Search Results - "MERCADER, JOSEP M."

Cardiometabolic risk factors for COVID-19 susceptibility and severity: A Mendelian randomization analysis by Leong, Aaron, Cole, Joanne B, Brenner, Laura N, Meigs, James B, Florez, Jose C, Mercader, Josep M

“…Epidemiological studies report associations of diverse cardiometabolic conditions including obesity with COVID-19 illness, but causality has not been…”
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Type 2 diabetes genetic loci informed by multi-trait associations point to disease mechanisms and subtypes: A soft clustering analysis by Udler, Miriam S, Kim, Jaegil, von Grotthuss, Marcin, Bonàs-Guarch, Sílvia, Cole, Joanne B, Chiou, Joshua, Boehnke, Michael, Laakso, Markku, Atzmon, Gil, Glaser, Benjamin, Mercader, Josep M, Gaulton, Kyle, Flannick, Jason, Getz, Gad, Florez, Jose C

“…Type 2 diabetes (T2D) is a heterogeneous disease for which (1) disease-causing pathways are incompletely understood and (2) subclassification may improve…”
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The impact of non-additive genetic associations on age-related complex diseases by Guindo-Martínez, Marta, Amela, Ramon, Bonàs-Guarch, Silvia, Puiggròs, Montserrat, Salvoro, Cecilia, Miguel-Escalada, Irene, Carey, Caitlin E., Cole, Joanne B., Rüeger, Sina, Atkinson, Elizabeth, Leong, Aaron, Sanchez, Friman, Ramon-Cortes, Cristian, Ejarque, Jorge, Palmer, Duncan S., Kurki, Mitja, Aragam, Krishna, Florez, Jose C., Badia, Rosa M., Mercader, Josep M., Torrents, David

“…Genome-wide association studies (GWAS) are not fully comprehensive, as current strategies typically test only the additive model, exclude the X chromosome, and…”
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Type 2 Diabetes Polygenic Score Predicts the Risk of Glucocorticoid-Induced Hyperglycemia in Patients Without Diabetes by Deutsch, Aaron J, Schroeder, Philip H, Mandla, Ravi, Kang, Sarah, Erenler, Feyza, Mercader, Josep M, Udler, Miriam S, Florez, Jose C, Brenner, Laura N

“…To assess whether increased genetic risk of type 2 diabetes (T2D) is associated with the development of hyperglycemia after glucocorticoid treatment. We…”
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SNPassoc: an R package to perform whole genome association studies by González, Juan R., Armengol, Lluís, Solé, Xavier, Guinó, Elisabet, Mercader, Josep M., Estivill, Xavier, Moreno, Víctor

“…The popularization of large-scale genotyping projects has led to the widespread adoption of genetic association studies as the tool of choice in the search for…”
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New insights into the expression profile and function of micro-ribonucleic acid in human spermatozoa by Salas-Huetos, Albert, M.Sc, Blanco, Joan, Ph.D, Vidal, Francesca, Ph.D, Mercader, Josep M., Ph.D, Garrido, Nicolás, Ph.D, Anton, Ester, Ph.D

“…Objective To characterize the microRNA (miRNA) expression profile in spermatozoa from human fertile individuals and their implications in human fertility…”
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Genome-wide association studies in the Japanese population identify seven novel loci for type 2 diabetes by Imamura, Minako, Takahashi, Atsushi, Yamauchi, Toshimasa, Hara, Kazuo, Yasuda, Kazuki, Grarup, Niels, Zhao, Wei, Wang, Xu, Huerta-Chagoya, Alicia, Hu, Cheng, Moon, Sanghoon, Long, Jirong, Kwak, Soo Heon, Rasheed, Asif, Saxena, Richa, Ma, Ronald C. W., Okada, Yukinori, Iwata, Minoru, Hosoe, Jun, Shojima, Nobuhiro, Iwasaki, Minaka, Fujita, Hayato, Suzuki, Ken, Danesh, John, Jørgensen, Torben, Jørgensen, Marit E., Witte, Daniel R., Brandslund, Ivan, Christensen, Cramer, Hansen, Torben, Mercader, Josep M., Flannick, Jason, Moreno-Macías, Hortensia, Burtt, Noël P., Zhang, Rong, Kim, Young Jin, Zheng, Wei, Singh, Jai Rup, Tam, Claudia H. T., Hirose, Hiroshi, Maegawa, Hiroshi, Ito, Chikako, Kaku, Kohei, Watada, Hirotaka, Tanaka, Yasushi, Tobe, Kazuyuki, Kawamori, Ryuzo, Kubo, Michiaki, Cho, Yoon Shin, Chan, Juliana C. N., Sanghera, Dharambir, Frossard, Philippe, Park, Kyong Soo, Shu, Xiao-Ou, Kim, Bong-Jo, Florez, Jose C., Tusié-Luna, Teresa, Jia, Weiping, Tai, E Shyong, Pedersen, Oluf, Saleheen, Danish, Maeda, Shiro, Kadowaki, Takashi

“…Genome-wide association studies (GWAS) have identified more than 80 susceptibility loci for type 2 diabetes (T2D), but most of its heritability still remains…”
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Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus by Julià, Antonio, López-Longo, Francisco Javier, Pérez Venegas, José J, Bonàs-Guarch, Silvia, Olivé, Àlex, Andreu, José Luís, Aguirre-Zamorano, Mª Ángeles, Vela, Paloma, Nolla, Joan M, de la Fuente, José Luís Marenco, Zea, Antonio, Pego-Reigosa, José María, Freire, Mercedes, Díez, Elvira, Rodríguez-Almaraz, Esther, Carreira, Patricia, Blanco, Ricardo, Taboada, Víctor Martínez, López-Lasanta, María, Corbeto, Mireia López, Mercader, Josep M, Torrents, David, Absher, Devin, Marsal, Sara, Fernández-Nebro, Antonio

“…Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with a complex genetic inheritance. Genome-wide association studies (GWAS) have…”
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Algorithms for the identification of prevalent diabetes in the All of Us Research Program validated using polygenic scores by Szczerbinski, Lukasz, Mandla, Ravi, Schroeder, Philip, Porneala, Bianca C., Li, Josephine H., Florez, Jose C., Mercader, Josep M., Udler, Miriam S., Manning, Alisa K.

“…The All of Us Research Program (AoU) is an initiative designed to gather a comprehensive and diverse dataset from at least one million individuals across the…”
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Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum by Ganna, Andrea, Satterstrom, F. Kyle, Zekavat, Seyedeh M., Das, Indraniel, Kurki, Mitja I., Churchhouse, Claire, Alfoldi, Jessica, Martin, Alicia R., Havulinna, Aki S., Byrnes, Andrea, Thompson, Wesley K., Nielsen, Philip R., Karczewski, Konrad J., Saarentaus, Elmo, Rivas, Manuel A., Gupta, Namrata, Pietiläinen, Olli, Emdin, Connor A., Lescai, Francesco, Bybjerg-Grauholm, Jonas, Flannick, Jason, Mercader, Josep M., Udler, Miriam, Laakso, Markku, Salomaa, Veikko, Hultman, Christina, Ripatti, Samuli, Hämäläinen, Eija, Moilanen, Jukka S., Körkkö, Jarmo, Kuismin, Outi, Nordentoft, Merete, Hougaard, David M., Mors, Ole, Werge, Thomas, Mortensen, Preben Bo, MacArthur, Daniel, Daly, Mark J., Sullivan, Patrick F., Locke, Adam E., Palotie, Aarno, Børglum, Anders D., Kathiresan, Sekar, Neale, Benjamin M.

“…There is a limited understanding about the impact of rare protein-truncating variants across multiple phenotypes. We explore the impact of this class of…”
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Brain-Derived Neurotrophic Factor Val66Met and Psychiatric Disorders: Meta-Analysis of Case-Control Studies Confirm Association to Substance-Related Disorders, Eating Disorders, and Schizophrenia by Gratacòs, Mònica, González, Juan R, Mercader, Josep M, de Cid, Rafael, Urretavizcaya, Mikel, Estivill, Xavier

“…Background There is an increasing recognition that the pathophysiology of mental disorders could be the result of deregulation of synaptic plasticity with…”
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Polygenic scores for longitudinal prediction of incident type 2 diabetes in an ancestrally and medically diverse primary care physician network: a patient cohort study by Mandla, Ravi, Schroeder, Philip, Porneala, Bianca, Florez, Jose C, Meigs, James B, Mercader, Josep M, Leong, Aaron

“…The clinical utility of genetic information for type 2 diabetes (T2D) prediction with polygenic scores (PGS) in ancestrally diverse, real-world US healthcare…”
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Circulating profiling reveals the effect of a polyunsaturated fatty acid-enriched diet on common microRNAs by Ortega, Francisco J., Cardona-Alvarado, Mónica I., Mercader, Josep M., Moreno-Navarrete, José M., Moreno, María, Sabater, Mònica, Fuentes-Batllevell, Núria, Ramírez-Chávez, Enrique, Ricart, Wifredo, Molina-Torres, Jorge, Pérez-Luque, Elva L., Fernández-Real, José M.

“…Consumption of long-chain polyunsaturated fatty acids (PUFAs), which are abundant in seafood and nuts, ameliorates components of the metabolic syndrome…”
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The Genetic Basis of Type 2 Diabetes in Hispanics and Latin Americans: Challenges and Opportunities by Mercader, Josep M, Florez, Jose C

“…Type 2 diabetes (T2D) affects 415 million people worldwide, and has a much higher prevalence in Hispanics (16.9%), compared to non-Hispanic whites (10.2%)…”
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Using metabolite profiling to construct and validate a metabolite risk score for predicting future weight gain by Geidenstam, Nina, Hsu, Yu-Han H, Astley, Christina M, Mercader, Josep M, Ridderstråle, Martin, Gonzalez, Maria E, Gonzalez, Clicerio, Hirschhorn, Joel N, Salem, Rany M

“…Excess weight gain throughout adulthood can lead to adverse clinical outcomes and are influenced by complex factors that are difficult to measure in…”
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PAIRUP-MS: Pathway analysis and imputation to relate unknowns in profiles from mass spectrometry-based metabolite data by Hsu, Yu-Han H, Churchhouse, Claire, Pers, Tune H, Mercader, Josep M, Metspalu, Andres, Fischer, Krista, Fortney, Kristen, Morgen, Eric K, Gonzalez, Clicerio, Gonzalez, Maria E, Esko, Tonu, Hirschhorn, Joel N

“…Metabolomics is a powerful approach for discovering biomarkers and for characterizing the biochemical consequences of genetic variation. While untargeted…”
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Adaptation to environmental factors shapes the organization of regulatory regions in microbial communities by Fernandez, Leyden, Mercader, Josep M, Planas-Fèlix, Mercè, Torrents, David

“…It has been shown in a number of metagenomic studies that the addition and removal of specific genes have allowed microbiomes to adapt to specific…”
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Proteomic analysis of cardiometabolic biomarkers and predictive modeling of severe outcomes in patients hospitalized with COVID-19 by Schroeder, Philip H, Brenner, Laura N, Kaur, Varinderpal, Cromer, Sara J, Armstrong, Katrina, LaRocque, Regina C, Ryan, Edward T, Meigs, James B, Florez, Jose C, Charles, Richelle C, Mercader, Josep M, Leong, Aaron

“…The high heterogeneity in the symptoms and severity of COVID-19 makes it challenging to identify high-risk patients early in the disease. Cardiometabolic…”
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Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug by Wu, Hao, Esteve, Eduardo, Tremaroli, Valentina, Khan, Muhammad Tanweer, Caesar, Robert, Mannerås-Holm, Louise, Ståhlman, Marcus, Olsson, Lisa M, Serino, Matteo, Planas-Fèlix, Mercè, Xifra, Gemma, Mercader, Josep M, Torrents, David, Burcelin, Rémy, Ricart, Wifredo, Perkins, Rosie, Fernàndez-Real, José Manuel, Bäckhed, Fredrik

“…A randomized clinical trial reveals that the antidiabetic effects of metformin are at least partially due to beneficial changes in the microbiota. Metformin is…”
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Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems by Mercader, Josep M, Puiggros, Montserrat, Segrè, Ayellet V, Planet, Evarist, Sorianello, Eleonora, Sebastian, David, Rodriguez-Cuenca, Sergio, Ribas, Vicent, Bonàs-Guarch, Sílvia, Draghici, Sorin, Yang, Chenjing, Mora, Sílvia, Vidal-Puig, Antoni, Dupuis, Josée, Florez, Jose C, Zorzano, Antonio, Torrents, David

“…Type 2 Diabetes (T2D) is a highly prevalent chronic metabolic disease with strong co-morbidity with obesity and cardiovascular diseases. There is growing…”
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