu, Yu, Taylor, Philip E., Ke, Bi-Xia, Richardson, Des R., Mercer, Julian F.B., La Fontaine, Sharon

“…The copper-transporting P-type ATPases (Cu-ATPases), ATP7A and ATP7B, are essential for the regulation of intracellular copper homeostasis. In this report we…”
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Contributions of rat Ctr1 to the uptake and toxicity of copper and platinum anticancer drugs in dorsal root ganglion neurons by Liu, Johnson J., Kim, Yaeseul, Yan, Fang, Ding, Qi, Ip, Virginia, Jong, Nancy N., Mercer, Julian F.B., McKeage, Mark J.

“…Dorsal root ganglion (DRG) neurons are affected by platinum-induced neurotoxicity and neurodegenerative processes associated with disturbed copper homeostasis…”
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Intracellular trafficking of the human Wilson protein: the role of the six N-terminal metal-binding sites by Cater, Michael A, Forbes, John, La Fontaine, Sharon, Cox, Diane, Mercer, Julian F B

“…The Wilson protein (ATP7B) is a copper-transporting CPx-type ATPase defective in the copper toxicity disorder Wilson disease. In hepatocytes, ATP7B delivers…”
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Copper: effects of deficiency and overload by Scheiber, Ivo, Dringen, Ralf, Mercer, Julian F B

“…Copper is an essential trace metal that is required for the catalysis of several important cellular enzymes. However, since an excess of copper can also harm…”
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